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Gene: Cyp4a8 (cytochrome P450, family 4, subfamily a, polypeptide 8) Rattus norvegicus
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Symbol: Cyp4a8
Name: cytochrome P450, family 4, subfamily a, polypeptide 8
Description: Exhibits monooxygenase activity. Involved in fatty acid metabolic process; kidney development; and response to testosterone. Localizes to the intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22); PARTICIPATES IN arachidonic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp4a12; CYPIVA12; CYPIVA8; cytochrome P450 4A12; cytochrome P450, 4a12; cytochrome P450-KP1; cytochrome P450-PP1; MGC93354; P450-KP1; P450-PP1
Orthologs:
No known orthologs. homologs ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05133,978,953 - 134,008,255 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,978,954 - 134,008,255 (-)Ensembl
Rnor_5.05137,769,865 - 137,799,167 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,546,858 - 135,578,199 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15135,552,083 - 135,583,425 (-)NCBI
Celera5127,340,416 - 127,371,735 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp4a8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628846
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.