Cyp4a8 (cytochrome P450, family 4, subfamily a, polypeptide 8) - Rat Genome Database

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Gene: Cyp4a8 (cytochrome P450, family 4, subfamily a, polypeptide 8) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp4a8
Name: cytochrome P450, family 4, subfamily a, polypeptide 8
RGD ID: 628846
Description: Enables fatty acid omega-hydroxylase activity. Involved in fatty acid metabolic process; kidney development; and response to testosterone. Located in endoplasmic reticulum membrane. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22); PARTICIPATES IN arachidonic acid metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp4a12; CYPIVA12; CYPIVA8; cytochrome P450 4A12; cytochrome P450, 4a12; cytochrome P450-KP1; cytochrome P450-PP1; MGC93354; P450-KP1; P450-PP1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Cyp4a8-ps1  
Candidate Gene For: Rf54
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85133,938,882 - 133,970,226 (-)NCBIGRCr8
mRatBN7.25128,702,130 - 128,733,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5128,702,131 - 128,733,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,384,778 - 131,406,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,114,432 - 133,136,521 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,136,126 - 133,158,217 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05133,978,953 - 134,008,255 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,978,954 - 134,008,255 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05137,769,865 - 137,799,167 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,546,858 - 135,578,199 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,552,083 - 135,583,425 (-)NCBI
Celera5127,340,416 - 127,371,735 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Ratautosomal recessive polycystic kidney disease  IEP 2303380mRNA:increased expression:kidneyRGD 
Cyp4a8Rathypertension  IEP 2303381 RGD 
Cyp4a8Rathypertension  IEP 2303383mRNA:decreased expression:kidney cortexRGD 

1 to 20 of 56 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of CYP4A8 mRNACTDPMID:32145629
Cyp4a8Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP4A8 mRNACTDPMID:27291303|PMID:32679240
Cyp4a8Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CYP4A8 mRNACTDPMID:21215274|PMID:32387183
Cyp4a8Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CYP4A8 mRNACTDPMID:21724226|PMID:33387578
Cyp4a8Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...CTDPMID:36041667
Cyp4a8Rat5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expressionEXP 6480464Omeprazole affects the expression of CYP4A8 mRNACTDPMID:19483382
Cyp4a8Rat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of CYP4A8 mRNACTDPMID:19483382
Cyp4a8Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of CYP4A8 mRNACTDPMID:31881176
Cyp4a8Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of CYP4A8 mRNACTDPMID:28959563
Cyp4a8Rataflatoxin B1 decreases expressionEXP 6480464Aflatoxin B1 results in decreased expression of CYP4A8 mRNACTDPMID:23630614|PMID:33354967
Cyp4a8Ratalpha-hexachlorocyclohexane increases expressionEXP 6480464alpha-hexachlorocyclohexane results in increased expression of CYP4A8 mRNACTDPMID:17785943
Cyp4a8Ratamiodarone affects expressionEXP 6480464Amiodarone affects the expression of CYP4A8 mRNACTDPMID:19483382
Cyp4a8Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CYP4A8 mRNACTDPMID:16483693
Cyp4a8Ratanthracen-2-amine decreases expressionEXP 64804642-anthramine results in decreased expression of CYP4A8 mRNACTDPMID:23038007
Cyp4a8Ratbenzbromarone affects expressionEXP 6480464Benzbromarone affects the expression of CYP4A8 mRNACTDPMID:19483382
Cyp4a8Ratbeta-naphthoflavone multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP4A8 mRNACTDPMID:18164116
Cyp4a8Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of CYP4A8 mRNACTDPMID:30903817|PMID:32145629
Cyp4a8Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...CTDPMID:36041667
Cyp4a8Ratbisphenol F multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ...CTDPMID:36041667
Cyp4a8Ratclofibrate affects expressionEXP 6480464Clofibrate affects the expression of CYP4A8 mRNACTDPMID:19483382

1 to 20 of 56 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Ratarachidonate metabolic process  IDA 2303409 RGD 
Cyp4a8Ratarachidonate metabolic process involved_inIBAMGI:3611747|MGI:88612|PANTHER:PTN000669780|RGD:2479|RGD:628846|RGD:631356|RGD:68945|UniProtKB:Q029281600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratfatty acid metabolic process involved_inIDA 8554841PMID:11139583UniProt 
Cyp4a8Ratfatty acid metabolic process involved_inIEAUniPathway:UPA001991600115GO_REF:0000041UniProtGO_REF:0000041
Cyp4a8Raticosanoid biosynthetic process involved_inIBAPANTHER:PTN000669780|RGD:2479|RGD:631356|RGD:689451600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratkidney development  IEP 2303411 RGD 
Cyp4a8Ratkidney development involved_inIBAPANTHER:PTN000669780|RGD:2479|RGD:628846|RGD:631356|RGD:689451600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratlauric acid metabolic process  IDA 2303410 RGD 
Cyp4a8Ratlauric acid metabolic process involved_inIBAPANTHER:PTN000669780|RGD:2479|RGD:628846|RGD:631356|RGD:689451600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratlauric acid metabolic process involved_inIDA 2303409PMID:15618658UniProt 
Cyp4a8Ratlinoleic acid metabolic process involved_inIBAPANTHER:PTN000669780|RGD:2479|RGD:631356|RGD:689451600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratlipid metabolic process involved_inIEAARBA:ARBA000285911600115GO_REF:0000117UniProtGO_REF:0000117
Cyp4a8Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Cyp4a8Ratresponse to testosterone  IEP 2303382 RGD 
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp4a8Ratendoplasmic reticulum membrane located_inIDA 2303409PMID:15618658UniProt 
Cyp4a8Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp4a8Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Ratalkane 1-monooxygenase activity enablesIBAMGI:88612|PANTHER:PTN000669780|RGD:2479|RGD:631356|RGD:68945|UniProtKB:Q029281600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratarachidonate monooxygenase activity enablesIBAPANTHER:PTN000669780|RGD:2479|RGD:631356|RGD:68945|UniProtKB:Q029281600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp4a8Ratarachidonate omega-hydroxylase activity enablesIEARHEA:397551600115GO_REF:0000116RHEAGO_REF:0000116
Cyp4a8Ratfatty acid omega-hydroxylase activity enablesIDA 2303409PMID:15618658UniProt 
Cyp4a8Ratheme binding enablesIEAInterPro:IPR001128|InterPro:IPR002401|InterPro:IPR0363961600115GO_REF:0000002InterProGO_REF:0000002
Cyp4a8Ratiron ion binding enablesIEAInterPro:IPR001128|InterPro:IPR002401|InterPro:IPR017972|InterPro:IPR0363961600115GO_REF:0000002InterProGO_REF:0000002
Cyp4a8Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp4a8Ratmonooxygenase activity enablesIDA 8554841PMID:11139583UniProt 
Cyp4a8Ratmonooxygenase activity enablesIEAUniProtKB-KW:KW-05031600115GO_REF:0000043UniProtGO_REF:0000043
Cyp4a8Ratmonooxygenase activity enablesIEAInterPro:IPR001128|InterPro:IPR002401|InterPro:IPR0363961600115GO_REF:0000002InterProGO_REF:0000002
Cyp4a8Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Cyp4a8Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128|InterPro:IPR002401|InterPro:IPR017972|InterPro:IPR0363961600115GO_REF:0000002InterProGO_REF:0000002
Cyp4a8Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEARHEA:171491600115GO_REF:0000116RHEAGO_REF:0000116
Cyp4a8Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAEC:1.14.14.11600115GO_REF:0000003UniProtGO_REF:0000003
Cyp4a8Ratoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAARBA:ARBA000277351600115GO_REF:0000117UniProtGO_REF:0000117
1 to 15 of 15 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Ratarachidonic acid metabolic pathway  IMP 2303409 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp4a8Ratarachidonic acid metabolic pathway  IEA 6907045 KEGGrno:00590
Cyp4a8Rateicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma  IEA 6907045 KEGGrno:03320
Cyp4a8Ratfatty acid metabolic pathway  IEA 6907045 KEGGrno:00071
Cyp4a8Ratretinol metabolic pathway   IEA 6907045 KEGGrno:00830

1 to 16 of 16 rows
#
Reference Title
Reference Citation
1. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. Cowart LA, etal., J Biol Chem. 2002 Sep 20;277(38):35105-12. Epub 2002 Jul 17.
2. Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. Dunn KM, etal., Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2455-65. Epub 2008 Oct 24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Covalently linked heme in cytochrome p4504a fatty acid hydroxylases. Hoch U and Ortiz De Montellano PR, J Biol Chem. 2001 Apr 6;276(14):11339-46. Epub 2001 Jan 3.
6. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Kroetz DL, etal., Mol Pharmacol. 1997 Sep;52(3):362-72.
7. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Nguyen X, etal., Am J Physiol. 1999 Jun;276(6 Pt 2):R1691-700.
8. Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. Park F, etal., Am J Physiol Renal Physiol. 2009 Jan 7.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Singh H and Schwartzman ML, Pharmacol Rep. 2008 Jan-Feb;60(1):29-37.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Cloning and characterization of a novel member of the cytochrome P450 subfamily IVA in rat prostate. Stromstedt M, etal., DNA Cell Biol 1990 Oct;9(8):569-77.
15. Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney. Yamaguchi Y, etal., Drug Metab Pharmacokinet. 2002;17(2):109-16.
16. Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. Zhou Y, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):11-8. Epub 2005 Dec 8.
1 to 16 of 16 rows
PMID:15489334   PMID:25865156  



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Variants in Cyp4a8
789 total Variants

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000012448
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 50 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat

1 to 10 of 50 rows
RH135045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25128,702,633 - 128,702,814 (+)MAPPERmRatBN7.2
Rnor_6.05133,979,457 - 133,979,637NCBIRnor6.0
Rnor_5.05137,770,369 - 137,770,549UniSTSRnor5.0
RGSC_v3.45135,547,362 - 135,547,542UniSTSRGSC3.4
Celera5127,340,920 - 127,341,100UniSTS
RH 3.4 Map5828.6UniSTS
Cytogenetic Map5q36UniSTS
AA893011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25128,702,186 - 128,702,420 (+)MAPPERmRatBN7.2
Rnor_6.05133,979,010 - 133,979,243NCBIRnor6.0
Rnor_5.05137,769,922 - 137,770,155UniSTSRnor5.0
RGSC_v3.45135,546,915 - 135,547,148UniSTSRGSC3.4
Celera5127,340,473 - 127,340,706UniSTS
RH 3.4 Map5836.0UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 17 47 78 76 47 25 47 5 166 61 28 42 37 29



Ensembl Acc Id: ENSRNOT00000012448   ⟹   ENSRNOP00000012448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5128,702,131 - 128,733,476 (-)Ensembl
Rnor_6.0 Ensembl5133,978,954 - 134,008,255 (-)Ensembl
RefSeq Acc Id: NM_031605   ⟹   NP_113793
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,938,882 - 133,970,226 (-)NCBI
mRatBN7.25128,702,130 - 128,733,476 (-)NCBI
Rnor_6.05133,978,953 - 134,008,255 (-)NCBI
Rnor_5.05137,769,865 - 137,799,167 (-)NCBI
RGSC_v3.45135,546,858 - 135,578,199 (-)RGD
Celera5127,340,416 - 127,371,735 (-)RGD
Sequence:
Protein RefSeqs NP_113793 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63485 (Get FASTA)   NCBI Sequence Viewer  
  AAH81771 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012448
  ENSRNOP00000012448.4
GenBank Protein P24464 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113793   ⟸   NM_031605
- UniProtKB: Q642E9 (UniProtKB/Swiss-Prot),   P24464 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012448   ⟸   ENSRNOT00000012448

Name Modeler Protein Id AA Range Protein Structure
AF-P24464-F1-model_v2 AlphaFold P24464 1-508 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693916
Promoter ID:EPDNEW_R4441
Type:multiple initiation site
Name:Cyp4a8_1
Description:cytochrome P450, family 4, subfamily a, polypeptide 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05134,008,268 - 134,008,328EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40296 BioCyc
Ensembl Genes ENSRNOG00000008842 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012448 ENTREZGENE
  ENSRNOT00000012448.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108258 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
KEGG Report rno:266674 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93354 IMAGE-MGC_LOAD
NCBI Gene 266674 ENTREZGENE
PANTHER CYTOCHROME P450 4A11-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4a8 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008842 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP4AC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642E9 ENTREZGENE
UniProt Secondary Q642E9 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp4a8  cytochrome P450, family 4, subfamily a, polypeptide 8  Cyp4a12  cytochrome P450, 4a12  Name updated 1299863 APPROVED
2003-02-27 Cyp4a12  cytochrome P450, 4a12      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_regulation expression is induced by androgen treatment of castrated rats 70705