FGFBP3 (fibroblast growth factor binding protein 3) - Rat Genome Database

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Gene: FGFBP3 (fibroblast growth factor binding protein 3) Homo sapiens
Analyze
Symbol: FGFBP3
Name: fibroblast growth factor binding protein 3
RGD ID: 1347294
HGNC Page HGNC
Description: Exhibits fibroblast growth factor binding activity and heparin binding activity. Involved in positive regulation of fibroblast growth factor receptor signaling pathway and positive regulation of vascular permeability. Localizes to extracellular region; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C10orf13; chromosome 10 open reading frame 13; FGF-binding protein 3; FGF-BP3; FGFBP-3; fibroblast growth factor-binding protein 3; MGC39320
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1091,906,584 - 91,909,486 (-)EnsemblGRCh38hg38GRCh38
GRCh381091,906,584 - 91,909,486 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371093,666,341 - 93,669,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361093,656,326 - 93,659,220 (-)NCBINCBI36hg18NCBI36
Build 341093,656,325 - 93,659,220NCBI
Celera1087,410,015 - 87,412,928 (-)NCBI
Cytogenetic Map10q23.32NCBI
HuRef1087,295,095 - 87,298,008 (-)NCBIHuRef
CHM1_11093,948,108 - 93,951,021 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15164054   PMID:15489334   PMID:16303743   PMID:18669637   PMID:21873635   PMID:23658023  


Genomics

Comparative Map Data
FGFBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1091,906,584 - 91,909,486 (-)EnsemblGRCh38hg38GRCh38
GRCh381091,906,584 - 91,909,486 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371093,666,341 - 93,669,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361093,656,326 - 93,659,220 (-)NCBINCBI36hg18NCBI36
Build 341093,656,325 - 93,659,220NCBI
Celera1087,410,015 - 87,412,928 (-)NCBI
Cytogenetic Map10q23.32NCBI
HuRef1087,295,095 - 87,298,008 (-)NCBIHuRef
CHM1_11093,948,108 - 93,951,021 (-)NCBICHM1_1
Fgfbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,894,950 - 36,896,999 (-)NCBIGRCm39mm39
GRCm39 Ensembl1936,894,950 - 36,897,015 (-)Ensembl
GRCm381936,917,550 - 36,919,599 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,917,550 - 36,919,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv371936,992,040 - 36,994,089 (-)NCBIGRCm37mm9NCBIm37
MGSCv361936,982,694 - 36,984,743 (-)NCBImm8
Celera1937,692,946 - 37,694,994 (-)NCBICelera
Cytogenetic Map19C2NCBI
Fgfbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,644,023 - 234,646,028 (-)NCBI
Rnor_6.0 Ensembl1255,555,050 - 255,557,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01255,555,050 - 255,557,055 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01263,030,909 - 263,032,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,188,007 - 241,190,012 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1231,736,345 - 231,738,350 (-)NCBICelera
Cytogenetic Map1q53NCBI
FGFBP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11092,176,159 - 92,178,928 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01088,655,350 - 88,657,282 (-)NCBIMhudiblu_PPA_v0panPan3
FGFBP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,398,604 - 6,402,008 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,400,234 - 6,401,013 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha286,576,150 - 6,577,507 (-)NCBI
ROS_Cfam_1.0286,654,254 - 6,655,611 (-)NCBI
UMICH_Zoey_3.1286,380,733 - 6,382,084 (-)NCBI
UNSW_CanFamBas_1.0286,413,932 - 6,415,289 (-)NCBI
UU_Cfam_GSD_1.0286,578,621 - 6,579,978 (-)NCBI
Fgfbp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,102,729 - 41,105,003 (+)NCBI
SpeTri2.0NW_0049366012,735,898 - 2,736,889 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFBP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,515,795 - 103,517,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,515,787 - 103,518,055 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FGFBP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,180,347 - 85,184,160 (-)NCBI
ChlSab1.1 Ensembl985,182,205 - 85,182,987 (-)Ensembl
Fgfbp3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247373,181,568 - 3,183,815 (-)NCBI

Position Markers
SHGC-34818  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371093,668,965 - 93,669,091UniSTSGRCh37
Build 361093,658,945 - 93,659,071RGDNCBI36
Celera1087,412,635 - 87,412,761RGD
Cytogenetic Map10q23.32UniSTS
HuRef1087,297,715 - 87,297,841UniSTS
GeneMap99-GB4 RH Map10440.85UniSTS
Whitehead-RH Map10533.3UniSTS
GeneMap99-G3 RH Map104440.0UniSTS
RH44571  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371093,668,917 - 93,669,091UniSTSGRCh37
Build 361093,658,897 - 93,659,071RGDNCBI36
Celera1087,412,587 - 87,412,761RGD
Cytogenetic Map10q23.32UniSTS
HuRef1087,297,667 - 87,297,841UniSTS
GeneMap99-GB4 RH Map10440.02UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:657
Count of miRNA genes:497
Interacting mature miRNAs:545
Transcripts:ENST00000311575
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 11 1 29 5 12 5 257 6 167 5 42 35 71
Low 2373 2159 1466 391 1312 233 3978 1803 3553 371 1390 1528 171 1 1171 2611 3
Below cutoff 49 825 229 225 608 225 121 383 13 42 18 45 2 33 106 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000311575   ⟹   ENSP00000339067
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1091,906,584 - 91,909,486 (-)Ensembl
RefSeq Acc Id: NM_152429   ⟹   NP_689642
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381091,906,584 - 91,909,486 (-)NCBI
GRCh371093,666,345 - 93,669,258 (-)RGD
Build 361093,656,326 - 93,659,220 (-)NCBI Archive
Celera1087,410,015 - 87,412,928 (-)RGD
HuRef1087,295,095 - 87,298,008 (-)ENTREZGENE
CHM1_11093,948,108 - 93,951,021 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_689642   ⟸   NM_152429
- Peptide Label: precursor
- UniProtKB: Q8TAT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000339067   ⟸   ENST00000311575

Promoters
RGD ID:7218145
Promoter ID:EPDNEW_H14818
Type:initiation region
Name:FGFBP3_1
Description:fibroblast growth factor binding protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381091,909,486 - 91,909,546EPDNEW
RGD ID:6787712
Promoter ID:HG_KWN:10549
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_152429,   UC009XTZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361093,658,061 - 93,659,357 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384)x1 copy number loss See cases [RCV000447362] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss PARP Inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q23.32-23.33(chr10:93186527-95820286)x1 copy number loss See cases [RCV000511278] Chr10:93186527..95820286 [GRCh37]
Chr10:10q23.32-23.33
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q23.32(chr10:93668341-93668663)x1 copy number loss not provided [RCV000749769] Chr10:93668341..93668663 [GRCh37]
Chr10:10q23.32
benign
GRCh37/hg19 10q23.32(chr10:93668341-93673004)x1 copy number loss not provided [RCV000749770] Chr10:93668341..93673004 [GRCh37]
Chr10:10q23.32
benign
GRCh37/hg19 10q23.32(chr10:93668371-93668612)x1 copy number loss not provided [RCV000749771] Chr10:93668371..93668612 [GRCh37]
Chr10:10q23.32
benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23428 AgrOrtholog
COSMIC FGFBP3 COSMIC
Ensembl Genes ENSG00000174721 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000339067 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000311575 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000174721 GTEx
HGNC ID HGNC:23428 ENTREZGENE
Human Proteome Map FGFBP3 Human Proteome Map
InterPro FGF1-bd UniProtKB/Swiss-Prot
KEGG Report hsa:143282 UniProtKB/Swiss-Prot
NCBI Gene 143282 ENTREZGENE
PANTHER PTHR15258 UniProtKB/Swiss-Prot
Pfam FGF-BP1 UniProtKB/Swiss-Prot
PharmGKB PA162388444 PharmGKB
UniProt FGFP3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RD68 UniProtKB/Swiss-Prot
  Q8NBN0 UniProtKB/Swiss-Prot