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Gene: CYP4A11 (cytochrome P450 family 4 subfamily A member 11) Homo sapiens
Symbol: CYP4A11
Name: cytochrome P450 family 4 subfamily A member 11
RGD ID: 730831
Description: Exhibits alkane 1-monooxygenase activity; arachidonic acid epoxygenase activity; and leukotriene-B4 20-monooxygenase activity. Involved in several processes, including icosanoid metabolic process; positive regulation of icosanoid secretion; and renal water homeostasis. Localizes to apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Implicated in hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; alkane-1 monooxygenase; CP4Y; CYP4A2; CYP4AII; CYPIVA11; cytochrome P-450HK-omega; cytochrome P450 4A11; cytochrome P450, family 4, subfamily A, polypeptide 11; cytochrome P450, subfamily IVA, polypeptide 11; cytochrome P450HL-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase; P450HL-omega
Related Pseudogenes: CYP4A26P   CYP4A27P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl146,929,177 - 46,941,484 (-)EnsemblGRCh38hg38GRCh38
GRCh38146,929,177 - 46,941,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37147,394,846 - 47,407,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,167,433 - 47,180,004 (-)NCBINCBI36hg18NCBI36
Build 34147,106,865 - 47,119,437NCBI
Celera145,682,030 - 45,694,343 (-)NCBI
Cytogenetic Map1p33NCBI
HuRef145,510,976 - 45,523,289 (-)NCBIHuRef
CHM1_1147,511,628 - 47,523,937 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP4A11
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730831
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.