Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CITED4 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of CITED4 mRNA | CTD | PMID:30723492 | 17alpha-ethynylestradiol | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CITED4 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of CITED4 mRNA | CTD | PMID:15834898 and PMID:17351261 | 17beta-estradiol | affects expression | ISO | CITED4 (Homo sapiens) | 6480464 | Estradiol affects the expression of CITED4 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CITED4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CITED4 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cited4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CITED4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CITED4 mRNA | CTD | PMID:22298810 | 2-hydroxypropanoic acid | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of CITED4 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CITED4 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Cited4 (Mus musculus) | 6480464 | bisphenol S affects the methylation of CITED4 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of CITED4 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CITED4 mRNA | CTD | PMID:24780913 and PMID:25825206 | aflatoxin B1 | affects expression | ISO | CITED4 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of CITED4 protein | CTD | PMID:20106945 | all-trans-retinoic acid | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of CITED4 mRNA | CTD | PMID:36189433 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CITED4 mRNA | CTD | PMID:16483693 | aristolochic acid A | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of CITED4 mRNA | CTD | PMID:33212167 | avobenzone | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | avobenzone results in increased expression of CITED4 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of CITED4 mRNA | CTD | PMID:20106945 and PMID:32234424 | benzo[a]pyrene | decreases methylation | ISO | CITED4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CITED4 3' UTR and Benzo(a)pyrene results in decreased methylation of CITED4 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | CITED4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CITED4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | Cited4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CITED4 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CITED4 mRNA | CTD | PMID:21839799 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CITED4 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CITED4 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CITED4 mRNA | CTD | PMID:33296240 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CITED4 gene | CTD | PMID:28505145 | bisphenol A | increases methylation | ISO | Cited4 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of CITED4 promoter | CTD | PMID:27312807 | bromobenzene | affects expression | EXP | | 6480464 | bromobenzene affects the expression of CITED4 mRNA | CTD | PMID:32479839 | butan-1-ol | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CITED4 mRNA | CTD | PMID:29432896 | butanal | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of CITED4 mRNA | CTD | PMID:26079696 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of CITED4 mRNA | CTD | PMID:33453195 | calcitriol | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of CITED4 mRNA | CTD | PMID:16002434 | cantharidin | decreases expression | ISO | Cited4 (Mus musculus) | 6480464 | Cantharidin results in decreased expression of CITED4 mRNA | CTD | PMID:36907384 | carbon nanotube | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of CITED4 mRNA | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of CITED4 mRNA | CTD | PMID:32715474 | choline | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CITED4 mRNA | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CITED4 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of CITED4 mRNA | CTD | PMID:27392435 | cocaine | decreases expression | EXP | | 6480464 | Cocaine results in decreased expression of CITED4 mRNA | CTD | PMID:27899881 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of CITED4 mRNA | CTD | PMID:30556269 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of CITED4 mRNA | CTD | PMID:30556269 | copper(II) sulfate | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of CITED4 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CITED4 mRNA | CTD | PMID:20106945 | dexamethasone | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CITED4 mRNA | CTD | PMID:28628672 | diazinon | increases methylation | ISO | CITED4 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of CITED4 gene | CTD | PMID:22964155 | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of CITED4 mRNA | CTD | PMID:21161181 | diquat | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Diquat results in increased expression of CITED4 mRNA | CTD | PMID:36851058 | disodium selenite | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of CITED4 mRNA | CTD | PMID:18175754 | doxorubicin | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of CITED4 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CITED4 mRNA | CTD | PMID:29391264 | ethanol | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Ethanol results in increased expression of CITED4 mRNA | CTD | PMID:30319688 | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of CITED4 mRNA | CTD | PMID:23962444 | folic acid | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | fonofos | increases methylation | ISO | CITED4 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of CITED4 promoter | CTD | PMID:22847954 | genistein | decreases expression | ISO | Cited4 (Mus musculus) | 6480464 | Genistein results in decreased expression of CITED4 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of CITED4 mRNA | CTD | PMID:33387578 | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of CITED4 mRNA | CTD | PMID:24915197 | indometacin | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CITED4 mRNA | CTD | PMID:28628672 | iron dichloride | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of CITED4 mRNA | CTD | PMID:35984750 | isobutanol | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CITED4 mRNA | CTD | PMID:29432896 | isoprenaline | decreases expression | ISO | Cited4 (Mus musculus) | 6480464 | Isoproterenol results in decreased expression of CITED4 mRNA | CTD | PMID:20003209 | L-methionine | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CITED4 mRNA | CTD | PMID:20938992 | lipopolysaccharide | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CITED4 mRNA | CTD | PMID:35877022 | melphalan | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Melphalan results in increased expression of CITED4 mRNA | CTD | PMID:22363485 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of CITED4 mRNA | CTD | PMID:19564919 | methamphetamine | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of CITED4 mRNA | CTD | PMID:36914120 | methamphetamine | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in decreased expression of CITED4 mRNA | CTD | PMID:19564919 | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Cited4 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of CITED4 mRNA | CTD | PMID:36189433 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | decreases expression | ISO | Cited4 (Mus musculus) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CITED4 mRNA | CTD | PMID:25566086 | N-nitrosodiethylamine | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Diethylnitrosamine results in decreased expression of CITED4 mRNA | CTD | PMID:21527772 | nitrofen | increases expression | EXP | | 6480464 | nitrofen results in increased expression of CITED4 mRNA | CTD | PMID:33484710 | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of CITED4 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] affects the expression of CITED4 mRNA | CTD | PMID:25729387 | oxybenzone | increases expression | EXP | | 6480464 | oxybenzone results in increased expression of CITED4 mRNA | CTD | PMID:30316929 | ozone | multiple interactions | ISO | CITED4 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of CITED4 mRNA | CTD | PMID:35430440 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CITED4 mRNA | CTD | PMID:32479839 and PMID:33387578 | parathion | increases methylation | ISO | CITED4 (Homo sapiens) | 6480464 | Parathion results in increased methylation of CITED4 promoter | CTD | PMID:22847954 | pentanal | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | pentanal results in increased expression of CITED4 mRNA | CTD | PMID:26079696 | progesterone | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Progesterone results in increased expression of CITED4 mRNA | CTD | PMID:22238285 | propanal | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of CITED4 mRNA | CTD | PMID:26079696 | rac-lactic acid | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of CITED4 mRNA | CTD | PMID:30851411 | SCH 23390 | multiple interactions | EXP | | 6480464 | [Methamphetamine co-treated with SCH 23390] results in decreased expression of CITED4 mRNA | CTD | PMID:19564919 | silicon dioxide | increases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of CITED4 mRNA | CTD | PMID:25895662 | sodium arsenate | decreases expression | ISO | Cited4 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of CITED4 mRNA | CTD | PMID:21795629 | sulforaphane | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of CITED4 mRNA | CTD | PMID:31838189 | sunitinib | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of CITED4 mRNA | CTD | PMID:31533062 | terbufos | increases methylation | ISO | CITED4 (Homo sapiens) | 6480464 | terbufos results in increased methylation of CITED4 promoter | CTD | PMID:22847954 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of CITED4 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] affects the expression of CITED4 mRNA | CTD | PMID:25729387 | topotecan | affects expression | EXP | | 6480464 | Topotecan affects the expression of CITED4 mRNA | CTD | PMID:25729387 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of CITED4 gene | CTD | PMID:27618143 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of CITED4 mRNA | CTD | PMID:33387578 | triclosan | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of CITED4 mRNA | CTD | PMID:30510588 | triptonide | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | triptonide results in increased expression of CITED4 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of CITED4 mRNA | CTD | PMID:19140230 | urethane | decreases expression | ISO | CITED4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CITED4 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | Cited4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of CITED4 mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | Cited4 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of CITED4 mRNA | CTD | PMID:20546886 and PMID:21427059 | |