Tmem35b (transmembrane protein 35B) - Rat Genome Database

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Gene: Tmem35b (transmembrane protein 35B) Rattus norvegicus
Analyze
Symbol: Tmem35b
Name: transmembrane protein 35B
RGD ID: 2319741
Description: Predicted to be located in membrane. Orthologous to human TMEM35B (transmembrane protein 35B); INTERACTS WITH acetamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC100361631; LOC100361631; Uncharacterized protein ZMYM6NB; ZMYM6 neighbor; Zmym6nb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,730,763 - 144,734,393 (+)NCBIGRCr8
mRatBN7.25139,446,317 - 139,449,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,444,399 - 139,449,947 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,142,396 - 142,146,010 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,912,376 - 143,915,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,913,178 - 143,916,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,188,323 - 145,191,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,188,323 - 145,191,953 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,958,333 - 148,961,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,568,703 - 146,572,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5137,941,225 - 137,944,855 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822  


Genomics

Comparative Map Data
Tmem35b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,730,763 - 144,734,393 (+)NCBIGRCr8
mRatBN7.25139,446,317 - 139,449,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,444,399 - 139,449,947 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,142,396 - 142,146,010 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,912,376 - 143,915,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,913,178 - 143,916,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,188,323 - 145,191,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,188,323 - 145,191,953 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,958,333 - 148,961,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,568,703 - 146,572,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5137,941,225 - 137,944,855 (+)NCBICelera
Cytogenetic Map5q36NCBI
TMEM35B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,981,380 - 34,985,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,981,380 - 34,985,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37135,446,981 - 35,450,948 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera133,720,736 - 33,724,550 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,564,643 - 33,568,464 (-)NCBIHuRef
CHM1_1135,562,840 - 35,566,661 (-)NCBICHM1_1
T2T-CHM13v2.0134,844,050 - 34,848,018 (-)NCBIT2T-CHM13v2.0
Tmem35b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,019,836 - 127,023,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,017,484 - 127,023,437 (+)EnsemblGRCm39 Ensembl
GRCm384127,126,043 - 127,129,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,123,691 - 127,129,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv374126,803,290 - 126,806,888 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,803,287 - 126,806,904 (+)NCBIMGSCv36mm8
Celera4125,459,651 - 125,463,232 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.29NCBI
Tmem35b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,086,500 - 13,091,751 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,087,976 - 13,091,467 (-)NCBIChiLan1.0ChiLan1.0
TMEM35B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,862,406 - 191,871,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,983,098 - 190,987,511 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,246,470 - 34,250,771 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,427,479 - 35,431,301 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl135,427,479 - 35,431,307 (-)Ensemblpanpan1.1panPan2
Tmem35b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,734,865 - 51,773,229 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,595,001 - 17,597,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,559,041 - 17,597,851 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM35B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,234,815 - 91,237,971 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,234,816 - 91,238,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM35B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,907,426 - 97,911,278 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,907,791 - 97,911,096 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603318,809,751 - 18,814,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem35b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,006,551 - 18,009,517 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,005,973 - 18,009,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000038888
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
AI555086  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,449,681 - 139,449,865 (+)MAPPERmRatBN7.2
Rnor_6.05145,191,688 - 145,191,871NCBIRnor6.0
Rnor_5.05148,961,698 - 148,961,881UniSTSRnor5.0
RGSC_v3.45146,572,068 - 146,572,251UniSTSRGSC3.4
Celera5137,944,590 - 137,944,773UniSTS
RH 3.4 Map5933.0UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038888   ⟹   ENSRNOP00000032686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5139,446,268 - 139,449,947 (+)Ensembl
Rnor_6.0 Ensembl5145,188,323 - 145,191,953 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117531   ⟹   ENSRNOP00000083972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5139,444,399 - 139,449,947 (+)Ensembl
RefSeq Acc Id: NM_001271137   ⟹   NP_001258066
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,730,763 - 144,734,393 (+)NCBI
mRatBN7.25139,446,317 - 139,449,947 (+)NCBI
Rnor_6.05145,188,323 - 145,191,953 (+)NCBI
Rnor_5.05148,958,333 - 148,961,963 (+)NCBI
Celera5137,941,225 - 137,944,855 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZYP5 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032686.6
  ENSRNOP00000083972.1
RefSeq Acc Id: NP_001258066   ⟸   NM_001271137
- Peptide Label: precursor
- UniProtKB: D3ZYP5 (UniProtKB/Swiss-Prot),   A0A8I6A107 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032686   ⟸   ENSRNOT00000038888
Ensembl Acc Id: ENSRNOP00000083972   ⟸   ENSRNOT00000117531

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYP5-F1-model_v2 AlphaFold D3ZYP5 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694047
Promoter ID:EPDNEW_R4572
Type:multiple initiation site
Name:Tmem35b_1
Description:transmembrane protein 35B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05145,188,301 - 145,188,361EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319741 AgrOrtholog
BioCyc Gene G2FUF-39858 BioCyc
Ensembl Genes ENSRNOG00000028083 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038888.7 UniProtKB/Swiss-Prot
  ENSRNOT00000117531.1 UniProtKB/TrEMBL
InterPro DoxX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TM35A/B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100361631 UniProtKB/Swiss-Prot
NCBI Gene 100361631 ENTREZGENE
PANTHER PTHR13163 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 35B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DoxX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem35b PhenoGen
RatGTEx ENSRNOG00000028083 RatGTEx
UniProt A0A8I6A107 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYP5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Tmem35b  transmembrane protein 35B  Zmym6nb  ZMYM6 neighbor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-22 Zmym6nb  ZMYM6 neighbor  LOC100361631  hypothetical protein LOC100361631  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361631  hypothetical protein LOC100361631      Symbol and Name status set to provisional 70820 PROVISIONAL