TMEM35B (transmembrane protein 35B) - Rat Genome Database

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Gene: TMEM35B (transmembrane protein 35B) Homo sapiens
Analyze
Symbol: TMEM35B
Name: transmembrane protein 35B
RGD ID: 5132761
HGNC Page HGNC:40021
Description: Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ26314; hypothetical protein LOC100506144; uncharacterized protein ZMYM6NB; ZMYM6 neighbor; ZMYM6 neighbor protein; ZMYM6NB
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,981,380 - 34,985,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,981,380 - 34,985,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37135,446,981 - 35,450,948 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera133,720,736 - 33,724,550 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,564,643 - 33,568,464 (-)NCBIHuRef
CHM1_1135,562,840 - 35,566,661 (-)NCBICHM1_1
T2T-CHM13v2.0134,844,050 - 34,848,018 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11181995   PMID:12477932   PMID:21103663   PMID:26638075   PMID:33961781   PMID:34079125   PMID:39468006  


Genomics

Comparative Map Data
TMEM35B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,981,380 - 34,985,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,981,380 - 34,985,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37135,446,981 - 35,450,948 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera133,720,736 - 33,724,550 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,564,643 - 33,568,464 (-)NCBIHuRef
CHM1_1135,562,840 - 35,566,661 (-)NCBICHM1_1
T2T-CHM13v2.0134,844,050 - 34,848,018 (-)NCBIT2T-CHM13v2.0
Tmem35b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,019,836 - 127,023,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,017,484 - 127,023,437 (+)EnsemblGRCm39 Ensembl
GRCm384127,126,043 - 127,129,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,123,691 - 127,129,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv374126,803,290 - 126,806,888 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,803,287 - 126,806,904 (+)NCBIMGSCv36mm8
Celera4125,459,651 - 125,463,232 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.29NCBI
Tmem35b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,730,763 - 144,734,393 (+)NCBIGRCr8
mRatBN7.25139,446,317 - 139,449,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,444,399 - 139,449,947 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,142,396 - 142,146,010 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,912,376 - 143,915,990 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,913,178 - 143,916,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,188,323 - 145,191,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,188,323 - 145,191,953 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,958,333 - 148,961,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,568,703 - 146,572,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5137,941,225 - 137,944,855 (+)NCBICelera
Cytogenetic Map5q36NCBI
Tmem35b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,086,500 - 13,091,751 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,087,976 - 13,091,467 (-)NCBIChiLan1.0ChiLan1.0
TMEM35B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,862,406 - 191,871,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,983,098 - 190,987,511 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,246,470 - 34,250,771 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,427,479 - 35,431,301 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl135,427,479 - 35,431,307 (-)Ensemblpanpan1.1panPan2
Tmem35b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,734,865 - 51,773,229 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,595,001 - 17,597,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,559,041 - 17,597,851 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM35B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,234,815 - 91,237,971 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,234,816 - 91,238,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM35B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,907,426 - 97,911,278 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,907,791 - 97,911,096 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603318,809,751 - 18,814,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem35b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,006,551 - 18,009,517 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,005,973 - 18,009,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM35B
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NR_037869.1(LOC653160):n.256C>T single nucleotide variant Malignant melanoma [RCV000064741] Chr1:34977330 [GRCh38]
Chr1:35442931 [GRCh37]
Chr1:35215518 [NCBI36]
Chr1:1p34.3		 not provided
GRCh38/hg38 1p34.3(chr1:34753938-36055310)x1 copy number loss See cases [RCV000137966] Chr1:34753938..36055310 [GRCh38]
Chr1:35219539..36520911 [GRCh37]
Chr1:34992126..36293498 [NCBI36]
Chr1:1p34.3		 likely pathogenic
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p34.3(chr1:34830287-36945093)x1 copy number loss See cases [RCV000448022] Chr1:34830287..36945093 [GRCh37]
Chr1:1p34.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease dominant intermediate C [RCV000708276] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p35.2-34.3(chr1:31562164-37421958)x3 copy number gain not provided [RCV000748949] Chr1:31562164..37421958 [GRCh37]
Chr1:1p35.2-34.3		 pathogenic
GRCh37/hg19 1p34.3(chr1:35403677-35581447)x3 copy number gain not provided [RCV000748957] Chr1:35403677..35581447 [GRCh37]
Chr1:1p34.3		 benign
GRCh37/hg19 1p35.1-34.3(chr1:32859415-36454915) copy number loss not provided [RCV000767772] Chr1:32859415..36454915 [GRCh37]
Chr1:1p35.1-34.3		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p34.3(chr1:34915050-36163162)x3 copy number gain not provided [RCV000847115] Chr1:34915050..36163162 [GRCh37]
Chr1:1p34.3		 uncertain significance
GRCh37/hg19 1p34.3(chr1:35321300-35944813)x1 copy number loss not provided [RCV000994333] Chr1:35321300..35944813 [GRCh37]
Chr1:1p34.3		 uncertain significance
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease, dominant intermediate C [RCV001308684] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1		 uncertain significance
GRCh37/hg19 1p35.1-33(chr1:33285582-47891811) copy number gain not specified [RCV002052781] Chr1:33285582..47891811 [GRCh37]
Chr1:1p35.1-33		 pathogenic
GRCh37/hg19 1p34.3(chr1:35104233-37357913)x1 copy number loss not provided [RCV002474552] Chr1:35104233..37357913 [GRCh37]
Chr1:1p34.3		 pathogenic
NM_001195156.2(TMEM35B):c.95T>C (p.Val32Ala) single nucleotide variant not specified [RCV004110834] Chr1:34985211 [GRCh38]
Chr1:35450812 [GRCh37]
Chr1:1p34.3		 uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
GRCh37/hg19 1p34.3(chr1:35208698-36530353)x1 copy number loss not provided [RCV004819710] Chr1:35208698..36530353 [GRCh37]
Chr1:1p34.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:136
Interacting mature miRNAs:139
Transcripts:ENST00000373337
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH98570  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37135,452,678 - 35,452,827UniSTSGRCh37
Build 36135,225,265 - 35,225,414RGDNCBI36
Celera133,726,280 - 33,726,429RGD
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map1p34.2UniSTS
HuRef133,570,194 - 33,570,343UniSTS
GeneMap99-GB4 RH Map1109.71UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2429 2787 2227 4914 1700 2319 4 600 1948 442 2268 7221 6431 52 3680 833 1705 1608 170

Sequence


Ensembl Acc Id: ENST00000373337   ⟹   ENSP00000362435
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl134,981,380 - 34,985,347 (-)Ensembl
RefSeq Acc Id: NM_001195156   ⟹   NP_001182085
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38134,981,380 - 34,985,347 (-)NCBI
GRCh37135,447,127 - 35,450,948 (-)ENTREZGENE
HuRef133,564,643 - 33,568,464 (-)ENTREZGENE
CHM1_1135,562,840 - 35,566,661 (-)NCBI
T2T-CHM13v2.0134,844,050 - 34,848,018 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182085 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH29439 (Get FASTA)   NCBI Sequence Viewer  
  CAM55984 (Get FASTA)   NCBI Sequence Viewer  
  EAX07432 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000362435
  ENSP00000362435.3
GenBank Protein Q8NCS4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001182085   ⟸   NM_001195156
- Peptide Label: precursor
- UniProtKB: Q8NCS4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000362435   ⟸   ENST00000373337

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8NCS4-F1-model_v2 AlphaFold Q8NCS4 1-154 view protein structure

Promoters
RGD ID:6854924
Promoter ID:EPDNEW_H627
Type:initiation region
Name:TMEM35B_1
Description:transmembrane protein 35B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38134,985,305 - 34,985,365EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:40021 AgrOrtholog
COSMIC TMEM35B COSMIC
Ensembl Genes ENSG00000243749 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373337 ENTREZGENE
  ENST00000373337.4 UniProtKB/Swiss-Prot
GTEx ENSG00000243749 GTEx
HGNC ID HGNC:40021 ENTREZGENE
Human Proteome Map TMEM35B Human Proteome Map
InterPro DoxX UniProtKB/Swiss-Prot
  TM35A/B UniProtKB/Swiss-Prot
KEGG Report hsa:100506144 UniProtKB/Swiss-Prot
NCBI Gene 100506144 ENTREZGENE
PANTHER PTHR13163 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 35B UniProtKB/Swiss-Prot
Pfam DoxX_2 UniProtKB/Swiss-Prot
PharmGKB PA166049044 PharmGKB
UniProt Q8NCS4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-17 TMEM35B  transmembrane protein 35B  ZMYM6NB  ZMYM6 neighbor  Symbol and/or name change 5135510 APPROVED