Slc2a1 (solute carrier family 2 member 1) - Rat Genome Database
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Gene: Slc2a1 (solute carrier family 2 member 1) Rattus norvegicus
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Symbol: Slc2a1
Name: solute carrier family 2 member 1
RGD ID: 3704
Description: Exhibits kinase binding activity and transmembrane transporter activity. Involved in several processes, including cellular hyperosmotic response; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Localizes to several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1); PARTICIPATES IN facilitative sugar transporter mediated glucose transport pathway; Glut1 deficiency syndrome pathway; hypoxia inducible factor pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glucose transporter type 1, erythrocyte/brain; GLUT-1; Glut1; GLUTB; GTG1; Gtg3; RATGTG1; solute carrier family 2 (facilitated glucose transporter) member 1; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1; solute carrier family 2,member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp103  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05138,154,677 - 138,182,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,964,114 - 141,992,634 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,690,801 - 139,719,021 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15139,696,029 - 139,724,247 (+)NCBI
Celera5131,243,786 - 131,272,021 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map5865.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
Ataxia  (ISO)
benign epilepsy with centrotemporal spikes  (ISO)
Breast Neoplasms  (ISO)
Capillary Hemangioma, Infantile  (ISO)
cataract  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease dominant intermediate C  (ISO)
childhood absence epilepsy  (ISO)
childhood onset GLUT1 deficiency syndrome 2  (ISO)
Colonic Neoplasms  (ISO)
Developmental Disabilities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
dystonia  (ISO)
dystonia 9  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IEP)
Fetal Growth Retardation  (IEP)
genetic disease  (ISO)
glomerulosclerosis  (ISO)
GLUT1 Deficiency Syndrome  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung's disease  (ISO)
hypertension  (IEP)
hypothyroidism  (IEP)
idiopathic generalized epilepsy 12  (ISO)
inherited metabolic disorder  (ISO)
intellectual disability  (ISO)
Liver Neoplasms  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
migraine  (ISO)
myelomeningocele  (ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
Peritoneal Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
Stomatin-Deficient Cryohydrocytosis with Mental Retardation, Seizures, Cataracts, and Massive Hepatosplenomegaly  (ISO)
type 2 diabetes mellitus  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dinitrophenol  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-deoxy-2-((18)F)fluoro-D-glucose  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxy-17beta-estradiol  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-O-methyl-D-glucose  (ISO)
3-Phenyl-1-propanol  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
7-hydroxyflavone  (ISO)
acadesine  (ISO)
acarbose  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-naphthoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthracene-1,8,9-triol  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azide  (EXP)
barbiturates  (ISO)
beauvericin  (ISO)
benzaldehyde  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
celecoxib  (ISO)
chloral hydrate  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
cholic acid  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
crotonaldehyde  (ISO)
cumene  (ISO)
curcumin  (ISO)
Cyclofenil  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
dacarbazine  (ISO)
daidzein  (ISO)
DDT  (ISO)
dehydroascorbic acid  (EXP,ISO)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
Fusaric acid  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin C  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferide  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-dehydroascorbic acid  (EXP,ISO)
L-mimosine  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
LY294002  (ISO)
menadione  (ISO)
mercaptoethanol  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylene blue  (ISO)
methylmercury chloride  (EXP,ISO)
Mezerein  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
Niclosamide  (ISO)
Niflumic acid  (ISO)
nimesulide  (ISO)
Nonidet P-40  (ISO)
ofloxacin  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
organoselenium compound  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
prostaglandin E2  (ISO)
protoporphyrin  (ISO)
Pyridostigmine bromide  (ISO)
pyrithiamine  (EXP)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
saccharin  (ISO)
sarpogrelate  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraethylenepentamine  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
tin(II) chloride (anhydrous)  (ISO)
tolbutamide  (ISO)
tolfenamic acid  (ISO)
toluene  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
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40. MGD data from the GO Consortium
41. NCBI rat LocusLink and RefSeq merged data July 26, 2002
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46. OMIM Disease Annotation Pipeline
47. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
48. Pipeline to import KEGG annotations from KEGG into RGD
49. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
50. Pipeline to import SMPDB annotations from SMPDB into RGD
51. Rakheja D, etal., Pediatr Dev Pathol. 2012 Jul-Aug;15(4):286-92. doi: 10.2350/12-01-1151-OA.1. Epub 2012 Apr 6.
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53. RGD automated data pipeline
54. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
55. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1429721   PMID:1714544   PMID:3198639   PMID:7589840   PMID:7593639   PMID:8457197   PMID:9751501   PMID:10198040   PMID:10227690   PMID:10394363   PMID:10862609   PMID:11172003  
PMID:11259273   PMID:11681785   PMID:12002265   PMID:12506324   PMID:12531786   PMID:14519432   PMID:14729246   PMID:14741039   PMID:15166316   PMID:15359219   PMID:15489334   PMID:15808844  
PMID:15811071   PMID:15855808   PMID:15975910   PMID:16091581   PMID:16140905   PMID:16162661   PMID:16449286   PMID:16461188   PMID:17189352   PMID:17369047   PMID:17369472   PMID:17878754  
PMID:18196278   PMID:18245775   PMID:18347014   PMID:18474279   PMID:18511518   PMID:18650261   PMID:18787834   PMID:18797165   PMID:18802725   PMID:18957618   PMID:19546347   PMID:19681047  
PMID:19841136   PMID:19950593   PMID:20375116   PMID:20458337   PMID:21069159   PMID:21141602   PMID:21562080   PMID:21605500   PMID:21613414   PMID:21624469   PMID:21773965   PMID:21791420  
PMID:22125125   PMID:22258767   PMID:22433294   PMID:22516433   PMID:22579067   PMID:22871113   PMID:23265586   PMID:23280796   PMID:23680377   PMID:23975336   PMID:24062089   PMID:24329691  
PMID:24382486   PMID:24610532   PMID:24726496   PMID:24739976   PMID:25101238   PMID:25982116   PMID:26347179   PMID:26590355   PMID:26953753   PMID:27078104   PMID:28495754   PMID:28993322  
PMID:29476059   PMID:29490264   PMID:30335140   PMID:30837370   PMID:31162576   PMID:31765739   PMID:32445055  


Genomics

Comparative Map Data
Slc2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05138,154,677 - 138,182,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,964,114 - 141,992,634 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,690,801 - 139,719,021 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15139,696,029 - 139,724,247 (+)NCBI
Celera5131,243,786 - 131,272,021 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map5865.0RGD
SLC2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl142,925,375 - 42,958,868 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl142,925,353 - 42,958,893 (-)EnsemblGRCh38hg38GRCh38
GRCh38142,925,353 - 42,958,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37143,391,046 - 43,424,847 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,164,102 - 43,197,088 (-)NCBINCBI36hg18NCBI36
Build 34143,060,611 - 43,093,594NCBI
Celera141,673,133 - 41,706,939 (-)NCBI
Cytogenetic Map1p34.2NCBI
HuRef141,511,000 - 41,544,561 (-)NCBIHuRef
CHM1_1143,507,796 - 43,541,586 (-)NCBICHM1_1
Slc2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,965,942 - 118,994,527 (+)NCBIGRCm39mm39
GRCm384119,108,745 - 119,137,330 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,108,711 - 119,137,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv374118,781,350 - 118,809,935 (+)NCBIGRCm37mm9NCBIm37
MGSCv364118,606,700 - 118,635,259 (+)NCBImm8
Celera4117,836,249 - 117,864,839 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
Slc2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,408,042 - 2,439,511 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,408,042 - 2,438,788 (-)NCBIChiLan1.0ChiLan1.0
SLC2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1143,600,733 - 43,634,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,600,733 - 43,634,143 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0142,224,273 - 42,257,184 (-)NCBIMhudiblu_PPA_v0panPan3
SLC2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl15463,237 - 493,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.115463,307 - 493,145 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Slc2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647424,205,878 - 24,236,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6168,534,655 - 168,690,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16168,535,398 - 168,561,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,057,568 - 156,059,070 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,974,567 - 90,007,977 (+)NCBI
ChlSab1.1 Ensembl2090,002,030 - 90,008,033 (+)Ensembl
Slc2a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248922,110,310 - 2,148,023 (-)NCBI

Position Markers
D5Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05138,180,823 - 138,180,950NCBIRnor6.0
Rnor_5.05141,990,560 - 141,990,687UniSTSRnor5.0
RGSC_v3.45139,716,946 - 139,717,074RGDRGSC3.4
RGSC_v3.45139,716,947 - 139,717,074UniSTSRGSC3.4
RGSC_v3.15139,722,172 - 139,722,300RGD
Celera5131,269,936 - 131,270,074UniSTS
Cytogenetic Map5q36.1UniSTS
RH 3.4 Map5868.7UniSTS
RH 3.4 Map5868.7RGD
RH 2.0 Map5861.1RGD
D5Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05138,181,618 - 138,181,849NCBIRnor6.0
Rnor_5.05141,991,355 - 141,991,586UniSTSRnor5.0
RGSC_v3.45139,717,741 - 139,717,973RGDRGSC3.4
RGSC_v3.45139,717,742 - 139,717,973UniSTSRGSC3.4
RGSC_v3.15139,722,967 - 139,723,199RGD
Celera5131,270,742 - 131,270,973UniSTS
Cytogenetic Map5q36.1UniSTS
Cytogenetic Map5q36UniSTS
RH 3.4 Map5867.2RGD
RH 3.4 Map5867.2UniSTS
RH 2.0 Map5860.2RGD
SHRSP x BN Map570.6499RGD
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05138,182,403 - 138,182,594NCBIRnor6.0
Rnor_5.05141,992,140 - 141,992,331UniSTSRnor5.0
RGSC_v3.45139,718,527 - 139,718,718UniSTSRGSC3.4
Celera5131,271,527 - 131,271,718UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map5q36.1UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05138,178,048 - 138,178,811NCBIRnor6.0
Rnor_5.05141,987,785 - 141,988,548UniSTSRnor5.0
RGSC_v3.45139,714,172 - 139,714,935UniSTSRGSC3.4
Celera5131,267,161 - 131,267,924UniSTS
Cytogenetic Map5q36.1UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05138,181,338 - 138,182,594NCBIRnor6.0
Rnor_5.05141,991,075 - 141,992,331UniSTSRnor5.0
Celera5131,270,462 - 131,271,718UniSTS
Cytogenetic Map5q36.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)593273130138273130Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)597921932149030144Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5100723739153577831Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5101265591141912026Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5102945579154732228Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5107119214152119214Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111278451156278451Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112279412157279412Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112279412157279412Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112279412157279412Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112279412157279412Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112279412157279412Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114140832159140832Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114140832159140832Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116767924161767924Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116767924161767924Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116767924161767924Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116767924161767924Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125455818149568944Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125455818157225114Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5129038716139099229Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130531300145726262Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133313668138454239Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133351969140120264Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134502121149030144Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134502140157212422Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:456
Count of miRNA genes:236
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000064452
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 23 18 13 18 74 35 39 10
Low 14 34 23 6 23 8 11 2 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064452   ⟹   ENSRNOP00000061340
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083700   ⟹   ENSRNOP00000072351
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5138,164,480 - 138,182,011 (+)Ensembl
RefSeq Acc Id: NM_138827   ⟹   NP_620182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,154,677 - 138,182,897 (+)NCBI
Rnor_5.05141,964,114 - 141,992,634 (+)NCBI
RGSC_v3.45139,690,801 - 139,719,021 (+)RGD
Celera5131,243,786 - 131,272,021 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41248 (Get FASTA)   NCBI Sequence Viewer  
  AAA41297 (Get FASTA)   NCBI Sequence Viewer  
  AAH61873 (Get FASTA)   NCBI Sequence Viewer  
  EDL90143 (Get FASTA)   NCBI Sequence Viewer  
  P11167 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_620182   ⟸   NM_138827
- UniProtKB: P11167 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072351   ⟸   ENSRNOT00000083700
RefSeq Acc Id: ENSRNOP00000061340   ⟸   ENSRNOT00000064452
Protein Domains
MFS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693972
Promoter ID:EPDNEW_R4497
Type:multiple initiation site
Name:Slc2a1_1
Description:solute carrier family 2 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,154,734 - 138,154,794EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 141991672 141991673 G T snv LE/OrlBarth (UDEL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3704 AgrOrtholog
Ensembl Genes ENSRNOG00000007284 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000061340 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072351 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064452 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083700 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598829 IMAGE-MGC_LOAD
InterPro Glu_transpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24778 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72306 IMAGE-MGC_LOAD
NCBI Gene 24778 ENTREZGENE
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC2A1 RGD
PhenoGen Slc2a1 PhenoGen
PRINTS GLUCTRSPORT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGRTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.3205 ENTREZGENE
UniProt A0A0G2K2S2_RAT UniProtKB/TrEMBL
  GTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a1  solute carrier family 2 member 1  Slc2a1  solute carrier family 2 (facilitated glucose transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc2a1  solute carrier family 2 (facilitated glucose transporter), member 1    solute carrier family 2,member 1  Name updated 1299863 APPROVED
2002-06-10 Slc2a1  solute carrier family 2,member 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease insulin treatment causes a redistribution to heart plasma membrane 628382
gene_drugs Doxorubicin also known as adriamycin a highly effective antineoplastic drug induces cardiotoxicity thus stimulating this gene and regulating glucose uptake in heart cells 628382
gene_expression expressed in cardiac myocytes 628382
gene_expression chronic food restriction decreases the expression of cardiac mRNA  
gene_expression expressed in mammary epithelial cells during pregnancy and lactation; expression decreases during weaning 1299031
gene_homology protein has 97.6% identity to human hepatoma hexose carrier protein 729978
gene_process responsible for glucose entry into the brain  
gene_process may be responsible for constitutive or basal glucose uptake  
gene_process enhances glucose uptake in the heart after undernutrition due to the increased protein distribution to the surface membrane 628382
gene_process major glucose carrier in heart 628429
gene_process plays a role in placental glucose transport 1299030
gene_product member of the sugar transporter family  
gene_protein predicted to encode 492 amino acid protein 729978
gene_regulation chronic food restriction decreases the expression of cardiac mRNA 628382
gene_regulation increased glucose transport and increased transporter accessibility to substrate is induced by AMP activated protein kinase 730230
gene_regulation cis-acting regulatory element in 3'-untranslated region (CAE2181-2190) plays a role in increase in gene expression during glucose deprivation and hypoxia 1299029
gene_regulation transcription factor Sp1 may be involved in regulation of expression during trophoblast differentiation 1299030