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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:73918
Term: 3-O-methyl-D-glucose
Definition: A D-aldohexose that is D-glucose in which the hydrogen of the hydroxy group at position 3 has been substituted by a methyl group. It is a non-metabolisable glucose analogue that is not phosphorylated by hexokinase and is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems.
Chemical ID: MESH:D019325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a1decreases transportISORGD:7372726480464CTDSLC2A1 protein mutant form results in decreased transport of 3-O-Methylglucose

PMID:11603379
Slc2a1increases uptakeISORGD:7372726480464CTDSLC2A1 protein results in increased uptake of 3-O-Methylglucose

PMID:10590023
Slc2a1multiple interactionsISORGD:7372726480464CTDPentobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose] Pentobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose] Phenobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose] Phenobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]

PMID:10590023
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