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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:15866
Term: 2-deoxy-D-glucose
Definition: A deoxyglucose that is D-glucose in which the hydroxy group at position 2 has been replaced by a hydrogen. It is an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent.
Chemical ID: MESH:D003847
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a1increases uptakeISORGD:7372726480464CTDSLC2A1 protein results in increased uptake of DeoxyglucosePMID:2173694
Slc2a1multiple interactionsISORGD:113056480464CTD[arsenite affects the localization of SLC2A1 protein] which results in increased uptake of DeoxyglucosePMID:14511371
Slc2a1multiple interactionsISORGD:7372726480464CTDSLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]PMID:2173694
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