Hk1 (hexokinase 1) - Rat Genome Database

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Gene: Hk1 (hexokinase 1) Rattus norvegicus
Analyze
Symbol: Hk1
Name: hexokinase 1
RGD ID: 2796
Description: Exhibits several functions, including ATP binding activity; glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Localizes to several cellular components, including caveola; cytosol; and mitochondrion. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1); PARTICIPATES IN glycolysis pathway; amino sugar metabolic pathway; french type sialuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: brain form hexokinase; hexokin; hexokinase type I; hexokinase-1; hexokinase-A; HK I; HKI; rathexokin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22030,230,488 - 30,332,161 (-)NCBI
Rnor_6.0 Ensembl2031,912,262 - 31,956,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02031,911,460 - 31,979,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02033,703,472 - 33,770,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2031,652,769 - 31,721,279 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-bromopyruvic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
graphite  (EXP)
hydralazine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
maneb  (ISO)
Meclofenoxate  (EXP)
meldonium  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
N-nitrosomorpholine  (EXP)
nickel dichloride  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylpropanolamine  (ISO)
pirinixic acid  (ISO)
plumbagin  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolbutamide  (ISO)
topotecan  (EXP)
triazines  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IDA)
cilium  (ISO)
cytosol  (IBA,IDA,IEA,ISO)
membrane raft  (IEA,ISO)
mitochondrial outer membrane  (IEA)
mitochondrion  (IBA,IDA,IEA,ISO)
protein-containing complex  (IDA)
sperm principal piece  (ISO)

Molecular Function

References

References - curated
1. Adams V, etal., Biochem Biophys Res Commun. 1991 Jun 28;177(3):1101-6.
2. Adams V, etal., Biochem Med Metab Biol. 1994 Oct;53(1):80-6.
3. Azoulay-Zohar H, etal., Biochem J. 2004 Jan 15;377(Pt 2):347-55.
4. Belfiore F, etal., Metabolism. 1976 May;25(5):483-93.
5. Beutner G, etal., Biochim Biophys Acta. 1998 Jan 5;1368(1):7-18.
6. Bianchi M and Magnani M, Blood Cells Mol Dis. 1995;21(1):2-8.
7. Bonnefond A, etal., Diabetes. 2009 Nov;58(11):2687-97. doi: 10.2337/db09-0652. Epub 2009 Aug 3.
8. Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
9. Cotroneo E, etal., Circ Res. 2015 May 8;116(10):1680-90. doi: 10.1161/CIRCRESAHA.116.305265. Epub 2015 Mar 12.
10. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Gelb BD, etal., Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):202-6.
13. González C, etal., Biochem Biophys Res Commun. 1964 Jul 1;16(4):347-52. doi: 10.1016/0006-291x(64)90038-5.
14. Iasevoli F, etal., J Neurosci Res. 2012 Sep;90(9):1756-67. doi: 10.1002/jnr.23071. Epub 2012 May 17.
15. Jiang L, etal., Biol Chem. 2013 Oct;394(10):1333-42. doi: 10.1515/hsz-2013-0201.
16. KEGG
17. Kottke M, etal., Biochim Biophys Acta. 1988 Aug 17;935(1):87-102.
18. Majewski N, etal., Mol Cell 2004 Dec 3;16(5):819-30.
19. Malone JI, etal., N Engl J Med. 1968 Nov 14;279(20):1071-7.
20. Mees G, etal., Cancer Biother Radiopharm. 2009 Oct;24(5):565-72. doi: 10.1089/cbr.2009.0621.
21. MGD data from the GO Consortium
22. Mulichak AM, etal., Nat Struct Biol. 1998 Jul;5(7):555-60.
23. Muthuraman P and Srikumar K, Eur J Pharm Sci. 2010 Sep 11;41(1):1-9. doi: 10.1016/j.ejps.2010.05.008. Epub 2010 May 16.
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
26. OMIM Disease Annotation Pipeline
27. Oudard S, etal., Bull Cancer. 2004 Jun;91(6):E184-200.
28. Pasdois P, etal., Biochem J. 2011 Jun 1;436(2):493-505. doi: 10.1042/BJ20101957.
29. Peters LL, etal., Blood Cells Mol Dis. 2001 Sep-Oct;27(5):850-60.
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Pipeline to import SMPDB annotations from SMPDB into RGD
33. Ratnakumari L and Murthy CR, Neurosci Lett. 1993 Oct 14;161(1):37-40.
34. Rauch MC, etal., J Cell Physiol. 2006 May;207(2):397-406.
35. RGD automated data pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Schwab DA and Wilson JE, J Biol Chem 1988 Mar 5;263(7):3220-4.
39. Schwab DA and Wilson JE, Proc Natl Acad Sci U S A 1989 Apr;86(8):2563-7.
40. Sharma S, etal., Indian J Cancer. 2011 Jul-Sep;48(3):323-7. doi: 10.4103/0019-509X.84943.
41. SOLS A and CRANE RK, J Biol Chem. 1954 Oct;210(2):581-95.
42. Srinivasan M, etal., Exp Biol Med (Maywood). 2003 Jan;228(1):15-23.
43. Sullivan LS, etal., Invest Ophthalmol Vis Sci. 2014 Sep 4;55(11):7147-58. doi: 10.1167/iovs.14-15419.
44. Tiedemann RE, etal., Blood. 2010 Feb 25;115(8):1594-604. doi: 10.1182/blood-2009-09-243980. Epub 2009 Dec 7.
45. Waskova-Arnostova P, etal., Cell Physiol Biochem. 2014;33(2):310-20. doi: 10.1159/000356671. Epub 2014 Jan 31.
46. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:3579310   PMID:3631958   PMID:12420306   PMID:12477932   PMID:12660493   PMID:14651853   PMID:15155459   PMID:15756812   PMID:16687649   PMID:16951044   PMID:17069463   PMID:17803972  
PMID:18165236   PMID:18308470   PMID:18509164   PMID:18614015   PMID:19144954   PMID:19228992   PMID:19889946   PMID:20060179   PMID:20833797   PMID:21179577   PMID:21408025   PMID:21700703  
PMID:22420779   PMID:22871113   PMID:23962723   PMID:25287584   PMID:26316108   PMID:27374331   PMID:28054552   PMID:28275929   PMID:29119535   PMID:29476059   PMID:29568061   PMID:32113849  
PMID:32283307  


Genomics

Comparative Map Data
Hk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22030,230,488 - 30,332,161 (-)NCBI
Rnor_6.0 Ensembl2031,912,262 - 31,956,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02031,911,460 - 31,979,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02033,703,472 - 33,770,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2031,652,769 - 31,721,279 (-)NCBICelera
Cytogenetic Map20q11NCBI
HK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1069,269,984 - 69,401,884 (+)EnsemblGRCh38hg38GRCh38
GRCh381069,269,991 - 69,401,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371071,029,756 - 71,161,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,699,762 - 70,831,641 (+)NCBINCBI36hg18NCBI36
Build 341070,748,628 - 70,831,641NCBI
Celera1064,305,609 - 64,438,051 (+)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1065,029,590 - 65,161,554 (+)NCBIHuRef
CHM1_11071,311,204 - 71,443,383 (+)NCBICHM1_1
Hk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,104,634 - 62,215,699 (-)NCBIGRCm39mm39
GRCm39 Ensembl1062,104,634 - 62,215,687 (-)Ensembl
GRCm381062,268,855 - 62,379,920 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,268,855 - 62,379,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371061,731,603 - 61,842,656 (-)NCBIGRCm37mm9NCBIm37
MGSCv361061,665,219 - 61,775,240 (-)NCBImm8
Celera1063,372,104 - 63,483,135 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.37NCBI
Hk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,731,584 - 21,816,324 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543721,733,314 - 21,824,303 (-)NCBIChiLan1.0ChiLan1.0
HK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11068,289,288 - 68,401,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1068,289,288 - 68,401,045 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01065,786,940 - 65,870,204 (+)NCBIMhudiblu_PPA_v0panPan3
HK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,396,761 - 20,516,889 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,421,526 - 20,518,211 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha420,527,050 - 20,646,926 (+)NCBI
ROS_Cfam_1.0420,668,689 - 20,788,765 (+)NCBI
UMICH_Zoey_3.1420,569,179 - 20,688,937 (+)NCBI
UNSW_CanFamBas_1.0420,773,025 - 20,892,822 (+)NCBI
UU_Cfam_GSD_1.0421,116,100 - 21,236,182 (+)NCBI
Hk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721360,574,470 - 60,681,207 (-)NCBI
SpeTri2.0NW_0049365219,067,062 - 9,139,112 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1472,351,149 - 72,460,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11472,383,328 - 72,460,927 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,486,933 - 78,521,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,917,501 - 62,029,737 (-)NCBI
ChlSab1.1 Ensembl961,917,440 - 62,001,843 (-)Ensembl
Vero_WHO_p1.0NW_02366604822,657,626 - 22,744,799 (-)NCBI
Hk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247543,594,478 - 3,656,231 (+)NCBI

Position Markers
D20Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,245,001 - 30,245,143 (+)MAPPER
Rnor_6.02031,925,975 - 31,926,116NCBIRnor6.0
Rnor_5.02033,717,506 - 33,717,647UniSTSRnor5.0
Celera2031,667,256 - 31,667,397UniSTS
Cytogenetic Map20q11UniSTS
RH94785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,230,678 - 30,230,947 (+)MAPPER
Rnor_6.02031,911,649 - 31,911,917NCBIRnor6.0
Rnor_5.02033,703,661 - 33,703,929UniSTSRnor5.0
Celera2031,652,958 - 31,653,226UniSTS
Cytogenetic Map20q11UniSTS
RH138498  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,294,387 - 30,294,517 (+)MAPPER
Rnor_6.02031,974,815 - 31,974,944NCBIRnor6.0
Rnor_5.02033,766,363 - 33,766,492UniSTSRnor5.0
Celera2031,716,632 - 31,716,761UniSTS
Cytogenetic Map20q11UniSTS
RH138930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,236,811 - 30,236,981 (+)MAPPER
Rnor_6.02031,917,782 - 31,917,951NCBIRnor6.0
Rnor_5.02033,709,794 - 33,709,963UniSTSRnor5.0
Celera2031,659,093 - 31,659,262UniSTS
Cytogenetic Map20q11UniSTS
AI029744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,230,529 - 30,230,724 (+)MAPPER
Rnor_6.02031,911,500 - 31,911,694NCBIRnor6.0
Rnor_5.02033,703,512 - 33,703,706UniSTSRnor5.0
Celera2031,652,809 - 31,653,003UniSTS
RH 3.4 Map20308.49UniSTS
Cytogenetic Map20q11UniSTS
BI275478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22030,236,508 - 30,236,702 (+)MAPPER
Rnor_6.02031,917,479 - 31,917,672NCBIRnor6.0
Rnor_5.02033,709,491 - 33,709,684UniSTSRnor5.0
Celera2031,658,790 - 31,658,983UniSTS
RH 3.4 Map20309.09UniSTS
Cytogenetic Map20q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201782709656205956Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201887215049108956Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202085847056205956Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202660884356205956Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202660884356205956Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202660884356205956Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202671232356205956Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)203091348156205956Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:95
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000072429
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5
Medium 3 43 38 22 19 22 1 1 74 35 36 11 1
Low 19 19 19 7 10 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072429   ⟹   ENSRNOP00000066611
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2031,912,262 - 31,956,649 (-)Ensembl
RefSeq Acc Id: NM_012734   ⟹   NP_036866
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22030,230,490 - 30,299,351 (-)NCBI
Rnor_6.02031,911,460 - 31,979,780 (-)NCBI
Rnor_5.02033,703,472 - 33,770,598 (-)NCBI
Celera2031,652,769 - 31,721,279 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098432   ⟹   XP_038954360
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22030,230,488 - 30,317,270 (-)NCBI
RefSeq Acc Id: XM_039098433   ⟹   XP_038954361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22030,230,511 - 30,332,161 (-)NCBI
RefSeq Acc Id: XM_039098434   ⟹   XP_038954362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22030,230,511 - 30,317,273 (-)NCBI
RefSeq Acc Id: XM_039098435   ⟹   XP_038954363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22030,230,511 - 30,301,816 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036866   ⟸   NM_012734
- Sequence:
RefSeq Acc Id: ENSRNOP00000066611   ⟸   ENSRNOT00000072429
RefSeq Acc Id: XP_038954360   ⟸   XM_039098432
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954361   ⟸   XM_039098433
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954362   ⟸   XM_039098434
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954363   ⟸   XM_039098435
- Peptide Label: isoform X2
Protein Domains
Hexokinase   Hexokinase_1   Hexokinase_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2796 AgrOrtholog
Ensembl Genes ENSRNOG00000046891 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000066611 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072429 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25058 UniProtKB/Swiss-Prot
NCBI Gene 25058 ENTREZGENE
PANTHER PTHR19443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hexokinase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hk1 PhenoGen
PROSITE HEXOKINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEXOKINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HXK1_RAT UniProtKB/Swiss-Prot
  M0RAQ6_RAT UniProtKB/TrEMBL
  O35917_RAT UniProtKB/TrEMBL
  O35918_RAT UniProtKB/TrEMBL
  P05708 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hk1  Hexokinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains both a glucose and an ATP binding site 632916