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Gene: Hk1 (hexokinase 1) Rattus norvegicus
Symbol: Hk1
Name: hexokinase 1
Description: Exhibits several functions, including ATP binding activity; glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Localizes to several cellular components, including caveola; cytosol; and mitochondrion. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1); PARTICIPATES IN glycolysis pathway; amino sugar metabolic pathway; french type sialuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 2-ethoxyethanol.
Type: protein-coding
Also known as: brain form hexokinase; hexokin; hexokinase type I; hexokinase-1; hexokinase-A; HK I; HKI; rathexokin
Homo sapiens (human) : HK1 (hexokinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Hk1 (hexokinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hk1 (hexokinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HK1 (hexokinase 1)
Canis lupus familiaris (dog) : HK1 (hexokinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hk1 (hexokinase 1)
Sus scrofa (pig) : HK1 (hexokinase 1)
Chlorocebus sabaeus (African green monkey) : HK1 (hexokinase 1)
Heterocephalus glaber (naked mole-rat) : Hk1 (hexokinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02031,911,460 - 31,979,780 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,912,262 - 31,956,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02033,703,472 - 33,770,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2031,652,769 - 31,721,279 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2796
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.