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Gene: Hk1 (hexokinase 1) Mus musculus
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Symbol: Hk1
Name: hexokinase 1
RGD ID: 10710
Description: Exhibits glucokinase activity and peptidoglycan binding activity. Involved in carbohydrate phosphorylation; positive regulation of cytokine production involved in immune response; and positive regulation of interleukin-1 beta production. Localizes to several cellular components, including membrane raft; mitochondrion; and sperm principal piece. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BB404130; dea; downeast anemia; hexokinase type I; hexokinase, tumor isozyme; hexokinase-1; HK I; Hk-1; Hk1-; Hk1-s; mHk1-; mHk1-s
Orthologs:
Homo sapiens (human) : HK1 (hexokinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hk1 (hexokinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hk1 (hexokinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HK1 (hexokinase 1)
Canis lupus familiaris (dog) : HK1 (hexokinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hk1 (hexokinase 1)
Sus scrofa (pig) : HK1 (hexokinase 1)
Chlorocebus sabaeus (African green monkey) : HK1 (hexokinase 1)
Heterocephalus glaber (naked mole-rat) : Hk1 (hexokinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,104,634 - 62,215,699 (-)NCBI
GRCm381062,268,855 - 62,379,920 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,268,855 - 62,379,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371061,731,603 - 61,842,656 (-)NCBIGRCm37mm9NCBIm37
MGSCv361061,665,219 - 61,775,240 (-)NCBImm8
Celera1063,372,104 - 63,483,135 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10710
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.