Slc2a3 (solute carrier family 2 member 3) - Rat Genome Database

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Gene: Slc2a3 (solute carrier family 2 member 3) Rattus norvegicus
Analyze
Symbol: Slc2a3
Name: solute carrier family 2 member 3
RGD ID: 3706
Description: Enables several functions, including dehydroascorbic acid transmembrane transporter activity; galactoside binding activity; and monosaccharide binding activity. Involved in several processes, including D-glucose import; dehydroascorbic acid transport; and response to Thyroglobulin triiodothyronine. Located in caveola and synaptic vesicle membrane. Is active in glutamatergic synapse and synaptic membrane. Biomarker of cataract and hypertension. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3); PARTICIPATES IN facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-D.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glucose transporter type 3, brain; GLUT-3; GLUT3; LOC100909595; solute carrier family 2 (facilitated glucose transporter), member 3; Solute carrier family 2 A3 (neuron glucose transporter); solute carrier family 2, facilitated glucose transporter member 3; solute carrier family 2, facilitated glucose transporter member 3-like; solute carrier family 2, member 2; solute carrier family 2, member 3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,632,887 - 157,698,034 (-)NCBIGRCr8
mRatBN7.24155,960,944 - 156,026,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,960,946 - 156,025,472 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,230,960 - 162,241,994 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04158,014,185 - 158,025,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,659,259 - 156,670,293 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,549,991 - 155,626,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,408,233 - 155,631,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,752,447 - 155,763,500 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,571,240 - 222,646,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,210,116 - 159,221,169 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,454,954 - 159,466,184 (-)NCBI
Celera4144,783,015 - 144,794,062 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
beta-maltose  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bruceine D  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
cisplatin  (ISO)
citalopram  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichromium trioxide  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxepin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fisetin  (ISO)
flecainide  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
galactose  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
imidacloprid  (EXP)
imipramine  (ISO)
ketoconazole  (ISO)
kynurenic acid  (ISO)
L-dehydroascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
loratadine  (ISO)
luteolin  (ISO)
maltose  (ISO)
maneb  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentamidine  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
quinidine  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotalol  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thalidomide  (ISO)
thimerosal  (ISO)
thioridazine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vorinostat  (ISO)
XL147  (ISO)
Yessotoxin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal membrane  (IEA,ISO)
aggresome  (ISO)
caveola  (IDA)
cell projection  (IEA)
cytoplasm  (IDA,ISO)
glutamatergic synapse  (IDA,IEP)
membrane  (ISO,ISS)
perikaryon  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)
synaptic membrane  (IDA,IEP)
synaptic vesicle membrane  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. Angulo C, etal., J Cell Physiol. 2008 Dec;217(3):708-16. doi: 10.1002/jcp.21545.
2. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
3. Analysis of the glucose transporter compliment of metabolically important tissues from the Milan hypertensive rat. Campbell IW, etal., Biochem Biophys Res Commun. 1995 Jun 26;211(3):780-91.
4. Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase. Cidad P, etal., Biochem J. 2004 Dec 15;384(Pt 3):629-36.
5. Decreased expression of glucose transport protein (Glut3) in aging and vitamin E deficiency. Fattoretti P, etal., Ann N Y Acad Sci 2002 Nov;973:293-6.
6. Activity-dependent regulation of surface glucose transporter-3. Ferreira JM, etal., J Neurosci. 2011 Feb 9;31(6):1991-9. doi: 10.1523/JNEUROSCI.1850-09.2011.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Increased expression of neuronal glucose transporter 3 but not glial glucose transporter 1 following severe diffuse traumatic brain injury in rats. Hamlin GP, etal., J Neurotrauma 2001 Oct;18(10):1011-8.
10. Influence of blood glucose on the expression of glucose trans-porter proteins 1 and 3 in the brain of diabetic rats. Hou WK, etal., Chin Med J (Engl). 2007 Oct 5;120(19):1704-9.
11. Type-2 diabetes down-regulates glucose transporter proteins and genes of the human blood leukocytes. Kipmen-Korgun D, etal., Scand J Clin Lab Invest. 2009;69(3):350-8.
12. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Langdown ML and Sugden MC, Mol Cell Endocrinol 2001 Dec 20;185(1-2):109-17.
13. Substrate specificity and kinetic parameters of GLUT3 in rat cerebellar granule neurons. Maher F, etal., Biochem J. 1996 May 1;315 ( Pt 3):827-31.
14. Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. Merriman-Smith BR, etal., Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3458-66.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons. Nagamatsu S, etal., FEBS Lett 1993 Nov 22;334(3):289-95.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
19. Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells. Rauch MC, etal., J Cell Physiol. 2006 May;207(2):397-406.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates. Santalucía T, etal., Mol Cell Endocrinol. 2006 Jun 7;251(1-2):9-16. Epub 2006 Apr 3.
23. Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets. Sato Y, etal., Tissue Cell. 1996 Dec;28(6):637-43.
24. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. Scheepers A, etal., JPEN J Parenter Enteral Nutr. 2004 Sep-Oct;28(5):364-71.
25. Glucose transporter (Glut1, Glut3) mRNA in human placenta of diabetic and non-diabetic pregnancies. Sciullo E, etal., Early Pregnancy. 1997 Sep;3(3):172-82.
26. Glucose transporter GLUT3 in the rat placental barrier: a possible machinery for the transplacental transfer of glucose. Shin BC, etal., Endocrinology. 1997 Sep;138(9):3997-4004.
27. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Simpson IA, etal., Ann Neurol. 1994 May;35(5):546-51.
28. Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin resistance. Stuart CA, etal., Metabolism. 2001 Jul;50(7):771-7.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Glucose transporter Glut3 is targeted to secretory vesicles in neurons and PC12 cells. Thoidis G, etal., J Biol Chem. 1999 May 14;274(20):14062-6.
31. Dynamic expression of glucose transporters 1 and 3 in the brain of diabetic rats with cerebral ischemia reperfusion. Zhang WW, etal., Chin Med J (Engl). 2009 Sep 5;122(17):1996-2001.
Additional References at PubMed
PMID:7475896   PMID:8457197   PMID:9228080   PMID:9477959   PMID:10862609   PMID:12477932   PMID:12506324   PMID:15033779   PMID:17213475   PMID:17416968   PMID:18084728   PMID:18474279  
PMID:18957618   PMID:19144954   PMID:19681047   PMID:20175235   PMID:20458337   PMID:20813712   PMID:21141602   PMID:21321936   PMID:21624469   PMID:22104347   PMID:22258767   PMID:22605548  
PMID:22871113   PMID:23851016   PMID:23975336   PMID:24382486   PMID:26176916   PMID:29582588   PMID:30296507   PMID:33856052  


Genomics

Comparative Map Data
Slc2a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84157,632,887 - 157,698,034 (-)NCBIGRCr8
mRatBN7.24155,960,944 - 156,026,000 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4155,960,946 - 156,025,472 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4162,230,960 - 162,241,994 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04158,014,185 - 158,025,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04156,659,259 - 156,670,293 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04155,549,991 - 155,626,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,408,233 - 155,631,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,752,447 - 155,763,500 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,571,240 - 222,646,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,210,116 - 159,221,169 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14159,454,954 - 159,466,184 (-)NCBI
Celera4144,783,015 - 144,794,062 (-)NCBICelera
Cytogenetic Map4q42NCBI
SLC2A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,919,230 - 7,936,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,919,230 - 8,019,007 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,071,826 - 8,088,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,963,094 - 7,980,138 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,963,093 - 7,980,138NCBI
Celera129,649,416 - 9,666,481 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,884,929 - 7,901,971 (-)NCBIHuRef
CHM1_1128,070,777 - 8,087,842 (-)NCBICHM1_1
T2T-CHM13v2.0127,933,413 - 7,950,362 (-)NCBIT2T-CHM13v2.0
Slc2a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,704,783 - 122,779,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6122,704,768 - 122,778,599 (-)EnsemblGRCm39 Ensembl
GRCm386122,727,809 - 122,802,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,727,809 - 122,801,640 (-)EnsemblGRCm38mm10GRCm38
MGSCv376122,677,827 - 122,692,763 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366122,693,445 - 122,708,138 (-)NCBIMGSCv36mm8
Celera6124,528,542 - 124,543,474 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map657.82NCBI
SLC2A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21013,481,590 - 13,498,784 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11213,478,349 - 13,495,543 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,045,058 - 8,062,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,406,287 - 8,423,746 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,408,457 - 8,423,466 (-)Ensemblpanpan1.1panPan2
SLC2A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,297,932 - 37,309,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,297,932 - 37,428,410 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,222,336 - 9,318,492 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,650,602 - 37,746,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,650,602 - 37,746,940 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,530,947 - 37,622,282 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,566,515 - 37,663,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,709,301 - 8,801,490 (+)NCBIUU_Cfam_GSD_1.0
SLC2A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1562,963,635 - 63,041,955 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,800,940 - 65,810,870 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,004,861 - 8,023,023 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366608997,770 - 114,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248605,069,246 - 5,153,435 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a3
333 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:67
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000011298, ENSRNOT00000071745
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
UniSTS:144426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24155,963,096 - 155,963,258 (+)MAPPERmRatBN7.2
Rnor_6.04155,752,471 - 155,752,632NCBIRnor6.0
Rnor_6.04155,552,144 - 155,552,305NCBIRnor6.0
Rnor_5.04222,573,393 - 222,573,554UniSTSRnor5.0
Rnor_5.04222,773,237 - 222,773,398UniSTSRnor5.0
RGSC_v3.44159,210,140 - 159,210,301UniSTSRGSC3.4
Celera4144,783,039 - 144,783,200UniSTS
Cytogenetic Map4q42UniSTS
Slc2a3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24155,962,997 - 155,963,119 (+)MAPPERmRatBN7.2
Rnor_6.04155,752,372 - 155,752,493NCBIRnor6.0
Rnor_6.04155,552,045 - 155,552,166NCBIRnor6.0
Rnor_5.04222,573,294 - 222,573,415UniSTSRnor5.0
Rnor_5.04222,773,138 - 222,773,259UniSTSRnor5.0
RGSC_v3.44159,210,041 - 159,210,162UniSTSRGSC3.4
Celera4144,782,940 - 144,783,061UniSTS
Cytogenetic Map4q42UniSTS
PMC20520P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24155,962,974 - 155,963,257 (+)MAPPERmRatBN7.2
Rnor_6.04155,752,349 - 155,752,631NCBIRnor6.0
Rnor_6.04155,552,022 - 155,552,304NCBIRnor6.0
Rnor_5.04222,573,271 - 222,573,553UniSTSRnor5.0
Rnor_5.04222,773,115 - 222,773,397UniSTSRnor5.0
RGSC_v3.44159,210,018 - 159,210,300UniSTSRGSC3.4
Celera4144,782,917 - 144,783,199UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
15 11 55 134 113 108 65 31 65 12 256 121 102 47 71 43

Sequence


Ensembl Acc Id: ENSRNOT00000011298   ⟹   ENSRNOP00000011298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,962,638 - 156,025,472 (-)Ensembl
Rnor_6.0 Ensembl4155,552,013 - 155,563,249 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071745   ⟹   ENSRNOP00000066684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,960,946 - 155,974,240 (-)Ensembl
Rnor_6.0 Ensembl4155,752,447 - 155,763,500 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085447   ⟹   ENSRNOP00000070121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4155,408,233 - 155,561,324 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088270   ⟹   ENSRNOP00000069413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4155,960,946 - 155,973,123 (-)Ensembl
Rnor_6.0 Ensembl4155,549,986 - 155,631,856 (-)Ensembl
RefSeq Acc Id: NM_001412552   ⟹   NP_001399481
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,632,887 - 157,697,413 (-)NCBI
mRatBN7.24155,960,944 - 156,025,472 (-)NCBI
RefSeq Acc Id: NM_017102   ⟹   NP_058798
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,632,887 - 157,646,186 (-)NCBI
mRatBN7.24155,960,944 - 155,974,243 (-)NCBI
Rnor_6.04155,552,120 - 155,563,167 (-)NCBI
Rnor_5.04222,571,240 - 222,646,977 (-)NCBI
RGSC_v3.44159,210,116 - 159,221,169 (-)RGD
Celera4144,783,015 - 144,794,062 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237296   ⟹   XP_006237358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,632,887 - 157,698,034 (-)NCBI
mRatBN7.24155,960,944 - 156,026,000 (-)NCBI
Rnor_6.04155,549,991 - 155,626,018 (-)NCBI
Rnor_5.04222,571,240 - 222,646,977 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063285612   ⟹   XP_063141682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,632,887 - 157,697,408 (-)NCBI
RefSeq Acc Id: XM_063285613   ⟹   XP_063141683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,632,887 - 157,697,391 (-)NCBI
RefSeq Acc Id: XM_063285614   ⟹   XP_063141684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84157,632,887 - 157,696,798 (-)NCBI
RefSeq Acc Id: NP_058798   ⟸   NM_017102
- Peptide Label: isoform 1
- UniProtKB: Q62729 (UniProtKB/Swiss-Prot),   Q07647 (UniProtKB/Swiss-Prot),   A0A0G2JT05 (UniProtKB/TrEMBL),   A6ILF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237358   ⟸   XM_006237296
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVB0 (UniProtKB/TrEMBL),   A0A0G2JSJ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070121   ⟸   ENSRNOT00000085447
Ensembl Acc Id: ENSRNOP00000011298   ⟸   ENSRNOT00000011298
Ensembl Acc Id: ENSRNOP00000069413   ⟸   ENSRNOT00000088270
Ensembl Acc Id: ENSRNOP00000066684   ⟸   ENSRNOT00000071745
RefSeq Acc Id: NP_001399481   ⟸   NM_001412552
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JVB0 (UniProtKB/TrEMBL),   A0A0G2JSJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141682   ⟸   XM_063285612
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVB0 (UniProtKB/TrEMBL),   A0A0G2JSJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141683   ⟸   XM_063285613
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVB0 (UniProtKB/TrEMBL),   A0A0G2JSJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141684   ⟸   XM_063285614
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVB0 (UniProtKB/TrEMBL),   A0A0G2JSJ3 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07647-F1-model_v2 AlphaFold Q07647 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693371
Promoter ID:EPDNEW_R3895
Type:single initiation site
Name:Slc2a3_1
Description:solute carrier family 2 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3896  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04155,563,290 - 155,563,350EPDNEW
RGD ID:13693386
Promoter ID:EPDNEW_R3896
Type:initiation region
Name:Slc2a3_2
Description:solute carrier family 2 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3895  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04155,631,808 - 155,631,868EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3706 AgrOrtholog
BioCyc Gene G2FUF-43145 BioCyc
Ensembl Genes ENSRNOG00000008376 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049298 Ensembl
Ensembl Transcript ENSRNOT00000011298.7 UniProtKB/TrEMBL
  ENSRNOT00000071745.2 UniProtKB/TrEMBL
  ENSRNOT00000088270.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6887820 IMAGE-MGC_LOAD
InterPro Glc_transpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25551 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72866 IMAGE-MGC_LOAD
NCBI Gene 25551 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc2a3 PhenoGen
PRINTS GLUCTRSPORT3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGRTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008376 RatGTEx
  ENSRNOG00000049298 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228128
UniProt A0A0G2JSJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JT05 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JVB0 ENTREZGENE, UniProtKB/TrEMBL
  A6ILF8 ENTREZGENE, UniProtKB/TrEMBL
  GTR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62729 ENTREZGENE
  Q6P506_RAT UniProtKB/TrEMBL
UniProt Secondary Q62729 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc2a3  solute carrier family 2 member 3  LOC100909595  solute carrier family 2, facilitated glucose transporter member 3-like  Data merged from RGD:6502547 737654 PROVISIONAL
2016-02-24 Slc2a3  solute carrier family 2 member 3  Slc2a3  solute carrier family 2 (facilitated glucose transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909595  solute carrier family 2, facilitated glucose transporter member 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Slc2a3  solute carrier family 2 (facilitated glucose transporter), member 3    solute carrier family 2, member 2  Name updated 1299863 APPROVED
2003-04-09 Slc2a3  solute carrier family 2, member 2    Solute carrier family 2 A3 (neuron glucose transporter)  Name updated 629478 APPROVED
2002-06-10 Slc2a3  Solute carrier family 2 A3 (neuron glucose transporter)      Symbol and Name status set to approved 70586 APPROVED