Pla2g5 (phospholipase A2, group V)

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Gene: Pla2g5 (phospholipase A2, group V) Rattus norvegicus

Analyze

Symbol:

Pla2g5

Name:

phospholipase A2, group V

RGD ID:

62051

Description:

Enables calcium-dependent phospholipase A2 activity and heparin binding activity. Involved in several processes, including arachidonic acid secretion; leukotriene biosynthetic process; and platelet activating factor biosynthetic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (phospholipase A2 group V); PARTICIPATES IN alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

calcium-dependent phospholipase A2; group V phospholipase A2; MGC93513; phosphatidylcholine 2-acylhydrolase 5; phospholipase A2 group V; phospholipase A2, group 5; PLA2-10

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLA2G5 (phospholipase A2 group V)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pla2g5 (phospholipase A2, group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pla2g5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLA2G5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLA2G5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pla2g5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLA2G5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLA2G5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pla2g5 (phospholipase A2 group V)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pla2g5 (phospholipase A2, group V)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PLA2G5 (phospholipase A2 group V)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pla2g2e	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	151,041,339 - 151,109,433 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,041,340 - 151,062,658 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,738,735 - 153,760,037 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,513,041 - 155,534,343 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,495,070 - 155,516,077 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,247,601 - 157,268,968 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,247,781 - 157,268,903 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	160,988,968 - 161,030,066 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,619,703 - 157,640,971 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	157,629,741 - 157,651,010 (-)	NCBI
Celera	5	149,429,045 - 149,450,195 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

familial benign fleck retina (ISO)

genetic disease (ISO)

hyperprolinemia type 2 (ISO)

late-onset retinal degeneration (ISO)

Parkinson's disease 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

ammonium chloride (EXP)

arachidonic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benazepril (EXP)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-D-glucosamine (EXP)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium atom (EXP)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

clofibrate (ISO)

Cuprizon (EXP)

dibutyl phthalate (EXP,ISO)

doxorubicin (EXP,ISO)

enzalutamide (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (EXP)

gentamycin (EXP)

glycidol (EXP)

hydrogen peroxide (ISO)

icosanoid (ISO)

isoliquiritigenin (ISO)

L-methionine (ISO)

lead diacetate (EXP)

leukotriene C4 (ISO)

lipopolysaccharide (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

N-formyl-L-methionyl-L-leucyl-L-phenylalanine (ISO)

N-nitrosodiethylamine (ISO)

naphthalene (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

pentanal (ISO)

peptidoglycan (ISO)

piperonyl butoxide (ISO)

progesterone (EXP,ISO)

propanal (ISO)

prostaglandin E2 (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sarin (ISO)

silicon dioxide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonic acid secretion (IBA,IDA,IEA,ISO)

cardiolipin acyl-chain remodeling (IEA,ISO,ISS)

fatty acid metabolic process (IEA)

leukotriene biosynthetic process (IDA,IEA,ISO)

lipid catabolic process (IEA)

low-density lipoprotein particle remodeling (ISO,ISS)

negative regulation of inflammatory response (ISO)

negative regulation of T cell proliferation (IBA)

phagosome-lysosome fusion (ISO,ISS)

phosphatidylcholine catabolic process (IEA,ISO,ISS)

phospholipid metabolic process (IBA,IEA,ISO)

platelet activating factor biosynthetic process (IDA)

positive regulation of antifungal innate immune response (ISO,ISS)

positive regulation of ERK1 and ERK2 cascade (IEA,ISO)

positive regulation of immune complex clearance by monocytes and macrophages (IEA,ISO,ISS)

positive regulation of macrophage derived foam cell differentiation (ISO,ISS)

positive regulation of opsonization (ISO,ISS)

positive regulation of phagocytosis (ISO,ISS)

positive regulation of phagosome maturation (ISO,ISS)

regulation of macrophage activation (ISO)

response to cAMP (IEP)

response to cytokine (IEP)

Cellular Component

cell surface (ISO)

early phagosome (ISO,ISS)

extracellular region (IEA)

Golgi apparatus (IEA)

perinuclear region of cytoplasm (IDA)

phagolysosome (ISO,ISS)

plasma membrane (IEA)

recycling endosome (IEA)

Molecular Function

calcium ion binding (IBA,IEA)

calcium-dependent phospholipase A2 activity (IBA,IDA)

calcium-independent phospholipase A2 activity (IEA,ISO)

heparin binding (IDA)

phospholipase A2 activity (IEA,ISO)

phospholipid binding (IBA)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alpha-linolenic acid metabolic pathway (IEA)

arachidonic acid metabolic pathway (IEA)

ether lipid metabolic pathway (IEA)

Fc epsilon receptor mediated signaling pathway (IEA)

glutamate signaling pathway (IEA)

glycerophospholipid metabolic pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

linoleic acid metabolic pathway (IEA)

long term depression (IEA)

mitogen activated protein kinase signaling pathway (IEA)

toxoplasmosis pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning, expression and partial characterization of a novel rat phospholipase A2.	Chen J, etal., Biochim Biophys Acta 1994 Nov 17;1215(1-2):115-20.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2.	Murakami M, etal., J Biol Chem. 1998 Jun 5;273(23):14411-23.
7.	Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms.	Murakami M, etal., J Biol Chem. 2001 Mar 30;276(13):10083-96. Epub 2000 Dec 5.
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15.	Group IIA and group V secretory phospholipase A(2): quantitative analysis of expression and secretion and determination of the localization and routing in rat mesangial cells.	van der Helm HA, etal., Biochim Biophys Acta. 2001 Jan 15;1530(1):86-96.

Additional References at PubMed

PMID:8943302	PMID:11830583	PMID:12477932	PMID:14962950	PMID:15003994	PMID:15489334	PMID:16407308	PMID:19342668	PMID:20432503	PMID:22837859	PMID:23533611	PMID:23567287
PMID:24910243

Genomics

Comparative Map Data

Pla2g5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	151,041,339 - 151,109,433 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,041,340 - 151,062,658 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,738,735 - 153,760,037 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,513,041 - 155,534,343 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,495,070 - 155,516,077 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,247,601 - 157,268,968 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,247,781 - 157,268,903 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	160,988,968 - 161,030,066 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,619,703 - 157,640,971 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	157,629,741 - 157,651,010 (-)	NCBI
Celera	5	149,429,045 - 149,450,195 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

PLA2G5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	20,028,408 - 20,091,911 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	20,028,179 - 20,091,911 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	20,396,687 - 20,418,404 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	20,269,288 - 20,290,981 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	20,142,143 - 20,162,959	NCBI
Celera	1	18,719,822 - 18,741,514 (+)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	18,642,531 - 18,664,224 (+)	NCBI		HuRef
CHM1_1	1	20,506,410 - 20,528,103 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,852,033 - 19,915,547 (+)	NCBI		T2T-CHM13v2.0

Pla2g5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	138,526,558 - 138,590,780 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	138,526,555 - 138,590,793 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	138,799,247 - 138,863,562 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	138,799,244 - 138,863,482 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,355,162 - 138,419,384 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,071,333 - 138,091,286 (-)	NCBI		MGSCv36	mm8
Celera	4	140,584,350 - 140,649,745 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.57	NCBI

Pla2g5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	710,271 - 723,142 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	662,281 - 721,507 (+)	NCBI	ChiLan1.0	ChiLan1.0

PLA2G5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	206,144,002 - 206,165,768 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,983,104 - 19,046,834 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	20,026,361 - 20,089,840 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	20,068,110 - 20,089,840 (+)	Ensembl	panpan1.1		panPan2

PLA2G5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	78,762,851 - 78,781,642 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	78,762,852 - 78,781,983 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,276,435 - 75,295,216 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,329,011 - 79,347,745 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,329,015 - 79,347,767 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,148,347 - 76,167,055 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,154,883 - 77,173,638 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,225,847 - 78,234,080 (-)	NCBI		UU_Cfam_GSD_1.0

Pla2g5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	40,307,140 - 40,326,035 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	6,131,884 - 6,150,819 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936474	6,131,915 - 6,150,810 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLA2G5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	78,302,062 - 78,376,220 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	78,365,697 - 78,376,383 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	72,541,431 - 72,565,649 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLA2G5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,465,341 - 112,487,082 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,464,033 - 112,487,089 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,696,670 - 3,719,131 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pla2g5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	5,196,215 - 5,207,232 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	5,196,215 - 5,207,138 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pla2g5
403 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	409
Count of miRNA genes:	211
Interacting mature miRNAs:	248
Transcripts:	ENSRNOT00000022716
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat

Markers in Region

RH143028

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	151,051,526 - 151,051,656 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	157,257,796 - 157,257,925	NCBI	Rnor6.0
Rnor_5.0	5	160,999,155 - 160,999,284	UniSTS	Rnor5.0
RGSC_v3.4	5	157,629,864 - 157,629,993	UniSTS	RGSC3.4
Celera	5	149,439,206 - 149,439,335	UniSTS
RH 3.4 Map	5	1034.1	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH144651

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	151,055,414 - 151,055,607 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	157,261,684 - 157,261,876	NCBI	Rnor6.0
Rnor_5.0	5	161,003,043 - 161,003,235	UniSTS	Rnor5.0
RGSC_v3.4	5	157,633,752 - 157,633,944	UniSTS	RGSC3.4
Celera	5	149,443,094 - 149,443,286	UniSTS
RH 3.4 Map	5	1033.2	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH134706

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	151,041,368 - 151,041,585 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	157,247,638 - 157,247,854	NCBI	Rnor6.0
Rnor_5.0	5	160,988,998 - 160,989,214	UniSTS	Rnor5.0
RGSC_v3.4	5	157,619,707 - 157,619,923	UniSTS	RGSC3.4
Celera	5	149,429,049 - 149,429,265	UniSTS
RH 3.4 Map	5	1033.5	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		25									14
Low	3	6	16	8	18	8	6	7	52		20	11	6
Below cutoff		8	25	17	1	17	2	4	18	27	6		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY651028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U03763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000022716 ⟹ ENSRNOP00000022715

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	151,041,340 - 151,062,658 (-)	Ensembl
Rnor_6.0 Ensembl	5	157,247,781 - 157,268,903 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098996 ⟹ ENSRNOP00000086169

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	151,041,340 - 151,048,608 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113045 ⟹ ENSRNOP00000087975

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	151,041,340 - 151,049,135 (-)	Ensembl

RefSeq Acc Id:

NM_017174 ⟹ NP_058870

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	151,041,365 - 151,062,634 (-)	NCBI
Rnor_6.0	5	157,247,634 - 157,268,903 (-)	NCBI
Rnor_5.0	5	160,988,968 - 161,030,066 (-)	NCBI
RGSC_v3.4	5	157,619,703 - 157,640,971 (-)	RGD
Celera	5	149,429,045 - 149,450,195 (-)	RGD

Sequence:

show sequence

GGGGGCTGAGCAGGATGTTGACTGGCTATCGTTCATTGAGCACTCTCACGATCAGCATCACGCA
CGGAATCCATCCTTCCTGTGTTGCAGCTTGTAGACCCTGATGCTTGGGCTGCCAGCATAAACGT
GGGGATCCAGACTCTGTCTACCGAGGCTGCCCATAGGGACAGGCCCTGGGAAGAGGAGCTGAGA
CCAGGCTAAAAAGAACCCAAGAAATGAAGCGCCTCCTCACGCTGGCTTGGTTCCTGGCTTGCAG
TGTGCCTGCAGTCCCAGGGGGCTTGCTAGAACTGAAGTCCATGATTGAGAAGGTGACTGGGAAG
AATGCCGTAAAGAACTATGGCTTCTACGGCTGCTACTGTGGCTGGGGCGGCCACGGGACCCCTA
AGGATGGCACTGATTGGTGCTGTCGGATGCACGACCGTTGTTATGGGCTACTGGAGGAGAAACA
CTGTGCCATCCGGACCCAGTCCTATGACTACAGATTCACACAGGACTTAGTCATCTGCGAACAC
GACTCCTTCTGTCCAGTGAGGCTTTGTGCTTGTGACCGGAAGCTGGTCTACTGCCTGAGGAGAA
ACCTCTGGAGTTACAACCGTCTTTACCAGTATTACCCCAACTTCCTCTGCTAATGTCCTCTGTG
GGCTCTCGCCGGGAGTGCCTCCCACAGTGGCGGCCCCCCTCGGCTGTATTCCTGATCCGTCCAC
CCAAGGTCTTGGATCTGCCTTCCTCTGTGTACCACTGGGCTGGACAGAGCCCAGGGTTACACCC
TACCCTCCAGAATCCTAGAGAGGGACTCTGATGTAGAGTCTGCGGACTCTGGATAGCTGAGCCT
GCACTTGCAGAATTTGGCGCTGGGCCCCGGAGCTCCCTCAGCTCCAGGCCAGTGTCGTGTTGAC
TTTCCTTTCAATTTCTGGAACCCAACTGCCATTACCACCCTCCAGAGACCTCTTACTAGAGGAG
AAGCCAAATTAACTCTATAAATCTGCCATGTAGCTATTAAATAAAACCCATTCACGAGGCGAGA
AGAACACCACCCCAGCACTCCCTCTGACAGGGCTGGGGTAGGAGTGCCAATGCTTCTCTAACCC
CTGAGGCATCTGTGCACCCTCTAGGATGGAGGTCAGGAAACAGGTGGGGGCCTTACATGCCTTT
CATGGTTTGTCTTGAGTTTATTTTCTTAAACCTTAGGGTCTTTCAAGCCAGACCTGGAGCTCAA
GATTCTTCTGGAGGAAGGTGAGACACAGCCCTATGCCACCTTGACGCTCCAGGCTAGAAAGGGA
CAGCCCCTAGCCCTGGCTTCTGCAACTGTGTGGTCTTGAACCTCCGTATAGTCCGAATCCCTCT
GGCTCTCCTCAAAATATAAAACAAGCCTCCTTCCAATAGCATATTGGTGCACACCCCTAATCCC
ATCACCTGGGAGGAGGAGGCGGCAGGAGCATCAGGAGTTCAAGGCCAGCTCCTGCCCCCTAGCA
GGGATGGTAGGCTGCATGAGAGTGTGTCTCAGAAAGAACCACCTGGTGCGGGTACAGGGATGCT
GGGATTCTGAGATGTCACTCAGTGCGGGAAAAGATTCAAGGAGGGGAACAGATCAATGGCAGAA
TGACTGTCTGTGCCGAGTTAAGGGCACTGAAAATCTCAGCTCATCTATCGCTTTATAGAAGATA
GAGCTTTGGGAGGAAGCAAGGCACTCTACAGTAAAGGAGTGGCCTTTCCAAGGAAGGGTCTAGG
CTCCTTCTTCTCCAGAACATGCACAGGACATAGGAGATCCATTATTTAGAGACCTTTCGTGTTC
GAACGTTTTCT

hide sequence

RefSeq Acc Id:

XM_006239139 ⟹ XP_006239201

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	151,041,339 - 151,062,691 (-)	NCBI
Rnor_6.0	5	157,247,601 - 157,268,968 (-)	NCBI
Rnor_5.0	5	160,988,968 - 161,030,066 (-)	NCBI

Sequence:

show sequence

ACAGAAGGGCCAGTGCTGTGCCAGCCTCTGCTTTTGCAGGACTTTCTGCCACCATGAAGGCTGT
TGGGGGCTGAGCAGGATGTTGACTGGCTATCGTTCATTGAGCACTCTCACGATCAGCATCACGC
ACGGAATCCATCCTTCCTGTGTTGCAGCTTGTAGACCCTGATGCTTGGGCTGCCAGCCATAAAC
GTGGGGATCCAGACTCTGTCTACCGAGGCTGCCCATAGGGACAGGCCCTGGGAAGAGGAGCTGA
GACCAGGCTAAAAAGAGTGGACTCACCAGGCATCCCAGTACCCTGAGGAGTTTAAGAAGACTTA
ATGGATGCTTGTGGATGCTGATGTGGCCTTGGACCTAGTGGGGGCTCAGAGAATGCTGAACTCT
CTCCTTCCTTCCTGAACCATCGTCTGTAGGAACCCCTCTGATAGGAAGTGCCCAAGAGGACAGT
TGTATGAGGTGACAGAGCATGATCCCGAGACCAGCCAACTCCCTGCTGGAATTAAATCTTGCAA
GAGAATTATCTGCAAGGGCTCCAAGCGGTTTTTTTTTTTTTAATTTCTCAGAGACCCTTGGATG
AACTGTTCTAGATGCTCCCCAGGGACCATAAAGCCCTAGTCCAAGGCCGGAGTTATTGTGAAAA
CTTGGGTTTTTTGGTGCAGGAGTGGCCAGGCCTTGCTTTGGCCTAGGCACTAGCCTGCTCCTCT
TACACCCAGAGAGCAAATAAGTTATGAGATGTTTAACTCATCCCGTGGGGATTTCCTGAGGCCC
GTTTGACGTGAGAAGCTGTTCTTGGAACTGAGATTAGACACCATTACATAGGAACTCTGCCTTC
AGGAGCCCAGCCTATCTCACCAGGCTTTCCTTGCCACAGCTGGGGACAGCTGCAACTCCTCTAC
AGGGGACCTGCGAACCCTCCCGCCCTACCACTCCACACCACTGCTAGTGTGACTGGAAGCTTGT
GTTCCGAGGCTGAACCCAAGAAATGAAGCGCCTCCTCACGCTGGCTTGGTTCCTGGCTTGCAGT
GTGCCTGCAGTCCCAGGGGGCTTGCTAGAACTGAAGTCCATGATTGAGAAGGTGACTGGGAAGA
ATGCCGTAAAGAACTATGGCTTCTACGGCTGCTACTGTGGCTGGGGCGGCCACGGGACCCCTAA
GGATGGCACTGATTGGTGCTGTCGGATGCACGACCGTTGTTATGGGCTACTGGAGGAGAAACAC
TGTGCCATCCGGACCCAGTCCTATGACTACAGATTCACACAGGACTTAGTCATCTGCGAACACG
ACTCCTTCTGTCCAGTGAGGCTTTGTGCTTGTGACCGGAAGCTGGTCTACTGCCTGAGGAGAAA
CCTCTGGAGTTACAACCGTCTTTACCAGTATTACCCCAACTTCCTCTGCTAATGTCCTCTGCGG
GCTCTGCCCCGGGAGTGCCTCCCACAGTGGCGGCCCCCCTCTGCTGTATTCCTGATCCGTCCAC
CCAAGGTCTTGGATCTGCCTTCCTCTGTGTACCACTGGGCTGGACAGAGCCCCAGGGTTACACT
CTACCCTCCAGAATCCTAGAGAGGGACTCTGATGTAGAGTCTGCGGACTCTGGATAGCTGAGCC
TGCACTTGCAGAATTTGGCGCTGGGCCCCGGAGCTCCCTCAGCTCCAGGCCAGTGTCGTGTTGA
CTTTCCTTTCAATTTCTGGAACCCAACTGCCATTACCACCCTCCAGAGACCTCTTACTAGAGGA
GAAGCCAAATTAACTCTATAAATCTGCCATGTAGCTATTAAATAAAACCCATTCACGAGGCGAG
AAGAACACCACCCCAGCACTCCCTCTGACAGGGCTGGGGTAGGAGTGCCAATGCTTCTCTAACC
CCTGAGGCATCTGTGCACCCTCTAGGATGGAGGTCAGGAAACAGGTGGGGGCCTTACATGCCTT
TCATGGTTTGTCTTGAGTTTATTTTCTTAAACCTTAGGGTCTTTCAAGCCAGACCTGGAGCTCA
AGATTCTTCTGGAGGAAGGTGAGACACAGCCCTATGCCACCTTGAGCTCCAGGCTAGAAAGGGA
CAGCCCCTAGCCCTGGCTTCTGCAACTGTGTGGTCTTGAACCTCCGTATAGTCCGAATCCCTCT
GGCTCTCCTCAAAATATAAAACAAGCCTCCTTCCAATAGCATATTGGTGCACACCCCTAATCCC
AGCACCTGGGAGGAGGAGGCGGCAGGAGCATCAGGAGTTCAAGGCCAGCTCCTGCCCCCTAGCA
GGGATGGTAGGCTGCATGAGAGTGTGTCTCAGAAAGAACCACCTGGTGCGGGTACAGGGATGCT
GGGATTCTGAGATGTCACTCAGTGCGGGAAAAGATTCAAGGAGGGGAACAGATCAATGGCAGAA
TGACTGTCTGTGCCGAGTTAAGGGCACTGAAAATCTCAGCTCATCTATCGCTTTATAGAAGATA
GAGCTTTCCCATAGCAACCTGACGGGAGGAAGCAAGGCACTCTACAGTAAAGGAGTGGCCTTTC
CAAGGAAGGGTCTAGGCTCCTTCTTCTCCAGAACATGCACAGGACATAGGAGATCCATATTTAG
AGACCTTTCGTGTTCGAACGTTTTCTAACTAAAGTTAATTATATTGAGATTACCCCGAA

hide sequence

RefSeq Acc Id:

XM_008764210 ⟹ XP_008762432

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	151,041,339 - 151,054,290 (-)	NCBI
Rnor_6.0	5	157,247,601 - 157,260,524 (-)	NCBI

Sequence:

show sequence

GTTTAGGGGCTGGAAAGGGGGTTGATGTAGTTGGGGCTGTCACAGTTGAGGCTGACTCAGTCGG
GCCTGTGCTGGTAGAGAAAGAGCCTGGAGACAGATGGCAATACCATGTGAGACTCAGGGTGAAC
ACGAAGCACAGGTTGCCAGGCTCGTGGCACAGAAGGGGTGACAGCGAGGTGACATGGAGGTCTC
TACATGGAAATGTGAGTTTTAGAGGAAAATGAAAGTTTCAGGAAGCCACTGGAGGCAAAAAGGA
AGGTGACACTTTTGGTTTTTGGGTTTTGAGGCGGAGTTTCATGTATCCCAGGCTGGGATTACAG
GACACCACACCCACTATGTACTGGTGCTGGGGATCGAACCTAGAGTCTCCTGCATGTCAGGCAG
ACACTCTATCAACCGAGTCCTCGAGCACAGCTCCTGGCCTCCCATTTAGGATGGCAAGGTCAGC
AGGCATTTGTGACAGAAGGGACAATTTGGGGAGCTGGCAAGTTAGCTTGGCAGGTAGACACTGC
TAAGCCTGCTTCCACAAACCCTATGTCTGAGCCCACCTGGGAGAGGGAGAGAACTGACTCCTAT
GAGCTGTCCTCCGACCTTTGCATGTCACGTGACCACCTCTCCACCACCACCCCGCTGTCCCCAA
GGAGAAGACCATTGGCCAAGAAGGAGAACCGAGATAGAAGAATAGACAGTTCAGTGTATGCGCC
TCTCCTAGCTGTCTCTCCTCACCAGAGAGCAGGGGCTCTGTCTCGTTCACCGCTGGATCCCCTC
TAGTGTCTGGCACACAGTGGACAGGTATTGTGTATTGAGTTGAGTTCCCAGGGCAACGTGGTTA
GGTCCTAGGGAGAGAAGTAGTCATGAGGGCTTCTCGCTGCTGCTGCTGCTGCTGTCGCTGCTGG
GAGAGATGGGAGGGAAAGAGGAGAGAAGGCCAGCAGTGCAGGGGAGCTATCTCAGGAAGTACAG
TGCTTGTCACACAAACCTCTGGCCTTGATCCTTAGAATTAGAAGAGAGCCAGGCCCAGTGGCAT
GCACCAATAGTCCTAGGTATCTCTTGGCTTGCTGGCCAGCCAATTTAGCTGCATTGGGAGCTCC
GGATCAAATCAGAAACCCACTCCAAAAAAACAAAGAGAGCAGTGCATTATGGGGGGGGGGGAGA
GAGGGAGAAAGGGAGAGCGAGAGAGAGACAGAGACAGAGGGACAGACAGAAAGAGACACAGAGA
GAGGTGAAGATAACTCATTCCAAAGCTTCTTTGTGAAGCAACAAGTATGAGGATTCACCCAAGT
GCATAACGTCCAACTTCTAGAACATTCCACCATTCATTTATTAGCATTGTTCAGACTTTACCAT
TATTATAAGCGTTAATACGTGCATTGAGTCATTAAAGCTCATGACGGCTCCTCAAAGCGGATGA
TATTTTCAGTTAGTGAGGACGTCGAGATTTGAACCCAGGATACAGAACCTATGACGCTACCCAC
TGAGCCATACACTCTTCTGTGCGACATTATTTTGCAGTTTGTCTGGTACTCTTCTCACTGGGCT
TATTGGGGGAGGGTCACCGTGTTCAAGTTTCATATGAAGAAACAGAGAGGTACAGCTATTCGCC
CAGGGTCACACAGCTACGAAGTGGCTCCGGGAGAAAAGCTGGGATTCAGTAGTGAGTGAGTCGG
ATGTCAACAGGTGGTACCAGATGCTAGGACTTGGGAGGTGGCATCTTGCAGCATCTCCAGAGGG
GCTCTACATGCTTCTGAGAAAGTCGGGGCAGGCAAGTTAGAAAGGGGAGGAGGAAGATTACCAC
CTGTACCCATGGCTGCTCTCGAGCTGAGGCTGAAGAAGACAGAACAAAATAGAAGCGGTTCTGT
GGGCTGGGAAACCACAAGGAACCAAAGACTGGATCATTCCACAAAGGCCCACTGTGGCAGCGGA
AGTGGAGACTGTGCCTGGGAGGGGATTTCAGGACTCTGTCTCTAGTCGGGTAATAGTCTCAGAC
CCAGGTCAACTCAAGCTAGCCTTTTCTGGATATCTCCCCTGAGAGCTCCCCAGCCCTGAGGCCT
GTATCAAGAATCTAGAGAAGGAAAAACAACAGGGGGTCTTGAAGTGGGCCTCCCTGAGTTCCCA
GGAATCTTGGAGGTGGCCCAGGCAGCGGTGTGGGAGGCGACCAGGACTGGTTTTAAACCAAGCA
GGCACAGCTGCTGCTTCTTCTCCTCCGGGACTGAGGACAGAGACTAGCAATCAGAACCCAAGAA
ATGAAGCGCCTCCTCACGCTGGCTTGGTTCCTGGCTTGCAGTGTGCCTGCAGTCCCAGGGGGCT
TGCTAGAACTGAAGTCCATGATTGAGAAGGTGACTGGGAAGAATGCCGTAAAGAACTATGGCTT
CTACGGCTGCTACTGTGGCTGGGGCGGCCACGGGACCCCTAAGGATGGCACTGATTGGTGCTGT
CGGATGCACGACCGTTGTTATGGGCTACTGGAGGAGAAACACTGTGCCATCCGGACCCAGTCCT
ATGACTACAGATTCACACAGGACTTAGTCATCTGCGAACACGACTCCTTCTGTCCAGTGAGGCT
TTGTGCTTGTGACCGGAAGCTGGTCTACTGCCTGAGGAGAAACCTCTGGAGTTACAACCGTCTT
TACCAGTATTACCCCAACTTCCTCTGCTAATGTCCTCTGCGGGCTCTGCCCCGGGAGTGCCTCC
CACAGTGGCGGCCCCCCTCTGCTGTATTCCTGATCCGTCCACCCAAGGTCTTGGATCTGCCTTC
CTCTGTGTACCACTGGGCTGGACAGAGCCCCAGGGTTACACTCTACCCTCCAGAATCCTAGAGA
GGGACTCTGATGTAGAGTCTGCGGACTCTGGATAGCTGAGCCTGCACTTGCAGAATTTGGCGCT
GGGCCCCGGAGCTCCCTCAGCTCCAGGCCAGTGTCGTGTTGACTTTCCTTTCAATTTCTGGAAC
CCAACTGCCATTACCACCCTCCAGAGACCTCTTACTAGAGGAGAAGCCAAATTAACTCTATAAA
TCTGCCATGTAGCTATTAAATAAAACCCATTCACGAGGCGAGAAGAACACCACCCCAGCACTCC
CTCTGACAGGGCTGGGGTAGGAGTGCCAATGCTTCTCTAACCCCTGAGGCATCTGTGCACCCTC
TAGGATGGAGGTCAGGAAACAGGTGGGGGCCTTACATGCCTTTCATGGTTTGTCTTGAGTTTAT
TTTCTTAAACCTTAGGGTCTTTCAAGCCAGACCTGGAGCTCAAGATTCTTCTGGAGGAAGGTGA
GACACAGCCCTATGCCACCTTGAGCTCCAGGCTAGAAAGGGACAGCCCCTAGCCCTGGCTTCTG
CAACTGTGTGGTCTTGAACCTCCGTATAGTCCGAATCCCTCTGGCTCTCCTCAAAATATAAAAC
AAGCCTCCTTCCAATAGCATATTGGTGCACACCCCTAATCCCAGCACCTGGGAGGAGGAGGCGG
CAGGAGCATCAGGAGTTCAAGGCCAGCTCCTGCCCCCTAGCAGGGATGGTAGGCTGCATGAGAG
TGTGTCTCAGAAAGAACCACCTGGTGCGGGTACAGGGATGCTGGGATTCTGAGATGTCACTCAG
TGCGGGAAAAGATTCAAGGAGGGGAACAGATCAATGGCAGAATGACTGTCTGTGCCGAGTTAAG
GGCACTGAAAATCTCAGCTCATCTATCGCTTTATAGAAGATAGAGCTTTCCCATAGCAACCTGA
CGGGAGGAAGCAAGGCACTCTACAGTAAAGGAGTGGCCTTTCCAAGGAAGGGTCTAGGCTCCTT
CTTCTCCAGAACATGCACAGGACATAGGAGATCCATATTTAGAGACCTTTCGTGTTCGAACGTT
TTCTAACTAAAGTTAATTATATTGAGATTACCCCGAA

hide sequence

RefSeq Acc Id:

XM_039109361 ⟹ XP_038965289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	151,041,339 - 151,109,433 (-)	NCBI

RefSeq Acc Id:

XM_039109362 ⟹ XP_038965290

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	151,041,339 - 151,109,426 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_058870	(Get FASTA)	NCBI Sequence Viewer
	XP_006239201	(Get FASTA)	NCBI Sequence Viewer
	XP_008762432	(Get FASTA)	NCBI Sequence Viewer
	XP_038965289	(Get FASTA)	NCBI Sequence Viewer
	XP_038965290	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA82112	(Get FASTA)	NCBI Sequence Viewer
	AAH85745	(Get FASTA)	NCBI Sequence Viewer
	AAT68714	(Get FASTA)	NCBI Sequence Viewer
	EDL80888	(Get FASTA)	NCBI Sequence Viewer
	EDL80889	(Get FASTA)	NCBI Sequence Viewer
	P51433	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058870 ⟸ NM_017174
- Peptide Label:	precursor
- UniProtKB:	Q6DQ96 (UniProtKB/Swiss-Prot), P51433 (UniProtKB/Swiss-Prot), A6ITI7 (UniProtKB/TrEMBL), A0A8I6A5J8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKRLLTLAWFLACSVPAVPGGLLELKSMIEKVTGKNAVKNYGFYGCYCGWGGHGTPKDGTDWCC RMHDRCYGLLEEKHCAIRTQSYDYRFTQDLVICEHDSFCPVRLCACDRKLVYCLRRNLWSYNRL YQYYPNFLC hide sequence

RefSeq Acc Id:	XP_006239201 ⟸ XM_006239139
- Peptide Label:	isoform X1
- UniProtKB:	Q6DQ96 (UniProtKB/Swiss-Prot), P51433 (UniProtKB/Swiss-Prot), A6ITI7 (UniProtKB/TrEMBL), A0A8I6A5J8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKRLLTLAWFLACSVPAVPGGLLELKSMIEKVTGKNAVKNYGFYGCYCGWGGHGTPKDGTDWCC RMHDRCYGLLEEKHCAIRTQSYDYRFTQDLVICEHDSFCPVRLCACDRKLVYCLRRNLWSYNRL YQYYPNFLC hide sequence

RefSeq Acc Id:	XP_008762432 ⟸ XM_008764210
- Peptide Label:	isoform X1
- UniProtKB:	Q6DQ96 (UniProtKB/Swiss-Prot), P51433 (UniProtKB/Swiss-Prot), A6ITI7 (UniProtKB/TrEMBL), A0A8I6A5J8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKRLLTLAWFLACSVPAVPGGLLELKSMIEKVTGKNAVKNYGFYGCYCGWGGHGTPKDGTDWCC RMHDRCYGLLEEKHCAIRTQSYDYRFTQDLVICEHDSFCPVRLCACDRKLVYCLRRNLWSYNRL YQYYPNFLC hide sequence

RefSeq Acc Id:

ENSRNOP00000022715 ⟸ ENSRNOT00000022716

RefSeq Acc Id:	XP_038965289 ⟸ XM_039109361
- Peptide Label:	isoform X1
- UniProtKB:	P51433 (UniProtKB/Swiss-Prot), Q6DQ96 (UniProtKB/Swiss-Prot), A6ITI7 (UniProtKB/TrEMBL), A0A8I6A5J8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038965290 ⟸ XM_039109362
- Peptide Label:	isoform X1
- UniProtKB:	P51433 (UniProtKB/Swiss-Prot), Q6DQ96 (UniProtKB/Swiss-Prot), A6ITI7 (UniProtKB/TrEMBL), A0A8I6A5J8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000087975 ⟸ ENSRNOT00000113045

RefSeq Acc Id:

ENSRNOP00000086169 ⟸ ENSRNOT00000098996

Protein Domains

Phospholipase A2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P51433-F1-model_v2	AlphaFold	P51433	1-137	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:62051	AgrOrtholog
BioCyc Gene	G2FUF-39440	BioCyc
Ensembl Genes	ENSRNOG00000016838	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000022715	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000086169.1	UniProtKB/TrEMBL
	ENSRNOP00000087975.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022716	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000098996.1	UniProtKB/TrEMBL
	ENSRNOT00000113045.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7192819	IMAGE-MGC_LOAD
InterPro	PLipase_A2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_Asp_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29354	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93513	IMAGE-MGC_LOAD
NCBI Gene	29354	ENTREZGENE
PANTHER	PHOSPHOLIPASE A2 GROUP V	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11716	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Phospholip_A2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pla2g5	PhenoGen
PRINTS	PHPHLIPASEA2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PA2_ASP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PA2_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	PA2c	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC210430
UniProt	A0A8I6A4T3_RAT	UniProtKB/TrEMBL
	A0A8I6A5J8	ENTREZGENE, UniProtKB/TrEMBL
	A6ITI7	ENTREZGENE, UniProtKB/TrEMBL
	A6ITI8_RAT	UniProtKB/TrEMBL
	P51433	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6DQ96	ENTREZGENE
UniProt Secondary	Q6DQ96	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Pla2g5	phospholipase A2, group V		phospholipase A2, group 5	Name updated	1299863	APPROVED
2002-06-10	Pla2g5	phospholipase A2, group 5			Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)