Akr7a3 (aldo-keto reductase family 7 member A3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Akr7a3 (aldo-keto reductase family 7 member A3) Rattus norvegicus
Analyze
Symbol: Akr7a3
Name: aldo-keto reductase family 7 member A3
RGD ID: 628635
Description: Enables aldo-keto reductase (NADPH) activity. Involved in aflatoxin catabolic process. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in cytoplasm. Orthologous to several human genes including AKR7A3 (aldo-keto reductase family 7 member A3); INTERACTS WITH 1,3-dinitrobenzene; 1-nitropropane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Afar; AFB1-AR; aflatoxin B1 aldehyde reductase; aflatoxin B1 aldehyde reductase member 1; aflatoxin B1 aldehyde reductase member 3; Akr7a1; aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase); rAFAR1
RGD Orthologs
Human
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,876,721 - 156,884,599 (+)NCBIGRCr8
mRatBN7.25151,590,968 - 151,601,394 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,584,479 - 151,601,394 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,292,151 - 154,300,047 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,066,511 - 156,074,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,047,478 - 156,055,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,801,120 - 157,813,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,801,163 - 157,813,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,540,977 - 161,553,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,139,986 - 158,147,516 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15158,150,024 - 158,157,553 (+)NCBI
Celera5149,973,124 - 149,980,999 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9,10-phenanthroquinone  (EXP,ISO)
acetamide  (EXP)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butylated hydroxyanisole  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cafestol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
diuron  (EXP)
emodin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethoxyquin  (EXP)
etofenprox  (EXP)
felbamate  (EXP)
finasteride  (EXP)
fipronil  (EXP)
fluconazole  (EXP)
flutamide  (EXP)
furan  (EXP)
gabapentin  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemfibrozil  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indole-3-methanol  (EXP)
kahweol  (EXP)
L-ethionine  (EXP)
lead diacetate  (EXP)
melatonin  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP)
mercury(0)  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (EXP)
naphthalenes  (ISO)
nefazodone  (EXP,ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxfendazole  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
sinigrin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
succinic semialdehyde  (EXP)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (EXP)
umbelliferone  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
Golgi apparatus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter. Ellis EM, etal., Carcinogenesis 2003 Apr;24(4):727-37.
2. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases. Ellis EM, etal., Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10350-4.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. Kozma E, etal., J Biol Chem 2002 May 3;277(18):16285-93. Epub 2002 Feb 11.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8395332   PMID:10383892   PMID:12071861   PMID:12477932   PMID:16189514   PMID:19056867   PMID:23376485   PMID:23533145   PMID:25416956   PMID:29383608   PMID:31515488  


Genomics

Comparative Map Data
Akr7a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,876,721 - 156,884,599 (+)NCBIGRCr8
mRatBN7.25151,590,968 - 151,601,394 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,584,479 - 151,601,394 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,292,151 - 154,300,047 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,066,511 - 156,074,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,047,478 - 156,055,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,801,120 - 157,813,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,801,163 - 157,813,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,540,977 - 161,553,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,139,986 - 158,147,516 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15158,150,024 - 158,157,553 (+)NCBI
Celera5149,973,124 - 149,980,999 (+)NCBICelera
Cytogenetic Map5q36NCBI
AKR7A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,274,229 - 19,288,770 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,282,573 - 19,288,770 (-)EnsemblGRCh38hg38GRCh38
GRCh37119,609,067 - 19,615,264 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,481,644 - 19,487,867 (-)NCBINCBI36Build 36hg18NCBI36
Build 34119,354,362 - 19,360,586NCBI
Celera117,936,048 - 17,942,271 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,855,438 - 17,861,662 (-)NCBIHuRef
CHM1_1119,718,377 - 19,724,602 (-)NCBICHM1_1
T2T-CHM13v2.0119,097,755 - 19,112,298 (-)NCBIT2T-CHM13v2.0
AKR7A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,826,569 - 207,832,727 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,941,860 - 206,949,514 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,241,298 - 18,248,142 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,287,926 - 19,294,576 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,288,100 - 19,294,041 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in Akr7a3
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:40
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000024160
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat

Markers in Region
BI275071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,601,823 - 151,602,057 (+)MAPPERmRatBN7.2
Rnor_6.05157,814,186 - 157,814,419NCBIRnor6.0
Rnor_6.05157,807,608 - 157,807,841NCBIRnor6.0
Rnor_5.05161,553,898 - 161,554,131UniSTSRnor5.0
Rnor_5.05161,547,422 - 161,547,655UniSTSRnor5.0
RGSC_v3.45158,147,946 - 158,148,179UniSTSRGSC3.4
Celera5149,981,429 - 149,981,662UniSTS
RH 3.4 Map51044.7UniSTS
Cytogenetic Map5q36UniSTS
AA891811  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,601,235 - 151,601,336 (+)MAPPERmRatBN7.2
Rnor_6.05157,813,598 - 157,813,698NCBIRnor6.0
Rnor_6.05157,807,020 - 157,807,120NCBIRnor6.0
Rnor_5.05161,553,310 - 161,553,410UniSTSRnor5.0
Rnor_5.05161,546,834 - 161,546,934UniSTSRnor5.0
RGSC_v3.45158,147,358 - 158,147,458UniSTSRGSC3.4
Celera5149,980,841 - 149,980,941UniSTS
RH 3.4 Map51047.0UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024160   ⟹   ENSRNOP00000024160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,584,479 - 151,601,394 (+)Ensembl
Rnor_6.0 Ensembl5157,801,163 - 157,813,756 (+)Ensembl
RefSeq Acc Id: NM_013215   ⟹   NP_037347
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85156,876,721 - 156,884,599 (+)NCBI
mRatBN7.25151,593,516 - 151,601,394 (+)NCBI
Rnor_6.05157,801,163 - 157,813,756 (+)NCBI
Rnor_5.05161,540,977 - 161,553,468 (+)NCBI
RGSC_v3.45158,139,986 - 158,147,516 (+)RGD
Celera5149,973,124 - 149,980,999 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109345   ⟹   XP_038965273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85156,876,850 - 156,884,598 (+)NCBI
mRatBN7.25151,593,662 - 151,601,393 (+)NCBI
RefSeq Acc Id: NP_037347   ⟸   NM_013215
- UniProtKB: Q68FZ3 (UniProtKB/Swiss-Prot),   Q5EBB7 (UniProtKB/Swiss-Prot),   Q9QX16 (UniProtKB/Swiss-Prot),   P38918 (UniProtKB/Swiss-Prot),   A6ITL5 (UniProtKB/TrEMBL),   A0A8L2QCW7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024160   ⟸   ENSRNOT00000024160
RefSeq Acc Id: XP_038965273   ⟸   XM_039109345
- Peptide Label: isoform X1
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38918-F1-model_v2 AlphaFold P38918 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694205
Promoter ID:EPDNEW_R4729
Type:multiple initiation site
Name:Akr7a3_1
Description:aldo-keto reductase family 7 member A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05157,801,154 - 157,801,214EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628635 AgrOrtholog
BioCyc Gene G2FUF-39416 BioCyc
Ensembl Genes ENSRNOG00000017899 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024160.3 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126881 IMAGE-MGC_LOAD
  IMAGE:7127297 IMAGE-MGC_LOAD
InterPro AKR UniProtKB/TrEMBL
  AKR_Detox_Biosynth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26760 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108733 IMAGE-MGC_LOAD
  MGC:93546 IMAGE-MGC_LOAD
NCBI Gene 26760 ENTREZGENE
PANTHER NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akr7a3 PhenoGen
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017899 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QCW7 ENTREZGENE, UniProtKB/TrEMBL
  A6ITL5 ENTREZGENE, UniProtKB/TrEMBL
  ARK73_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBB7 ENTREZGENE
  Q68FZ3 ENTREZGENE
  Q9QX16 ENTREZGENE
UniProt Secondary Q5EBB7 UniProtKB/Swiss-Prot
  Q68FZ3 UniProtKB/Swiss-Prot
  Q9QX16 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Akr7a3  aldo-keto reductase family 7 member A3  Akr7a3  aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Akr7a3  aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)  Afar  aflatoxin B1 aldehyde reductase  Symbol and Name updated 1299863 APPROVED
2003-02-27 Afar  aflatoxin B1 aldehyde reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 632009
gene_product belongs to the subfamily of aldo-keto reductases 632009