Map3k6 (mitogen-activated protein kinase kinase kinase 6) - Rat Genome Database

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Gene: Map3k6 (mitogen-activated protein kinase kinase kinase 6) Rattus norvegicus
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Symbol: Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
RGD ID: 1304625
Description: Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in JNK cascade; p38MAPK cascade; and protein phosphorylation. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC313022
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,724,029 - 150,736,113 (+)NCBIGRCr8
mRatBN7.25145,440,126 - 145,452,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,143,644 - 148,155,529 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,913,247 - 149,925,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,898,266 - 149,910,136 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,435,679 - 151,448,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,436,464 - 151,448,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,100,704 - 155,113,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,873,619 - 151,885,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,883,659 - 151,908,484 (-)NCBI
Celera5143,861,707 - 143,873,572 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k6RatCOVID-19  ISOMAP3K6 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744

1 to 20 of 140 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k6Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP3K6 mRNA]CTDPMID:31150632
Map3k6Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of MAP3K6 mRNACTDPMID:30723492
Map3k6Rat17beta-estradiol increases expressionISOMap3k6 (Mus musculus)6480464Estradiol results in increased expression of MAP3K6 mRNACTDPMID:19484750
Map3k6Rat17beta-estradiol decreases expressionISOMap3k6 (Mus musculus)6480464Estradiol results in decreased expression of MAP3K6 mRNACTDPMID:39298647
Map3k6Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOMAP3K6 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of MAP3K6 mRNACTDPMID:29581250
Map3k6Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:27291303
Map3k6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMap3k6 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MAP3K6 mRNACTDPMID:17035482
Map3k6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMAP3K6 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MAP3K6 mRNACTDPMID:26238291
Map3k6Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMap3k6 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of MAP3K6 mRNACTDPMID:25975270
Map3k6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMap3k6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MAP3K6 mRNACTDPMID:21570461
Map3k6Rat2,4,6-trinitrobenzenesulfonic acid decreases expressionEXP 6480464Trinitrobenzenesulfonic Acid results in decreased expression of MAP3K6 mRNACTDPMID:23537331
Map3k6Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of MAP3K6 mRNACTDPMID:21346803
Map3k6Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of MAP3K6 mRNACTDPMID:21346803
Map3k6Rat2-palmitoylglycerol increases expressionISOMAP3K6 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of MAP3K6 mRNACTDPMID:37199045
Map3k6Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOMAP3K6 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MAP3K6 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MAP3K6 mRNACTDPMID:28628672
Map3k6Rat4,4'-sulfonyldiphenol increases methylationISOMap3k6 (Mus musculus)6480464bisphenol S results in increased methylation of MAP3K6 exon and bisphenol S results in increased methylation of MAP3K6 promoterCTDPMID:33297965
Map3k6Rat4,4'-sulfonyldiphenol increases expressionISOMap3k6 (Mus musculus)6480464bisphenol S results in increased expression of MAP3K6 mRNACTDPMID:37611474
Map3k6Rat4,4'-sulfonyldiphenol affects methylationISOMap3k6 (Mus musculus)6480464bisphenol S affects the methylation of MAP3K6 geneCTDPMID:31683443
Map3k6Rat4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid decreases expressionISOMAP3K6 (Homo sapiens)6480464Am 580 results in decreased expression of MAP3K6 mRNACTDPMID:16982809
Map3k6Rat5-aza-2'-deoxycytidine affects expressionISOMAP3K6 (Homo sapiens)6480464Decitabine affects the expression of MAP3K6 mRNACTDPMID:23300844

1 to 20 of 140 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k6RatJNK cascade involved_inIBAFB:FBgn0014006 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map3k6RatMAPK cascade involved_inIEAInterPro:IPR0439691600115GO_REF:0000002InterProGO_REF:0000002
Map3k6Ratp38MAPK cascade involved_inIBAMGI:1346876 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map3k6Ratprotein phosphorylation involved_inISOMAP3K6 (Homo sapiens)1624291 PMID:9875215RGDPMID:9875215

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k6RatATP binding enablesISOMAP3K6 (Homo sapiens)1624291 PMID:9875215RGDPMID:9875215
Map3k6RatATP binding enablesIEAUniProtKB:O95382 and ensembl:ENSP000003501951600115GO_REF:0000107EnsemblGO_REF:0000107
Map3k6RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Map3k6RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Map3k6RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Map3k6Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Map3k6Ratmagnesium ion binding enablesISOMAP3K6 (Homo sapiens)1624291 PMID:9875215RGDPMID:9875215
Map3k6Ratmagnesium ion binding enablesIEAUniProtKB:O95382 and ensembl:ENSP000003501951600115GO_REF:0000107EnsemblGO_REF:0000107
Map3k6RatMAP kinase kinase kinase activity enablesISOMAP3K6 (Homo sapiens)1624291 PMID:9875215RGDPMID:9875215
Map3k6RatMAP kinase kinase kinase activity enablesIEAEC:2.7.11.251600115GO_REF:0000003UniProtGO_REF:0000003
Map3k6RatMAP kinase kinase kinase activity enablesIBAMGI:1346876 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map3k6RatMAP kinase kinase kinase activity enablesIEAUniProtKB:O95382 and ensembl:ENSP000003501951600115GO_REF:0000107EnsemblGO_REF:0000107
Map3k6RatMAP kinase kinase kinase activity enablesIEAARBA:ARBA000498511600115GO_REF:0000117UniProtGO_REF:0000117
Map3k6Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Map3k6Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Map3k6Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Map3k6Ratprotein binding enablesISOMAP3K6 (Homo sapiens)1624291UniProtKB:P31947 more ...RGDPMID:19935702 more ...
Map3k6Ratprotein binding enablesISOMap3k6 (Mus musculus)1624291UniProtKB:Q99683 and PMID:17210579RGDPMID:17210579
Map3k6Ratprotein kinase activity enablesIEAInterPro:IPR000719 and InterPro:IPR0082711600115GO_REF:0000002InterProGO_REF:0000002
Map3k6Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
1 to 20 of 21 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k6Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Map3k6Ratp38 MAPK signaling pathway   ISOMAP3K6 (Homo sapiens)6484113 PIDPID:200018

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9875215  



Map3k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,724,029 - 150,736,113 (+)NCBIGRCr8
mRatBN7.25145,440,126 - 145,452,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,143,644 - 148,155,529 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,913,247 - 149,925,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,898,266 - 149,910,136 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,435,679 - 151,448,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,436,464 - 151,448,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,100,704 - 155,113,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,873,619 - 151,885,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,883,659 - 151,908,484 (-)NCBI
Celera5143,861,707 - 143,873,572 (+)NCBICelera
Cytogenetic Map5q36NCBI
MAP3K6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,355,184 - 27,366,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,355,184 - 27,366,961 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,681,675 - 27,693,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,554,257 - 27,565,924 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,365,811 - 27,377,479NCBI
Celera126,078,953 - 26,090,620 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,937,810 - 25,949,477 (-)NCBIHuRef
CHM1_1127,796,403 - 27,808,071 (-)NCBICHM1_1
T2T-CHM13v2.0127,196,422 - 27,208,199 (-)NCBIT2T-CHM13v2.0
Map3k6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,965,290 - 132,980,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,968,129 - 132,980,240 (+)EnsemblGRCm39 Ensembl
GRCm384133,237,979 - 133,252,929 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,240,818 - 133,252,929 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,796,733 - 132,808,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,512,894 - 132,525,004 (+)NCBIMGSCv36mm8
Celera4131,406,471 - 131,418,534 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Map3k6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,616,997 - 6,629,206 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,616,997 - 6,628,745 (-)NCBIChiLan1.0ChiLan1.0
MAP3K6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,511,898 - 199,525,275 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11198,617,568 - 198,629,253 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,607,436 - 26,619,463 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,663,250 - 27,674,240 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,662,777 - 27,673,987 (-)Ensemblpanpan1.1panPan2
MAP3K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,904,611 - 72,916,280 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,905,244 - 72,917,057 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,481,563 - 69,494,283 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,465,488 - 73,478,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,466,663 - 73,478,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,291,490 - 70,304,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,303,724 - 71,315,393 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,299,020 - 72,312,519 (+)NCBIUU_Cfam_GSD_1.0
Map3k6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,842,814 - 45,854,132 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,664,725 - 11,679,507 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,667,482 - 11,680,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,573,329 - 84,585,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,573,327 - 84,585,428 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,144,525 - 78,156,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,421,677 - 105,433,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,421,829 - 105,433,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,024,967 - 11,036,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,252,230 - 11,262,930 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,250,859 - 11,263,378 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Map3k6
43 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 151876206 151876207 G A snv FHL/EurMcwi (MCW), FHL/EurMcwi (ICL) View more Information


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 155108472 155108473 C T snv BDIX/NemOda (KyushuU) View more Information
5 155112989 155112990 C T snv SBH/Ygl (KNAW), SBH/Ygl (MCW) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 151447816 151447817 C T snv SBH/Ygl (RGD), SBH/Ygl (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000012463
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 42 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat

1 to 10 of 42 rows
RH130321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,451,946 - 145,452,157 (+)MAPPERmRatBN7.2
Rnor_6.05151,448,063 - 151,448,273NCBIRnor6.0
Rnor_5.05155,113,236 - 155,113,446UniSTSRnor5.0
RGSC_v3.45151,873,674 - 151,873,884UniSTSRGSC3.4
Celera5143,873,307 - 143,873,517UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000012463   ⟹   ENSRNOP00000012463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)Ensembl
Rnor_6.0 Ensembl5151,436,464 - 151,448,328 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093926   ⟹   ENSRNOP00000080621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)Ensembl
RefSeq Acc Id: NM_001107909   ⟹   NP_001101379
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,724,245 - 150,736,113 (+)NCBI
mRatBN7.25145,440,346 - 145,452,212 (+)NCBI
Rnor_6.05151,436,464 - 151,448,328 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
RGSC_v3.45151,873,619 - 151,885,483 (-)RGD
Celera5143,861,707 - 143,873,572 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239019   ⟹   XP_006239081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,724,030 - 150,736,112 (+)NCBI
mRatBN7.25145,440,127 - 145,452,213 (+)NCBI
Rnor_6.05151,435,679 - 151,448,329 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239020   ⟹   XP_006239082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,724,029 - 150,736,112 (+)NCBI
mRatBN7.25145,440,126 - 145,452,213 (+)NCBI
Rnor_6.05151,435,679 - 151,448,329 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239022   ⟹   XP_006239084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,724,927 - 150,736,112 (+)NCBI
mRatBN7.25145,441,024 - 145,452,213 (+)NCBI
Rnor_6.05151,437,518 - 151,448,329 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764137   ⟹   XP_008762359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,724,047 - 150,736,112 (+)NCBI
mRatBN7.25145,440,154 - 145,452,213 (+)NCBI
Rnor_6.05151,435,692 - 151,448,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109779   ⟹   XP_038965707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,724,717 - 150,736,112 (+)NCBI
mRatBN7.25145,440,821 - 145,452,213 (+)NCBI
RefSeq Acc Id: NP_001101379   ⟸   NM_001107909
- UniProtKB: D3ZFL3 (UniProtKB/TrEMBL),   A6ISW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239081   ⟸   XM_006239019
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006239082   ⟸   XM_006239020
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006239084   ⟸   XM_006239022
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008762359   ⟸   XM_008764137
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZR53 (UniProtKB/TrEMBL)
- Sequence:
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFL3-F1-model_v2 AlphaFold D3ZFL3 1-1292 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694109
Promoter ID:EPDNEW_R4633
Type:multiple initiation site
Name:Map3k6_1
Description:mitogen-activated protein kinase kinase kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,436,435 - 151,436,495EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39639 BioCyc
Ensembl Genes ENSRNOG00000008936 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012463 ENTREZGENE
  ENSRNOT00000012463.6 UniProtKB/TrEMBL
  ENSRNOT00000093926 ENTREZGENE
  ENSRNOT00000093926.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DRHyd-ASK UniProtKB/TrEMBL
  DUF4071 UniProtKB/TrEMBL
  HisK-N-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MAP3K_PH UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:313022 UniProtKB/TrEMBL
NCBI Gene 313022 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam ASK_PH UniProtKB/TrEMBL
  DRHyd-ASK UniProtKB/TrEMBL
  DUF4071 UniProtKB/TrEMBL
  HisK-N-like UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k6 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008936 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A8I5ZR53 ENTREZGENE, UniProtKB/TrEMBL
  A6ISW1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFL3 ENTREZGENE, UniProtKB/TrEMBL
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Map3k6  mitogen-activated protein kinase kinase kinase 6   Map3k6_predicted  mitogen-activated protein kinase kinase kinase 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k6_predicted  mitogen-activated protein kinase kinase kinase 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED