Map3k6 (mitogen-activated protein kinase kinase kinase 6) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Map3k6 (mitogen-activated protein kinase kinase kinase 6) Rattus norvegicus
Analyze
Symbol: Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
RGD ID: 1304625
Description: Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in protein phosphorylation. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC313022
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25145,440,126 - 145,452,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,143,644 - 148,155,529 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05149,913,247 - 149,925,128 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05149,898,266 - 149,910,136 (+)NCBIRnor_WKY
Rnor_6.05151,435,679 - 151,448,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,436,464 - 151,448,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,100,704 - 155,113,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,873,619 - 151,885,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,883,659 - 151,908,484 (-)NCBI
Celera5143,861,707 - 143,873,572 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
hydrogen sulfide  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9875215  


Genomics

Comparative Map Data
Map3k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25145,440,126 - 145,452,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,143,644 - 148,155,529 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05149,913,247 - 149,925,128 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05149,898,266 - 149,910,136 (+)NCBIRnor_WKY
Rnor_6.05151,435,679 - 151,448,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,436,464 - 151,448,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,100,704 - 155,113,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,873,619 - 151,885,483 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,883,659 - 151,908,484 (-)NCBI
Celera5143,861,707 - 143,873,572 (+)NCBICelera
Cytogenetic Map5q36NCBI
MAP3K6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,355,184 - 27,366,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl127,355,184 - 27,366,961 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,681,675 - 27,693,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,554,257 - 27,565,924 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,365,811 - 27,377,479NCBI
Celera126,078,953 - 26,090,620 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,937,810 - 25,949,477 (-)NCBIHuRef
CHM1_1127,796,403 - 27,808,071 (-)NCBICHM1_1
T2T-CHM13v2.0127,196,422 - 27,208,199 (-)NCBIT2T-CHM13v2.0
Map3k6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,965,290 - 132,980,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,968,129 - 132,980,240 (+)EnsemblGRCm39 Ensembl
GRCm384133,237,979 - 133,252,929 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,240,818 - 133,252,929 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,796,733 - 132,808,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,512,894 - 132,525,004 (+)NCBIMGSCv36mm8
Celera4131,406,471 - 131,418,534 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
Map3k6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,616,997 - 6,629,206 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,616,997 - 6,628,745 (-)NCBIChiLan1.0ChiLan1.0
MAP3K6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,663,250 - 27,674,240 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,662,777 - 27,673,987 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,607,436 - 26,619,463 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAP3K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,904,611 - 72,916,280 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,905,244 - 72,917,057 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,481,563 - 69,494,283 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,465,488 - 73,478,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,466,663 - 73,478,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,291,490 - 70,304,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,303,724 - 71,315,393 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,299,020 - 72,312,519 (+)NCBIUU_Cfam_GSD_1.0
Map3k6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,842,814 - 45,854,132 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,664,725 - 11,679,507 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647411,667,482 - 11,680,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,573,329 - 84,585,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,573,327 - 84,585,428 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,144,525 - 78,156,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,421,677 - 105,433,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,421,829 - 105,433,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,024,967 - 11,036,597 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,252,230 - 11,262,930 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,250,859 - 11,263,378 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k6
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:84
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000012463
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
RH130321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,451,946 - 145,452,157 (+)MAPPERmRatBN7.2
Rnor_6.05151,448,063 - 151,448,273NCBIRnor6.0
Rnor_5.05155,113,236 - 155,113,446UniSTSRnor5.0
RGSC_v3.45151,873,674 - 151,873,884UniSTSRGSC3.4
Celera5143,873,307 - 143,873,517UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 6
Low 3 43 38 22 19 22 8 11 68 34 41 5 8
Below cutoff 17 17 17 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012463   ⟹   ENSRNOP00000012463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)Ensembl
Rnor_6.0 Ensembl5151,436,464 - 151,448,328 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093926   ⟹   ENSRNOP00000080621
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,440,346 - 145,452,212 (+)Ensembl
RefSeq Acc Id: NM_001107909   ⟹   NP_001101379
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25145,440,346 - 145,452,212 (+)NCBI
Rnor_6.05151,436,464 - 151,448,328 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
RGSC_v3.45151,873,619 - 151,885,483 (-)RGD
Celera5143,861,707 - 143,873,572 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239019   ⟹   XP_006239081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25145,440,127 - 145,452,213 (+)NCBI
Rnor_6.05151,435,679 - 151,448,329 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239020   ⟹   XP_006239082
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25145,440,126 - 145,452,213 (+)NCBI
Rnor_6.05151,435,679 - 151,448,329 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239022   ⟹   XP_006239084
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25145,441,024 - 145,452,213 (+)NCBI
Rnor_6.05151,437,518 - 151,448,329 (+)NCBI
Rnor_5.05155,100,704 - 155,113,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764137   ⟹   XP_008762359
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25145,440,154 - 145,452,213 (+)NCBI
Rnor_6.05151,435,692 - 151,448,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109779   ⟹   XP_038965707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25145,440,821 - 145,452,213 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101379   ⟸   NM_001107909
- UniProtKB: D3ZFL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239081   ⟸   XM_006239019
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006239082   ⟸   XM_006239020
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006239084   ⟸   XM_006239022
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008762359   ⟸   XM_008764137
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZR53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012463   ⟸   ENSRNOT00000012463
RefSeq Acc Id: XP_038965707   ⟸   XM_039109779
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000080621   ⟸   ENSRNOT00000093926
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFL3-F1-model_v2 AlphaFold D3ZFL3 1-1292 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694109
Promoter ID:EPDNEW_R4633
Type:multiple initiation site
Name:Map3k6_1
Description:mitogen-activated protein kinase kinase kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,436,435 - 151,436,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304625 AgrOrtholog
BioCyc Gene G2FUF-39639 BioCyc
Ensembl Genes ENSRNOG00000008936 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012463 ENTREZGENE
  ENSRNOP00000012463.5 UniProtKB/TrEMBL
  ENSRNOP00000080621 ENTREZGENE
  ENSRNOP00000080621.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012463 ENTREZGENE
  ENSRNOT00000012463.6 UniProtKB/TrEMBL
  ENSRNOT00000093926 ENTREZGENE
  ENSRNOT00000093926.1 UniProtKB/TrEMBL
InterPro DRHyd-ASK UniProtKB/TrEMBL
  DUF4071 UniProtKB/TrEMBL
  HisK-N-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MAP3K_PH UniProtKB/TrEMBL
  MAPK5/6/15 UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:313022 UniProtKB/TrEMBL
NCBI Gene 313022 ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam ASK_PH UniProtKB/TrEMBL
  DRHyd-ASK UniProtKB/TrEMBL
  DUF4071 UniProtKB/TrEMBL
  HisK-N-like UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k6 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SAM_homology UniProtKB/TrEMBL
UniProt A0A8I5ZR53 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFL3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Map3k6  mitogen-activated protein kinase kinase kinase 6   Map3k6_predicted  mitogen-activated protein kinase kinase kinase 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k6_predicted  mitogen-activated protein kinase kinase kinase 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED