RGD:58522976 Rat Genome Database

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Variant: RGD:58522976 -  Rattus norvegicus

RGD ID: 58522976
Genic Status: GENIC
Type: SNV (SO:0001483) 
Associated Genes: Map3k6  
Reference Nucleotide: C
Variant Nucleotide: T
Position
Assembly Chr Position
Rnor_5.0 5 155,108,472
JBrowse: View Region in Genome Browser (JBrowse)
Model




Gene Symbol:Map3k6
Accession:NM_001107909
Location:EXON
Amino Acid Prediction: A to V (nonsynonymous)
Amino Acid Position: 665
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment   NO -1.295 -3.163 +1.868 282 2 NP_001101379 2clq +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVAGRGCARSRPLSVVYVLTREPGPGVEPGSGTEAEPLPLRCLREAC
AQLQSTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLEVSNSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQAL
REDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGVGTEALLTPLVGRLVRLLEATPTDSCGYFRETI
RQDIRKARERFSGQQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYT
FALNRRNRPGDREKALAVLLPLVKHEGPVAPDLYCMCGRIYKDMFFSSSFQSTGHLEQAYHWYRKAFDVEPSLHSGINAA
VLLIAAGKHFDDSEELQLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVME
TFLLYQHFRPTPEPSGGPVLRAHFWLHFLLQSCQPFKATPPQEDQCLVLVLEINKVLLPARLEIQGADPMSAVTLSLLEP
ETQDDPSSWTFPVTSICGISASKLDQRCCFLYALPPAQDVQLCFPSVERCRWFCSQIQVLVMNPDSSAPTEEAEGTREVL
EFDYEYSETGERLVLGKGTYGVVYVGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLK
IFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAG
ITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGWPPFHELGSPQAAMFQVGMYKVHPPVPSSLSAEA
QAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTPRPSGTPSSTSSPSADSATQSQTFPRPQAPSQHPPSPP
KRCLSYGDTSQLRVPEESAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQEVPILAENLLDQEQDSRLSRNHVELLLRC
LGAQIHTPNRRQLAQELRALQAQLRAQSLSPALLKGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDAE
AEKKAVSPKSEEWSQGESQQKPLESQPPLQSQLPPEQEPPSLMIQLGLLRAETDRLRDILAEKERECQALVQQALHRVHA
ETRTYALASETPATLPKDQKLVQWLQDLSVDPTTIQTLLSHSFTLQTLLTCATQDDLVYTRIRGGMVCRIWRAILAQRAG
ATSVTPGPRDAE*

Gene Symbol:Map3k6
Accession:XM_006239019
Location:EXON
Amino Acid Prediction: A to V (nonsynonymous)
Amino Acid Position: 665
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment     -1.397 -3.155 +1.758 248 2 XP_006239081 2clq +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVAGRGCARSRPLSVVYVLTREPGPGVEPGSGTEAEPLPLRCLREAC
AQLQSTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLEVSNSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQAL
REDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGVGTEALLTPLVGRLVRLLEATPTDSCGYFRETI
RQDIRKARERFSGQQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYT
FALNRRNRPGDREKALAVLLPLVKHEGPVAPDLYCMCGRIYKDMFFSSSFQSTGHLEQAYHWYRKAFDVEPSLHSGINAA
VLLIAAGKHFDDSEELQLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVME
TFLLYQHFRPTPEPSGGPVLRAHFWLHFLLQSCQPFKATPPQEDQCLVLVLEINKVLLPARLEIQGADPMSAVTLSLLEP
ETQDDPSSWTFPVTSICGISASKLDQRCCFLYALPPAQDVQLCFPSVERCRWFCSQIQVLVMNPDSSAPTEEAEGTREVL
EFDYEYSETGERLVLGKGTYGVVYVGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLK
IFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAG
ITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGWPPFHELGSPQAAMFQVGMYKVHPPVPSSLSAEA
QAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTPRPSGTPSSTSSPSADSATQSQTFPRPQAPSQHPPSPP
KRCLSYGDTSQLRVPEESAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQEVPILAENLLDQEQDSRLSRNHVELLLRC
LGAQIHTPNRRQLAQELRALQAQLRAQSLSPALLKGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDAE
AEKKAVSPKSEEWSQGESQQKPLESQPPLQSQLPPEQEPPSLMIQLGLLRAETDRLRDILAEKERECQALVQQALHRVHA
ETRTYALASETPATLPKDQKLVQWLQDLSVDPTTIQTLLSHSFTLQTLLTCATQDDLVYTRIRYILGPPAVNHVAPASNM
RASPALWACLDSSLKTTGEQVLLGIAVPNERAGAAFWLNYIDP*

Gene Symbol:Map3k6
Accession:XM_006239020
Location:EXON
Amino Acid Prediction: A to V (nonsynonymous)
Amino Acid Position: 657
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment     -1.095 -3.088 +1.993 481 2 XP_006239082 2clq +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVAGRGCARSRPLSVVYVLTREPGPGVEPGSGTEAEPLPLRCLREAC
AQLQSTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLEVSNSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQAL
RDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGVGTEALLTPLVGRLVRLLEATPTDSCGYFRETIRQDIRKAR
ERFSGQQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNR
PGDREKALAVLLPLVKHEGPVAPDLYCMCGRIYKDMFFSSSFQSTGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGK
HFDDSEELQLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHF
RPTPEPSGGPVLRAHFWLHFLLQSCQPFKATPPQEDQCLVLVLEINKVLLPARLEIQGADPMSAVTLSLLEPETQDDPSS
WTFPVTSICGISASKLDQRCCFLYALPPAQDVQLCFPSVERCRWFCSQIQVLVMNPDSSAPTEEAEGTREVLEFDYEYSE
TGERLVLGKGTYGVVYVGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPG
GSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETF
TGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGWPPFHELGSPQAAMFQVGMYKVHPPVPSSLSAEAQAFLLRTF
EPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTPRPSGTPSSTSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGD
TSQLRVPEESAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQEVPILAENLLDQEQDSRLSRNHVELLLRCLGAQIHTP
NRRQLAQELRALQAQLRAQSLSPALLKGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDAEAEKKAVSP
KSEEWSQGESQQKPLESQPPLQSQLPPEQEPPSLMIQLGLLRAETDRLRDILAEKERECQALVQQALHRVHAETRTYALA
SETPATLPKDQKLVQWLQDLSVDPTTIQTLLSHSFTLQTLLTCATQDDLVYTRIRYILGPPAVNHVAPASNMRASPALWA
CLDSSLKTTGEQVLLGIAVPNERAGAAFWLNYIDP*

Gene Symbol:Map3k6
Accession:XM_006239022
Location:EXON
Amino Acid Prediction: A to V (nonsynonymous)
Amino Acid Position: 457
Polyphen Predictions
Prediction Basis Effect Site Score1 Score2 Diff Number Observed Structures Protein ID PDB ID Inverted
probably damaging alignment     -1.295 -3.163 +1.868 285 2 XP_006239084 2clq +
Amino Acid Sequence
(Calculated using NCBI transcript definition)
MCSSVPRQSSLTCRPFVRMFSRRTRGYFRETIRQDIRKARERFSGQQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDV
QDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKHEGPVAPDLYCMCGRIYKDMFFSS
SFQSTGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGKHFDDSEELQLIGMKLGCLLARKGCVEKMQYYWDVGFYLGA
QILANDPIQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPSGGPVLRAHFWLHFLLQSCQPFKATPPQEDQCLV
LVLEINKVLLPARLEIQGADPMSAVTLSLLEPETQDDPSSWTFPVTSICGISASKLDQRCCFLYALPPAQDVQLCFPSVE
RCRWFCSQIQVLVMNPDSSAPTEEAEGTREVLEFDYEYSETGERLVLGKGTYGVVYVGRDRHTRVRIAIKEIPERDSRFS
QPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRI
VHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGWP
PFHELGSPQAAMFQVGMYKVHPPVPSSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTPRPSGT
PSSTSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQLRVPEESAAEEPASPEESSGLSLLHQESKRRAMLAAV
LEQEVPILAENLLDQEQDSRLSRNHVELLLRCLGAQIHTPNRRQLAQELRALQAQLRAQSLSPALLKGPLFAFPDAVKQI
LRRRQIRPHWMFVLDSLLSRAVRAALAVLDAEAEKKAVSPKSEEWSQGESQQKPLESQPPLQSQLPPEQEPPSLMIQLGL
LRAETDRLRDILAEKERECQALVQQALHRVHAETRTYALASETPATLPKDQKLVQWLQDLSVDPTTIQTLLSHSFTLQTL
LTCATQDDLVYTRIRYILGPPAVNHVAPASNMRASPALWACLDSSLKTTGEQVLLGIAVPNERAGAAFWLNYIDP*
BDIX/NemOda (KyushuU)