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Gene: Efcab14 (EF-hand calcium binding domain 14) Rattus norvegicus

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Symbol:

Efcab14

Name:

EF-hand calcium binding domain 14

RGD ID:

1310351

Description:

Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Orthologous to human EFCAB14 (EF-hand calcium binding domain 14); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

EF-hand calcium-binding domain-containing protein 14; hypothetical protein LOC298425; LOC298425; RGD1310351; similar to RIKEN cDNA 4732418C07; uncharacterized protein LOC298425

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EFCAB14 (EF-hand calcium binding domain 14)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Efcab14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Efcab14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EFCAB14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EFCAB14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Efcab14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EFCAB14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EFCAB14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Efcab14 (EF-hand calcium binding domain 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Efcab14 (EF-hand calcium binding domain 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EFCAB14 (EF-hand calcium binding domain 14)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	efcab14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	134,454,908 - 134,493,714 (+)	NCBI		GRCr8
mRatBN7.2	5	129,218,139 - 129,258,628 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	129,218,424 - 129,258,625 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	131,829,477 - 131,868,485 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	133,584,348 - 133,623,355 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	133,606,497 - 133,645,507 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	134,594,012 - 134,632,168 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	134,593,517 - 134,633,935 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	138,378,398 - 138,418,288 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	136,000,971 - 136,039,727 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	136,006,646 - 136,043,451 (+)	NCBI
Celera	5	127,753,648 - 127,791,352 (+)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-bromohexadecanoic acid (ISO)

4,4'-sulfonyldiphenol (EXP)

acrylamide (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

dibutyl phthalate (EXP)

disodium selenite (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

ethanol (ISO)

folic acid (ISO)

glycidyl methacrylate (ISO)

inulin (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thimerosal (ISO)

thioacetamide (EXP)

triphenyl phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

Molecular Function

calcium ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Efcab14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	134,454,908 - 134,493,714 (+)	NCBI		GRCr8
mRatBN7.2	5	129,218,139 - 129,258,628 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	129,218,424 - 129,258,625 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	131,829,477 - 131,868,485 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	133,584,348 - 133,623,355 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	133,606,497 - 133,645,507 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	134,594,012 - 134,632,168 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	134,593,517 - 134,633,935 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	138,378,398 - 138,418,288 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	136,000,971 - 136,039,727 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	136,006,646 - 136,043,451 (+)	NCBI
Celera	5	127,753,648 - 127,791,352 (+)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

EFCAB14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	46,675,159 - 46,719,114 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	46,674,659 - 46,719,146 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	47,140,831 - 47,184,786 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	46,913,420 - 46,957,323 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	45,428,182 - 45,472,087 (-)	NCBI		Celera
Cytogenetic Map	1	p33	NCBI
HuRef	1	45,256,327 - 45,300,230 (-)	NCBI		HuRef
CHM1_1	1	47,257,836 - 47,301,734 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	46,552,399 - 46,596,351 (-)	NCBI		T2T-CHM13v2.0

Efcab14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	115,594,914 - 115,634,590 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	115,594,941 - 115,634,524 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	115,737,716 - 115,777,393 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	115,737,744 - 115,777,327 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	115,410,678 - 115,449,932 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	115,236,005 - 115,275,259 (+)	NCBI		MGSCv36	mm8
Celera	4	114,475,708 - 114,514,923 (+)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	53.06	NCBI

Efcab14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	11,619,964 - 11,657,295 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	11,619,010 - 11,653,516 (+)	NCBI	ChiLan1.0	ChiLan1.0

EFCAB14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	180,089,291 - 180,133,873 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	179,230,896 - 179,275,492 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	45,977,600 - 46,021,535 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	47,332,388 - 47,376,371 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	47,332,388 - 47,376,066 (-)	Ensembl	panpan1.1		panPan2

EFCAB14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	13,749,605 - 13,794,563 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	13,749,508 - 13,905,790 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	13,870,305 - 13,913,820 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	13,900,321 - 13,943,859 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	13,900,282 - 14,056,527 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	13,701,430 - 13,744,944 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	13,769,786 - 13,813,494 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	13,839,292 - 13,882,813 (+)	NCBI		UU_Cfam_GSD_1.0

Efcab14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	61,845,606 - 61,881,664 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	27,669,006 - 27,705,646 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	27,669,008 - 27,706,634 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EFCAB14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	164,777,970 - 164,821,367 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	164,777,972 - 164,821,371 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	152,321,774 - 152,363,918 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EFCAB14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	86,092,215 - 86,134,712 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	86,093,273 - 86,131,417 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	30,858,490 - 30,900,991 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Efcab14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624906	2,548,265 - 2,590,606 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	764
Count of miRNA genes:	308
Interacting mature miRNAs:	390
Transcripts:	ENSRNOT00000013471
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

BE120109

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	129,218,313 - 129,218,464 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	134,593,615 - 134,593,765	NCBI	Rnor6.0
Rnor_5.0	5	138,378,558 - 138,378,708	UniSTS	Rnor5.0
RGSC_v3.4	5	136,001,144 - 136,001,294	UniSTS	RGSC3.4
Celera	5	127,753,226 - 127,753,376	UniSTS
RH 3.4 Map	5	836.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH139027

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	1	1555.9	UniSTS
Cytogenetic Map	5	q36	UniSTS

BF390489

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	129,223,605 - 129,223,775 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	134,598,907 - 134,599,076	NCBI	Rnor6.0
Rnor_5.0	5	138,383,850 - 138,384,019	UniSTS	Rnor5.0
RGSC_v3.4	5	136,006,349 - 136,006,518	UniSTS	RGSC3.4
Celera	5	127,758,529 - 127,758,698	UniSTS
RH 3.4 Map	5	824.7	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013471 ⟹ ENSRNOP00000013471

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,218,424 - 129,258,625 (+)	Ensembl
Rnor_6.0 Ensembl	5	134,593,517 - 134,633,935 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094831 ⟹ ENSRNOP00000082263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,218,424 - 129,250,043 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100267 ⟹ ENSRNOP00000078819

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,218,424 - 129,256,568 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107760 ⟹ ENSRNOP00000097002

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,218,424 - 129,258,625 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110729 ⟹ ENSRNOP00000084355

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	129,218,424 - 129,258,625 (+)	Ensembl

RefSeq Acc Id:

NM_001106677 ⟹ NP_001100147

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	134,455,476 - 134,493,714 (+)	NCBI
mRatBN7.2	5	129,218,711 - 129,256,954 (+)	NCBI
Rnor_6.0	5	134,594,012 - 134,632,168 (+)	NCBI
Rnor_5.0	5	138,378,398 - 138,418,288 (+)	NCBI
RGSC_v3.4	5	136,000,971 - 136,039,727 (+)	RGD
Celera	5	127,753,648 - 127,791,352 (+)	NCBI

Sequence:

show sequence

GCTTCTGGAGCACTCCTAGAAATATTGGCTGCCTACACGACTAAGACTCTCGTGCTTGACTTAG
TGGGTTGTTTTTGTTTTGTTTTCCTTTTGACAGGTAATAGTTGTTTCAGGAAGTTATCCATTTG
GATCGCCAGTTCCTTGGCCATCTCTATGTAACTCCCCCTCCCCACCCCCCATCCATCTGAGCCC
AATTTCCTCTGGGCTCCATTCTCCAGCCCTAACTAGATCTGGTCAGTCCCACCTCTGGGTGGGA
GTGATCAGGGGGCTCTGGCCCAGGATTTCCAACCCTGGAAGGCAGCTCCAAGTCAGCGAGAGAG
TTGGGTTTTGGCTACGAACCTGGCAGCTCAGGAGTGGGCCCGCCACTCACCCCCCACAAAAAGA
TGAAAAAGCGCAAAGAACTCAATGCATTGATCGGCTTGGCTGGTGACAGTCGGAGAAAGAAGAC
CAAGCAAGGCTCAAGTAGCCATCGCCTGCTTCGCACTGAACCTCCTGACTCAGACTCAGCGTCC
AGCTCAGAGGAAGAGGAATTTGGAGCAATTGGAAATCGCTCTCGTTTTGTCAAGGGAGACTATG
TCCGATGCTGCAAGATCTGCTATCCCCTCTGTGCCTTTGTCATCCTCGCAGCCTGTGTTGTGGC
CTGCGTGGGCTTGGTGTGGATGCAAATGGCTCTCAAGGAGGATCTGGATGTCCTCAAGGAAAAA
TTTCGAACAATGGAGTCTAATCAGAAAAGCTCATTCCAGGAAATCCCCAAACTTAATGAAGAAC
TTCTCAGCAAAGAAAAGCAACTTGAGAAGATTGAGTCTGGGGAGCTGGGCTTAAGCAGAGTCTG
GACCAACATCACAGAAATGAATAAGCAGATTTCTCTGTTGAGTTCTGCAGTAAACCACCTAAAA
GCCAATGTCAAGTCAGCCGCAGACTTACTTAGCCTGCCTAGCACTGTAGAGGGACTTCAGAAGA
GTGTCGCTTCCATTGGCAATACGTTGAACAGTGTCAGCCTTGCTGTAGAGGCAATACAGAAGAC
CGTGGATGAACACAAGGCCACCTTGGAGTTACTGCAGGGCAGTGTGGAGACCAATGGAAGCAAC
CAAATCATGCCATCGCCTCCGCCTCCATCAGAACTTGACAACAGAACCCACAGTGAAAGTGCAA
AACAGGATATCCTGTACCTGCACAACTCCTTAGAGGAGGTCAACAGTACTGTAGTGGGATACCA
GAGACAGAATGACCTTAAACTCAAGGGGATGAGCGAGACCCTCAGTAACCTGACACAGAGACTC
GACCTGATAGAAAGTGATGTGGTTGCACTGAGCAAAGCAGAACAGAGAACAAACGTGAGCTCCA
GCATGATGGGTAATAGGGCTGCCAGTCTGAAAAGAGAGTCTTCGATGACCAACAGAACTGATGC
TGTAAAGGCCCAAAGCATAAAGAAAGAAGATAATTCAAATTCTCAGGTATCGGGGCTGCGAGAA
AAACTGCAGCTGATCAGTGCTCTCACAAACAAACCCGAAAGCAACAGGCCTCCAGAGACCACAG
ATGAGGAGCAAGTACAGAACTTCACATCAGATCCTTCAACATTGCCAAAATTCTCACAGTTTCT
TGGAGACCAAACTGAGACCCAACTAAAACCTATCTCCCTGCCTGGGATTTCTAGCATCAAAGAT
CTTCAGGATTTATTCCACAAGACTGGTCAAGATGTGGATGGGATGCTGACCTACCAGGAAATCT
GGAATTCCCTAGGTTCTGCCATGCCAAGACCAGAACACTTGAGAGCATTTGATTCCAATGGAGA
CGGGAGATACTCCTTCCTGGAGCTAAGAGTAGCTTTAGGTATCTAGTCCCATCAGACATAAATG
ATGGATGAAATGGATGTGCAGCCCGGACTACCTAAAATCTACTTACCTAAAAAGGAAAAAAAAA
AACTCTTAACCAACTCATCAGTCCTCCAGCCCTTCATACTACTGTAGCAAACACATTGTCACCT
TTTAACTTGTTTGAAAATGCTATTTAAAAAAATTATTTTTTTAAAAAAAATTTTACTTAAAATA
TGATGTTTGGAAATCTATGATTTCATGAAGCCAGTGAGATCTTGTAACTTAAAGTTGTCAGGAA
AAAATAATAAAGCTCTCTTCTCTTTCCTGTTTTTGAGGGGAAGAGAATTTACCTTTTAAAGCTG
GAAAGTGTGTGTGTATAGAGATAATAAGTCACTGTTTATATTTCATATGAATTTGCCTTAAATT
AGCTGCACTTTATAGAGCCTCAGAATACGTCTTTTCTTTGAAAGAGGAGTCTTTTGTTTGTACA
TATGTAAAATGAAAGATTGTGCATATTGCATAGACAGAAGGTTGGCTTTGAACAGAATGAATGG
ATAACTTGTTATGAGTAGTTGACAGTCTGCTCTGGGTGGCAGCTGAAACTCTTCACATCTCCTT
AAGGCAACCCTCAGATGCCTGGGCGCTACTATAGGGTTGAAGCTGGGACATCAGTTCAGGTATG
GATGCTATGCAGAGGGTGCCAGTTCTGAGCTCAGGAACATCAGATTCCGGGCCATTGCTCCTAT
TCCTAACCTAAGAACCAGAGAAGTCTTACTGGGATATTCCTCATTTTTAATTATCTTTGAAGGT
TTATGAGCATAAAGTTACTCAGTGGGAAATTGCTTTCCCATCAAGTAAGCGAGATTGTCTTCTC
TACCCACCCACTCCAGACTACCTTAAAGTTGTGACTGCCTACCTTCTGCACCATGTCCAGTCTG
GAATGGGAAGGCTCATGTCCTGGGTTGCTATGCCCAAGAGCTAGTTGCCCAGAGCACTAGAGAA
AAGCTCTGAGTTTTGACTTGGGAAACAGTACCTTTAGGGATTTTACCTTTAGGATAACCAAGTA
CTTGCTCTATTTCTTGGCAGGTTGCCTAAAGCCAAAATGTAGTCAGATGAAACACGAAATCATA
TTCTTTCCTCATTGTTCCCTCAGAGGGAGCTATGGGCTTTCTGTCCAGAGGATGCCGCATGGAG
CAGGAGCCTTCTGGTGATGGGGTCAGTTTTCCCAGGTCTAAAGGCAGGTGTCATGCTTCCCCTT
TACATGCTTTGTGGGCAAGTCAGGAAAGGTCTGACTAGAAGGAACTCGCCTTTCACCAACATGT
TGAGAACACTCAGTGTTCTTAGGGGTCTCGGGGCAACTCCAGTAGAAGACCTTACAGAACCACA
CATTGCTATAGCCAGTCAGGGAAACACTGGGGATGCTGTTGTGATAGTATAGATCACTCCTACC
TAATTTTGTTCAAGTTGCCCTGTCAGCTGTGGATACACTCTGGTATCCTCAAACCTTTAAAGAC
ATTTGTTTTTCCCTTCGCCTTGCTTTGCTTTGCTTTTTATGTTTTGTTTCTTTTTTATGATATT
CAGTTTAGTGTTGTTTTTT

hide sequence

RefSeq Acc Id:

XM_039109592 ⟹ XP_038965520

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	134,454,909 - 134,493,478 (+)	NCBI
mRatBN7.2	5	129,218,139 - 129,258,628 (+)	NCBI

RefSeq Acc Id:

XM_063287401 ⟹ XP_063143471

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	134,454,908 - 134,484,457 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100147	(Get FASTA)	NCBI Sequence Viewer
	XP_038965520	(Get FASTA)	NCBI Sequence Viewer
	XP_063143471	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90308	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013471.5
	ENSRNOP00000078819.1
	ENSRNOP00000082263.1
	ENSRNOP00000084355.1
	ENSRNOP00000097002.1

RefSeq Acc Id:

NP_001100147 ⟸ NM_001106677

- UniProtKB:

D3ZTM7 (UniProtKB/TrEMBL), A6JZ45 (UniProtKB/TrEMBL), A0A8I6AQN0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKKRKELNALIGLAGDSRRKKTKQGSSSHRLLRTEPPDSDSASSSEEEEFGAIGNRSRFVKGDY
VRCCKICYPLCAFVILAACVVACVGLVWMQMALKEDLDVLKEKFRTMESNQKSSFQEIPKLNEE
LLSKEKQLEKIESGELGLSRVWTNITEMNKQISLLSSAVNHLKANVKSAADLLSLPSTVEGLQK
SVASIGNTLNSVSLAVEAIQKTVDEHKATLELLQGSVETNGSNQIMPSPPPPSELDNRTHSESA
KQDILYLHNSLEEVNSTVVGYQRQNDLKLKGMSETLSNLTQRLDLIESDVVALSKAEQRTNVSS
SMMGNRAASLKRESSMTNRTDAVKAQSIKKEDNSNSQVSGLREKLQLISALTNKPESNRPPETT
DEEQVQNFTSDPSTLPKFSQFLGDQTETQLKPISLPGISSIKDLQDLFHKTGQDVDGMLTYQEI
WNSLGSAMPRPEHLRAFDSNGDGRYSFLELRVALGI

hide sequence

Ensembl Acc Id:

ENSRNOP00000013471 ⟸ ENSRNOT00000013471

RefSeq Acc Id:	XP_038965520 ⟸ XM_039109592
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZLM3 (UniProtKB/TrEMBL), A0A8I6AQN0 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000078819 ⟸ ENSRNOT00000100267

Ensembl Acc Id:

ENSRNOP00000097002 ⟸ ENSRNOT00000107760

Ensembl Acc Id:

ENSRNOP00000082263 ⟸ ENSRNOT00000094831

Ensembl Acc Id:

ENSRNOP00000084355 ⟸ ENSRNOT00000110729

RefSeq Acc Id:	XP_063143471 ⟸ XM_063287401
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZUW4 (UniProtKB/TrEMBL)

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTM7-F1-model_v2	AlphaFold	D3ZTM7	1-484	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693923

Promoter ID:

EPDNEW_R4448

Type:

initiation region

Name:

Efcab14_1

Description:

EF-hand calcium binding domain 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	134,593,479 - 134,593,539	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310351	AgrOrtholog
BioCyc Gene	G2FUF-40279	BioCyc
Ensembl Genes	ENSRNOG00000010091	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013471.8	UniProtKB/TrEMBL
	ENSRNOT00000094831.1	UniProtKB/TrEMBL
	ENSRNOT00000100267.1	UniProtKB/TrEMBL
	ENSRNOT00000107760.1	UniProtKB/TrEMBL
	ENSRNOT00000110729.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.1490	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	EFCAB14	UniProtKB/TrEMBL
KEGG Report	rno:298425	UniProtKB/TrEMBL
NCBI Gene	298425	ENTREZGENE
PANTHER	EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 14	UniProtKB/TrEMBL
	PTHR15717	UniProtKB/TrEMBL
PhenoGen	Efcab14	PhenoGen
PROSITE	EF_HAND_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010091	RatGTEx
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A8I5ZLM3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZUW4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZXN8_RAT	UniProtKB/TrEMBL
	A0A8I6AQN0	ENTREZGENE, UniProtKB/TrEMBL
	A6JZ45	ENTREZGENE, UniProtKB/TrEMBL
	D3ZTM7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-12-10	Efcab14	EF-hand calcium binding domain 14	RGD1310351	similar to RIKEN cDNA 4732418C07	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1310351	similar to RIKEN cDNA 4732418C07	RGD1310351_predicted	similar to RIKEN cDNA 4732418C07 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1310351_predicted	similar to RIKEN cDNA 4732418C07 (predicted)	LOC298425_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC298425_predicted	similar to RIKEN cDNA 4732418C07 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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