Pik3r3 (phosphoinositide-3-kinase regulatory subunit 3) - Rat Genome Database

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Gene: Pik3r3 (phosphoinositide-3-kinase regulatory subunit 3) Rattus norvegicus
Analyze
Symbol: Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
RGD ID: 621042
Description: Enables 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; insulin receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be part of phosphatidylinositol 3-kinase complex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p55PIK; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase p55 subunit; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); PI3-kinase p85 subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; ptdIns-3-kinase p85-gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,936,790 - 135,009,303 (+)NCBIGRCr8
mRatBN7.25129,700,925 - 129,772,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,318,324 - 132,396,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,072,913 - 134,151,457 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,095,352 - 134,173,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,069,972 - 135,145,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,074,297 - 135,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,858,124 - 138,930,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,497,494 - 136,566,473 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,502,719 - 136,571,699 (+)NCBI
Celera5128,230,224 - 128,297,191 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxycholic acid  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
estrone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
hexestrol  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
maneb  (ISO)
melphalan  (ISO)
mestranol  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
Nookatone  (EXP)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway   (IEA)
epidermal growth factor/neuregulin signaling pathway   (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway   (IEA)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
4. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. Inukai K, etal., J Biol Chem 1996 Mar 8;271(10):5317-20.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. Nowakowska-Zajdel E, etal., Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):781-7.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. Wang G, etal., Mol Cancer Ther. 2014 Jul;13(7):1837-47. doi: 10.1158/1535-7163.MCT-14-0049. Epub 2014 May 16.
14. Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. Wang G, etal., Oncogene. 2015 Feb 12;34(7):912-21. doi: 10.1038/onc.2014.30. Epub 2014 Mar 17.
15. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
16. MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. Zhu Y, etal., Oncol Rep. 2017 Apr;37(4):2185-2192. doi: 10.3892/or.2017.5458. Epub 2017 Feb 16.
Additional References at PubMed
PMID:7542745   PMID:20624904   PMID:25388664   PMID:28341552  


Genomics

Comparative Map Data
Pik3r3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,936,790 - 135,009,303 (+)NCBIGRCr8
mRatBN7.25129,700,925 - 129,772,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,318,324 - 132,396,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,072,913 - 134,151,457 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,095,352 - 134,173,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,069,972 - 135,145,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,074,297 - 135,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,858,124 - 138,930,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,497,494 - 136,566,473 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,502,719 - 136,571,699 (+)NCBI
Celera5128,230,224 - 128,297,191 (+)NCBICelera
Cytogenetic Map5q35NCBI
PIK3R3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,040,140 - 46,174,901 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,040,140 - 46,133,036 (-)EnsemblGRCh38hg38GRCh38
GRCh37146,505,812 - 46,640,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,278,399 - 46,370,901 (-)NCBINCBI36Build 36hg18NCBI36
Build 34146,217,832 - 46,310,334NCBI
Celera144,793,099 - 44,886,009 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,620,825 - 44,713,687 (-)NCBIHuRef
CHM1_1146,622,976 - 46,715,844 (-)NCBICHM1_1
T2T-CHM13v2.0145,917,331 - 46,052,095 (-)NCBIT2T-CHM13v2.0
Pik3r3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,078,593 - 116,160,253 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,030,581 - 116,157,038 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl4116,078,815 - 116,160,253 (+)EnsemblGRCm39 Ensembl
GRCm384116,221,400 - 116,303,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,173,384 - 116,299,841 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,221,618 - 116,303,056 (+)EnsemblGRCm38mm10GRCm38
MGSCv374115,894,519 - 115,975,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,719,846 - 115,800,988 (+)NCBIMGSCv36mm8
Celera4114,959,917 - 115,043,525 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.1NCBI
PIK3R3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,672,682 - 180,765,512 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,814,236 - 179,907,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,345,946 - 45,481,031 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,700,153 - 46,835,812 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,700,153 - 46,792,920 (-)Ensemblpanpan1.1panPan2
LOC100856339
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,222,059 - 14,357,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,235,824 - 14,353,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,339,320 - 14,478,832 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,369,954 - 14,509,881 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,387,484 - 14,509,849 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,170,772 - 14,310,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,239,288 - 14,378,669 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,308,726 - 14,448,356 (+)NCBIUU_Cfam_GSD_1.0
Pik3r3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,270,346 - 61,346,909 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,095,100 - 27,171,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,095,125 - 27,171,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100511937
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,268,568 - 165,402,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,268,260 - 165,402,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,797,396 - 152,914,712 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12086,651,692 - 86,748,670 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2086,651,520 - 86,745,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603330,235,811 - 30,332,860 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pik3r3
200 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:128
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000000157
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat

Markers in Region
D5Rat201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,712,378 - 129,712,586 (+)MAPPERmRatBN7.2
Rnor_6.05135,085,475 - 135,085,682NCBIRnor6.0
Rnor_5.05138,869,546 - 138,869,753UniSTSRnor5.0
RGSC_v3.45136,507,976 - 136,508,184RGDRGSC3.4
RGSC_v3.45136,507,977 - 136,508,184UniSTSRGSC3.4
RGSC_v3.15136,513,195 - 136,513,538RGD
Celera5128,240,707 - 128,240,922UniSTS
SHRSP x BN Map568.3499RGD
SHRSP x BN Map568.3499UniSTS
Cytogenetic Map5q36UniSTS
RH144265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,700,290 - 129,700,414 (+)MAPPERmRatBN7.2
Rnor_6.05135,073,388 - 135,073,511NCBIRnor6.0
Rnor_5.05138,857,423 - 138,857,546UniSTSRnor5.0
RGSC_v3.45136,495,889 - 136,496,012UniSTSRGSC3.4
Celera5128,228,619 - 128,228,742UniSTS
RH 3.4 Map5837.8UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 28 17 4 16 4 74 35 41 11
Low 2 15 40 37 3 37 8 11 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000157   ⟹   ENSRNOP00000000157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)Ensembl
Rnor_6.0 Ensembl5135,074,297 - 135,142,488 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096934   ⟹   ENSRNOP00000088375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)Ensembl
RefSeq Acc Id: NM_022213   ⟹   NP_071549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,938,606 - 135,009,303 (+)NCBI
mRatBN7.25129,701,892 - 129,772,591 (+)NCBI
Rnor_6.05135,074,993 - 135,142,291 (+)NCBI
Rnor_5.05138,858,124 - 138,930,177 (+)NCBI
RGSC_v3.45136,497,494 - 136,566,473 (+)RGD
Celera5128,230,224 - 128,297,191 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238714   ⟹   XP_006238776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,937,723 - 135,009,303 (+)NCBI
mRatBN7.25129,701,061 - 129,772,591 (+)NCBI
Rnor_6.05135,074,158 - 135,145,633 (+)NCBI
Rnor_5.05138,858,124 - 138,930,177 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110698   ⟹   XP_038966626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,937,799 - 135,009,303 (+)NCBI
mRatBN7.25129,701,199 - 129,772,591 (+)NCBI
RefSeq Acc Id: XM_039110699   ⟹   XP_038966627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,936,790 - 135,009,303 (+)NCBI
mRatBN7.25129,700,925 - 129,772,591 (+)NCBI
RefSeq Acc Id: NP_071549   ⟸   NM_022213
- UniProtKB: Q63789 (UniProtKB/Swiss-Prot),   G3V605 (UniProtKB/TrEMBL),   A6JZ71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238776   ⟸   XM_006238714
- Peptide Label: isoform X1
- UniProtKB: Q63789 (UniProtKB/Swiss-Prot),   G3V605 (UniProtKB/TrEMBL),   A6JZ71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000157   ⟸   ENSRNOT00000000157
RefSeq Acc Id: XP_038966627   ⟸   XM_039110699
- Peptide Label: isoform X1
- UniProtKB: Q63789 (UniProtKB/Swiss-Prot),   G3V605 (UniProtKB/TrEMBL),   A6JZ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966626   ⟸   XM_039110698
- Peptide Label: isoform X1
- UniProtKB: Q63789 (UniProtKB/Swiss-Prot),   G3V605 (UniProtKB/TrEMBL),   A6JZ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088375   ⟸   ENSRNOT00000096934
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63789-F1-model_v2 AlphaFold Q63789 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693933
Promoter ID:EPDNEW_R4458
Type:multiple initiation site
Name:Pik3r3_1
Description:phosphoinositide-3-kinase regulatory subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,074,325 - 135,074,385EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621042 AgrOrtholog
BioCyc Gene G2FUF-40257 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000000145 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000157 ENTREZGENE
  ENSRNOT00000000157.4 UniProtKB/TrEMBL
  ENSRNOT00000096934.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60664 UniProtKB/Swiss-Prot
NCBI Gene 60664 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3r3 PhenoGen
PRINTS PI3KINASEP85 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000145 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A9P1_RAT UniProtKB/TrEMBL
  A6JZ71 ENTREZGENE, UniProtKB/TrEMBL
  G3V605 ENTREZGENE, UniProtKB/TrEMBL
  P55G_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pik3r3  phosphoinositide-3-kinase regulatory subunit 3  Pik3r3  phosphoinositide-3-kinase, regulatory subunit 3 (gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3r3  phosphoinositide-3-kinase, regulatory subunit 3 (gamma)  Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)  Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3    phosphatidylinositol 3-kinase p55 subunit  Name updated 1299863 APPROVED
2002-08-07 Pik3r3  phosphatidylinositol 3-kinase p55 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression ubiquitously expressed; enriched in brain 68289