Grik3 (glutamate ionotropic receptor kainate type subunit 3) - Rat Genome Database

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Gene: Grik3 (glutamate ionotropic receptor kainate type subunit 3) Rattus norvegicus
Analyze
Symbol: Grik3
Name: glutamate ionotropic receptor kainate type subunit 3
RGD ID: 71027
Description: Enables glutamate-gated receptor activity and identical protein binding activity. Involved in negative regulation of glutamatergic synaptic transmission. Acts upstream of or within regulation of membrane potential. Located in dendrite cytoplasm; perikaryon; and terminal bouton. Is active in cochlear hair cell ribbon synapse and presynaptic membrane. Orthologous to human GRIK3 (glutamate ionotropic receptor kainate type subunit 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GluK3; gluR-7; GluR7; glutamate receptor 7; glutamate receptor ionotropic, kainate 3; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic kainate 3; glutamate receptor, ionotropic, kainate 3; kainate receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85143,052,442 - 143,268,873 (+)NCBIGRCr8
mRatBN7.25137,767,865 - 137,989,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,767,865 - 137,984,307 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5140,472,191 - 140,689,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05142,242,199 - 142,459,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05142,249,392 - 142,466,887 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05143,500,441 - 143,715,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5143,500,441 - 143,715,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05147,265,647 - 147,485,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45144,842,374 - 145,058,047 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15144,852,366 - 145,068,040 (+)NCBI
Celera5136,284,413 - 136,500,298 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bleomycin A2  (EXP)
calcitriol  (ISO)
celecoxib  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
fonofos  (ISO)
glycidol  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
manganese(II) chloride  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
terbufos  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit. Bettler B, etal., Neuron 1992 Feb;8(2):257-65.
2. Localization of kainate receptors in inner and outer hair cell synapses. Fujikawa T, etal., Hear Res. 2014 Aug;314:20-32. doi: 10.1016/j.heares.2014.05.001. Epub 2014 May 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Localization and function of pre- and postsynaptic kainate receptors in the rat globus pallidus. Jin XT, etal., Eur J Neurosci. 2006 Jan;23(2):374-86.
6. Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery. Kumari J, etal., Sci Rep. 2019 Jul 16;9(1):10254. doi: 10.1038/s41598-019-46770-z.
7. High-affinity kainate and domoate receptors in rat brain. Lomeli H, etal., FEBS Lett 1992 Jul 28;307(2):139-43.
8. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
9. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. Montague AA and Greer CA, J Comp Neurol. 1999 Mar 8;405(2):233-46. doi: 10.1002/(sici)1096-9861(19990308)405:2<233::aid-cne7>3.0.co;2-a.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. Schiffer HH, etal., J Neurosci. 2000 Dec 15;20(24):9025-33.
17. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Schiffer HH, etal., Neuron 1997 Nov;19(5):1141-6.
18. Structural and compositional diversity in the kainate receptor family. Selvakumar P, etal., Cell Rep. 2021 Oct 26;37(4):109891. doi: 10.1016/j.celrep.2021.109891.
19. Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. Venskutonyte R, etal., J Struct Biol. 2011 Dec;176(3):307-14. doi: 10.1016/j.jsb.2011.08.014. Epub 2011 Sep 1.
Additional References at PubMed
PMID:7719709   PMID:9144652   PMID:11122333   PMID:12823458   PMID:15805114   PMID:17158174   PMID:17620617   PMID:19180187   PMID:23141068   PMID:24264036  


Genomics

Comparative Map Data
Grik3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85143,052,442 - 143,268,873 (+)NCBIGRCr8
mRatBN7.25137,767,865 - 137,989,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5137,767,865 - 137,984,307 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5140,472,191 - 140,689,693 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05142,242,199 - 142,459,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05142,249,392 - 142,466,887 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05143,500,441 - 143,715,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5143,500,441 - 143,715,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05147,265,647 - 147,485,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45144,842,374 - 145,058,047 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15144,852,366 - 145,068,040 (+)NCBI
Celera5136,284,413 - 136,500,298 (+)NCBICelera
Cytogenetic Map5q36NCBI
GRIK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38136,795,527 - 37,034,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl136,795,527 - 37,034,515 (-)EnsemblGRCh38hg38GRCh38
GRCh37137,261,128 - 37,500,116 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36137,039,201 - 37,272,431 (-)NCBINCBI36Build 36hg18NCBI36
Build 34136,935,706 - 37,168,937NCBI
Celera135,537,937 - 35,776,956 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef135,378,101 - 35,617,482 (-)NCBIHuRef
CHM1_1137,377,032 - 37,615,785 (-)NCBICHM1_1
T2T-CHM13v2.0136,659,019 - 36,898,269 (-)NCBIT2T-CHM13v2.0
Grik3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394125,384,025 - 125,607,966 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4125,384,493 - 125,607,966 (+)EnsemblGRCm39 Ensembl
GRCm384125,490,259 - 125,714,173 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4125,490,700 - 125,714,173 (+)EnsemblGRCm38mm10GRCm38
MGSCv374125,168,075 - 125,391,417 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364124,993,135 - 125,210,652 (+)NCBIMGSCv36mm8
Celera4123,816,415 - 124,039,344 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map458.91NCBI
Grik3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545214,725,097 - 14,933,658 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545214,719,072 - 14,933,613 (-)NCBIChiLan1.0ChiLan1.0
GRIK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,812,527 - 190,051,624 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,940,771 - 189,180,310 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0136,060,594 - 36,312,781 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1137,413,660 - 37,651,769 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl137,415,254 - 37,651,705 (-)Ensemblpanpan1.1panPan2
GRIK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1155,331,746 - 5,550,975 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl155,331,717 - 5,549,181 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,577,336 - 5,796,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0155,469,481 - 5,690,516 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl155,468,814 - 5,690,461 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1155,323,496 - 5,544,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0155,389,938 - 5,612,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0155,405,832 - 5,626,868 (+)NCBIUU_Cfam_GSD_1.0
Grik3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505853,325,517 - 53,538,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647419,156,172 - 19,363,542 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647419,151,896 - 19,363,497 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl692,880,303 - 93,128,569 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1692,880,297 - 93,128,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2685,950,875 - 86,193,744 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12095,832,480 - 96,069,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2095,832,864 - 96,063,577 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603320,731,558 - 20,968,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476419,655,782 - 19,860,119 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476419,649,780 - 19,860,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grik3
1412 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:173
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000045513
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5134972980138113556Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
D5Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,961,769 - 137,961,935 (+)MAPPERmRatBN7.2
Rnor_6.05143,693,010 - 143,693,175NCBIRnor6.0
Rnor_5.05147,457,971 - 147,458,136UniSTSRnor5.0
RGSC_v3.45145,035,510 - 145,035,673RGDRGSC3.4
RGSC_v3.45145,035,511 - 145,035,676UniSTSRGSC3.4
RGSC_v3.15145,045,503 - 145,045,666RGD
Celera5136,477,762 - 136,477,927UniSTS
Cytogenetic Map5q36UniSTS
D5Uia4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,790,781 - 137,791,027 (+)MAPPERmRatBN7.2
Rnor_6.05143,523,348 - 143,523,593NCBIRnor6.0
Rnor_5.05147,288,554 - 147,288,799UniSTSRnor5.0
RGSC_v3.45144,865,363 - 144,865,613RGDRGSC3.4
RGSC_v3.45144,865,364 - 144,865,613UniSTSRGSC3.4
RGSC_v3.15144,875,356 - 144,875,606RGD
Celera5136,307,335 - 136,307,580UniSTS
Cytogenetic Map5q36UniSTS
D5Uia6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,790,781 - 137,791,023 (+)MAPPERmRatBN7.2
Rnor_6.05143,523,348 - 143,523,589NCBIRnor6.0
Rnor_5.05147,288,554 - 147,288,795UniSTSRnor5.0
RGSC_v3.45144,865,363 - 144,865,608RGDRGSC3.4
RGSC_v3.45144,865,364 - 144,865,609UniSTSRGSC3.4
RGSC_v3.15144,875,356 - 144,875,601RGD
Celera5136,307,335 - 136,307,576UniSTS
Cytogenetic Map5q36UniSTS
Glur7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,983,408 - 137,983,670 (+)MAPPERmRatBN7.2
Rnor_6.05143,714,648 - 143,714,909NCBIRnor6.0
Rnor_5.05147,479,609 - 147,479,870UniSTSRnor5.0
RGSC_v3.45145,057,149 - 145,057,410UniSTSRGSC3.4
Celera5136,499,400 - 136,499,661UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:479317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25137,896,104 - 137,897,785 (+)MAPPERmRatBN7.2
Rnor_6.05143,627,451 - 143,629,131NCBIRnor6.0
Rnor_5.05147,392,456 - 147,394,136UniSTSRnor5.0
RGSC_v3.45144,969,788 - 144,971,468UniSTSRGSC3.4
Celera5136,412,059 - 136,413,739UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 40 113 85 81 53 20 53 6 182 80 93 33 60 28

Sequence


Ensembl Acc Id: ENSRNOT00000045513   ⟹   ENSRNOP00000048216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5137,767,865 - 137,984,307 (+)Ensembl
Rnor_6.0 Ensembl5143,500,441 - 143,715,546 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103338   ⟹   ENSRNOP00000089586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5137,899,781 - 137,984,307 (+)Ensembl
RefSeq Acc Id: NM_001112716   ⟹   NP_001106187
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85143,052,442 - 143,268,873 (+)NCBI
mRatBN7.25137,767,865 - 137,984,307 (+)NCBI
Rnor_6.05143,500,441 - 143,715,546 (+)NCBI
Rnor_5.05147,265,647 - 147,485,816 (+)NCBI
RGSC_v3.45144,842,374 - 145,058,047 (+)RGD
Celera5136,284,413 - 136,500,298 (+)RGD
Sequence:
RefSeq Acc Id: NM_181373   ⟹   NP_852038
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85143,052,442 - 143,268,873 (+)NCBI
mRatBN7.25137,767,865 - 137,984,307 (+)NCBI
Rnor_6.05143,500,441 - 143,715,546 (+)NCBI
Rnor_5.05147,265,647 - 147,485,816 (+)NCBI
RGSC_v3.45144,842,374 - 145,058,047 (+)RGD
Celera5136,284,413 - 136,500,298 (+)RGD
Sequence:
RefSeq Acc Id: NP_852038   ⟸   NM_181373
- Peptide Label: isoform 2 precursor
- UniProtKB: P42264 (UniProtKB/Swiss-Prot),   O35420 (UniProtKB/Swiss-Prot),   A6IS79 (UniProtKB/TrEMBL),   G3V9I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106187   ⟸   NM_001112716
- Peptide Label: isoform 1 precursor
- UniProtKB: P42264 (UniProtKB/Swiss-Prot),   O35420 (UniProtKB/Swiss-Prot),   A6IS78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048216   ⟸   ENSRNOT00000045513
Ensembl Acc Id: ENSRNOP00000089586   ⟸   ENSRNOT00000103338
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42264-F1-model_v2 AlphaFold P42264 1-919 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71027 AgrOrtholog
BioCyc Gene G2FUF-39920 BioCyc
Ensembl Genes ENSRNOG00000008992 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045513.4 UniProtKB/TrEMBL
  ENSRNOT00000103338.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298521 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Grik3 ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grik3 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008992 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GHG4_RAT UniProtKB/TrEMBL
  A6IS78 ENTREZGENE, UniProtKB/TrEMBL
  A6IS79 ENTREZGENE, UniProtKB/TrEMBL
  G3V9I2 ENTREZGENE, UniProtKB/TrEMBL
  GRIK3_RAT UniProtKB/Swiss-Prot
  O35420 ENTREZGENE
  P42264 ENTREZGENE
UniProt Secondary O35420 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik3  glutamate ionotropic receptor kainate type subunit 3  Grik3  glutamate receptor, ionotropic, kainate 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Grik3  glutamate receptor, ionotropic, kainate 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference