Zmpste24 (zinc metallopeptidase STE24) - Rat Genome Database

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Gene: Zmpste24 (zinc metallopeptidase STE24) Rattus norvegicus
Symbol: Zmpste24
Name: zinc metallopeptidase STE24
RGD ID: 1305570
Description: Predicted to enable double-stranded DNA binding activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to act upstream of or within several processes, including heart development; regulation of intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in membrane and nuclear envelope. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24); INTERACTS WITH acetamide; bisphenol A; gentamycin.
Type: protein-coding
Previously known as: CAAX prenyl protease 1 homolog; LOC313564; zinc metallopeptidase, STE24 homolog; zinc metallopeptidase, STE24 homolog (S. cerevisiae); zinc metalloproteinase, STE24 homolog; zinc metalloproteinase, STE24 homolog (S. cerevisiae)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85139,912,395 - 139,945,532 (-)NCBIGRCr8
mRatBN7.25134,627,218 - 134,660,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,355,779 - 137,387,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,112,274 - 139,144,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,132,865 - 139,164,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,982,404 - 140,015,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,777,121 - 143,808,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,644,119 - 141,677,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15141,649,218 - 141,682,222 (-)NCBI
Celera5133,182,210 - 133,213,802 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
biological_process  (ND)
bone mineralization  (ISO)
CAAX-box protein processing  (IBA)
calcium ion import into sarcoplasmic reticulum  (ISO)
CAMKK-AMPK signaling cascade  (ISO)
cardiac conduction  (ISO)
cardiac muscle cell development  (ISO)
cardiac ventricle development  (ISO)
cellular lipid metabolic process  (ISO)
cellular response to gamma radiation  (ISO)
chromatin organization  (ISO)
chromosome organization  (ISO)
determination of adult lifespan  (ISO)
DNA damage response  (ISO)
DNA repair  (ISO)
epidermis development  (ISO)
epigenetic regulation of gene expression  (ISO)
growth plate cartilage development  (ISO)
hair follicle development  (ISO)
heart morphogenesis  (ISO)
inflammatory cell apoptotic process  (ISO)
kidney morphogenesis  (ISO)
liver development  (ISO)
maintenance of rDNA  (ISO)
multicellular organism growth  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of miRNA processing  (ISO)
neuromuscular process  (ISO)
nuclear envelope organization  (ISO)
nucleus organization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gene expression via chromosomal CpG island demethylation  (ISO)
prenylated protein catabolic process  (ISO)
protein maturation  (ISO)
protein processing  (ISO)
regulation of autophagy  (ISO)
regulation of blood circulation  (ISO)
regulation of bone mineralization  (ISO)
regulation of cell shape  (ISO)
regulation of cellular senescence  (ISO)
regulation of defense response to virus  (ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of fibroblast proliferation  (ISO)
regulation of glucose metabolic process  (ISO)
regulation of heart contraction  (ISO)
regulation of hormone metabolic process  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of mitotic cell cycle DNA replication  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of stress-activated protein kinase signaling cascade  (ISO)
regulation of termination of RNA polymerase I transcription  (ISO)
regulation of TOR signaling  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to DNA damage checkpoint signaling  (ISO)
thymus development  (ISO)
ventricular cardiac muscle tissue development  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. Agarwal AK, etal., Hum Mol Genet. 2003 Aug 15;12(16):1995-2001.
2. Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice. de Carlos F, etal., J Anat. 2008 Nov;213(5):509-19. doi: 10.1111/j.1469-7580.2008.00970.x.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. Moulson CL, etal., J Invest Dermatol. 2005 Nov;125(5):913-9.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing. Peinado JR, etal., Mol Cell Proteomics. 2011 Nov;10(11):M111.008094. doi: 10.1074/mcp.M111.008094. Epub 2011 Aug 9.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11399759   PMID:11923874   PMID:15608054   PMID:15980864   PMID:16079796   PMID:16511604   PMID:17652517   PMID:18443001   PMID:19056867   PMID:19946888   PMID:20961378   PMID:21522133  
PMID:21746928   PMID:23117660   PMID:23376485   PMID:23686339   PMID:23695662   PMID:25002582   PMID:27498005   PMID:27799555   PMID:28246125  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr85139,912,395 - 139,945,532 (-)NCBIGRCr8
mRatBN7.25134,627,218 - 134,660,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,355,779 - 137,387,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,112,274 - 139,144,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,132,865 - 139,164,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,982,404 - 140,015,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,777,121 - 143,808,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,644,119 - 141,677,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15141,649,218 - 141,682,222 (-)NCBI
Celera5133,182,210 - 133,213,802 (-)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38140,258,236 - 40,294,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,258,041 - 40,294,180 (+)EnsemblGRCh38hg38GRCh38
GRCh37140,723,908 - 40,759,852 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,496,320 - 40,532,443 (+)NCBINCBI36Build 36hg18NCBI36
Build 34140,392,871 - 40,428,944NCBI
Celera139,006,122 - 39,042,251 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,842,523 - 38,878,354 (+)NCBIHuRef
CHM1_1140,839,331 - 40,875,788 (+)NCBICHM1_1
T2T-CHM13v2.0140,127,713 - 40,163,687 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394120,916,434 - 120,955,452 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,916,434 - 120,955,438 (-)EnsemblGRCm39 Ensembl
GRCm384121,059,237 - 121,098,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4121,059,237 - 121,098,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv374120,731,843 - 120,770,848 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364120,556,873 - 120,595,878 (-)NCBIMGSCv36mm8
Celera4119,770,178 - 119,809,143 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map456.8NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495553781,920 - 134,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495553782,724 - 134,609 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21186,522,556 - 186,570,943 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,660,166 - 185,708,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,545,264 - 39,589,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,869,076 - 40,912,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,869,076 - 40,912,747 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1152,669,546 - 2,708,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,670,326 - 2,709,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,927,171 - 2,965,754 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,756,132 - 2,794,814 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,756,136 - 2,794,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,663,629 - 2,702,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,723,834 - 2,762,460 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,739,878 - 2,778,521 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505856,210,295 - 56,253,058 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647422,034,801 - 22,077,986 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647422,035,059 - 22,077,846 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl696,008,455 - 96,062,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,008,307 - 96,057,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,129,860 - 89,133,461 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12092,605,495 - 92,648,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,605,309 - 92,648,114 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,227,800 - 24,273,781 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476422,723,291 - 22,778,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,723,643 - 22,777,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Zmpste24
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:38
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25134,628,889 - 134,629,104 (+)MAPPERmRatBN7.2
Rnor_6.05139,984,076 - 139,984,290NCBIRnor6.0
Rnor_5.05143,777,517 - 143,777,731UniSTSRnor5.0
RGSC_v3.45141,644,515 - 141,644,729UniSTSRGSC3.4
Celera5133,182,606 - 133,182,820UniSTS
RH 3.4 Map5877.1UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25134,627,279 - 134,627,383 (+)MAPPERmRatBN7.2
Rnor_6.05139,982,466 - 139,982,569NCBIRnor6.0
Rnor_5.05143,775,907 - 143,776,010UniSTSRnor5.0
RGSC_v3.45141,642,905 - 141,643,008UniSTSRGSC3.4
Celera5133,180,996 - 133,181,099UniSTS
RH 3.4 Map5888.9UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 42 57 41 19 41 8 9 74 35 40 11 8
Low 1 2 1
Below cutoff


RefSeq Acc Id: ENSRNOT00000016410   ⟹   ENSRNOP00000016410
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)Ensembl
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)Ensembl
RefSeq Acc Id: NM_001107974   ⟹   NP_001101444
Rat AssemblyChrPosition (strand)Source
GRCr85139,913,671 - 139,945,532 (-)NCBI
mRatBN7.25134,628,494 - 134,660,360 (-)NCBI
Rnor_6.05139,983,680 - 140,015,541 (-)NCBI
Rnor_5.05143,777,121 - 143,808,982 (-)NCBI
RGSC_v3.45141,644,119 - 141,677,211 (-)RGD
Celera5133,182,210 - 133,213,802 (-)RGD
RefSeq Acc Id: XM_017593398   ⟹   XP_017448887
Rat AssemblyChrPosition (strand)Source
GRCr85139,912,395 - 139,945,502 (-)NCBI
mRatBN7.25134,627,218 - 134,660,296 (-)NCBI
Rnor_6.05139,982,404 - 140,015,449 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101444 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448887 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80355 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016410
RefSeq Acc Id: NP_001101444   ⟸   NM_001107974
- UniProtKB: D4A5K6 (UniProtKB/TrEMBL),   A6IS04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448887   ⟸   XM_017593398
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016410   ⟸   ENSRNOT00000016410
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5K6-F1-model_v2 AlphaFold D4A5K6 1-475 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693995
Promoter ID:EPDNEW_R4520
Type:initiation region
Description:zinc metallopeptidase STE24
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.05140,015,429 - 140,015,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305570 AgrOrtholog
BioCyc Gene G2FUF-40039 BioCyc
Ensembl Genes ENSRNOG00000012054 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016410 ENTREZGENE
  ENSRNOT00000016410.6 UniProtKB/TrEMBL
Gene3D-CATH Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
InterPro CAXX_Prtase_1 UniProtKB/TrEMBL
  Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
KEGG Report rno:313564 UniProtKB/TrEMBL
Pfam Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
PhenoGen Zmpste24 PhenoGen
RatGTEx ENSRNOG00000012054 RatGTEx

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Zmpste24  zinc metallopeptidase STE24  Zmpste24  zinc metallopeptidase, STE24 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zmpste24  zinc metallopeptidase, STE24 homolog (S. cerevisiae)   Zmpste24_predicted  zinc metallopeptidase, STE24 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zmpste24_predicted  zinc metallopeptidase, STE24 homolog (S. cerevisiae) (predicted)    zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Zmpste24_predicted  zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED