Zmpste24 (zinc metallopeptidase STE24) - Rat Genome Database

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Gene: Zmpste24 (zinc metallopeptidase STE24) Rattus norvegicus
Analyze
Symbol: Zmpste24
Name: zinc metallopeptidase STE24
RGD ID: 1305570
Description: Predicted to enable double-stranded DNA binding activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to act upstream of or within several processes, including heart development; regulation of intracellular signal transduction; and regulation of primary metabolic process. Predicted to be located in membrane and nuclear envelope. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24); INTERACTS WITH acetamide; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CAAX prenyl protease 1 homolog; LOC313564; zinc metallopeptidase, STE24 homolog; zinc metallopeptidase, STE24 homolog (S. cerevisiae); zinc metalloproteinase, STE24 homolog; zinc metalloproteinase, STE24 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,912,395 - 139,945,532 (-)NCBIGRCr8
mRatBN7.25134,627,218 - 134,660,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,355,779 - 137,387,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,112,274 - 139,144,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,132,865 - 139,164,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,982,404 - 140,015,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,777,121 - 143,808,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,644,119 - 141,677,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15141,649,218 - 141,682,222 (-)NCBI
Celera5133,182,210 - 133,213,802 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
Zmpste24RatCraniomandibular Disorders  ISOZmpste24 (Mus musculus)10043096 RGD 
Zmpste24Ratlipodystrophy  ISOZmpste24 (Mus musculus)10043099 RGD 
Zmpste24RatPremature Aging  ISOZmpste24 (Mus musculus)10043096 RGD 
Zmpste24Ratrestrictive dermopathy  ISOZMPSTE24 (Homo sapiens)10043097DNA:duplication:exon:c.591dupT (human)RGD 
Object Symbol
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Original Reference(s)
Zmpste24RatCharcot-Marie-Tooth disease dominant intermediate C  ISOZMPSTE24 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Zmpste24Ratgenetic disease  ISOZMPSTE24 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Zmpste24Ratmandibuloacral dysplasia  ISOZMPSTE24 (Homo sapiens)8554872ClinVar Annotator: match by term: Mandibuloacral dysplasiaClinVarPMID:25741868
Zmpste24Ratmandibuloacral dysplasia type B lipodystrophy  ISOZMPSTE24 (Homo sapiens)8554872ClinVar Annotator: match by term: Mandibuloacral dysplasia with type B lipodystrophyClinVarPMID:12913070 more ...
Zmpste24Ratrestrictive dermopathy  ISOZMPSTE24 (Homo sapiens)8554872ClinVar Annotator: match by term: Lethal tight skin contracture syndromeClinVarPMID:12913070 more ...
Zmpste24Ratrestrictive dermopathy 1  ISOZMPSTE24 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12913070 more ...
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Original Reference(s)
Zmpste24RatAcro-Osteolysis  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12913070 and PMID:17152860
Zmpste24RatCraniofacial Abnormalities  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17152860
Zmpste24Ratfocal segmental glomerulosclerosis  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17152860
Zmpste24RatHIV-Associated Lipodystrophy Syndrome  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18230615
Zmpste24Ratlipodystrophy  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12913070
Zmpste24RatMandibular Diseases  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12913070
Zmpste24Ratmandibuloacral dysplasia type B lipodystrophy  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Zmpste24Ratprogeria  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23217256
Zmpste24Ratrestrictive dermopathy  ISOZMPSTE24 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Zmpste24RatEmery-Dreifuss muscular dystrophy  ISSZmpste24 (Mus musculus)13592920OMIM:181350 more ...MouseDO 
Zmpste24Ratfamilial partial lipodystrophy  ISSZmpste24 (Mus musculus)13592920OMIM:151660 more ...MouseDO 
Zmpste24Ratprogeria  ISSZmpste24 (Mus musculus)13592920OMIM:176670MouseDO 
Object Symbol
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Original Reference(s)
Zmpste24Ratmandibuloacral dysplasia type B lipodystrophy  ISOZMPSTE24 (Homo sapiens)7240710 OMIM 
Zmpste24Ratrestrictive dermopathy 1  ISOZMPSTE24 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Zmpste24Rat(1->4)-beta-D-glucan multiple interactionsISOZmpste24 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ZMPSTE24 mRNACTDPMID:36331819
Zmpste24Rat1,2-dimethylhydrazine decreases expressionISOZmpste24 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ZMPSTE24 mRNACTDPMID:22206623
Zmpste24Rat1,2-dimethylhydrazine multiple interactionsISOZmpste24 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZMPSTE24 mRNACTDPMID:22206623
Zmpste24Rat17alpha-ethynylestradiol multiple interactionsISOZmpste24 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZMPSTE24 mRNACTDPMID:17942748
Zmpste24Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOZmpste24 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZMPSTE24 mRNACTDPMID:17942748
Zmpste24Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOZmpste24 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of ZMPSTE24 mRNACTDPMID:31961203
Zmpste24Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOZmpste24 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ZMPSTE24 mRNACTDPMID:20702594 and PMID:21570461
Zmpste24Rat2,3,7,8-Tetrachlorodibenzofuran affects expressionISOZmpste24 (Mus musculus)64804642 more ...CTDPMID:20702594
Zmpste24Rat4,4'-sulfonyldiphenol decreases expressionISOZmpste24 (Mus musculus)6480464bisphenol S results in decreased expression of ZMPSTE24 mRNACTDPMID:39298647
Zmpste24Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of ZMPSTE24 mRNACTDPMID:31881176
Zmpste24Ratacrylamide increases expressionISOZMPSTE24 (Homo sapiens)6480464Acrylamide results in increased expression of ZMPSTE24 mRNACTDPMID:32763439
Zmpste24Rataflatoxin B1 increases methylationISOZMPSTE24 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ZMPSTE24 geneCTDPMID:27153756
Zmpste24Ratarsane multiple interactionsISOZMPSTE24 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ZMPSTE24 mRNACTDPMID:39836092
Zmpste24Ratarsenic atom multiple interactionsISOZMPSTE24 (Homo sapiens)6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ZMPSTE24 mRNACTDPMID:39836092
Zmpste24Ratarsenous acid increases expressionISOZMPSTE24 (Homo sapiens)6480464Arsenic Trioxide results in increased expression of ZMPSTE24 mRNACTDPMID:20458559
Zmpste24Ratatrazine decreases expressionISOZMPSTE24 (Homo sapiens)6480464Atrazine results in decreased expression of ZMPSTE24 mRNACTDPMID:22378314
Zmpste24Ratbenzo[a]pyrene increases expressionISOZmpste24 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of ZMPSTE24 mRNACTDPMID:22228805
Zmpste24Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of ZMPSTE24 mRNACTDPMID:25181051
Zmpste24Ratbisphenol A increases expressionISOZMPSTE24 (Homo sapiens)6480464bisphenol A results in increased expression of ZMPSTE24 proteinCTDPMID:34186270
Zmpste24Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of ZMPSTE24 mRNACTDPMID:34947998

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Biological Process
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Original Reference(s)
Zmpste24Ratadult walking behavior acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:11923874RGDPMID:11923874
Zmpste24Ratadult walking behavior acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratbiological_process  ND 159840705/2015: no relevant rat dataRGD 
Zmpste24Ratbone mineralization acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratbone mineralization acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:1888594 PMID:23686339RGDPMID:23686339
Zmpste24RatCAAX-box protein processing involved_inIBAPANTHER:PTN000012712 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Zmpste24RatCAAX-box protein processing involved_inIEAUniRule:UR0010807721600115GO_REF:0000104UniProtGO_REF:0000104
Zmpste24RatCAAX-box protein processing involved_inIEAInterPro:IPR0270571600115GO_REF:0000002InterProGO_REF:0000002
Zmpste24Ratcalcium ion import into sarcoplasmic reticulum acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:27799555RGDPMID:27799555
Zmpste24Ratcalcium ion import into sarcoplasmic reticulum acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24RatCAMKK-AMPK signaling cascade acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:18443001RGDPMID:18443001
Zmpste24RatCAMKK-AMPK signaling cascade acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratcardiac conduction acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:27799555RGDPMID:27799555
Zmpste24Ratcardiac conduction acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratcardiac muscle cell development acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:11923874RGDPMID:11923874
Zmpste24Ratcardiac muscle cell development acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratcardiac ventricle development acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:11923874RGDPMID:11923874
Zmpste24Ratcardiac ventricle development acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratcellular response to gamma radiation acts_upstream_of_or_withinIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratcellular response to gamma radiation acts_upstream_of_or_withinISOZmpste24 (Mus musculus)1624291MGI:2180033 PMID:15980864RGDPMID:15980864
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Cellular Component
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Original Reference(s)
Zmpste24Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Zmpste24Ratendoplasmic reticulum membrane is_active_inIBAPANTHER:PTN000012714 and SGD:S0000038781600115GO_REF:0000033GO_CentralGO_REF:0000033
Zmpste24Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Zmpste24Ratmembrane located_inISOZmpste24 (Mus musculus)1624291 PMID:11399759RGDPMID:11399759
Zmpste24Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Zmpste24Ratmembrane located_inIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratnuclear envelope located_inISOZmpste24 (Mus musculus)1624291 PMID:15980864RGDPMID:15980864
Zmpste24Ratnuclear envelope located_inIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratprotein-containing complex part_ofISOZMPSTE24 (Homo sapiens)1624291 PMID:28246125RGDPMID:28246125
Zmpste24Ratprotein-containing complex part_ofIEAUniProtKB:O75844 and ensembl:ENSP000003618451600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Zmpste24Ratdouble-stranded DNA binding enablesIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratdouble-stranded DNA binding enablesISOZmpste24 (Mus musculus)1624291MGI:1347476 PMID:23117660RGDPMID:23117660
Zmpste24Ratendopeptidase activity enablesIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratendopeptidase activity enablesIEAUniProtKB:O75844 and ensembl:ENSP000003618451600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratendopeptidase activity enablesIEAARBA:ARBA000281311600115GO_REF:0000117UniProtGO_REF:0000117
Zmpste24Ratendopeptidase activity enablesISOZmpste24 (Mus musculus)1624291 PMID:17652517RGDPMID:17652517
Zmpste24Ratendopeptidase activity enablesISOZMPSTE24 (Homo sapiens)1624291 PMID:33293369RGDPMID:33293369
Zmpste24Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Zmpste24Ratmetal ion binding enablesIEAUniRule:UR0010807721600115GO_REF:0000104UniProtGO_REF:0000104
Zmpste24Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Zmpste24Ratmetalloendopeptidase activity enablesIEAUniProtKB:Q80W54 and ensembl:ENSMUSP000000539001600115GO_REF:0000107EnsemblGO_REF:0000107
Zmpste24Ratmetalloendopeptidase activity enablesIEAInterPro:IPR0019151600115GO_REF:0000002InterProGO_REF:0000002
Zmpste24Ratmetalloendopeptidase activity enablesIEAUniRule:UR0010807721600115GO_REF:0000104UniProtGO_REF:0000104
Zmpste24Ratmetalloendopeptidase activity enablesISOZmpste24 (Mus musculus)1624291MGI:2158363 PMID:11399759 more ...RGDPMID:11399759 more ...
Zmpste24Ratmetalloendopeptidase activity enablesIBAMGI:1890508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Zmpste24Ratmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
Zmpste24Ratmetallopeptidase activity enablesIEAARBA:ARBA000274021600115GO_REF:0000117UniProtGO_REF:0000117
Zmpste24Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Zmpste24Ratpeptidase activity enablesIEAInterPro:IPR0270571600115GO_REF:0000002InterProGO_REF:0000002
Zmpste24Ratprotein binding enablesISOZMPSTE24 (Homo sapiens)1624291UniProtKB:C5E519 more ...RGDPMID:23539603 more ...
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Reference Title
Reference Citation
1. Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. Agarwal AK, etal., Hum Mol Genet. 2003 Aug 15;12(16):1995-2001.
2. Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice. de Carlos F, etal., J Anat. 2008 Nov;213(5):509-19. doi: 10.1111/j.1469-7580.2008.00970.x.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. Moulson CL, etal., J Invest Dermatol. 2005 Nov;125(5):913-9.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing. Peinado JR, etal., Mol Cell Proteomics. 2011 Nov;10(11):M111.008094. doi: 10.1074/mcp.M111.008094. Epub 2011 Aug 9.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:11399759   PMID:11923874   PMID:15608054   PMID:15980864   PMID:16079796   PMID:16511604   PMID:17652517   PMID:18443001   PMID:19056867   PMID:19946888   PMID:20961378   PMID:21522133  
PMID:21746928   PMID:23117660   PMID:23376485   PMID:23686339   PMID:23695662   PMID:25002582   PMID:27498005   PMID:27799555   PMID:28246125  



Zmpste24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,912,395 - 139,945,532 (-)NCBIGRCr8
mRatBN7.25134,627,218 - 134,660,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,355,779 - 137,387,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,112,274 - 139,144,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,132,865 - 139,164,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,982,404 - 140,015,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,777,121 - 143,808,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,644,119 - 141,677,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15141,649,218 - 141,682,222 (-)NCBI
Celera5133,182,210 - 133,213,802 (-)NCBICelera
Cytogenetic Map5q36NCBI
ZMPSTE24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,258,236 - 40,294,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,258,041 - 40,294,180 (+)EnsemblGRCh38hg38GRCh38
GRCh37140,723,908 - 40,759,852 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,496,320 - 40,532,443 (+)NCBINCBI36Build 36hg18NCBI36
Build 34140,392,871 - 40,428,944NCBI
Celera139,006,122 - 39,042,251 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,842,523 - 38,878,354 (+)NCBIHuRef
CHM1_1140,839,331 - 40,875,788 (+)NCBICHM1_1
T2T-CHM13v2.0140,127,713 - 40,163,687 (+)NCBIT2T-CHM13v2.0
Zmpste24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,916,434 - 120,955,452 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,916,434 - 120,955,438 (-)EnsemblGRCm39 Ensembl
GRCm384121,059,237 - 121,098,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4121,059,237 - 121,098,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv374120,731,843 - 120,770,848 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364120,556,873 - 120,595,878 (-)NCBIMGSCv36mm8
Celera4119,770,178 - 119,809,143 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map456.8NCBI
Zmpste24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553781,920 - 134,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495553782,724 - 134,609 (+)NCBIChiLan1.0ChiLan1.0
ZMPSTE24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,522,556 - 186,570,943 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,660,166 - 185,708,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,545,264 - 39,589,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,869,076 - 40,912,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,869,076 - 40,912,747 (+)Ensemblpanpan1.1panPan2
ZMPSTE24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,669,546 - 2,708,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,670,326 - 2,709,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,927,171 - 2,965,754 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,756,132 - 2,794,814 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,756,136 - 2,794,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,663,629 - 2,702,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,723,834 - 2,762,460 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,739,878 - 2,778,521 (-)NCBIUU_Cfam_GSD_1.0
Zmpste24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,210,295 - 56,253,058 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647422,034,801 - 22,077,986 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647422,035,059 - 22,077,846 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZMPSTE24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,008,455 - 96,062,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,008,307 - 96,057,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,129,860 - 89,133,461 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZMPSTE24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,605,495 - 92,648,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,605,309 - 92,648,114 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,227,800 - 24,273,781 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zmpste24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,723,291 - 22,778,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,723,643 - 22,777,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Zmpste24
92 total Variants

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000016410
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat

1 to 10 of 45 rows
RH135308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25134,628,889 - 134,629,104 (+)MAPPERmRatBN7.2
Rnor_6.05139,984,076 - 139,984,290NCBIRnor6.0
Rnor_5.05143,777,517 - 143,777,731UniSTSRnor5.0
RGSC_v3.45141,644,515 - 141,644,729UniSTSRGSC3.4
Celera5133,182,606 - 133,182,820UniSTS
RH 3.4 Map5877.1UniSTS
Cytogenetic Map5q36UniSTS
AI175477  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25134,627,279 - 134,627,383 (+)MAPPERmRatBN7.2
Rnor_6.05139,982,466 - 139,982,569NCBIRnor6.0
Rnor_5.05143,775,907 - 143,776,010UniSTSRnor5.0
RGSC_v3.45141,642,905 - 141,643,008UniSTSRGSC3.4
Celera5133,180,996 - 133,181,099UniSTS
RH 3.4 Map5888.9UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016410   ⟹   ENSRNOP00000016410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)Ensembl
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)Ensembl
RefSeq Acc Id: NM_001107974   ⟹   NP_001101444
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,913,671 - 139,945,532 (-)NCBI
mRatBN7.25134,628,494 - 134,660,360 (-)NCBI
Rnor_6.05139,983,680 - 140,015,541 (-)NCBI
Rnor_5.05143,777,121 - 143,808,982 (-)NCBI
RGSC_v3.45141,644,119 - 141,677,211 (-)RGD
Celera5133,182,210 - 133,213,802 (-)RGD
Sequence:
RefSeq Acc Id: XM_017593398   ⟹   XP_017448887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,912,395 - 139,945,502 (-)NCBI
mRatBN7.25134,627,218 - 134,660,296 (-)NCBI
Rnor_6.05139,982,404 - 140,015,449 (-)NCBI
Sequence:
Protein RefSeqs NP_001101444 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448887 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80355 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016410
  ENSRNOP00000016410.4
RefSeq Acc Id: NP_001101444   ⟸   NM_001107974
- UniProtKB: D4A5K6 (UniProtKB/TrEMBL),   A6IS04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448887   ⟸   XM_017593398
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000016410   ⟸   ENSRNOT00000016410
CAAX prenyl protease 1 N-terminal   Peptidase M48

Name Modeler Protein Id AA Range Protein Structure
AF-D4A5K6-F1-model_v2 AlphaFold D4A5K6 1-475 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693995
Promoter ID:EPDNEW_R4520
Type:initiation region
Name:Zmpste24_1
Description:zinc metallopeptidase STE24
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05140,015,429 - 140,015,489EPDNEW


1 to 17 of 17 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40039 BioCyc
Ensembl Genes ENSRNOG00000012054 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016410 ENTREZGENE
  ENSRNOT00000016410.6 UniProtKB/TrEMBL
Gene3D-CATH Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
InterPro CAXX_Prtase_1 UniProtKB/TrEMBL
  Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
KEGG Report rno:313564 UniProtKB/TrEMBL
NCBI Gene 313564 ENTREZGENE
PANTHER CAAX PRENYL PROTEASE 1 UniProtKB/TrEMBL
Pfam Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
PhenoGen Zmpste24 PhenoGen
RatGTEx ENSRNOG00000012054 RatGTEx
UniProt A6IS04 ENTREZGENE, UniProtKB/TrEMBL
  D4A5K6 ENTREZGENE, UniProtKB/TrEMBL
1 to 17 of 17 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Zmpste24  zinc metallopeptidase STE24  Zmpste24  zinc metallopeptidase, STE24 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zmpste24  zinc metallopeptidase, STE24 homolog (S. cerevisiae)   Zmpste24_predicted  zinc metallopeptidase, STE24 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zmpste24_predicted  zinc metallopeptidase, STE24 homolog (S. cerevisiae) (predicted)    zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Zmpste24_predicted  zinc metalloproteinase, STE24 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED