ZMPSTE24 (zinc metallopeptidase STE24) - Rat Genome Database

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Gene: ZMPSTE24 (zinc metallopeptidase STE24) Canis lupus familiaris
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Symbol: ZMPSTE24
Name: zinc metallopeptidase STE24
RGD ID: 12288549
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN adult walking behavior (ortholog); bone mineralization (ortholog); calcium ion import into sarcoplasmic reticulum (ortholog); ASSOCIATED WITH Acro-Osteolysis (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN membrane (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: CAAX prenyl protease 1 homolog; zinc metallopeptidase STE24 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,669,546 - 2,708,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,670,326 - 2,709,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,927,171 - 2,965,754 (-)NCBI
ROS_Cfam_1.0152,756,132 - 2,794,814 (-)NCBI
UMICH_Zoey_3.1152,663,629 - 2,702,258 (-)NCBI
UNSW_CanFamBas_1.0152,723,834 - 2,762,460 (-)NCBI
UU_Cfam_GSD_1.0152,739,878 - 2,778,521 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (IEA,ISO)
bone mineralization  (IEA,ISO)
CAAX-box protein processing  (IBA,IEA)
calcium ion import into sarcoplasmic reticulum  (IEA,ISO)
CAMKK-AMPK signaling cascade  (IEA,ISO)
cardiac conduction  (IEA,ISO)
cardiac muscle cell development  (IEA,ISO)
cardiac ventricle development  (IEA,ISO)
cellular lipid metabolic process  (IEA,ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to gamma radiation  (IEA,ISO)
chromatin organization  (ISO)
chromosome organization  (ISO)
determination of adult lifespan  (IEA,ISO)
DNA repair  (IEA,ISO)
epidermis development  (ISO)
growth plate cartilage development  (IEA,ISO)
hair follicle development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
histone H2A phosphorylation  (IEA,ISO)
histone H2B acetylation  (ISO)
histone H2B-K5 acetylation  (IEA,ISO)
hypomethylation of CpG island  (IEA,ISO)
inflammatory cell apoptotic process  (IEA,ISO)
kidney morphogenesis  (IEA,ISO)
liver development  (IEA,ISO)
maintenance of rDNA  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of production of miRNAs involved in gene silencing by miRNA  (IEA,ISO)
neuromuscular process  (IEA,ISO)
nuclear envelope organization  (IEA,ISO)
nucleus organization  (ISO)
positive regulation of gene expression  (ISO)
prenylated protein catabolic process  (IEA,ISO)
protein processing  (ISO)
regulation of autophagy  (IEA,ISO)
regulation of blood circulation  (ISO)
regulation of bone mineralization  (IEA,ISO)
regulation of cell shape  (IEA,ISO)
regulation of cellular senescence  (IEA,ISO)
regulation of defense response to virus  (IEA,ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
regulation of DNA methylation  (ISO)
regulation of fibroblast proliferation  (IEA,ISO)
regulation of glucose metabolic process  (IEA,ISO)
regulation of heart contraction  (ISO)
regulation of histone H4 acetylation  (ISO)
regulation of histone H4-K16 acetylation  (IEA,ISO)
regulation of hormone metabolic process  (IEA,ISO)
regulation of lipid metabolic process  (IEA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of mitotic cell cycle DNA replication  (IEA,ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
regulation of stress-activated protein kinase signaling cascade  (IEA,ISO)
regulation of termination of RNA polymerase I transcription  (IEA,ISO)
regulation of TOR signaling  (IEA,ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA,ISO)
response to DNA damage checkpoint signaling  (IEA,ISO)
thymus development  (IEA,ISO)
ventricular cardiac muscle tissue development  (IEA,ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
ZMPSTE24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,669,546 - 2,708,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,670,326 - 2,709,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,927,171 - 2,965,754 (-)NCBI
ROS_Cfam_1.0152,756,132 - 2,794,814 (-)NCBI
UMICH_Zoey_3.1152,663,629 - 2,702,258 (-)NCBI
UNSW_CanFamBas_1.0152,723,834 - 2,762,460 (-)NCBI
UU_Cfam_GSD_1.0152,739,878 - 2,778,521 (-)NCBI
ZMPSTE24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl140,258,041 - 40,294,180 (+)EnsemblGRCh38hg38GRCh38
GRCh38140,258,078 - 40,294,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37140,723,908 - 40,759,852 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,496,320 - 40,532,443 (+)NCBINCBI36hg18NCBI36
Build 34140,392,871 - 40,428,944NCBI
Celera139,006,122 - 39,042,251 (+)NCBI
Cytogenetic Map1p34.2NCBI
HuRef138,842,523 - 38,878,354 (+)NCBIHuRef
CHM1_1140,839,331 - 40,875,788 (+)NCBICHM1_1
Zmpste24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,916,434 - 120,955,452 (-)NCBIGRCm39mm39
GRCm39 Ensembl4120,916,434 - 120,955,438 (-)Ensembl
GRCm384121,059,237 - 121,098,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4121,059,237 - 121,098,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv374120,731,843 - 120,770,848 (-)NCBIGRCm37mm9NCBIm37
MGSCv364120,556,873 - 120,595,878 (-)NCBImm8
Celera4119,770,178 - 119,809,143 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
Zmpste24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25134,627,218 - 134,660,360 (-)NCBI
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05139,982,404 - 140,015,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05143,777,121 - 143,808,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,644,119 - 141,677,211 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15141,649,218 - 141,682,222 (-)NCBI
Celera5133,182,210 - 133,213,802 (-)NCBICelera
Cytogenetic Map5q36NCBI
Zmpste24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553781,920 - 134,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495553782,724 - 134,609 (+)NCBIChiLan1.0ChiLan1.0
ZMPSTE24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1140,869,076 - 40,912,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,869,076 - 40,912,747 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0139,545,264 - 39,589,721 (+)NCBIMhudiblu_PPA_v0panPan3
Zmpste24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,210,295 - 56,253,058 (+)NCBI
SpeTri2.0NW_00493647422,035,059 - 22,077,846 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZMPSTE24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,008,455 - 96,062,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,008,307 - 96,057,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,129,860 - 89,133,461 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZMPSTE24
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,605,495 - 92,648,110 (-)NCBI
ChlSab1.1 Ensembl2092,605,309 - 92,648,114 (-)Ensembl
Vero_WHO_p1.0NW_02366603324,227,800 - 24,273,781 (+)NCBI
Zmpste24
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476422,723,643 - 22,777,517 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 2 18 2 3 2 6 12 8 10 6
Low 3 4 4 3 4 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004818   ⟹   ENSCAFP00000004464
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl152,670,926 - 2,709,160 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070472   ⟹   ENSCAFP00000051844
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl152,670,326 - 2,709,160 (-)Ensembl
RefSeq Acc Id: XM_022427760   ⟹   XP_022283468
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1152,671,086 - 2,708,480 (-)NCBI
Dog10K_Boxer_Tasha152,928,706 - 2,965,754 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038495402   ⟹   XP_038351330
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1152,663,629 - 2,702,258 (-)NCBI
RefSeq Acc Id: XM_038557759   ⟹   XP_038413687
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0152,739,878 - 2,778,518 (-)NCBI
RefSeq Acc Id: XM_038557760   ⟹   XP_038413688
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0152,741,412 - 2,778,521 (-)NCBI
RefSeq Acc Id: XM_038621633   ⟹   XP_038477561
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0152,723,834 - 2,762,457 (-)NCBI
RefSeq Acc Id: XM_038621634   ⟹   XP_038477562
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0152,725,368 - 2,762,460 (-)NCBI
RefSeq Acc Id: XM_038687415   ⟹   XP_038543343
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0152,756,132 - 2,794,811 (-)NCBI
RefSeq Acc Id: XM_038687416   ⟹   XP_038543344
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0152,757,666 - 2,794,814 (-)NCBI
RefSeq Acc Id: XM_539577   ⟹   XP_539577
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1152,669,546 - 2,708,465 (-)NCBI
Dog10K_Boxer_Tasha152,927,171 - 2,965,751 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_539577   ⟸   XM_539577
- Peptide Label: isoform X1
- UniProtKB: F1PY82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022283468   ⟸   XM_022427760
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000051844   ⟸   ENSCAFT00000070472
RefSeq Acc Id: ENSCAFP00000004464   ⟸   ENSCAFT00000004818
RefSeq Acc Id: XP_038351330   ⟸   XM_038495402
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038477561   ⟸   XM_038621633
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038477562   ⟸   XM_038621634
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038543343   ⟸   XM_038687415
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038543344   ⟸   XM_038687416
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038413687   ⟸   XM_038557759
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038413688   ⟸   XM_038557760
- Peptide Label: isoform X2
Protein Domains
Peptidase_M48   Peptidase_M48_N

Promoters
RGD ID:13685842
Promoter ID:EPDNEW_C3911
Type:multiple initiation site
Name:ZMPSTE24_1
Description:zinc metallopeptidase STE24
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1152,708,433 - 2,708,493EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000004464 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000051844 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004818 UniProtKB/TrEMBL
  ENSCAFT00000070472 UniProtKB/TrEMBL
InterPro CAXX_Prtase_1 UniProtKB/TrEMBL
  Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
NCBI Gene ZMPSTE24 ENTREZGENE
PANTHER PTHR10120 UniProtKB/TrEMBL
Pfam Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
UniProt A0A5F4CG47_CANLF UniProtKB/TrEMBL
  F1PY82 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48644 ENTREZGENE