RGMA (repulsive guidance molecule BMP co-receptor a) - Rat Genome Database

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Gene: RGMA (repulsive guidance molecule BMP co-receptor a) Homo sapiens
Analyze
Symbol: RGMA
Name: repulsive guidance molecule BMP co-receptor a
RGD ID: 1323724
HGNC Page HGNC
Description: Enables transferrin receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum. Implicated in multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family, member A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1593,035,273 - 93,089,204 (-)EnsemblGRCh38hg38GRCh38
GRCh381593,035,271 - 93,089,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371593,578,501 - 93,632,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361591,387,641 - 91,433,437 (-)NCBINCBI36hg18NCBI36
Build 341591,387,640 - 91,433,437NCBI
Celera1569,998,187 - 70,044,004 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1569,723,091 - 69,768,218 (-)NCBIHuRef
CHM1_11593,427,333 - 93,473,451 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:11076863   PMID:11230166   PMID:11256614   PMID:14702039   PMID:15084667   PMID:15258590   PMID:15489334   PMID:15489336   PMID:15975920   PMID:16169070   PMID:16216939   PMID:16303743  
PMID:16344560   PMID:16381901   PMID:17472960   PMID:17606441   PMID:17615080   PMID:18367154   PMID:18485097   PMID:19273616   PMID:19303019   PMID:19458235   PMID:19698085   PMID:21044950  
PMID:21183991   PMID:21467223   PMID:21617229   PMID:21873635   PMID:22076499   PMID:22367090   PMID:22396795   PMID:22566498   PMID:22728873   PMID:23028342   PMID:23376485   PMID:24024966  
PMID:25133637   PMID:25940091   PMID:26496610   PMID:26721439   PMID:28842419   PMID:29478698   PMID:30798120   PMID:31899158   PMID:32296183   PMID:33997000  


Genomics

Comparative Map Data
RGMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1593,035,273 - 93,089,204 (-)EnsemblGRCh38hg38GRCh38
GRCh381593,035,271 - 93,089,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371593,578,501 - 93,632,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361591,387,641 - 91,433,437 (-)NCBINCBI36hg18NCBI36
Build 341591,387,640 - 91,433,437NCBI
Celera1569,998,187 - 70,044,004 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1569,723,091 - 69,768,218 (-)NCBIHuRef
CHM1_11593,427,333 - 93,473,451 (-)NCBICHM1_1
Rgma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,025,268 - 73,069,647 (+)NCBIGRCm39mm39
GRCm39 Ensembl773,025,257 - 73,069,647 (+)Ensembl
GRCm38773,375,520 - 73,419,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,375,509 - 73,419,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,520,406 - 80,564,785 (+)NCBIGRCm37mm9NCBIm37
MGSCv36773,249,020 - 73,293,410 (+)NCBImm8
Celera770,823,178 - 70,867,680 (+)NCBICelera
Cytogenetic Map7D1NCBI
Rgma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21127,128,934 - 127,172,918 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1127,128,934 - 127,172,918 (+)Ensembl
Rnor_6.01134,699,053 - 134,742,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,699,299 - 134,742,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,725,212 - 135,768,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,547,399 - 128,591,304 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11128,641,975 - 128,668,760 (+)NCBI
Celera1119,260,496 - 119,304,476 (+)NCBICelera
Cytogenetic Map1q31NCBI
Rgma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541621,221,023 - 21,261,831 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541621,221,023 - 21,261,831 (-)NCBIChiLan1.0ChiLan1.0
RGMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11590,922,199 - 90,951,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1590,922,199 - 90,956,179 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01571,728,669 - 71,774,447 (-)NCBIMhudiblu_PPA_v0panPan3
RGMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,044,342 - 47,089,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,061,910 - 47,089,294 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha349,744,736 - 49,788,688 (+)NCBI
ROS_Cfam_1.0347,453,705 - 47,497,710 (+)NCBI
UMICH_Zoey_3.1346,971,723 - 47,015,658 (+)NCBI
UNSW_CanFamBas_1.0347,203,068 - 47,247,025 (+)NCBI
UU_Cfam_GSD_1.0347,534,393 - 47,578,334 (+)NCBI
Rgma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640136,541,660 - 136,581,389 (-)NCBI
SpeTri2.0NW_0049364839,753,112 - 9,792,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl785,921,586 - 85,968,888 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1785,921,524 - 85,968,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2791,815,011 - 91,862,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12911,592,929 - 11,638,955 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2911,592,604 - 11,638,860 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605935,022,501 - 35,068,477 (+)NCBIVero_WHO_p1.0
Rgma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476810,739,674 - 10,778,036 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
A008J37  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,587,471 - 93,587,683UniSTSGRCh37
Build 361591,388,475 - 91,388,687RGDNCBI36
Celera1569,999,022 - 69,999,234RGD
Cytogenetic Map15q26.1UniSTS
HuRef1569,723,926 - 69,724,138UniSTS
GeneMap99-GB4 RH Map15336.34UniSTS
NCBI RH Map15720.2UniSTS
G63723  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,626,957 - 93,627,058UniSTSGRCh37
Build 361591,427,961 - 91,428,062RGDNCBI36
Celera1570,038,513 - 70,038,614RGD
Cytogenetic Map15q26.1UniSTS
HuRef1569,763,417 - 69,763,518UniSTS
TNG Radiation Hybrid Map1537678.0UniSTS
RGMA__6886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,586,619 - 93,587,232UniSTSGRCh37
Build 361591,387,623 - 91,388,236RGDNCBI36
Celera1569,998,170 - 69,998,783RGD
HuRef1569,723,074 - 69,723,687UniSTS
WI-17713  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37371,005,249 - 71,005,379UniSTSGRCh37
Build 36371,087,939 - 71,088,069RGDNCBI36
Celera370,932,173 - 70,932,303RGD
Celera1570,030,106 - 70,030,235UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3p14.1UniSTS
HuRef1569,755,010 - 69,755,139UniSTS
HuRef371,004,166 - 71,004,296UniSTS
GeneMap99-GB4 RH Map3215.23UniSTS
Whitehead-RH Map3249.2UniSTS
RH47538  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,586,702 - 93,586,791UniSTSGRCh37
Build 361591,387,706 - 91,387,795RGDNCBI36
Celera1569,998,253 - 69,998,342RGD
Cytogenetic Map15q26.1UniSTS
HuRef1569,723,157 - 69,723,246UniSTS
GeneMap99-GB4 RH Map15337.25UniSTS
NCBI RH Map15720.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10921
Count of miRNA genes:1133
Interacting mature miRNAs:1419
Transcripts:ENST00000329082, ENST00000425933, ENST00000538818, ENST00000542321, ENST00000543599, ENST00000554387, ENST00000555584, ENST00000555598, ENST00000556087, ENST00000556658, ENST00000556950, ENST00000557301, ENST00000557420, ENST00000557608
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1717 585 28 38 85 1 2508 1690 2168 9 949 73 38 546 1769
Low 616 1904 1243 178 644 52 1787 474 1522 269 444 1391 132 1 658 1019 5 2
Below cutoff 68 500 402 360 865 363 51 26 39 124 57 126 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001166283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC013394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL390083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC140838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC151132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ782935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ782957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA183348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA295545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA453869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA512691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA805034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC317516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ515840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000329082   ⟹   ENSP00000330005
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,035,273 - 93,089,204 (-)Ensembl
RefSeq Acc Id: ENST00000425933   ⟹   ENSP00000404442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,043,406 - 93,073,710 (-)Ensembl
RefSeq Acc Id: ENST00000542321   ⟹   ENSP00000440025
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,043,416 - 93,073,148 (-)Ensembl
RefSeq Acc Id: ENST00000543599   ⟹   ENSP00000442498
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,043,406 - 93,088,523 (-)Ensembl
RefSeq Acc Id: ENST00000554387   ⟹   ENSP00000451505
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,043,417 - 93,073,680 (-)Ensembl
RefSeq Acc Id: ENST00000555584
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,052,272 - 93,063,069 (-)Ensembl
RefSeq Acc Id: ENST00000555598   ⟹   ENSP00000451709
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,052,320 - 93,088,523 (-)Ensembl
RefSeq Acc Id: ENST00000556658   ⟹   ENSP00000456290
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,044,956 - 93,073,663 (-)Ensembl
RefSeq Acc Id: ENST00000556950   ⟹   ENSP00000452350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,072,967 - 93,088,653 (-)Ensembl
RefSeq Acc Id: ENST00000557301   ⟹   ENSP00000452126
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,044,818 - 93,074,128 (-)Ensembl
RefSeq Acc Id: ENST00000557420   ⟹   ENSP00000452170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,044,947 - 93,073,145 (-)Ensembl
RefSeq Acc Id: ENST00000557608
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,066,006 - 93,073,134 (-)Ensembl
RefSeq Acc Id: ENST00000650169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1593,044,749 - 93,058,841 (-)Ensembl
RefSeq Acc Id: NM_001166283   ⟹   NP_001159755
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,987 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,458,219 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166286   ⟹   NP_001159758
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,156 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,457,392 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166287   ⟹   NP_001159759
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,088,523 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,472,760 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166288   ⟹   NP_001159760
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,680 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,457,942 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166289   ⟹   NP_001159761
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,710 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,457,942 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020211   ⟹   NP_064596
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,089,211 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
Build 361591,387,641 - 91,433,437 (-)NCBI Archive
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,473,451 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001159759   ⟸   NM_001166287
- Peptide Label: isoform 2 precursor
- UniProtKB: Q96B86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001159755   ⟸   NM_001166283
- Peptide Label: isoform 1
- UniProtKB: Q96B86 (UniProtKB/Swiss-Prot),   A0A0A0MTQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159760   ⟸   NM_001166288
- Peptide Label: isoform 2 precursor
- UniProtKB: Q96B86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001159761   ⟸   NM_001166289
- Peptide Label: isoform 2 precursor
- UniProtKB: Q96B86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001159758   ⟸   NM_001166286
- Peptide Label: isoform 2 precursor
- UniProtKB: Q96B86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_064596   ⟸   NM_020211
- Peptide Label: isoform 3 precursor
- UniProtKB: Q96B86 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000451709   ⟸   ENST00000555598
RefSeq Acc Id: ENSP00000440025   ⟸   ENST00000542321
RefSeq Acc Id: ENSP00000452350   ⟸   ENST00000556950
RefSeq Acc Id: ENSP00000456290   ⟸   ENST00000556658
RefSeq Acc Id: ENSP00000452126   ⟸   ENST00000557301
RefSeq Acc Id: ENSP00000404442   ⟸   ENST00000425933
RefSeq Acc Id: ENSP00000452170   ⟸   ENST00000557420
RefSeq Acc Id: ENSP00000442498   ⟸   ENST00000543599
RefSeq Acc Id: ENSP00000330005   ⟸   ENST00000329082
RefSeq Acc Id: ENSP00000451505   ⟸   ENST00000554387
Protein Domains
RGM_C   RGM_N

Promoters
RGD ID:6810809
Promoter ID:HG_ACW:28186
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:RGMA.EAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361591,387,966 - 91,388,466 (-)MPROMDB
RGD ID:7230621
Promoter ID:EPDNEW_H21056
Type:initiation region
Name:RGMA_1
Description:repulsive guidance molecule family member a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21057  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,073,156 - 93,073,216EPDNEW
RGD ID:7230623
Promoter ID:EPDNEW_H21057
Type:initiation region
Name:RGMA_2
Description:repulsive guidance molecule family member a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21056  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,089,200 - 93,089,260EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q26.1-26.3(chr15:89679237-101978958)x3 copy number gain See cases [RCV000052354] Chr15:89679237..101978958 [GRCh38]
Chr15:90222468..102519161 [GRCh37]
Chr15:88023472..100336684 [NCBI36]
Chr15:15q26.1-26.3
pathogenic
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3
pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3 copy number gain See cases [RCV000052347] Chr15:77543797..101843411 [GRCh38]
Chr15:77836139..102383614 [GRCh37]
Chr15:75623194..100201137 [NCBI36]
Chr15:15q24.3-26.3
pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:84169153-101904929)x3 copy number gain See cases [RCV000052352] Chr15:84169153..101904929 [GRCh38]
Chr15:84837905..102445132 [GRCh37]
Chr15:82628909..100262655 [NCBI36]
Chr15:15q25.2-26.3
pathogenic
GRCh38/hg38 15q26.1(chr15:92780719-93487233)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052135]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052135]|See cases [RCV000052135] Chr15:92780719..93487233 [GRCh38]
Chr15:93323949..94030462 [GRCh37]
Chr15:91124953..91831466 [NCBI36]
Chr15:15q26.1
uncertain significance
GRCh38/hg38 15q26.1(chr15:92170113-93438995)x1 copy number loss See cases [RCV000053225] Chr15:92170113..93438995 [GRCh38]
Chr15:92713343..93982224 [GRCh37]
Chr15:90514347..91783228 [NCBI36]
Chr15:15q26.1
pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:83711377-101843270)x3 copy number gain See cases [RCV000135858] Chr15:83711377..101843270 [GRCh38]
Chr15:84380129..102383473 [GRCh37]
Chr15:82171133..100200996 [NCBI36]
Chr15:15q25.2-26.3
pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:87904735-101843270)x3 copy number gain See cases [RCV000135568] Chr15:87904735..101843270 [GRCh38]
Chr15:88447966..102383473 [GRCh37]
Chr15:86248970..100200996 [NCBI36]
Chr15:15q25.3-26.3
pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:82859676-101810992)x3 copy number gain See cases [RCV000136849] Chr15:82859676..101810992 [GRCh38]
Chr15:83528428..102351195 [GRCh37]
Chr15:81325482..100168718 [NCBI36]
Chr15:15q25.2-26.3
pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85826665-101920998)x4 copy number gain See cases [RCV000137264] Chr15:85826665..101920998 [GRCh38]
Chr15:86369896..102461201 [GRCh37]
Chr15:84170900..100278724 [NCBI36]
Chr15:15q25.3-26.3
pathogenic
GRCh38/hg38 15q26.1(chr15:93070246-93607464)x3 copy number gain See cases [RCV000138876] Chr15:93070246..93607464 [GRCh38]
Chr15:93613475..94150693 [GRCh37]
Chr15:91414479..91951697 [NCBI36]
Chr15:15q26.1
uncertain significance
GRCh38/hg38 15q26.1(chr15:92900864-93043584)x1 copy number loss See cases [RCV000139809] Chr15:92900864..93043584 [GRCh38]
Chr15:93444094..93586814 [GRCh37]
Chr15:91245098..91387818 [NCBI36]
Chr15:15q26.1
likely pathogenic|uncertain significance
GRCh38/hg38 15q26.1-26.3(chr15:93041524-101941326)x3 copy number gain See cases [RCV000141431] Chr15:93041524..101941326 [GRCh38]
Chr15:93584754..102481529 [GRCh37]
Chr15:91385758..100299052 [NCBI36]
Chr15:15q26.1-26.3
pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85397539-101888909)x3 copy number gain See cases [RCV000141899] Chr15:85397539..101888909 [GRCh38]
Chr15:85940770..102429112 [GRCh37]
Chr15:83741774..100246635 [NCBI36]
Chr15:15q25.3-26.3
pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3
pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3
pathogenic
GRCh38/hg38 15q26.1-26.3(chr15:88676575-98364743)x3 copy number gain See cases [RCV000142727] Chr15:88676575..98364743 [GRCh38]
Chr15:89219806..98907972 [GRCh37]
Chr15:87020810..96725495 [NCBI36]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q24.2-26.3(chr15:76061144-102429112)x3 copy number gain See cases [RCV000511332] Chr15:76061144..102429112 [GRCh37]
Chr15:15q24.2-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:92197136-102354857)x1 copy number loss See cases [RCV000240535] Chr15:92197136..102354857 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3
pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3
likely pathogenic
GRCh37/hg19 15q25.2-26.3(chr15:85089467-102495441)x3 copy number gain See cases [RCV000449119] Chr15:85089467..102495441 [GRCh37]
Chr15:15q25.2-26.3
pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90346994-102354798) copy number loss See cases [RCV000447603] Chr15:90346994..102354798 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:89924847-102429112)x3 copy number gain See cases [RCV000445978] Chr15:89924847..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q25.1-26.3(chr15:80648093-102429112)x3 copy number gain See cases [RCV000445705] Chr15:80648093..102429112 [GRCh37]
Chr15:15q25.1-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86148286-102511616)x3 copy number gain See cases [RCV000448044] Chr15:86148286..102511616 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
GRCh37/hg19 15q25.3-26.1(chr15:88295992-94215607)x1 copy number loss See cases [RCV000448680] Chr15:88295992..94215607 [GRCh37]
Chr15:15q25.3-26.1
pathogenic
GRCh37/hg19 15q26.1(chr15:91589712-93889459)x1 copy number loss See cases [RCV000448390] Chr15:91589712..93889459 [GRCh37]
Chr15:15q26.1
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:93148806-102429112)x3 copy number gain See cases [RCV000511719] Chr15:93148806..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86899001-98734014)x3 copy number gain See cases [RCV000511629] Chr15:86899001..98734014 [GRCh37]
Chr15:15q25.3-26.3
likely pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:89743929-102429112)x3 copy number gain not provided [RCV000683718] Chr15:89743929..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q23-26.3(chr15:71329220-102270758)x3 copy number gain not provided [RCV000683703] Chr15:71329220..102270758 [GRCh37]
Chr15:15q23-26.3
pathogenic
GRCh37/hg19 15q24.3-26.3(chr15:77479244-102429112)x3 copy number gain not provided [RCV000683710] Chr15:77479244..102429112 [GRCh37]
Chr15:15q24.3-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:88385150-102461162)x3 copy number gain not provided [RCV000738864] Chr15:88385150..102461162 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90277151-102376761)x3 copy number gain not provided [RCV000751387] Chr15:90277151..102376761 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
NM_001166283.1(RGMA):c.38+2T>C single nucleotide variant not provided [RCV000881400] Chr15:93073717 [GRCh38]
Chr15:93616946 [GRCh37]
Chr15:15q26.1
benign
NM_001166283.1(RGMA):c.948C>T (p.Asp316=) single nucleotide variant not provided [RCV000884063] Chr15:93045427 [GRCh38]
Chr15:93588657 [GRCh37]
Chr15:15q26.1
benign
GRCh37/hg19 15q26.1-26.3(chr15:90288175-102429112)x3 copy number gain not provided [RCV000846885] Chr15:90288175..102429112 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q26.1(chr15:91229877-93677014)x1 copy number loss not provided [RCV000847986] Chr15:91229877..93677014 [GRCh37]
Chr15:15q26.1
pathogenic
GRCh37/hg19 15q26.1(chr15:93498365-93714012)x3 copy number gain not provided [RCV000849254] Chr15:93498365..93714012 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q26.1(chr15:93601771-94043109)x3 copy number gain not provided [RCV000849988] Chr15:93601771..94043109 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q25.3-26.3(chr15:87189245-102429112)x1 copy number loss not provided [RCV001006718] Chr15:87189245..102429112 [GRCh37]
Chr15:15q25.3-26.3
pathogenic
GRCh37/hg19 15q26.1(chr15:93451635-93885876)x3 copy number gain not provided [RCV001006724] Chr15:93451635..93885876 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q26.1(chr15:93373121-93747449)x3 copy number gain not provided [RCV001006723] Chr15:93373121..93747449 [GRCh37]
Chr15:15q26.1
uncertain significance
GRCh37/hg19 15q26.1-26.3(chr15:92335751-102399741)x1 copy number loss not provided [RCV001537887] Chr15:92335751..102399741 [GRCh37]
Chr15:15q26.1-26.3
pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86962053-102531392)x1 copy number loss See cases [RCV001263026] Chr15:86962053..102531392 [GRCh37]
Chr15:15q25.3-26.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30308 AgrOrtholog
COSMIC RGMA COSMIC
Ensembl Genes ENSG00000182175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000330005 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000404442 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000440025 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000442498 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000451505 UniProtKB/TrEMBL
  ENSP00000451709 UniProtKB/TrEMBL
  ENSP00000452126 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000452170 UniProtKB/TrEMBL
  ENSP00000452350 UniProtKB/TrEMBL
  ENSP00000456290 UniProtKB/TrEMBL
Ensembl Transcript ENST00000329082 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000425933 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000542321 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000543599 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000554387 UniProtKB/TrEMBL
  ENST00000555598 UniProtKB/TrEMBL
  ENST00000556658 UniProtKB/TrEMBL
  ENST00000556950 UniProtKB/TrEMBL
  ENST00000557301 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000557420 UniProtKB/TrEMBL
GTEx ENSG00000182175 GTEx
HGNC ID HGNC:30308 ENTREZGENE
Human Proteome Map RGMA Human Proteome Map
InterPro RGM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:56963 UniProtKB/Swiss-Prot
NCBI Gene 56963 ENTREZGENE
OMIM 607362 OMIM
PANTHER PTHR31428 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31428:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA128394693 PharmGKB
UniProt A0A0A0MTQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JL92_HUMAN UniProtKB/TrEMBL
  A1L187_HUMAN UniProtKB/TrEMBL
  C6G485_HUMAN UniProtKB/TrEMBL
  F5H7G2_HUMAN UniProtKB/TrEMBL
  G3V3Z3_HUMAN UniProtKB/TrEMBL
  G3V4C2_HUMAN UniProtKB/TrEMBL
  G3V545_HUMAN UniProtKB/TrEMBL
  Q96B86 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RTW1 UniProtKB/Swiss-Prot
  B7Z5S8 UniProtKB/Swiss-Prot
  F5GXQ7 UniProtKB/Swiss-Prot
  F5GZU6 UniProtKB/Swiss-Prot
  G3V518 UniProtKB/Swiss-Prot
  Q0JV97 UniProtKB/Swiss-Prot
  Q8NC80 UniProtKB/Swiss-Prot
  Q9H0E6 UniProtKB/Swiss-Prot
  Q9NPM3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-16 RGMA  repulsive guidance molecule BMP co-receptor a    repulsive guidance molecule family member a  Symbol and/or name change 5135510 APPROVED
2013-11-12 RGMA  repulsive guidance molecule family member a    RGM domain family, member A  Symbol and/or name change 5135510 APPROVED