RGMA (repulsive guidance molecule BMP co-receptor a) - Rat Genome Database

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Gene: RGMA (repulsive guidance molecule BMP co-receptor a) Homo sapiens
Analyze
Symbol: RGMA
Name: repulsive guidance molecule BMP co-receptor a
RGD ID: 1323724
HGNC Page HGNC:30308
Description: Enables transferrin receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum. Implicated in multiple sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family, member A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381593,035,271 - 93,089,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1593,035,271 - 93,089,211 (-)EnsemblGRCh38hg38GRCh38
GRCh371593,578,501 - 93,632,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361591,387,641 - 91,433,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 341591,387,640 - 91,433,437NCBI
Celera1569,998,187 - 70,044,004 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1569,723,091 - 69,768,218 (-)NCBIHuRef
CHM1_11593,427,333 - 93,473,451 (-)NCBICHM1_1
T2T-CHM13v2.01590,797,572 - 90,851,558 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbamazepine  (EXP)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
Cuprizon  (ISO)
dexamethasone  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (EXP)
fulvestrant  (EXP)
gentamycin  (ISO)
indometacin  (EXP)
Licochalcone B  (EXP)
mercury dibromide  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylphenidate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
niclosamide  (EXP)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paraquat  (ISO)
PCB138  (ISO)
phenylmercury acetate  (EXP)
propanal  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
zaragozic acid A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Induction of repulsive guidance molecule in neurons following sciatic nerve injury. Doya H, etal., J Chem Neuroanat. 2006 Aug;32(1):74-7. Epub 2006 Jul 24.
2. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Hata K, etal., J Cell Biol. 2006 Apr 10;173(1):47-58. Epub 2006 Apr 3.
3. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina. Schnichels S, etal., Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):39-50. doi: 10.1007/s00417-011-1791-9. Epub 2011 Sep 2.
7. Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model. Song MY, etal., Mol Med Rep. 2015 Mar;11(3):1738-44. doi: 10.3892/mmr.2014.2993. Epub 2014 Nov 21.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. Wang T, etal., Mol Neurobiol. 2013 Jun;47(3):903-13. doi: 10.1007/s12035-012-8385-3. Epub 2012 Dec 30.
10. Electrical stimulation of olfactory bulb downregulates RGMa expression after ischemia/reperfusion injury in rats. Zhang G, etal., Brain Res Bull. 2011 Oct 10;86(3-4):254-61. doi: 10.1016/j.brainresbull.2011.08.002. Epub 2011 Aug 5.
Additional References at PubMed
PMID:11076863   PMID:11230166   PMID:11256614   PMID:14702039   PMID:15084667   PMID:15258590   PMID:15489334   PMID:15489336   PMID:15975920   PMID:16169070   PMID:16216939   PMID:16303743  
PMID:16344560   PMID:16381901   PMID:17472960   PMID:17606441   PMID:17615080   PMID:18367154   PMID:18485097   PMID:19273616   PMID:19303019   PMID:19458235   PMID:19698085   PMID:21044950  
PMID:21183991   PMID:21467223   PMID:21617229   PMID:21873635   PMID:22076499   PMID:22367090   PMID:22396795   PMID:22566498   PMID:22728873   PMID:23028342   PMID:23376485   PMID:24024966  
PMID:25133637   PMID:25940091   PMID:26496610   PMID:26721439   PMID:28842419   PMID:29478698   PMID:30798120   PMID:31899158   PMID:32296183   PMID:33997000   PMID:35028889   PMID:35255492  
PMID:35748872  


Genomics

Comparative Map Data
RGMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381593,035,271 - 93,089,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1593,035,271 - 93,089,211 (-)EnsemblGRCh38hg38GRCh38
GRCh371593,578,501 - 93,632,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361591,387,641 - 91,433,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 341591,387,640 - 91,433,437NCBI
Celera1569,998,187 - 70,044,004 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1569,723,091 - 69,768,218 (-)NCBIHuRef
CHM1_11593,427,333 - 93,473,451 (-)NCBICHM1_1
T2T-CHM13v2.01590,797,572 - 90,851,558 (-)NCBIT2T-CHM13v2.0
Rgma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,025,268 - 73,069,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,025,257 - 73,069,647 (+)EnsemblGRCm39 Ensembl
GRCm38773,375,520 - 73,419,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,375,509 - 73,419,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,520,406 - 80,564,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36773,249,020 - 73,293,410 (+)NCBIMGSCv36mm8
Celera770,823,178 - 70,867,680 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map741.85NCBI
Rgma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81136,538,782 - 136,582,763 (+)NCBIGRCr8
mRatBN7.21127,128,934 - 127,172,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,128,934 - 127,172,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,121,700 - 135,165,733 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,291,803 - 142,335,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,115,277 - 135,159,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,699,053 - 134,742,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,699,299 - 134,742,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,725,212 - 135,768,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,547,399 - 128,591,304 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11128,641,975 - 128,668,760 (+)NCBI
Celera1119,260,496 - 119,304,476 (+)NCBICelera
Cytogenetic Map1q31NCBI
Rgma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541621,221,023 - 21,261,831 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541621,221,023 - 21,261,831 (-)NCBIChiLan1.0ChiLan1.0
RGMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21682,590,158 - 82,635,904 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11586,288,195 - 86,333,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01571,728,669 - 71,774,447 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11590,922,199 - 90,951,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1590,922,199 - 90,956,179 (-)Ensemblpanpan1.1panPan2
RGMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,044,342 - 47,089,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,061,910 - 47,089,294 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha349,744,736 - 49,788,688 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,453,705 - 47,497,710 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,453,784 - 47,498,695 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,971,723 - 47,015,658 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,203,068 - 47,247,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,534,393 - 47,578,334 (+)NCBIUU_Cfam_GSD_1.0
Rgma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640136,541,660 - 136,581,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364839,766,275 - 9,793,001 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364839,753,112 - 9,792,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl785,921,594 - 85,968,888 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1785,921,524 - 85,968,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2791,815,011 - 91,862,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12911,592,929 - 11,638,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2911,592,604 - 11,638,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605935,022,501 - 35,068,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476810,751,991 - 10,778,050 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476810,739,674 - 10,778,036 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RGMA
35 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q26.1-26.3(chr15:89679237-101978958)x3 copy number gain See cases [RCV000052354] Chr15:89679237..101978958 [GRCh38]
Chr15:90222468..102519161 [GRCh37]
Chr15:88023472..100336684 [NCBI36]
Chr15:15q26.1-26.3		 pathogenic
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3		 pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3 copy number gain See cases [RCV000052347] Chr15:77543797..101843411 [GRCh38]
Chr15:77836139..102383614 [GRCh37]
Chr15:75623194..100201137 [NCBI36]
Chr15:15q24.3-26.3		 pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:84169153-101904929)x3 copy number gain See cases [RCV000052352] Chr15:84169153..101904929 [GRCh38]
Chr15:84837905..102445132 [GRCh37]
Chr15:82628909..100262655 [NCBI36]
Chr15:15q25.2-26.3		 pathogenic
GRCh38/hg38 15q26.1(chr15:92780719-93487233)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052135]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052135]|See cases [RCV000052135] Chr15:92780719..93487233 [GRCh38]
Chr15:93323949..94030462 [GRCh37]
Chr15:91124953..91831466 [NCBI36]
Chr15:15q26.1		 uncertain significance
GRCh38/hg38 15q26.1(chr15:92170113-93438995)x1 copy number loss See cases [RCV000053225] Chr15:92170113..93438995 [GRCh38]
Chr15:92713343..93982224 [GRCh37]
Chr15:90514347..91783228 [NCBI36]
Chr15:15q26.1		 pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:83711377-101843270)x3 copy number gain See cases [RCV000135858] Chr15:83711377..101843270 [GRCh38]
Chr15:84380129..102383473 [GRCh37]
Chr15:82171133..100200996 [NCBI36]
Chr15:15q25.2-26.3		 pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:87904735-101843270)x3 copy number gain See cases [RCV000135568] Chr15:87904735..101843270 [GRCh38]
Chr15:88447966..102383473 [GRCh37]
Chr15:86248970..100200996 [NCBI36]
Chr15:15q25.3-26.3		 pathogenic
GRCh38/hg38 15q25.2-26.3(chr15:82859676-101810992)x3 copy number gain See cases [RCV000136849] Chr15:82859676..101810992 [GRCh38]
Chr15:83528428..102351195 [GRCh37]
Chr15:81325482..100168718 [NCBI36]
Chr15:15q25.2-26.3		 pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85826665-101920998)x4 copy number gain See cases [RCV000137264] Chr15:85826665..101920998 [GRCh38]
Chr15:86369896..102461201 [GRCh37]
Chr15:84170900..100278724 [NCBI36]
Chr15:15q25.3-26.3		 pathogenic
GRCh38/hg38 15q26.1(chr15:93070246-93607464)x3 copy number gain See cases [RCV000138876] Chr15:93070246..93607464 [GRCh38]
Chr15:93613475..94150693 [GRCh37]
Chr15:91414479..91951697 [NCBI36]
Chr15:15q26.1		 uncertain significance
GRCh38/hg38 15q26.1(chr15:92900864-93043584)x1 copy number loss See cases [RCV000139809] Chr15:92900864..93043584 [GRCh38]
Chr15:93444094..93586814 [GRCh37]
Chr15:91245098..91387818 [NCBI36]
Chr15:15q26.1		 likely pathogenic|uncertain significance
GRCh38/hg38 15q26.1-26.3(chr15:93041524-101941326)x3 copy number gain See cases [RCV000141431] Chr15:93041524..101941326 [GRCh38]
Chr15:93584754..102481529 [GRCh37]
Chr15:91385758..100299052 [NCBI36]
Chr15:15q26.1-26.3		 pathogenic
GRCh38/hg38 15q25.3-26.3(chr15:85397539-101888909)x3 copy number gain See cases [RCV000141899] Chr15:85397539..101888909 [GRCh38]
Chr15:85940770..102429112 [GRCh37]
Chr15:83741774..100246635 [NCBI36]
Chr15:15q25.3-26.3		 pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3		 pathogenic
GRCh38/hg38 15q26.1-26.3(chr15:88676575-98364743)x3 copy number gain See cases [RCV000142727] Chr15:88676575..98364743 [GRCh38]
Chr15:89219806..98907972 [GRCh37]
Chr15:87020810..96725495 [NCBI36]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q24.2-26.3(chr15:76061144-102429112)x3 copy number gain See cases [RCV000511332] Chr15:76061144..102429112 [GRCh37]
Chr15:15q24.2-26.3		 pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:92197136-102354857)x1 copy number loss See cases [RCV000240535] Chr15:92197136..102354857 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3		 pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q25.2-26.3(chr15:85089467-102495441)x3 copy number gain See cases [RCV000449119] Chr15:85089467..102495441 [GRCh37]
Chr15:15q25.2-26.3		 pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90346994-102354798) copy number loss See cases [RCV000447603] Chr15:90346994..102354798 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:89924847-102429112)x3 copy number gain See cases [RCV000445978] Chr15:89924847..102429112 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q25.1-26.3(chr15:80648093-102429112)x3 copy number gain See cases [RCV000445705] Chr15:80648093..102429112 [GRCh37]
Chr15:15q25.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86148286-102511616)x3 copy number gain See cases [RCV000448044] Chr15:86148286..102511616 [GRCh37]
Chr15:15q25.3-26.3		 pathogenic
GRCh37/hg19 15q25.3-26.1(chr15:88295992-94215607)x1 copy number loss See cases [RCV000448680] Chr15:88295992..94215607 [GRCh37]
Chr15:15q25.3-26.1		 pathogenic
GRCh37/hg19 15q26.1(chr15:91589712-93889459)x1 copy number loss See cases [RCV000448390] Chr15:91589712..93889459 [GRCh37]
Chr15:15q26.1		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:93148806-102429112)x3 copy number gain See cases [RCV000511719] Chr15:93148806..102429112 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86899001-98734014)x3 copy number gain See cases [RCV000511629] Chr15:86899001..98734014 [GRCh37]
Chr15:15q25.3-26.3		 likely pathogenic
NM_020211.3(RGMA):c.1238T>C (p.Leu413Pro) single nucleotide variant Inborn genetic diseases [RCV003255111] Chr15:93045113 [GRCh38]
Chr15:93588343 [GRCh37]
Chr15:15q26.1		 uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:89743929-102429112)x3 copy number gain not provided [RCV000683718] Chr15:89743929..102429112 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q23-26.3(chr15:71329220-102270758)x3 copy number gain not provided [RCV000683703] Chr15:71329220..102270758 [GRCh37]
Chr15:15q23-26.3		 pathogenic
GRCh37/hg19 15q24.3-26.3(chr15:77479244-102429112)x3 copy number gain not provided [RCV000683710] Chr15:77479244..102429112 [GRCh37]
Chr15:15q24.3-26.3		 pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:88385150-102461162)x3 copy number gain not provided [RCV000738864] Chr15:88385150..102461162 [GRCh37]
Chr15:15q25.3-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q26.1-26.3(chr15:90277151-102376761)x3 copy number gain not provided [RCV000751387] Chr15:90277151..102376761 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
NM_020211.3(RGMA):c.62G>A (p.Arg21Lys) single nucleotide variant Inborn genetic diseases [RCV003268418] Chr15:93072984 [GRCh38]
Chr15:93616213 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.15-686T>C single nucleotide variant not provided [RCV000881400] Chr15:93073717 [GRCh38]
Chr15:93616946 [GRCh37]
Chr15:15q26.1		 benign
NM_020211.3(RGMA):c.924C>T (p.Asp308=) single nucleotide variant not provided [RCV000884063] Chr15:93045427 [GRCh38]
Chr15:93588657 [GRCh37]
Chr15:15q26.1		 benign
GRCh37/hg19 15q26.1-26.3(chr15:90288175-102429112)x3 copy number gain not provided [RCV000846885] Chr15:90288175..102429112 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q26.1(chr15:91229877-93677014)x1 copy number loss not provided [RCV000847986] Chr15:91229877..93677014 [GRCh37]
Chr15:15q26.1		 pathogenic
GRCh37/hg19 15q26.1(chr15:93498365-93714012)x3 copy number gain not provided [RCV000849254] Chr15:93498365..93714012 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q26.1(chr15:93601771-94043109)x3 copy number gain not provided [RCV000849988] Chr15:93601771..94043109 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.1166A>G (p.Asn389Ser) single nucleotide variant Inborn genetic diseases [RCV003274703] Chr15:93045185 [GRCh38]
Chr15:93588415 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.371C>T (p.Pro124Leu) single nucleotide variant Inborn genetic diseases [RCV003249162] Chr15:93052267 [GRCh38]
Chr15:93595497 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.1057G>A (p.Glu353Lys) single nucleotide variant Inborn genetic diseases [RCV003239965] Chr15:93045294 [GRCh38]
Chr15:93588524 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q25.3-26.3(chr15:87189245-102429112)x1 copy number loss not provided [RCV001006718] Chr15:87189245..102429112 [GRCh37]
Chr15:15q25.3-26.3		 pathogenic
GRCh37/hg19 15q26.1(chr15:93451635-93885876)x3 copy number gain not provided [RCV001006724] Chr15:93451635..93885876 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q26.1(chr15:93373121-93747449)x3 copy number gain not provided [RCV001006723] Chr15:93373121..93747449 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q26.1-26.3(chr15:92335751-102399741)x1 copy number loss not provided [RCV001537887] Chr15:92335751..102399741 [GRCh37]
Chr15:15q26.1-26.3		 pathogenic
GRCh37/hg19 15q25.3-26.3(chr15:86962053-102531392)x1 copy number loss See cases [RCV001263026] Chr15:86962053..102531392 [GRCh37]
Chr15:15q25.3-26.3		 pathogenic
GRCh37/hg19 15q25.3-26.2(chr15:88465861-94411846)x1 copy number loss not provided [RCV001795547] Chr15:88465861..94411846 [GRCh37]
Chr15:15q25.3-26.2		 pathogenic
GRCh37/hg19 15q26.1(chr15:89520451-93926491)x1 copy number loss not provided [RCV001827973] Chr15:89520451..93926491 [GRCh37]
Chr15:15q26.1		 pathogenic
NM_020211.3(RGMA):c.482C>T (p.Thr161Met) single nucleotide variant Inborn genetic diseases [RCV002753274] Chr15:93052156 [GRCh38]
Chr15:93595386 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.307G>A (p.Val103Ile) single nucleotide variant Inborn genetic diseases [RCV002990523] Chr15:93052331 [GRCh38]
Chr15:93595561 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.711C>G (p.Asp237Glu) single nucleotide variant Inborn genetic diseases [RCV002754736] Chr15:93045640 [GRCh38]
Chr15:93588870 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.15-695A>C single nucleotide variant Inborn genetic diseases [RCV002840559] Chr15:93073726 [GRCh38]
Chr15:93616955 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q24.3-26.3(chr15:77512817-102035027)x3 copy number gain not provided [RCV002475797] Chr15:77512817..102035027 [GRCh37]
Chr15:15q24.3-26.3		 pathogenic
NM_020211.3(RGMA):c.23T>C (p.Leu8Pro) single nucleotide variant Inborn genetic diseases [RCV002882686] Chr15:93073023 [GRCh38]
Chr15:93616252 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.706A>G (p.Met236Val) single nucleotide variant Inborn genetic diseases [RCV002822412] Chr15:93045645 [GRCh38]
Chr15:93588875 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.15-713G>A single nucleotide variant Inborn genetic diseases [RCV002705202] Chr15:93073744 [GRCh38]
Chr15:93616973 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.464C>T (p.Ser155Leu) single nucleotide variant Inborn genetic diseases [RCV002845292] Chr15:93052174 [GRCh38]
Chr15:93595404 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.1322C>T (p.Pro441Leu) single nucleotide variant Inborn genetic diseases [RCV002660824] Chr15:93045029 [GRCh38]
Chr15:93588259 [GRCh37]
Chr15:15q26.1		 likely benign
NM_020211.3(RGMA):c.1058A>G (p.Glu353Gly) single nucleotide variant Inborn genetic diseases [RCV002887109] Chr15:93045293 [GRCh38]
Chr15:93588523 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.40G>A (p.Ala14Thr) single nucleotide variant Inborn genetic diseases [RCV002845694] Chr15:93073006 [GRCh38]
Chr15:93616235 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.1037G>T (p.Ser346Ile) single nucleotide variant Inborn genetic diseases [RCV002787068] Chr15:93045314 [GRCh38]
Chr15:93588544 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.748G>A (p.Gly250Ser) single nucleotide variant Inborn genetic diseases [RCV002788488] Chr15:93045603 [GRCh38]
Chr15:93588833 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.530G>A (p.Arg177His) single nucleotide variant Inborn genetic diseases [RCV002965460] Chr15:93052108 [GRCh38]
Chr15:93595338 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.316A>G (p.Ile106Val) single nucleotide variant Inborn genetic diseases [RCV002832352] Chr15:93052322 [GRCh38]
Chr15:93595552 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.67G>A (p.Ala23Thr) single nucleotide variant Inborn genetic diseases [RCV002960903] Chr15:93072979 [GRCh38]
Chr15:93616208 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.74G>C (p.Arg25Pro) single nucleotide variant Inborn genetic diseases [RCV002718188] Chr15:93072972 [GRCh38]
Chr15:93616201 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.1318G>A (p.Val440Ile) single nucleotide variant Inborn genetic diseases [RCV003196333] Chr15:93045033 [GRCh38]
Chr15:93588263 [GRCh37]
Chr15:15q26.1		 likely benign
NM_020211.3(RGMA):c.383C>T (p.Thr128Met) single nucleotide variant Inborn genetic diseases [RCV003196025] Chr15:93052255 [GRCh38]
Chr15:93595485 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q25.2-26.3(chr15:84228005-102264590)x3 copy number gain not provided [RCV003222840] Chr15:84228005..102264590 [GRCh37]
Chr15:15q25.2-26.3		 pathogenic
NM_020211.3(RGMA):c.220G>A (p.Glu74Lys) single nucleotide variant Inborn genetic diseases [RCV003206467] Chr15:93052418 [GRCh38]
Chr15:93595648 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.55A>G (p.Met19Val) single nucleotide variant Inborn genetic diseases [RCV003210156] Chr15:93072991 [GRCh38]
Chr15:93616220 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.515G>A (p.Arg172Lys) single nucleotide variant Inborn genetic diseases [RCV003208927] Chr15:93052123 [GRCh38]
Chr15:93595353 [GRCh37]
Chr15:15q26.1		 uncertain significance
NM_020211.3(RGMA):c.154A>C (p.Lys52Gln) single nucleotide variant Inborn genetic diseases [RCV003193520] Chr15:93052484 [GRCh38]
Chr15:93595714 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q24.1-26.3(chr15:75165490-102520892)x3 copy number gain See cases [RCV003329502] Chr15:75165490..102520892 [GRCh37]
Chr15:15q24.1-26.3		 pathogenic
NM_020211.3(RGMA):c.970C>G (p.Gln324Glu) single nucleotide variant Inborn genetic diseases [RCV003383482] Chr15:93045381 [GRCh38]
Chr15:93588611 [GRCh37]
Chr15:15q26.1		 uncertain significance
GRCh37/hg19 15q26.1(chr15:93531889-93588745)x1 copy number loss not specified [RCV003987124] Chr15:93531889..93588745 [GRCh37]
Chr15:15q26.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10921
Count of miRNA genes:1133
Interacting mature miRNAs:1419
Transcripts:ENST00000329082, ENST00000425933, ENST00000538818, ENST00000542321, ENST00000543599, ENST00000554387, ENST00000555584, ENST00000555598, ENST00000556087, ENST00000556658, ENST00000556950, ENST00000557301, ENST00000557420, ENST00000557608
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
A008J37  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,587,471 - 93,587,683UniSTSGRCh37
Build 361591,388,475 - 91,388,687RGDNCBI36
Celera1569,999,022 - 69,999,234RGD
Cytogenetic Map15q26.1UniSTS
HuRef1569,723,926 - 69,724,138UniSTS
GeneMap99-GB4 RH Map15336.34UniSTS
NCBI RH Map15720.2UniSTS
G63723  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,626,957 - 93,627,058UniSTSGRCh37
Build 361591,427,961 - 91,428,062RGDNCBI36
Celera1570,038,513 - 70,038,614RGD
Cytogenetic Map15q26.1UniSTS
HuRef1569,763,417 - 69,763,518UniSTS
TNG Radiation Hybrid Map1537678.0UniSTS
RGMA__6886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,586,619 - 93,587,232UniSTSGRCh37
Build 361591,387,623 - 91,388,236RGDNCBI36
Celera1569,998,170 - 69,998,783RGD
HuRef1569,723,074 - 69,723,687UniSTS
WI-17713  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37371,005,249 - 71,005,379UniSTSGRCh37
Build 36371,087,939 - 71,088,069RGDNCBI36
Celera370,932,173 - 70,932,303RGD
Celera1570,030,106 - 70,030,235UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3p14.1UniSTS
HuRef1569,755,010 - 69,755,139UniSTS
HuRef371,004,166 - 71,004,296UniSTS
GeneMap99-GB4 RH Map3215.23UniSTS
Whitehead-RH Map3249.2UniSTS
RH47538  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371593,586,702 - 93,586,791UniSTSGRCh37
Build 361591,387,706 - 91,387,795RGDNCBI36
Celera1569,998,253 - 69,998,342RGD
Cytogenetic Map15q26.1UniSTS
HuRef1569,723,157 - 69,723,246UniSTS
GeneMap99-GB4 RH Map15337.25UniSTS
NCBI RH Map15720.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1717 585 28 38 85 1 2508 1690 2168 9 949 73 38 546 1769
Low 616 1904 1243 178 644 52 1787 474 1522 269 444 1391 132 1 658 1019 5 2
Below cutoff 68 500 402 360 865 363 51 26 39 124 57 126 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001166283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC013394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL390083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC140838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC151132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ782935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ782957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA183348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA295545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA453869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA512691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA805034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC317516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ515840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF511221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000329082   ⟹   ENSP00000330005
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,035,271 - 93,089,211 (-)Ensembl
RefSeq Acc Id: ENST00000425933   ⟹   ENSP00000404442
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,043,406 - 93,073,710 (-)Ensembl
RefSeq Acc Id: ENST00000542321   ⟹   ENSP00000440025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,043,416 - 93,073,148 (-)Ensembl
RefSeq Acc Id: ENST00000543599   ⟹   ENSP00000442498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,043,406 - 93,088,523 (-)Ensembl
RefSeq Acc Id: ENST00000554387   ⟹   ENSP00000451505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,043,417 - 93,073,680 (-)Ensembl
RefSeq Acc Id: ENST00000555584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,052,272 - 93,063,069 (-)Ensembl
RefSeq Acc Id: ENST00000555598   ⟹   ENSP00000451709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,052,320 - 93,088,523 (-)Ensembl
RefSeq Acc Id: ENST00000556658   ⟹   ENSP00000456290
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,044,956 - 93,073,663 (-)Ensembl
RefSeq Acc Id: ENST00000556950   ⟹   ENSP00000452350
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,072,967 - 93,088,653 (-)Ensembl
RefSeq Acc Id: ENST00000557301   ⟹   ENSP00000452126
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,044,818 - 93,074,128 (-)Ensembl
RefSeq Acc Id: ENST00000557420   ⟹   ENSP00000452170
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,044,947 - 93,073,145 (-)Ensembl
RefSeq Acc Id: ENST00000557608
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,066,006 - 93,073,134 (-)Ensembl
RefSeq Acc Id: ENST00000650169
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1593,044,749 - 93,058,841 (-)Ensembl
RefSeq Acc Id: NM_001166283   ⟹   NP_001159755
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,987 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,458,219 (-)NCBI
T2T-CHM13v2.01590,797,572 - 90,836,331 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166286   ⟹   NP_001159758
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,156 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,457,392 (-)NCBI
T2T-CHM13v2.01590,797,572 - 90,835,500 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166287   ⟹   NP_001159759
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,088,523 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,472,760 (-)NCBI
T2T-CHM13v2.01590,797,572 - 90,850,870 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166288   ⟹   NP_001159760
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,680 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,457,942 (-)NCBI
T2T-CHM13v2.01590,797,572 - 90,836,024 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166289   ⟹   NP_001159761
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,073,710 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,457,942 (-)NCBI
T2T-CHM13v2.01590,797,572 - 90,836,054 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020211   ⟹   NP_064596
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,035,271 - 93,089,211 (-)NCBI
GRCh371593,586,636 - 93,632,443 (-)ENTREZGENE
Build 361591,387,641 - 91,433,437 (-)NCBI Archive
HuRef1569,723,091 - 69,768,218 (-)ENTREZGENE
CHM1_11593,427,333 - 93,473,451 (-)NCBI
T2T-CHM13v2.01590,797,572 - 90,851,558 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001159755 (Get FASTA)   NCBI Sequence Viewer  
  NP_001159758 (Get FASTA)   NCBI Sequence Viewer  
  NP_001159759 (Get FASTA)   NCBI Sequence Viewer  
  NP_001159760 (Get FASTA)   NCBI Sequence Viewer  
  NP_001159761 (Get FASTA)   NCBI Sequence Viewer  
  NP_064596 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH15886 (Get FASTA)   NCBI Sequence Viewer  
  AAI27827 (Get FASTA)   NCBI Sequence Viewer  
  AAI40839 (Get FASTA)   NCBI Sequence Viewer  
  AAI51133 (Get FASTA)   NCBI Sequence Viewer  
  ACS13733 (Get FASTA)   NCBI Sequence Viewer  
  BAC11285 (Get FASTA)   NCBI Sequence Viewer  
  BAC11321 (Get FASTA)   NCBI Sequence Viewer  
  BAC11330 (Get FASTA)   NCBI Sequence Viewer  
  BAF84054 (Get FASTA)   NCBI Sequence Viewer  
  BAG54165 (Get FASTA)   NCBI Sequence Viewer  
  BAH13014 (Get FASTA)   NCBI Sequence Viewer  
  CAB66760 (Get FASTA)   NCBI Sequence Viewer  
  CAB98207 (Get FASTA)   NCBI Sequence Viewer  
  CAF86163 (Get FASTA)   NCBI Sequence Viewer  
  CAF86186 (Get FASTA)   NCBI Sequence Viewer  
  CAF86838 (Get FASTA)   NCBI Sequence Viewer  
  EAX02166 (Get FASTA)   NCBI Sequence Viewer  
  EAX02167 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000330005
  ENSP00000330005.7
  ENSP00000404442
  ENSP00000404442.2
  ENSP00000440025
  ENSP00000440025.2
  ENSP00000442498
  ENSP00000442498.1
  ENSP00000451505.1
  ENSP00000451709.1
  ENSP00000452126
  ENSP00000452126.1
  ENSP00000452170.1
  ENSP00000452350.1
  ENSP00000456290.1
GenBank Protein Q96B86 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001159759   ⟸   NM_001166287
- Peptide Label: isoform 2 precursor
- UniProtKB: C6G485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159755   ⟸   NM_001166283
- Peptide Label: isoform 1
- UniProtKB: A0A0A0MTQ4 (UniProtKB/TrEMBL),   C6G485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159760   ⟸   NM_001166288
- Peptide Label: isoform 2 precursor
- UniProtKB: C6G485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159761   ⟸   NM_001166289
- Peptide Label: isoform 2 precursor
- UniProtKB: C6G485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159758   ⟸   NM_001166286
- Peptide Label: isoform 2 precursor
- UniProtKB: C6G485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_064596   ⟸   NM_020211
- Peptide Label: isoform 3 precursor
- UniProtKB: Q9H0E6 (UniProtKB/Swiss-Prot),   Q8NC80 (UniProtKB/Swiss-Prot),   Q0JV97 (UniProtKB/Swiss-Prot),   G3V518 (UniProtKB/Swiss-Prot),   F5GZU6 (UniProtKB/Swiss-Prot),   F5GXQ7 (UniProtKB/Swiss-Prot),   B7Z5S8 (UniProtKB/Swiss-Prot),   B2RTW1 (UniProtKB/Swiss-Prot),   Q9NPM3 (UniProtKB/Swiss-Prot),   Q96B86 (UniProtKB/Swiss-Prot),   C6G485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000451709   ⟸   ENST00000555598
RefSeq Acc Id: ENSP00000440025   ⟸   ENST00000542321
RefSeq Acc Id: ENSP00000452350   ⟸   ENST00000556950
RefSeq Acc Id: ENSP00000456290   ⟸   ENST00000556658
RefSeq Acc Id: ENSP00000452126   ⟸   ENST00000557301
RefSeq Acc Id: ENSP00000404442   ⟸   ENST00000425933
RefSeq Acc Id: ENSP00000452170   ⟸   ENST00000557420
RefSeq Acc Id: ENSP00000442498   ⟸   ENST00000543599
RefSeq Acc Id: ENSP00000330005   ⟸   ENST00000329082
RefSeq Acc Id: ENSP00000451505   ⟸   ENST00000554387
Protein Domains
Repulsive guidance molecule C-terminal   Repulsive guidance molecule N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96B86-F1-model_v2 AlphaFold Q96B86 1-450 view protein structure

Promoters
RGD ID:6810809
Promoter ID:HG_ACW:28186
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:RGMA.EAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361591,387,966 - 91,388,466 (-)MPROMDB
RGD ID:7230621
Promoter ID:EPDNEW_H21056
Type:initiation region
Name:RGMA_1
Description:repulsive guidance molecule family member a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21057  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,073,156 - 93,073,216EPDNEW
RGD ID:7230623
Promoter ID:EPDNEW_H21057
Type:initiation region
Name:RGMA_2
Description:repulsive guidance molecule family member a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21056  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381593,089,200 - 93,089,260EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30308 AgrOrtholog
COSMIC RGMA COSMIC
Ensembl Genes ENSG00000182175 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000329082 ENTREZGENE
  ENST00000329082.12 UniProtKB/Swiss-Prot
  ENST00000425933 ENTREZGENE
  ENST00000425933.6 UniProtKB/Swiss-Prot
  ENST00000542321 ENTREZGENE
  ENST00000542321.6 UniProtKB/Swiss-Prot
  ENST00000543599 ENTREZGENE
  ENST00000543599.5 UniProtKB/Swiss-Prot
  ENST00000554387.5 UniProtKB/TrEMBL
  ENST00000555598.1 UniProtKB/TrEMBL
  ENST00000556658.1 UniProtKB/TrEMBL
  ENST00000556950.1 UniProtKB/TrEMBL
  ENST00000557301 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000557301.2 UniProtKB/Swiss-Prot
  ENST00000557420.1 UniProtKB/TrEMBL
Gene3D-CATH Mog1/PsbP, alpha/beta/alpha sandwich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000182175 GTEx
HGNC ID HGNC:30308 ENTREZGENE
Human Proteome Map RGMA Human Proteome Map
InterPro RGM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:56963 UniProtKB/Swiss-Prot
NCBI Gene 56963 ENTREZGENE
OMIM 607362 OMIM
PANTHER PTHR31428 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31428:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA128394693 PharmGKB
UniProt A0A0A0MTQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JL92_HUMAN UniProtKB/TrEMBL
  A1L187_HUMAN UniProtKB/TrEMBL
  B2RTW1 ENTREZGENE
  B7Z5S8 ENTREZGENE
  C6G485 ENTREZGENE, UniProtKB/TrEMBL
  F5GXQ7 ENTREZGENE
  F5GZU6 ENTREZGENE
  F5H7G2_HUMAN UniProtKB/TrEMBL
  G3V3Z3_HUMAN UniProtKB/TrEMBL
  G3V4C2_HUMAN UniProtKB/TrEMBL
  G3V518 ENTREZGENE
  G3V545_HUMAN UniProtKB/TrEMBL
  Q0JV97 ENTREZGENE
  Q8NC80 ENTREZGENE
  Q96B86 ENTREZGENE
  Q9H0E6 ENTREZGENE
  Q9NPM3 ENTREZGENE
  RGMA_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2RTW1 UniProtKB/Swiss-Prot
  B7Z5S8 UniProtKB/Swiss-Prot
  F5GXQ7 UniProtKB/Swiss-Prot
  F5GZU6 UniProtKB/Swiss-Prot
  G3V518 UniProtKB/Swiss-Prot
  Q0JV97 UniProtKB/Swiss-Prot
  Q8NC80 UniProtKB/Swiss-Prot
  Q9H0E6 UniProtKB/Swiss-Prot
  Q9NPM3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-16 RGMA  repulsive guidance molecule BMP co-receptor a    repulsive guidance molecule family member a  Symbol and/or name change 5135510 APPROVED
2013-11-12 RGMA  repulsive guidance molecule family member a    RGM domain family, member A  Symbol and/or name change 5135510 APPROVED