Rgma (repulsive guidance molecule BMP co-receptor a) - Rat Genome Database

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Gene: Rgma (repulsive guidance molecule BMP co-receptor a) Rattus norvegicus
Analyze
Symbol: Rgma
Name: repulsive guidance molecule BMP co-receptor a
RGD ID: 1311983
Description: Predicted to enable coreceptor activity and transferrin receptor binding activity. Involved in negative regulation of axon regeneration; negative regulation of collateral sprouting; and positive regulation of neuron projection development. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in plasma membrane. Used to study middle cerebral artery infarction. Biomarker of middle cerebral artery infarction; sciatic neuropathy; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC308739; repulsive guidance molecule A; repulsive guidance molecule family member A; RGM domain family, member A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eae30
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81136,538,782 - 136,582,763 (+)NCBIGRCr8
mRatBN7.21127,128,934 - 127,172,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,128,934 - 127,172,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,121,700 - 135,165,733 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,291,803 - 142,335,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,115,277 - 135,159,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,699,053 - 134,742,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,699,299 - 134,742,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,725,212 - 135,768,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,547,399 - 128,591,304 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11128,641,975 - 128,668,760 (+)NCBI
Celera1119,260,496 - 119,304,476 (+)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dieldrin  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
Licochalcone B  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Induction of repulsive guidance molecule in neurons following sciatic nerve injury. Doya H, etal., J Chem Neuroanat. 2006 Aug;32(1):74-7. Epub 2006 Jul 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Hata K, etal., J Cell Biol. 2006 Apr 10;173(1):47-58. Epub 2006 Apr 3.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.
6. TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Okamura Y, etal., Neurosci Res. 2011 Sep;71(1):63-70. doi: 10.1016/j.neures.2011.05.012. Epub 2011 May 27.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina. Schnichels S, etal., Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):39-50. doi: 10.1007/s00417-011-1791-9. Epub 2011 Sep 2.
11. Repulsive guidance molecule a regulates hippocampal mossy fiber branching in vitro. Shibata K, etal., Neuroreport. 2013 Aug 7;24(11):609-15. doi: 10.1097/WNR.0b013e3283632c08.
12. Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model. Song MY, etal., Mol Med Rep. 2015 Mar;11(3):1738-44. doi: 10.3892/mmr.2014.2993. Epub 2014 Nov 21.
13. Peptides derived from repulsive guidance molecule act as antagonists. Suda M, etal., Biochem Biophys Res Commun. 2008 Jul 4;371(3):501-4. doi: 10.1016/j.bbrc.2008.04.114. Epub 2008 Apr 29.
14. CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. Wang T, etal., Mol Neurobiol. 2013 Jun;47(3):903-13. doi: 10.1007/s12035-012-8385-3. Epub 2012 Dec 30.
15. Electrical stimulation of olfactory bulb downregulates RGMa expression after ischemia/reperfusion injury in rats. Zhang G, etal., Brain Res Bull. 2011 Oct 10;86(3-4):254-61. doi: 10.1016/j.brainresbull.2011.08.002. Epub 2011 Aug 5.
Additional References at PubMed
PMID:14749425   PMID:15845084   PMID:15975920   PMID:17389603   PMID:17472960   PMID:17996222   PMID:20457227   PMID:21290411   PMID:22692600   PMID:22728873   PMID:23184880   PMID:23376485  
PMID:26651291   PMID:26843113   PMID:29061393   PMID:29396549   PMID:32779334   PMID:38306928  


Genomics

Comparative Map Data
Rgma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81136,538,782 - 136,582,763 (+)NCBIGRCr8
mRatBN7.21127,128,934 - 127,172,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,128,934 - 127,172,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,121,700 - 135,165,733 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,291,803 - 142,335,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,115,277 - 135,159,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,699,053 - 134,742,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,699,299 - 134,742,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,725,212 - 135,768,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,547,399 - 128,591,304 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11128,641,975 - 128,668,760 (+)NCBI
Celera1119,260,496 - 119,304,476 (+)NCBICelera
Cytogenetic Map1q31NCBI
RGMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381593,035,271 - 93,089,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1593,035,271 - 93,089,211 (-)EnsemblGRCh38hg38GRCh38
GRCh371593,578,501 - 93,632,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361591,387,641 - 91,433,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 341591,387,640 - 91,433,437NCBI
Celera1569,998,187 - 70,044,004 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1569,723,091 - 69,768,218 (-)NCBIHuRef
CHM1_11593,427,333 - 93,473,451 (-)NCBICHM1_1
T2T-CHM13v2.01590,797,572 - 90,851,558 (-)NCBIT2T-CHM13v2.0
Rgma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,025,268 - 73,069,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,025,257 - 73,069,647 (+)EnsemblGRCm39 Ensembl
GRCm38773,375,520 - 73,419,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,375,509 - 73,419,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,520,406 - 80,564,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36773,249,020 - 73,293,410 (+)NCBIMGSCv36mm8
Celera770,823,178 - 70,867,680 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map741.85NCBI
Rgma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541621,221,023 - 21,261,831 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541621,221,023 - 21,261,831 (-)NCBIChiLan1.0ChiLan1.0
RGMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21682,590,158 - 82,635,904 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11586,288,195 - 86,333,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01571,728,669 - 71,774,447 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11590,922,199 - 90,951,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1590,922,199 - 90,956,179 (-)Ensemblpanpan1.1panPan2
RGMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,044,342 - 47,089,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,061,910 - 47,089,294 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha349,744,736 - 49,788,688 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,453,705 - 47,497,710 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,453,784 - 47,498,695 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,971,723 - 47,015,658 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,203,068 - 47,247,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,534,393 - 47,578,334 (+)NCBIUU_Cfam_GSD_1.0
Rgma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640136,541,660 - 136,581,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364839,766,275 - 9,793,001 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364839,753,112 - 9,792,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl785,921,594 - 85,968,888 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1785,921,524 - 85,968,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2791,815,011 - 91,862,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12911,592,929 - 11,638,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2911,592,604 - 11,638,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605935,022,501 - 35,068,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476810,751,991 - 10,778,050 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476810,739,674 - 10,778,036 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgma
155 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:649
Count of miRNA genes:254
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000068766
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)183547917128547917Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
2325726Eae30Experimental allergic encephalomyelitis QTL 30nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1123053310128593844Rat

Markers in Region
AA819234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,172,765 - 127,172,858 (+)MAPPERmRatBN7.2
Rnor_6.01134,742,359 - 134,742,451NCBIRnor6.0
Rnor_5.01135,768,256 - 135,768,348UniSTSRnor5.0
RGSC_v3.41128,591,152 - 128,591,244UniSTSRGSC3.4
Celera1119,304,324 - 119,304,416UniSTS
RH 3.4 Map1982.2UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 90 89 58 25 58 6 217 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000068766   ⟹   ENSRNOP00000061067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,128,934 - 127,172,918 (+)Ensembl
Rnor_6.0 Ensembl1134,699,299 - 134,742,514 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1134,715,209 - 134,741,356 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118102   ⟹   ENSRNOP00000090452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1127,159,261 - 127,172,918 (+)Ensembl
RefSeq Acc Id: NM_001107524   ⟹   NP_001100994
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81136,538,782 - 136,582,763 (+)NCBI
mRatBN7.21127,128,934 - 127,172,918 (+)NCBI
Rnor_6.01134,699,053 - 134,742,511 (+)NCBI
Rnor_5.01135,725,212 - 135,768,409 (+)NCBI
RGSC_v3.41128,547,399 - 128,591,304 (+)RGD
Celera1119,260,496 - 119,304,476 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100994 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08503 (Get FASTA)   NCBI Sequence Viewer  
  EDM08504 (Get FASTA)   NCBI Sequence Viewer  
  EDM08505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061067
  ENSRNOP00000061067.1
  ENSRNOP00000090452.1
RefSeq Acc Id: NP_001100994   ⟸   NM_001107524
- UniProtKB: D4A188 (UniProtKB/TrEMBL),   A6JBX6 (UniProtKB/TrEMBL),   A6JBX8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061067   ⟸   ENSRNOT00000068766
Ensembl Acc Id: ENSRNOP00000090452   ⟸   ENSRNOT00000118102
Protein Domains
Repulsive guidance molecule C-terminal   Repulsive guidance molecule N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A188-F1-model_v2 AlphaFold D4A188 1-449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690113
Promoter ID:EPDNEW_R638
Type:initiation region
Name:Rgma_1
Description:repulsive guidance molecule family member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01134,715,269 - 134,715,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311983 AgrOrtholog
BioCyc Gene G2FUF-58894 BioCyc
Ensembl Genes ENSRNOG00000012874 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068766 ENTREZGENE
  ENSRNOT00000068766.3 UniProtKB/TrEMBL
  ENSRNOT00000118102.1 UniProtKB/TrEMBL
Gene3D-CATH Mog1/PsbP, alpha/beta/alpha sandwich UniProtKB/TrEMBL
InterPro RGM UniProtKB/TrEMBL
  RGM_C UniProtKB/TrEMBL
  RGM_N UniProtKB/TrEMBL
KEGG Report rno:308739 UniProtKB/TrEMBL
NCBI Gene 308739 ENTREZGENE
PANTHER PTHR31428 UniProtKB/TrEMBL
  PTHR31428:SF4 UniProtKB/TrEMBL
Pfam RGM_C UniProtKB/TrEMBL
  RGM_N UniProtKB/TrEMBL
PhenoGen Rgma PhenoGen
RatGTEx ENSRNOG00000012874 RatGTEx
UniProt A0A8I6ACJ0_RAT UniProtKB/TrEMBL
  A6JBX6 ENTREZGENE, UniProtKB/TrEMBL
  A6JBX8 ENTREZGENE, UniProtKB/TrEMBL
  D4A188 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-18 Rgma  repulsive guidance molecule BMP co-receptor a  Rgma  repulsive guidance molecule family member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-19 Rgma  repulsive guidance molecule family member A  Rgma  RGM domain family, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rgma  RGM domain family, member A   Rgma_predicted  RGM domain family, member A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rgma_predicted  RGM domain family, member A (predicted)      Symbol and Name status set to approved 70820 APPROVED