RGD Reference Report - RGMa inhibition promotes axonal growth and recovery after spinal cord injury. - Rat Genome Database

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RGMa inhibition promotes axonal growth and recovery after spinal cord injury.

Authors: Hata, K  Fujitani, M  Yasuda, Y  Doya, H  Saito, T  Yamagishi, S  Mueller, BK  Yamashita, T 
Citation: Hata K, etal., J Cell Biol. 2006 Apr 10;173(1):47-58. Epub 2006 Apr 3.
RGD ID: 9850138
Pubmed: (View Article at PubMed) PMID:16585268
DOI: Full-text: DOI:10.1083/jcb.200508143

Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of the RhoA-Rho kinase pathway. RGMa expression is observed in oligodendrocytes, myelinated fibers, and neurons of the adult rat spinal cord and is induced around the injury site after spinal cord injury. We developed an antibody to RGMa that efficiently blocks the effect of RGMa in vitro. Intrathecal administration of the antibody to rats with thoracic spinal cord hemisection results in significant axonal growth of the corticospinal tract and improves functional recovery. Thus, RGMa plays an important role in limiting axonal regeneration after CNS injury and the RGMa antibody offers a possible therapeutic agent in clinical conditions characterized by a failure of CNS regeneration.


Disease Annotations    

Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Rgma  (repulsive guidance molecule BMP co-receptor a)

Genes (Mus musculus)
Rgma  (repulsive guidance molecule family member A)

Genes (Homo sapiens)
RGMA  (repulsive guidance molecule BMP co-receptor a)

Additional Information