C1qb (complement C1q B chain) - Rat Genome Database

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Gene: C1qb (complement C1q B chain) Rattus norvegicus
Analyze
Symbol: C1qb
Name: complement C1q B chain
RGD ID: 2229
Description: Predicted to enable identical protein binding activity. Involved in response to glucocorticoid. Located in synapse. Part of complement component C1 complex. Biomarker of ocular hypertension. Orthologous to human C1QB (complement C1q B chain); PARTICIPATES IN Chagas disease pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adia; adiponectin a; complement C1q subcomponent subunit B; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,118,843 - 149,124,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,118,846 - 149,124,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,816,561 - 151,822,125 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,590,844 - 153,596,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,572,841 - 153,578,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,246,444 - 155,251,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,246,447 - 155,252,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,008,943 - 159,014,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,647,524 - 155,653,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15155,657,561 - 155,663,111 (-)NCBI
Celera5147,516,569 - 147,522,120 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
choline  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
Diisodecyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
doramapimod  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hexachlorobenzene  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indoles  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methcathinone  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
troglitazone  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. C1Q synthesis by tissue mononuclear phagocytes from normal and from damaged rat liver: up-regulation by dexamethasone, down-regulation by interferon gamma, and lipopolysaccharide. Armbrust T, etal., Hepatology. 1997 Jul;26(1):98-106.
2. Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. Byrnes KR, etal., Glia. 2006 Mar;53(4):420-33.
3. Expression of complement C1qB and C4 mRNAs during rat brain development. Johnson SA, etal., Brain Res Dev Brain Res. 1994 Jul 15;80(1-2):163-74.
4. Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Johnson SA, etal., Neurobiol Aging. 1992 Nov-Dec;13(6):641-8.
5. Retinal synthesis and deposition of complement components induced by ocular hypertension. Kuehn MH, etal., Exp Eye Res. 2006 Sep;83(3):620-8. Epub 2006 May 4.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions. Pasinetti GM, etal., Synapse. 1999 Mar 15;31(4):278-84.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro. Rozovsky I, etal., Neuroscience. 1994 Oct;62(3):741-58.
16. Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis. Schwaeble W, etal., J Immunol 1995 Nov 15;155(10):4971-8.
17. The classical complement cascade mediates CNS synapse elimination. Stevens B, etal., Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036.
18. Genetically determined susceptibility to neurodegeneration is associated with expression of inflammatory genes. Swanberg M, etal., Neurobiol Dis. 2006 Oct;24(1):67-88. Epub 2006 Aug 23.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8464426   PMID:10964938   PMID:21795542   PMID:22516433   PMID:23376485   PMID:24006456   PMID:24939307   PMID:25931508   PMID:27033548   PMID:29476059   PMID:36464147  


Genomics

Comparative Map Data
C1qb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,118,843 - 149,124,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,118,846 - 149,124,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,816,561 - 151,822,125 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,590,844 - 153,596,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,572,841 - 153,578,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,246,444 - 155,251,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,246,447 - 155,252,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,008,943 - 159,014,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,647,524 - 155,653,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15155,657,561 - 155,663,111 (-)NCBI
Celera5147,516,569 - 147,522,120 (-)NCBICelera
Cytogenetic Map5q36NCBI
C1QB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,653,236 - 22,661,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,652,762 - 22,661,637 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,979,729 - 22,988,130 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,852,269 - 22,860,616 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,731,192 - 22,733,433NCBI
Celera121,304,397 - 21,312,691 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef121,224,021 - 21,232,298 (+)NCBIHuRef
CHM1_1123,092,196 - 23,100,535 (+)NCBICHM1_1
T2T-CHM13v2.0122,478,246 - 22,486,577 (+)NCBIT2T-CHM13v2.0
C1qb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,607,437 - 136,613,511 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4136,607,440 - 136,613,498 (-)EnsemblGRCm39 Ensembl
GRCm384136,880,126 - 136,886,200 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,880,129 - 136,886,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,436,060 - 136,442,092 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,152,221 - 136,158,253 (-)NCBIMGSCv36mm8
Celera4135,087,605 - 135,093,669 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.05NCBI
C1qb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,769,752 - 2,772,534 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,765,844 - 2,771,695 (+)NCBIChiLan1.0ChiLan1.0
C1QB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11203,389,167 - 203,397,493 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,838,514 - 21,846,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,787,003 - 22,795,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,786,685 - 22,797,581 (+)Ensemblpanpan1.1panPan2
C1QB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,650,440 - 76,655,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,650,586 - 76,655,549 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,155,325 - 73,160,431 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,209,671 - 77,214,788 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,209,676 - 77,214,730 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,030,566 - 74,035,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,038,974 - 75,044,092 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,042,588 - 76,047,706 (-)NCBIUU_Cfam_GSD_1.0
C1QB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,601,665 - 80,607,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,601,680 - 80,606,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,625,450 - 74,629,848 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C1QB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,003,036 - 110,011,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,002,864 - 110,011,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660336,302,466 - 6,310,665 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C1qb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247647,376,967 - 7,383,445 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247647,377,013 - 7,382,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C1qb
40 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:78
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000017060
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
BI274524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,119,022 - 149,119,177 (+)MAPPERmRatBN7.2
Rnor_6.05155,246,624 - 155,246,778NCBIRnor6.0
Rnor_5.05159,009,123 - 159,009,277UniSTSRnor5.0
RGSC_v3.45155,647,703 - 155,647,857UniSTSRGSC3.4
Celera5147,516,749 - 147,516,903UniSTS
RH 3.4 Map51008.8UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 53 37 19 37 8 11 68 27 30 11 8
Low 10 4 4 4 6 8 11
Below cutoff 2

Sequence


RefSeq Acc Id: ENSRNOT00000017060   ⟹   ENSRNOP00000017060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,118,846 - 149,124,407 (-)Ensembl
Rnor_6.0 Ensembl5155,246,447 - 155,252,003 (-)Ensembl
RefSeq Acc Id: NM_019262   ⟹   NP_062135
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,118,843 - 149,124,394 (-)NCBI
Rnor_6.05155,246,444 - 155,251,995 (-)NCBI
Rnor_5.05159,008,943 - 159,014,494 (-)NCBI
RGSC_v3.45155,647,524 - 155,653,074 (-)RGD
Celera5147,516,569 - 147,522,120 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062135 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA50440 (Get FASTA)   NCBI Sequence Viewer  
  EDL80823 (Get FASTA)   NCBI Sequence Viewer  
  EDL80824 (Get FASTA)   NCBI Sequence Viewer  
  EDL80825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017060
  ENSRNOP00000017060.3
GenBank Protein P31721 (Get FASTA)   NCBI Sequence Viewer  
  SOR70285 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062135   ⟸   NM_019262
- Peptide Label: precursor
- UniProtKB: P31721 (UniProtKB/Swiss-Prot),   G3V7N9 (UniProtKB/TrEMBL),   A6ITC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017060   ⟸   ENSRNOT00000017060
Protein Domains
C1q   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31721-F1-model_v2 AlphaFold P31721 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694173
Promoter ID:EPDNEW_R4698
Type:initiation region
Name:C1qb_1
Description:complement C1q B chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05155,251,945 - 155,252,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2229 AgrOrtholog
BioCyc Gene G2FUF-39489 BioCyc
Ensembl Genes ENSRNOG00000012749 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017060 ENTREZGENE
  ENSRNOT00000017060.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C1q_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29687 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29687 ENTREZGENE
PANTHER C1Q DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB C1QB RGD
PhenoGen C1qb PhenoGen
PRINTS COMPLEMNTC1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012749 RatGTEx
SMART C1Q UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229411
UniProt A6ITC2_RAT UniProtKB/TrEMBL
  A6ITC3 ENTREZGENE, UniProtKB/TrEMBL
  A6ITC4_RAT UniProtKB/TrEMBL
  C1QB_RAT UniProtKB/Swiss-Prot
  G3V7N9 ENTREZGENE, UniProtKB/TrEMBL
  P31721 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 C1qb  complement C1q B chain  C1qb  complement component 1, q subcomponent, B chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-05 C1qb  complement component 1, q subcomponent, B chain  C1qb  complement component 1, q subcomponent, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 C1qb  complement component 1, q subcomponent, beta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in red pulp of the spleen and mainly of the monocyte-macrophage lineage 69784
gene_process involved in the innate immune response 69784