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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2229
Species: Rattus norvegicus
RGD Object: Gene
Symbol: C1qb
Name: complement C1q B chain
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C1qbaffects methylationISOC1QB (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of C1QB promoterPMID:27901495
C1qbdecreases expressionISOC1qb (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of C1QB mRNAPMID:19770486
C1qbincreases expressionISOC1qb (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of C1QB mRNAPMID:22228805
C1qbincreases methylationISOC1QB (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of C1QB 3' UTRPMID:27901495
C1qbmultiple interactionsISOC1qb (Mus musculus)6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of C1QB mRNA]PMID:22228805
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