Edn2 (endothelin 2) - Rat Genome Database

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Gene: Edn2 (endothelin 2) Rattus norvegicus
Symbol: Edn2
Name: endothelin 2
RGD ID: 2533
Description: Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in several processes, including ovarian follicle rupture; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of hormone secretion. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human EDN2 (endothelin 2); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; BQ 123.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Endothelin isopeptide 2; endothelin-2; ET-2; Et2; PPET2; preproendothelin-2; RNEDN2S01; vasoactive intestinal contractor; VIC
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp7  
Candidate Gene For: Bp7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25133,751,316 - 133,756,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,751,217 - 133,756,814 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5136,479,131 - 136,484,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05138,235,562 - 138,241,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05138,256,179 - 138,261,668 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,098,472 - 139,106,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,891,221 - 142,896,115 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45140,742,686 - 140,747,580 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15140,747,827 - 140,753,399 (+)NCBI
Celera5132,309,615 - 132,315,113 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function
endothelin B receptor binding  (IBA,IEA,ISO)
hormone activity  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. Bloch KD, etal., Genomics 1991 May;10(1):236-42.
2. Association between diastolic blood pressure and variants of the endothelin-1 and endothelin-2 genes. Brown MJ, etal., J Cardiovasc Pharmacol. 2000;35(4 Suppl 2):S41-43.
3. Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts. Brunner F, etal., J Mol Cell Cardiol. 1992 Nov;24(11):1291-305.
4. Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment. Chon H, etal., Hypertension. 2004 May;43(5):947-51. Epub 2004 Mar 8.
5. Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract. de la Monte SM, etal., J Histochem Cytochem. 1995 Feb;43(2):203-9.
6. Structure and organization of the rat endothelin-2 gene. Deng AY Mamm Genome 1997 Feb;8(2):157.
7. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9
8. The effect of endothelin-1, endothelin-2 and endothelin-3 in early cerulein-induced acute pancreatitis in rats. Dlugosz JW, etal., Rocz Akad Med Bialymst. 2004;49:85-92.
9. Inhibition by phosphoramidon of the regional haemodynamic effects of proendothelin-2 and -3 in conscious rats. Gardiner SM, etal., Br J Pharmacol. 1992 Oct;107(2):584-90.
10. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein. Guimaraes CL, etal., Hypertension. 1992 Feb;19(2 Suppl):II79-86.
14. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Kakinuma Y, etal., Life Sci. 1999;65(16):1671-83.
15. Endothelin activation of an inwardly rectifying K+ current in atrial cells. Kim D Circ Res. 1991 Jul;69(1):250-5.
16. Endothelin-2 in ovarian follicle rupture. Ko C, etal., Endocrinology. 2006 Apr;147(4):1770-9. Epub 2006 Jan 12.
17. Serum level of endothelin-1 and -2 in pregnancies complicated by EPH gestosis. Leszczynska-Gorzelak B, etal., Gynecol Obstet Invest. 1997;43(1):37-40.
18. Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan. Mattera GG, etal., Br J Pharmacol. 1993 Sep;110(1):331-7.
19. Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways. Mazzocchi G, etal., Endocrinology. 1997 Jun;138(6):2333-7.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Inhibitory and facilitatory presynaptic effects of endothelin on sympathetic cotransmission in the rat isolated tail artery. Mutafova-Yambolieva VN and Westfall DP, Br J Pharmacol. 1998 Jan;123(1):136-42.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Contractile responses of smooth muscle cells differentiated from rat neural stem cells. Oishi K, etal., J Physiol. 2002 Apr 1;540(Pt 1):139-52.
24. Contractile responses and myosin phosphorylation in reconstituted fibers of smooth muscle cells from the rat cerebral artery. Oishi K, etal., Jpn J Pharmacol. 2002 Sep;90(1):36-50.
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Differential effects of ET-1, ET-2, and ET-3 on pancreatic microcirculation, tissue integrity, and inflammation. Plusczyk T, etal., Dig Dis Sci. 2001 Jun;46(6):1343-51.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. [Plasma concentrations of endothelin-1 and endothelin-2 in patients with pulmonary hypertension] Salomon P, etal., Pol Merkuriusz Lek. 1999 Sep;7(39):111-3.
31. Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion. Samson WK and Skala KD, Endocrinology. 1992 May;130(5):2964-70.
32. Endothelin-mediated calcium signaling in preglomerular smooth muscle cells. Schroeder AC, etal., Hypertension. 2000 Jan;35(1 Pt 2):280-6.
33. Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension. Sharma P, etal., J Hypertens. 1999 Sep;17(9):1281-7.
34. Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum. Sullivan AM and Morton AJ, J Neurochem. 1996 Oct;67(4):1409-18.
35. Plasma endothelin in patients with acute aortic disease. Wagner A, etal., Resuscitation. 2002 Apr;53(1):71-6.
36. Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Watanabe T, etal., Circ Res. 1991 Aug;69(2):370-7.
Additional References at PubMed
PMID:1713452   PMID:1917960   PMID:2649896   PMID:2768235   PMID:8982507   PMID:9422810   PMID:9492062   PMID:9696419   PMID:12207323   PMID:15691296   PMID:15948191   PMID:20450830  
PMID:22406300   PMID:22874467   PMID:22972036   PMID:23676500   PMID:23941276   PMID:25613530  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25133,751,316 - 133,756,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,751,217 - 133,756,814 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5136,479,131 - 136,484,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05138,235,562 - 138,241,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05138,256,179 - 138,261,668 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,098,472 - 139,106,396 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,891,221 - 142,896,115 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45140,742,686 - 140,747,580 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15140,747,827 - 140,753,399 (+)NCBI
Celera5132,309,615 - 132,315,113 (+)NCBICelera
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38141,478,775 - 41,484,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl141,478,775 - 41,484,683 (-)EnsemblGRCh38hg38GRCh38
GRCh37141,944,446 - 41,950,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36141,717,033 - 41,722,884 (-)NCBINCBI36Build 36hg18NCBI36
Build 34141,613,539 - 41,619,390NCBI
Celera140,227,695 - 40,233,596 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef140,062,640 - 40,068,539 (-)NCBIHuRef
CHM1_1142,060,834 - 42,066,733 (-)NCBICHM1_1
T2T-CHM13v2.0141,348,976 - 41,370,636 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394120,018,403 - 120,024,557 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,018,403 - 120,024,557 (+)EnsemblGRCm39 Ensembl
GRCm384120,161,206 - 120,167,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4120,161,206 - 120,167,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv374119,834,029 - 119,839,965 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364119,659,068 - 119,664,996 (+)NCBIMGSCv36mm8
Celera4118,876,990 - 118,882,911 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.77NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555371,228,070 - 1,233,797 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555371,228,062 - 1,233,784 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11184,468,920 - 184,476,318 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0140,777,582 - 40,783,410 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1142,092,811 - 42,098,721 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl142,092,811 - 42,098,721 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1151,647,966 - 1,654,272 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,648,077 - 1,654,272 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha151,906,346 - 1,911,819 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0151,736,878 - 1,742,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,736,155 - 1,742,351 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,643,415 - 1,648,886 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,703,305 - 1,708,777 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0151,718,751 - 1,724,224 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505857,236,189 - 57,239,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,060,905 - 23,064,566 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647423,061,219 - 23,064,525 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl6169,744,568 - 169,758,283 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16169,751,956 - 169,758,011 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12091,425,979 - 91,432,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2091,426,747 - 91,431,973 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603325,447,580 - 25,453,538 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624892870,259 - 877,387 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624892861,976 - 879,044 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Edn2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:82
Interacting mature miRNAs:86
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5 RGD
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,752,562 - 133,752,767 (+)MAPPERmRatBN7.2
Rnor_6.05139,102,145 - 139,102,349NCBIRnor6.0
Rnor_5.05142,892,468 - 142,892,672UniSTSRnor5.0
RGSC_v3.45140,743,932 - 140,744,137RGDRGSC3.4
RGSC_v3.45140,743,933 - 140,744,137UniSTSRGSC3.4
RGSC_v3.15140,749,159 - 140,749,363RGD
Celera5132,310,862 - 132,311,066UniSTS
RH 3.4 Map5875.2UniSTS
RH 3.4 Map5875.2RGD
RH 2.0 Map5877.1RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,752,611 - 133,752,762 (+)MAPPERmRatBN7.2
Rnor_6.05139,102,194 - 139,102,344NCBIRnor6.0
Rnor_5.05142,892,517 - 142,892,667UniSTSRnor5.0
RGSC_v3.45140,743,808 - 140,744,258RGDRGSC3.4
RGSC_v3.45140,743,982 - 140,744,132UniSTSRGSC3.4
RGSC_v3.15140,749,208 - 140,749,358RGD
Celera5132,310,911 - 132,311,061UniSTS
RH 3.4 Map5875.0RGD
RH 3.4 Map5875.0UniSTS
RH 2.0 Map5873.5RGD
FHH x ACI Map570.92RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,749,410 - 133,749,643 (+)MAPPERmRatBN7.2
Rnor_6.05139,098,997 - 139,099,229NCBIRnor6.0
Rnor_5.05142,889,320 - 142,889,552UniSTSRnor5.0
RGSC_v3.45140,740,781 - 140,741,013UniSTSRGSC3.4
RGSC_v3.45140,740,721 - 140,741,152RGDRGSC3.4
RGSC_v3.15140,746,007 - 140,746,239RGD
Celera5132,307,710 - 132,307,942UniSTS
RH 3.4 Map5867.2RGD
RH 3.4 Map5867.2UniSTS
RH 2.0 Map5874.1RGD
SHRSP x BN Map571.7299RGD
FHH x ACI Map570.92RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25133,750,605 - 133,750,820 (+)MAPPERmRatBN7.2
Rnor_6.05139,100,192 - 139,100,406NCBIRnor6.0
Rnor_5.05142,890,515 - 142,890,729UniSTSRnor5.0
RGSC_v3.45140,741,976 - 140,742,190UniSTSRGSC3.4
Celera5132,308,905 - 132,309,119UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1
Low 3 3 1 1 3 2 19
Below cutoff 29 14 10 4 10 6 6 9 3 5 5 6


RefSeq Acc Id: ENSRNOT00000012569   ⟹   ENSRNOP00000012569
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5133,751,217 - 133,756,814 (+)Ensembl
Rnor_6.0 Ensembl5139,100,898 - 139,105,792 (+)Ensembl
RefSeq Acc Id: NM_012549   ⟹   NP_036681
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.25133,751,316 - 133,756,814 (+)NCBI
Rnor_6.05139,100,898 - 139,106,396 (+)NCBI
Rnor_5.05142,891,221 - 142,896,115 (+)NCBI
RGSC_v3.45140,742,686 - 140,747,580 (+)RGD
Celera5132,309,615 - 132,315,113 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB39213 (Get FASTA)   NCBI Sequence Viewer  
  EDL80332 (Get FASTA)   NCBI Sequence Viewer  
  P23943 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036681   ⟸   NM_012549
- Peptide Label: precursor
- UniProtKB: P23943 (UniProtKB/Swiss-Prot),   G3V771 (UniProtKB/TrEMBL),   A6IRY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012569   ⟸   ENSRNOT00000012569

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23943-F1-model_v2 AlphaFold P23943 1-176 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2533 AgrOrtholog
BioCyc Gene G2FUF-40073 BioCyc
Ensembl Genes ENSRNOG00000009390 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012569 ENTREZGENE
  ENSRNOP00000012569.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012569 ENTREZGENE
  ENSRNOT00000012569.4 UniProtKB/TrEMBL
InterPro Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothelin_toxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothln-like_toxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24324 UniProtKB/TrEMBL
PANTHER PTHR13874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13874:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Edn2 PhenoGen
SMART END UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EDN2_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Edn2  Endothelin isopeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in pituitary and medulla oblongata 734466