RGD Reference Report - Plasma endothelin in patients with acute aortic disease. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Plasma endothelin in patients with acute aortic disease.

Authors: Wagner, A  Domanovits, H  Holzer, M  Kofler, J  Roggla, M  Mullner, M  Oschatz, E  Prager, M  Grimm, M  Sterz, F  Laggner, AN 
Citation: Wagner A, etal., Resuscitation. 2002 Apr;53(1):71-6.
RGD ID: 1580915
Pubmed: (View Article at PubMed) PMID:11947982

PURPOSE AND BACKGROUND: We investigated the plasma levels of endothelin 1/2 in patients with acute symptoms relating to a known or newly diagnosed aortic aneurysm in order to investigate the possible role of peptides in the development of the disease. METHODS: Endothelin 1/2 plasma levels were determined in patients admitted to the emergency unit with suspected acute aortic disease. The history, type of aneurysm, outcome and laboratory findings were determined and compared to endothelin 1/2 levels collected on admission. RESULTS: In patients with ruptured aneurysm (n=27) or acute aortic dissection (n=18) the endothelin 1/2 median levels were higher 1.1 (25th and 75th quartile 0.7, 1.7) fmol/ml than in patients (n=20) with pre-existing aneurysm 0.7 (0.4, 1.1) fmol/ml (P=0.013). Patients who died had significantly higher endothelin levels 1.3 (0.8, 1.9) fmol/ml than the survivors 0.8 (0.5, 1.4) fmol/ml (P=0.04). In a logistic regression analysis, only a higher blood pressure on admission was an independent predictor of survival. CONCLUSION: Endothelin 1/2 levels are elevated in patients with acute dissection or ruptured aneurysm, but they are not an independent predictor of survival.

Annotation

Disease Annotations    
Aortic Rupture  (IEP,ISO)
Dissecting Aneurysm  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Edn2  (endothelin 2)

Genes (Mus musculus)
Edn2  (endothelin 2)

Genes (Homo sapiens)
EDN2  (endothelin 2)


Additional Information