RGD Reference Report - Endothelin-2 in ovarian follicle rupture. - Rat Genome Database

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Endothelin-2 in ovarian follicle rupture.

Authors: Ko, C  Gieske, MC  Al-Alem, L  Hahn, Y  Su, W  Gong, MC  Iglarz, M  Koo, Y 
Citation: Ko C, etal., Endocrinology. 2006 Apr;147(4):1770-9. Epub 2006 Jan 12.
RGD ID: 1581792
Pubmed: PMID:16410304   (View Abstract at PubMed)
DOI: DOI:10.1210/en.2005-1228   (Journal Full-text)

The ovulatory process is activated by a surge of LH, a pituitary gonadotropin, which initiates a cohort of dramatic changes in biochemical, physical, and gene expression in the ovary, leading to follicle rupture and oocyte release. Here we report the identification of endothelin-2 (EDN2) as a last moment-trigger of follicle rupture. In the ovary, EDN2 is exclusively and transiently expressed in the granulosa cells immediately before ovulation. Administration of EDN2 to the ovarian tissue induced rapid contraction, whereas addition of tezosentan, an endothelin receptor antagonist, diminishes the EDN2 effect. In vivo, treatment of tezosentan before ovulation substantially decreases gonadotropin-induced superovulation. As a target tissue of EDN2 action, we identified a layer of smooth muscle cells in the follicular wall of each follicle. Taken together, our data indicate that EDN2 induces follicular rupture by constricting periovulatory follicles.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Edn2Ratovarian follicle rupture  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Edn2  (endothelin 2)


Additional Information