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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | RGD:1620894 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of MARCKSL1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1620894 | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of MARCKSL1 mRNA] | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | RGD:1352052 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of MARCKSL1 mRNA | CTD | PMID:30165855 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MARCKSL1 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MARCKSL1 mRNA | CTD | PMID:32741896 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:1352052 | 6480464 | 2 more ... | CTD | PMID:19095052 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MARCKSL1 mRNA | CTD | PMID:22298810, PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1620894 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MARCKSL1 mRNA | CTD | PMID:33956508 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MARCKSL1 mRNA | CTD | PMID:32109520, PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases phosphorylation | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased phosphorylation of MARCKSL1 protein | CTD | PMID:23298284 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | RGD:1620894 | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of MARCKSL1 mRNA | CTD | PMID:17982090 | 2-methylcholine | affects expression | ISO | RGD:1352052 | 6480464 | beta-methylcholine affects the expression of MARCKSL1 mRNA | CTD | PMID:21179406 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1352052 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MARCKSL1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARCKSL1 mRNA | CTD | PMID:28628672 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1352052 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of MARCKSL1 mRNA | CTD | PMID:12419474 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1620894 | 6480464 | Fenretinide results in increased expression of MARCKSL1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of MARCKSL1 mRNA | CTD | PMID:24780913 | aflatoxin B1 | affects expression | ISO | RGD:1352052 | 6480464 | Aflatoxin B1 affects the expression of MARCKSL1 protein | CTD | PMID:20106945 | all-trans-retinoic acid | decreases expression | ISO | RGD:1352052 | 6480464 | Tretinoin results in decreased expression of MARCKSL1 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MARCKSL1 mRNA | CTD | PMID:16483693 | aristolochic acid | increases expression | ISO | RGD:1352052 | 6480464 | aristolochic acid I results in increased expression of MARCKSL1 mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | RGD:1352052 | 6480464 | Atrazine results in decreased expression of MARCKSL1 mRNA | CTD | PMID:22378314 | benzatropine | multiple interactions | ISO | RGD:1352052 | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein | CTD | PMID:34122009 | benzo[a]pyrene | increases expression | ISO | RGD:1352052 | 6480464 | Benzo(a)pyrene results in increased expression of MARCKSL1 mRNA | CTD | PMID:20064835, PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | RGD:1352052 | 6480464 | Benzo(a)pyrene affects the methylation of MARCKSL1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | RGD:1352052 | 6480464 | Benzo(a)pyrene results in decreased methylation of MARCKSL1 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:1620894 | 6480464 | Benzo(a)pyrene results in increased expression of MARCKSL1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | increases expression | ISO | RGD:1352052 | 6480464 | 7 more ... | CTD | PMID:19150397 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:1620894 | 6480464 | Mustard Gas results in increased expression of MARCKSL1 mRNA | CTD | PMID:15674843 | bisphenol A | increases expression | ISO | RGD:1352052 | 6480464 | bisphenol A results in increased expression of MARCKSL1 mRNA | CTD | PMID:25047013 | bisphenol A | affects expression | ISO | RGD:1352052 | 6480464 | bisphenol A affects the expression of MARCKSL1 mRNA | CTD | PMID:30903817 | bisphenol A | multiple interactions | ISO | RGD:1352052 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MARCKSL1 mRNA | CTD | PMID:28628672 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of MARCKSL1 gene | CTD | PMID:28505145 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of MARCKSL1 mRNA | CTD | PMID:25181051 | bisphenol F | multiple interactions | ISO | RGD:1352052 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARCKSL1 mRNA | CTD | PMID:28628672 | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of MARCKSL1 mRNA | CTD | PMID:24136188 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of MARCKSL1 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | ISO | RGD:1620894 | 6480464 | [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of MARCKSL1 mRNA | CTD | PMID:31904401 | cadmium dichloride | multiple interactions | ISO | RGD:1620894 | 6480464 | [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of MARCKSL1 mRNA | CTD | PMID:31904401 | carbon nanotube | decreases expression | ISO | RGD:1620894 | 6480464 | Nanotubes, Carbon analog results in decreased expression of MARCKSL1 mRNA | CTD | PMID:25620056 | carbon nanotube | increases expression | ISO | RGD:1620894 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | cobalt dichloride | decreases expression | ISO | RGD:1620894 | 6480464 | cobaltous chloride results in decreased expression of MARCKSL1 mRNA | CTD | PMID:21139344 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of MARCKSL1 mRNA | CTD | PMID:24386269 | cobalt dichloride | decreases expression | ISO | RGD:1352052 | 6480464 | cobaltous chloride results in decreased expression of MARCKSL1 mRNA | CTD | PMID:19320972 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of MARCKSL1 mRNA | CTD | PMID:20187946 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of MARCKSL1 mRNA | CTD | PMID:26577399 | Cuprizon | multiple interactions | ISO | RGD:1352052 | 6480464 | [Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein | CTD | PMID:34122009 | cyclosporin A | decreases expression | ISO | RGD:1352052 | 6480464 | Cyclosporine results in decreased expression of MARCKSL1 mRNA | CTD | PMID:20106945 more ... | dexamethasone | multiple interactions | ISO | RGD:1352052 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MARCKSL1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARCKSL1 mRNA | CTD | PMID:28628672 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of MARCKSL1 mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | ISO | RGD:1620894 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MARCKSL1 mRNA | CTD | PMID:30529165 | doxorubicin | decreases expression | ISO | RGD:1352052 | 6480464 | Doxorubicin results in decreased expression of MARCKSL1 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of MARCKSL1 mRNA | CTD | PMID:29391264 | enzyme inhibitor | multiple interactions | ISO | RGD:1352052 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MARCKSL1 protein | CTD | PMID:23301498 | folic acid | multiple interactions | ISO | RGD:1620894 | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of MARCKSL1 mRNA] | CTD | PMID:22206623 | folic acid | decreases expression | ISO | RGD:1620894 | 6480464 | Folic Acid results in decreased expression of MARCKSL1 mRNA | CTD | PMID:25629700 | formaldehyde | increases expression | ISO | RGD:1352052 | 6480464 | Formaldehyde results in increased expression of MARCKSL1 mRNA | CTD | PMID:23649840 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of MARCKSL1 mRNA | CTD | PMID:27387713 | hydrogen peroxide | decreases expression | ISO | RGD:1352052 | 6480464 | Hydrogen Peroxide results in decreased expression of MARCKSL1 mRNA | CTD | PMID:12419474 | indometacin | multiple interactions | ISO | RGD:1352052 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MARCKSL1 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MARCKSL1 mRNA | CTD | PMID:28628672 | lead diacetate | decreases expression | ISO | RGD:1620894 | 6480464 | lead acetate results in decreased expression of MARCKSL1 mRNA | CTD | PMID:25270620 | Licochalcone B | increases expression | ISO | RGD:1352052 | 6480464 | licochalcone B results in increased expression of MARCKSL1 mRNA | CTD | PMID:33647349 | lipopolysaccharide | increases expression | ISO | RGD:1620894 | 6480464 | Lipopolysaccharides results in increased expression of MARCKSL1 mRNA | CTD | PMID:12057914 more ... | mifepristone | increases expression | ISO | RGD:1352052 | 6480464 | Mifepristone results in increased expression of MARCKSL1 mRNA | CTD | PMID:17584828 | N-Nitrosopyrrolidine | increases expression | ISO | RGD:1352052 | 6480464 | N-Nitrosopyrrolidine results in increased expression of MARCKSL1 mRNA | CTD | PMID:32234424 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of MARCKSL1 mRNA | CTD | PMID:24136188 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of MARCKSL1 mRNA | CTD | PMID:24136188 | O-methyleugenol | increases expression | ISO | RGD:1352052 | 6480464 | methyleugenol results in increased expression of MARCKSL1 mRNA | CTD | PMID:32234424 | paracetamol | increases expression | ISO | RGD:1352052 | 6480464 | Acetaminophen results in increased expression of MARCKSL1 mRNA | CTD | PMID:21420995, PMID:29067470 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of MARCKSL1 mRNA | CTD | PMID:33387578 | pentachlorophenol | increases expression | ISO | RGD:1620894 | 6480464 | Pentachlorophenol results in increased expression of MARCKSL1 mRNA | CTD | PMID:23892564 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:1620894 | 6480464 | [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of MARCKSL1 mRNA | CTD | PMID:31904401 | pirinixic acid | multiple interactions | ISO | RGD:1352052 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MARCKSL1 mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | ISO | RGD:1620894 | 6480464 | pirinixic acid results in decreased expression of MARCKSL1 mRNA | CTD | PMID:17426115, PMID:18445702 | progesterone | decreases expression | ISO | RGD:1352052 | 6480464 | Progesterone results in decreased expression of MARCKSL1 mRNA | CTD | PMID:21795739 | raloxifene | affects expression | ISO | RGD:1352052 | 6480464 | Raloxifene Hydrochloride affects the expression of MARCKSL1 mRNA | CTD | PMID:14699072 | rotenone | increases expression | ISO | RGD:1620894 | 6480464 | Rotenone results in increased expression of MARCKSL1 mRNA | CTD | PMID:32937126 | silicon dioxide | increases expression | ISO | RGD:1620894 | 6480464 | Silicon Dioxide results in increased expression of MARCKSL1 mRNA | CTD | PMID:23221170 | silicon dioxide | increases expression | ISO | RGD:1352052 | 6480464 | Silicon Dioxide results in increased expression of MARCKSL1 mRNA | CTD | PMID:25351596 | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide results in decreased expression of MARCKSL1 mRNA | CTD | PMID:32721576 | silver atom | decreases expression | ISO | RGD:1620894 | 6480464 | Silver results in decreased expression of MARCKSL1 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | RGD:1620894 | 6480464 | Silver results in decreased expression of MARCKSL1 mRNA | CTD | PMID:27131904 | sodium arsenite | decreases expression | ISO | RGD:1352052 | 6480464 | sodium arsenite results in decreased expression of MARCKSL1 mRNA | CTD | PMID:34032870 | sodium dichromate | decreases expression | ISO | RGD:1352052 | 6480464 | sodium bichromate results in decreased expression of MARCKSL1 mRNA | CTD | PMID:12760830 | sodium dodecyl sulfate | increases expression | ISO | RGD:1352052 | 6480464 | Sodium Dodecyl Sulfate results in increased expression of MARCKSL1 mRNA | CTD | PMID:31734321 | succimer | multiple interactions | ISO | RGD:1620894 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of MARCKSL1 mRNA | CTD | PMID:21641980 | tamoxifen | affects expression | ISO | RGD:1352052 | 6480464 | Tamoxifen affects the expression of MARCKSL1 mRNA | CTD | PMID:14699072 | temozolomide | increases expression | ISO | RGD:1352052 | 6480464 | Temozolomide results in increased expression of MARCKSL1 mRNA | CTD | PMID:31758290 | testosterone | increases expression | ISO | RGD:1352052 | 6480464 | Testosterone results in increased expression of MARCKSL1 mRNA | CTD | PMID:33359661 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MARCKSL1 mRNA | CTD | PMID:32741896 | tetrachloromethane | decreases expression | ISO | RGD:1620894 | 6480464 | Carbon Tetrachloride results in decreased expression of MARCKSL1 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of MARCKSL1 mRNA | CTD | PMID:34492290 | triptonide | increases expression | ISO | RGD:1620894 | 6480464 | triptonide results in increased expression of MARCKSL1 mRNA | CTD | PMID:33045310 | tunicamycin | decreases expression | ISO | RGD:1352052 | 6480464 | Tunicamycin results in decreased expression of MARCKSL1 mRNA | CTD | PMID:22378314, PMID:29453283 | urethane | increases expression | ISO | RGD:1352052 | 6480464 | Urethane results in increased expression of MARCKSL1 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | RGD:1620894 | 6480464 | Valproic Acid affects the expression of MARCKSL1 mRNA | CTD | PMID:17292431 | valproic acid | decreases expression | ISO | RGD:1352052 | 6480464 | Valproic Acid results in decreased expression of MARCKSL1 mRNA | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RGD:1620894 | 6480464 | Valproic Acid results in decreased expression of MARCKSL1 mRNA | CTD | PMID:19136453, PMID:20546886 | vancomycin | decreases expression | ISO | RGD:1620894 | 6480464 | Vancomycin results in decreased expression of MARCKSL1 mRNA | CTD | PMID:18930951 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of MARCKSL1 mRNA | CTD | PMID:22570695 | vorinostat | decreases expression | ISO | RGD:1352052 | 6480464 | vorinostat results in decreased expression of MARCKSL1 mRNA | CTD | PMID:27188386 | |