Marcksl1 (MARCKS-like 1) - Rat Genome Database

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Gene: Marcksl1 (MARCKS-like 1) Rattus norvegicus
Analyze
Symbol: Marcksl1
Name: MARCKS-like 1
RGD ID: 621197
Description: Predicted to enable actin filament binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration. Is active in presynaptic cytosol; presynaptic membrane; and synaptic vesicle. Biomarker of visual epilepsy. Orthologous to human MARCKSL1 (MARCKS like 1); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; Leishmaniasis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: brain protein F52; F52; LOC100911122; LOC102550530; mac-MARCKS; macMARCKS; macrophage myristoylated alanine-rich C kinase substrate; MARCKS-like protein; MARCKS-like protein 1; MARCKS-related protein; MARCKS-related protein-like; MGC93399; Mlp; myristoylated alanine-rich C kinase substrate
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,135,827 - 147,138,150 (+)NCBIGRCr8
mRatBN7.25141,851,491 - 141,853,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,850,110 - 141,853,817 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,552,854 - 144,555,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,322,681 - 146,325,004 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,319,205 - 146,321,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,714,163 - 147,716,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,714,163 - 147,716,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,034,161 - 86,035,603 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,669,499 - 148,672,337NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,679,537 - 148,682,375NCBI
Celera5140,326,977 - 140,329,076 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coumarin  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
mifepristone  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels. Bertaso F, etal., J Neurochem. 2006 Oct;99(1):288-98. doi: 10.1111/j.1471-4159.2006.04121.x.
2. Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells. Chang S, etal., J Biol Chem. 1996 Jan 12;271(2):1174-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. McNamara RK and Lenox RH, J Neurosci Res. 2000 Nov 1;62(3):416-26.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons. Yang H, etal., Hypertension 2002 Feb;39(2 Pt 2):567-72.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:17688421   PMID:20458337   PMID:22751924   PMID:25002582  


Genomics

Comparative Map Data
Marcksl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85147,135,827 - 147,138,150 (+)NCBIGRCr8
mRatBN7.25141,851,491 - 141,853,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,850,110 - 141,853,817 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,552,854 - 144,555,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,322,681 - 146,325,004 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,319,205 - 146,321,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,714,163 - 147,716,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,714,163 - 147,716,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,034,161 - 86,035,603 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,669,499 - 148,672,337NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,679,537 - 148,682,375NCBI
Celera5140,326,977 - 140,329,076 (+)NCBICelera
Cytogenetic Map5q36NCBI
MARCKSL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,333,839 - 32,336,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,333,839 - 32,336,233 (-)EnsemblGRCh38hg38GRCh38
GRCh37132,799,440 - 32,801,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,572,027 - 32,574,410 (-)NCBINCBI36Build 36hg18NCBI36
Build 34132,468,533 - 32,470,916NCBI
Celera131,069,907 - 31,072,301 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef130,914,738 - 30,917,220 (-)NCBIHuRef
CHM1_1132,914,874 - 32,917,284 (-)NCBICHM1_1
T2T-CHM13v2.0132,191,757 - 32,194,151 (-)NCBIT2T-CHM13v2.0
Marcksl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,407,374 - 129,409,774 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,407,374 - 129,409,778 (+)EnsemblGRCm39 Ensembl
GRCm384129,513,581 - 129,515,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,513,581 - 129,515,985 (+)EnsemblGRCm38mm10GRCm38
MGSCv374129,190,825 - 129,193,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364129,015,948 - 129,018,279 (+)NCBIMGSCv36mm8
Celera4127,855,422 - 127,857,822 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
Marcksl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545210,669,067 - 10,671,850 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545210,669,067 - 10,671,491 (-)NCBIChiLan1.0ChiLan1.0
MARCKSL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,490,541 - 194,493,092 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,612,030 - 193,614,434 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0131,620,171 - 31,622,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1132,626,617 - 32,628,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl132,627,376 - 32,628,463 (-)Ensemblpanpan1.1panPan2
MARCKSL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,898,750 - 68,901,139 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,892,492 - 68,901,031 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,479,538 - 65,481,927 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,465,266 - 69,467,655 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,465,110 - 69,467,658 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,302,208 - 66,304,597 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,297,880 - 67,300,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,296,419 - 68,298,808 (+)NCBIUU_Cfam_GSD_1.0
LOC101964231
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,529,282 - 49,543,723 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647415,362,701 - 15,365,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCKSL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl688,786,175 - 88,787,766 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1688,785,412 - 88,787,772 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,879,516 - 82,881,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARCKSL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,527,281 - 100,529,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603316,155,228 - 16,157,608 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marcksl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,552,956 - 15,554,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,552,195 - 15,554,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Marcksl1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:66
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000012663
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat

Markers in Region
RH127908  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05151,445,233 - 151,445,420NCBIRnor5.0
Rnor_5.0186,018,419 - 86,018,606NCBIRnor5.0
RGSC_v3.45148,672,112 - 148,672,298UniSTSRGSC3.4
Celera5140,328,851 - 140,329,037UniSTS
Celera179,298,721 - 79,298,907UniSTS
Cytogenetic Map5q36UniSTS
RH125343  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05151,445,154 - 151,445,375NCBIRnor5.0
Rnor_5.0186,018,464 - 86,018,685NCBIRnor5.0
RGSC_v3.45148,672,033 - 148,672,253UniSTSRGSC3.4
Celera5140,328,772 - 140,328,992UniSTS
Celera179,298,642 - 79,298,862UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 45 3
Medium 3 33 47 31 19 31 1 1 29 27 38 11 1
Low 10 10 10 10 7 10 8 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000012663   ⟹   ENSRNOP00000012663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5141,851,474 - 141,853,817 (+)Ensembl
Rnor_6.0 Ensembl5147,714,163 - 147,716,485 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100784   ⟹   ENSRNOP00000091316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5141,850,110 - 141,853,814 (+)Ensembl
RefSeq Acc Id: NM_030862   ⟹   NP_110489
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85147,135,827 - 147,138,150 (+)NCBI
mRatBN7.25141,851,491 - 141,853,814 (+)NCBI
Rnor_6.05147,714,163 - 147,716,486 (+)NCBI
Rnor_5.0186,034,161 - 86,035,603 (-)NCBI
RGSC_v3.45148,669,499 - 148,672,337 (+)RGD
Celera5140,326,977 - 140,329,076 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_110489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81789 (Get FASTA)   NCBI Sequence Viewer  
  CAC18528 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012663
  ENSRNOP00000012663.4
  ENSRNOP00000087964.1
  ENSRNOP00000091316.1
  ENSRNOP00055039495
  ENSRNOP00060033094
  ENSRNOP00065033533
GenBank Protein Q9EPH2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110489   ⟸   NM_030862
- UniProtKB: Q9EPH2 (UniProtKB/Swiss-Prot),   A6J9R3 (UniProtKB/TrEMBL),   A0A8I6AFB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012663   ⟸   ENSRNOT00000012663
RefSeq Acc Id: ENSRNOP00000091316   ⟸   ENSRNOT00000100784

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPH2-F1-model_v2 AlphaFold Q9EPH2 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694066
Promoter ID:EPDNEW_R4591
Type:single initiation site
Name:Marcksl1_1
Description:MARCKS-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,714,146 - 147,714,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621197 AgrOrtholog
BioCyc Gene G2FUF-39797 BioCyc
Ensembl Genes ENSRNOG00000009113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000066033 UniProtKB/Swiss-Prot
  ENSRNOG00055027689 UniProtKB/Swiss-Prot
  ENSRNOG00060023201 UniProtKB/Swiss-Prot
  ENSRNOG00065023930 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012663 ENTREZGENE
  ENSRNOT00000012663.8 UniProtKB/Swiss-Prot
  ENSRNOT00000100784.1 UniProtKB/TrEMBL
  ENSRNOT00000111046.1 UniProtKB/Swiss-Prot
  ENSRNOT00055047967 UniProtKB/Swiss-Prot
  ENSRNOT00060040103 UniProtKB/Swiss-Prot
  ENSRNOT00065041063 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134056 IMAGE-MGC_LOAD
InterPro MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93399 IMAGE-MGC_LOAD
NCBI Gene 81520 ENTREZGENE
PANTHER MARCKS-RELATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Marcksl1 PhenoGen
PRINTS MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MARCKS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARCKS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009113 RatGTEx
  ENSRNOG00000066033 RatGTEx
  ENSRNOG00055027689 RatGTEx
  ENSRNOG00060023201 RatGTEx
  ENSRNOG00065023930 RatGTEx
UniProt A0A8I6AFB9 ENTREZGENE, UniProtKB/TrEMBL
  A6J9R3 ENTREZGENE, UniProtKB/TrEMBL
  MRP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Marcksl1  MARCKS-like 1  LOC102550530  MARCKS-related protein-like  Data merged from RGD:7603447 737654 PROVISIONAL
2015-07-29 Marcksl1  MARCKS-like 1  LOC100911122  MARCKS-related protein-like  Data merged from RGD:6495142 737654 PROVISIONAL
2013-12-18 LOC102550530  MARCKS-related protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100911122  MARCKS-related protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Marcksl1  MARCKS-like 1  Mlp  MARCKS-like protein  Symbol and Name updated 1299863 APPROVED
2004-09-10 Mlp  MARCKS-like protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mlp  MARCKS-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL