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Gene: Spen (spen family transcriptional repressor) Rattus norvegicus
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Symbol: Spen
Name: spen family transcriptional repressor
Description: Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of neurogenesis; and positive regulation of transcription, DNA-templated. Predicted to localize to the nucleoplasm and transcriptional repressor complex. Orthologous to human SPEN (spen family transcriptional repressor); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 2-methylcholine (ortholog); 3,3',5-triiodo-L-thyronine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC298604; LOC690911; rCG30673-like; RGD1564662; similar to Msx-2 interacting nuclear target protein; similar to Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein); SPEN homolog, transcriptional regulator; spen homolog, transcriptional regulator (Drosophila); uncharacterized protein LOC690911
Orthologs:
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Mus musculus (house mouse) : Spen (spen family transcription repressor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spen (spen family transcriptional repressor)
Pan paniscus (bonobo/pygmy chimpanzee) : SPEN (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Sus scrofa (pig) : SPEN (spen family transcriptional repressor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)Ensembl
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Spen
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1589867
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.