Gene: Aldh4a1 (aldehyde dehydrogenase 4 family, member A1) Rattus norvegicus
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Symbol:
Aldh4a1
Name:
aldehyde dehydrogenase 4 family, member A1
RGD ID:
1624206
Description:
Predicted to have 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in oxidation-reduction process and proline catabolic process to glutamate. Predicted to localize to integral component of membrane and mitochondrial matrix. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; acetamide.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; LOC641316; P5C dehydrogenase; similar to aldehyde dehydrogenase 4 family, member A1
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 158,090,238 - 158,115,725 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 158,042,587 - 158,135,733 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 161,829,323 - 161,854,796 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 158,437,691 - 158,453,827 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 5 150,256,652 - 150,282,086 (+) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
hyperprolinemia ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Hyperprolinemia ClinVar hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Deficiency of pyrroline-5-carboxylate reductase ClinVar PMID:25741868 , PMID:28492532 hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Deficiency of pyrroline-5-carboxylate reductase ClinVar PMID:25741868 hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Deficiency of pyrroline-5-carboxylate reductase ClinVar hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Deficiency of pyrroline-5-carboxylate reductase ClinVar PMID:26822237 , PMID:28492532 hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by OMIM:239510 ClinVar PMID:9700195 hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by OMIM:239510 ClinVar PMID:2624476 , PMID:9700195 hyperprolinemia type 2 ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Hyperprolinemia type 2 ClinVar PMID:28492532 intellectual disability ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:25741868 intellectual disability ISO RGD:1346272 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:25741868 , PMID:28492532
Imported Annotations - CTD
hyperprolinemia type 2 ISO RGD:1346272 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25641190 non-alcoholic fatty liver disease ISO RGD:1346272 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29718361 pre-malignant neoplasm ISO RGD:1346272 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21472284 Imported Annotations - OMIM
hyperprolinemia type 2 ISO RGD:1346272 7240710 OMIM
(+)-dexrazoxane multiple interactions ISO RGD:1618187 6480464 [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA CTD PMID:26873546 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALDH4A1 mRNA] CTD PMID:31150632 1,1-dichloroethene decreases expression ISO RGD:1618187 6480464 vinylidene chloride results in decreased expression of ALDH4A1 mRNA CTD PMID:26682919 1,2-dimethylhydrazine decreases expression ISO RGD:1618187 6480464 1, 2-Dimethylhydrazine results in decreased expression of ALDH4A1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:1618187 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of ALDH4A1 mRNA] CTD PMID:22206623 17beta-estradiol decreases expression ISO RGD:1346272 6480464 Estradiol results in decreased expression of ALDH4A1 mRNA CTD PMID:19619570 17beta-estradiol multiple interactions ISO RGD:1346272 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH4A1 mRNA CTD PMID:19619570 2,3,7,8-tetrabromodibenzodioxine decreases expression ISO RGD:1618187 6480464 2 more ... CTD PMID:27604104 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1346272 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ALDH4A1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1618187 6480464 Tetrachlorodibenzodioxin affects the expression of ALDH4A1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1346272 6480464 Tetrachlorodibenzodioxin results in decreased expression of ALDH4A1 mRNA CTD PMID:19619570 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of ALDH4A1 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1346272 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA more ... CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1346272 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA CTD PMID:28628672 4-hydroxyphenyl retinamide increases expression ISO RGD:1618187 6480464 Fenretinide results in increased expression of ALDH4A1 mRNA CTD PMID:28973697 8'-apo-beta,psi-caroten-8'-al decreases expression ISO RGD:1346272 6480464 apocarotenal results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of ALDH4A1 mRNA CTD PMID:31881176 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of ALDH4A1 mRNA CTD PMID:28959563 aflatoxin B1 affects expression ISO RGD:1346272 6480464 Aflatoxin B1 affects the expression of ALDH4A1 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1346272 6480464 Aflatoxin B1 results in decreased expression of ALDH4A1 mRNA CTD PMID:27153756 aflatoxin B2 decreases methylation ISO RGD:1346272 6480464 aflatoxin B2 results in decreased methylation of ALDH4A1 3' UTR CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:1346272 6480464 Tretinoin results in decreased expression of ALDH4A1 mRNA CTD PMID:23724009 arsane affects methylation ISO RGD:1346272 6480464 Arsenic affects the methylation of ALDH4A1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1346272 6480464 Arsenic affects the methylation of ALDH4A1 gene CTD PMID:25304211 arsenous acid multiple interactions ISO RGD:1346272 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH4A1 protein] CTD PMID:26598702 atrazine decreases expression ISO RGD:1346272 6480464 Atrazine results in decreased expression of ALDH4A1 mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of ALDH4A1 mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression ISO RGD:1346272 6480464 Benzo(a)pyrene results in decreased expression of ALDH4A1 mRNA CTD PMID:20106945 , PMID:32234424 beta-carotene decreases expression ISO RGD:1346272 6480464 beta Carotene results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1618187 6480464 Diethylhexyl Phthalate results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ALDH4A1 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:1346272 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ALDH4A1 mRNA CTD PMID:28628672 bisphenol F multiple interactions ISO RGD:1346272 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ALDH4A1 mRNA CTD PMID:28628672 butylated hydroxyanisole increases expression ISO RGD:1618187 6480464 Butylated Hydroxyanisole results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of ALDH4A1 mRNA CTD PMID:19167457 cadmium atom increases expression ISO RGD:1346272 6480464 Cadmium results in increased expression of ALDH4A1 mRNA CTD PMID:24376830 calcitriol multiple interactions ISO RGD:1346272 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ALDH4A1 mRNA CTD PMID:21592394 calcitriol increases expression ISO RGD:1346272 6480464 Calcitriol results in increased expression of ALDH4A1 mRNA CTD PMID:21592394 carbon nanotube decreases expression ISO RGD:1618187 6480464 Nanotubes, Carbon analog results in decreased expression of ALDH4A1 mRNA, Nanotubes, Carbon results in decreased expression of ALDH4A1 mRNA CTD PMID:25554681 , PMID:25620056 choline multiple interactions ISO RGD:1618187 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH4A1 mRNA CTD PMID:20938992 cisplatin multiple interactions ISO RGD:1346272 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of ALDH4A1 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1346272 6480464 Cisplatin results in increased expression of ALDH4A1 mRNA CTD PMID:27392435 clofibric acid increases expression ISO RGD:1618187 6480464 Clofibric Acid results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 copper(II) sulfate decreases expression ISO RGD:1346272 6480464 Copper Sulfate results in decreased expression of ALDH4A1 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1346272 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of ALDH4A1 mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:1346272 6480464 Cyclosporine results in decreased expression of ALDH4A1 mRNA CTD PMID:20106945 more ... cyclosporin A decreases expression ISO RGD:1618187 6480464 Cyclosporine results in decreased expression of ALDH4A1 mRNA CTD PMID:23830897 dexamethasone increases expression ISO RGD:1346272 6480464 Dexamethasone results in increased expression of ALDH4A1 mRNA CTD PMID:25047013 dexamethasone multiple interactions ISO RGD:1346272 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA more ... CTD PMID:28628672 diarsenic trioxide multiple interactions ISO RGD:1346272 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ALDH4A1 protein] CTD PMID:26598702 doxorubicin multiple interactions ISO RGD:1618187 6480464 [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA CTD PMID:26873546 doxorubicin decreases expression ISO RGD:1346272 6480464 Doxorubicin results in decreased expression of ALDH4A1 mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:1618187 6480464 Doxorubicin results in decreased expression of ALDH4A1 mRNA, Doxorubicin results in decreased expression of ALDH4A1 protein CTD PMID:21251210 , PMID:26873546 elemental selenium increases expression ISO RGD:1346272 6480464 Selenium results in increased expression of ALDH4A1 mRNA CTD PMID:19244175 ethanol increases expression ISO RGD:1618187 6480464 Ethanol results in increased expression of ALDH4A1 mRNA CTD PMID:30319688 fenamidone increases expression ISO RGD:1618187 6480464 fenamidone results in increased expression of ALDH4A1 mRNA CTD PMID:27029645 folic acid multiple interactions ISO RGD:1618187 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH4A1 mRNA more ... CTD PMID:20938992 , PMID:22206623 furan increases expression EXP 6480464 furan results in increased expression of ALDH4A1 mRNA CTD PMID:26194646 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of ALDH4A1 mRNA CTD PMID:24136188 indometacin multiple interactions ISO RGD:1346272 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ALDH4A1 mRNA more ... CTD PMID:28628672 L-methionine multiple interactions ISO RGD:1618187 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH4A1 mRNA CTD PMID:20938992 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of ALDH4A1 mRNA CTD PMID:28801915 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of ALDH4A1 mRNA CTD PMID:30467583 O-methyleugenol decreases expression ISO RGD:1346272 6480464 methyleugenol results in decreased expression of ALDH4A1 mRNA CTD PMID:32234424 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of ALDH4A1 protein CTD PMID:31369848 paracetamol affects expression ISO RGD:1618187 6480464 Acetaminophen affects the expression of ALDH4A1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1346272 6480464 Acetaminophen results in decreased expression of ALDH4A1 mRNA CTD PMID:29067470 paracetamol multiple interactions ISO RGD:1618187 6480464 [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ALDH4A1 protein CTD PMID:25499718 perfluorononanoic acid decreases expression ISO RGD:1346272 6480464 perfluorononanoic acid results in decreased expression of ALDH4A1 mRNA CTD PMID:32588087 phlorizin decreases expression ISO RGD:1618187 6480464 Phlorhizin results in decreased expression of ALDH4A1 mRNA CTD PMID:22538082 pirinixic acid multiple interactions ISO RGD:1618187 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH4A1 mRNA CTD PMID:19710929 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1618187 6480464 Pregnenolone Carbonitrile results in increased expression of ALDH4A1 mRNA CTD PMID:28903501 propanal increases expression ISO RGD:1346272 6480464 propionaldehyde results in increased expression of ALDH4A1 mRNA CTD PMID:26079696 quercetin decreases expression ISO RGD:1346272 6480464 Quercetin results in decreased expression of ALDH4A1 mRNA CTD PMID:21632981 quercetin decreases expression ISO RGD:1618187 6480464 Quercetin results in decreased expression of ALDH4A1 mRNA CTD PMID:16455785 resveratrol multiple interactions ISO RGD:1346272 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of ALDH4A1 mRNA CTD PMID:19167446 resveratrol increases expression ISO RGD:1618187 6480464 resveratrol results in increased expression of ALDH4A1 mRNA, resveratrol results in increased expression of ALDH4A1 protein CTD PMID:22610192 , PMID:25505154 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of ALDH4A1 mRNA CTD PMID:28374803 selenium atom increases expression ISO RGD:1346272 6480464 Selenium results in increased expression of ALDH4A1 mRNA CTD PMID:19244175 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of ALDH4A1 protein CTD PMID:29459688 spironolactone increases expression ISO RGD:1618187 6480464 Spironolactone results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 sulforaphane decreases expression ISO RGD:1346272 6480464 sulforafan results in decreased expression of ALDH4A1 mRNA CTD PMID:31838189 sunitinib decreases expression ISO RGD:1346272 6480464 Sunitinib results in decreased expression of ALDH4A1 mRNA CTD PMID:31533062 tert-butyl hydroperoxide decreases expression ISO RGD:1346272 6480464 tert-Butylhydroperoxide results in decreased expression of ALDH4A1 mRNA CTD PMID:15336504 testosterone increases expression ISO RGD:1346272 6480464 Testosterone results in increased expression of ALDH4A1 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1346272 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ALDH4A1 mRNA CTD PMID:21592394 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALDH4A1 mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:1618187 6480464 Carbon Tetrachloride results in decreased expression of ALDH4A1 mRNA CTD PMID:31919559 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of ALDH4A1 mRNA CTD PMID:31150632 triclosan decreases expression ISO RGD:1346272 6480464 Triclosan results in decreased expression of ALDH4A1 mRNA CTD PMID:30510588 valproic acid decreases expression ISO RGD:1346272 6480464 Valproic Acid results in decreased expression of ALDH4A1 mRNA CTD PMID:29154799 valproic acid affects expression ISO RGD:1618187 6480464 Valproic Acid affects the expression of ALDH4A1 mRNA CTD PMID:17292431 vancomycin increases expression ISO RGD:1618187 6480464 Vancomycin results in increased expression of ALDH4A1 mRNA CTD PMID:18930951
Gene-Chemical Interaction Annotations
