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Gene: Aldh4a1 (aldehyde dehydrogenase 4 family, member A1) Rattus norvegicus
Symbol: Aldh4a1
Name: aldehyde dehydrogenase 4 family, member A1
RGD ID: 1624206
Description: Predicted to have 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in oxidation-reduction process and proline catabolic process to glutamate. Predicted to localize to integral component of membrane and mitochondrial matrix. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; acetamide.
Type: protein-coding
Also known as: aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; LOC641316; P5C dehydrogenase; similar to aldehyde dehydrogenase 4 family, member A1
Homo sapiens (human) : ALDH4A1 (aldehyde dehydrogenase 4 family member A1)  HGNC  Alliance
Mus musculus (house mouse) : Aldh4a1 (aldehyde dehydrogenase 4 family, member A1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh4a1 (aldehyde dehydrogenase 4 family member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH4A1 (aldehyde dehydrogenase 4 family member A1)
Canis lupus familiaris (dog) : ALDH4A1 (aldehyde dehydrogenase 4 family member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh4a1 (aldehyde dehydrogenase 4 family member A1)
Sus scrofa (pig) : ALDH4A1 (aldehyde dehydrogenase 4 family member A1)
Chlorocebus sabaeus (African green monkey) : ALDH4A1 (aldehyde dehydrogenase 4 family member A1)
Heterocephalus glaber (naked mole-rat) : Aldh4a1 (aldehyde dehydrogenase 4 family member A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05158,090,238 - 158,115,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5158,042,587 - 158,135,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,829,323 - 161,854,796 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,437,691 - 158,453,827 (+)NCBIRGSC3.4rn4RGSC3.4
Celera5150,256,652 - 150,282,086 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Aldh4a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1624206
Created: 2007-05-03
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.