Aldh4a1 (aldehyde dehydrogenase 4 family, member A1) - Rat Genome Database

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Gene: Aldh4a1 (aldehyde dehydrogenase 4 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh4a1
Name: aldehyde dehydrogenase 4 family, member A1
RGD ID: 1624206
Description: Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; LOC641316; P5C dehydrogenase; similar to aldehyde dehydrogenase 4 family, member A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25151,880,002 - 151,905,491 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5151,830,701 - 151,925,345 (+)Ensembl
Rnor_6.05158,090,238 - 158,115,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5158,042,587 - 158,135,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,829,323 - 161,854,796 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,437,691 - 158,453,827 (+)NCBIRGSC3.4rn4RGSC3.4
Celera5150,256,652 - 150,282,086 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butylated hydroxyanisole  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP)
spironolactone  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
triclosan  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:4015840   PMID:8621661   PMID:12477932   PMID:14651853   PMID:15057822   PMID:18614015   PMID:22516612   PMID:23928095  


Genomics

Comparative Map Data
Aldh4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25151,880,002 - 151,905,491 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5151,830,701 - 151,925,345 (+)Ensembl
Rnor_6.05158,090,238 - 158,115,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5158,042,587 - 158,135,733 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,829,323 - 161,854,796 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,437,691 - 158,453,827 (+)NCBIRGSC3.4rn4RGSC3.4
Celera5150,256,652 - 150,282,086 (+)NCBICelera
Cytogenetic Map5q36NCBI
ALDH4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38118,871,430 - 18,902,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl118,871,430 - 18,902,724 (-)EnsemblGRCh38hg38GRCh38
GRCh37119,197,924 - 19,229,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,070,513 - 19,101,659 (-)NCBINCBI36hg18NCBI36
Build 34118,943,231 - 18,974,378NCBI
Celera117,525,220 - 17,556,609 (-)NCBI
Cytogenetic Map1p36.13NCBI
HuRef117,442,100 - 17,473,468 (-)NCBIHuRef
CHM1_1119,307,273 - 19,338,658 (-)NCBICHM1_1
T2T-CHM13v2.0118,691,214 - 18,722,363 (-)NCBI
Aldh4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394139,348,404 - 139,377,002 (+)NCBIGRCm39mm39
GRCm39 Ensembl4139,350,177 - 139,377,001 (+)Ensembl
GRCm384139,622,871 - 139,649,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,622,866 - 139,649,690 (+)EnsemblGRCm38mm10GRCm38
MGSCv374139,178,809 - 139,205,606 (+)NCBIGRCm37mm9NCBIm37
MGSCv364138,895,086 - 138,921,763 (+)NCBImm8
Celera4141,417,063 - 141,444,074 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.79NCBI
Aldh4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955527338,593 - 372,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955527338,593 - 369,528 (+)NCBIChiLan1.0ChiLan1.0
ALDH4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1118,878,421 - 18,909,615 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl118,878,421 - 18,909,615 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0117,829,723 - 17,861,008 (-)NCBIMhudiblu_PPA_v0panPan3
ALDH4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,688,078 - 79,712,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,688,086 - 79,710,540 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,202,258 - 76,226,797 (+)NCBI
ROS_Cfam_1.0280,311,305 - 80,335,987 (+)NCBI
ROS_Cfam_1.0 Ensembl280,311,248 - 80,335,984 (+)Ensembl
UMICH_Zoey_3.1277,070,827 - 77,093,559 (+)NCBI
UNSW_CanFamBas_1.0278,080,932 - 78,105,430 (+)NCBI
UU_Cfam_GSD_1.0279,151,584 - 79,176,100 (+)NCBI
Aldh4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505839,392,819 - 39,421,970 (-)NCBI
SpeTri2.0NW_0049364745,217,601 - 5,246,718 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH4A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,374,002 - 77,404,036 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1677,373,999 - 77,404,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,494,105 - 71,512,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120113,661,850 - 113,693,665 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660332,463,684 - 2,495,495 (-)NCBIVero_WHO_p1.0
Aldh4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,051,178 - 4,082,142 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247644,051,999 - 4,081,954 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH133354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,905,182 - 151,905,385 (+)MAPPERmRatBN7.2
Rnor_6.05158,115,417 - 158,115,619NCBIRnor6.0
Rnor_5.05161,854,488 - 161,854,690UniSTSRnor5.0
RGSC_v3.45158,453,519 - 158,453,721UniSTSRGSC3.4
Celera5150,281,778 - 150,281,980UniSTS
RH 3.4 Map51046.2UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 27 46 41 41 1 23 35 21 1
Low 3 16 11 19 8 10 51 20 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077863   ⟹   ENSRNOP00000072481
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,909,648 - 151,925,345 (+)Ensembl
Rnor_6.0 Ensembl5158,119,894 - 158,135,733 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079516   ⟹   ENSRNOP00000069536
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,857,371 - 151,905,482 (+)Ensembl
Rnor_6.0 Ensembl5158,090,238 - 158,115,725 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080108   ⟹   ENSRNOP00000069221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,831,503 - 151,918,134 (+)Ensembl
Rnor_6.0 Ensembl5158,069,725 - 158,128,523 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088766   ⟹   ENSRNOP00000075011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,857,371 - 151,901,630 (+)Ensembl
Rnor_6.0 Ensembl5158,090,173 - 158,115,751 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090593   ⟹   ENSRNOP00000069936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,830,701 - 151,873,075 (+)Ensembl
Rnor_6.0 Ensembl5158,042,587 - 158,083,311 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092026   ⟹   ENSRNOP00000069040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,857,371 - 151,904,072 (+)Ensembl
Rnor_6.0 Ensembl5158,090,268 - 158,114,306 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095029   ⟹   ENSRNOP00000077405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,858,983 - 151,918,134 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101164   ⟹   ENSRNOP00000083484
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,858,038 - 151,876,946 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117654   ⟹   ENSRNOP00000085310
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,909,648 - 151,925,345 (+)Ensembl
RefSeq Acc Id: NM_001134698   ⟹   NP_001128170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,880,002 - 151,905,491 (+)NCBI
Rnor_6.05158,090,238 - 158,115,725 (+)NCBI
Rnor_5.05161,829,323 - 161,854,796 (+)NCBI
RGSC_v3.45158,437,691 - 158,453,827 (+)RGD
Celera5150,256,652 - 150,282,086 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128170 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68153 (Get FASTA)   NCBI Sequence Viewer  
  EDL80928 (Get FASTA)   NCBI Sequence Viewer  
  P0C2X9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001128170   ⟸   NM_001134698
- UniProtKB: B4F768 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069040   ⟸   ENSRNOT00000092026
RefSeq Acc Id: ENSRNOP00000069221   ⟸   ENSRNOT00000080108
RefSeq Acc Id: ENSRNOP00000069536   ⟸   ENSRNOT00000079516
RefSeq Acc Id: ENSRNOP00000069936   ⟸   ENSRNOT00000090593
RefSeq Acc Id: ENSRNOP00000072481   ⟸   ENSRNOT00000077863
RefSeq Acc Id: ENSRNOP00000075011   ⟸   ENSRNOT00000088766
RefSeq Acc Id: ENSRNOP00000077405   ⟸   ENSRNOT00000095029
RefSeq Acc Id: ENSRNOP00000083484   ⟸   ENSRNOT00000101164
RefSeq Acc Id: ENSRNOP00000085310   ⟸   ENSRNOT00000117654
Protein Domains
Aldedh

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C2X9-F1-model_v2 AlphaFold P0C2X9 1-563 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1624206 AgrOrtholog
BioCyc Gene G2FUF-39408 BioCyc
BioCyc Pathway ARGASEDEG-PWY [L-arginine degradation I (arginase pathway)] BioCyc
  PROUT-PWY [L-proline degradation I] BioCyc
Ensembl Genes ENSRNOG00000061876 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069040.2 UniProtKB/TrEMBL
  ENSRNOP00000069221.2 UniProtKB/TrEMBL
  ENSRNOP00000069536 ENTREZGENE
  ENSRNOP00000069536.2 UniProtKB/TrEMBL
  ENSRNOP00000069936.2 UniProtKB/TrEMBL
  ENSRNOP00000075011.2 UniProtKB/TrEMBL
  ENSRNOP00000077405.1 UniProtKB/TrEMBL
  ENSRNOP00000085310.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079516 ENTREZGENE
  ENSRNOT00000079516.2 UniProtKB/TrEMBL
  ENSRNOT00000080108.2 UniProtKB/TrEMBL
  ENSRNOT00000088766.2 UniProtKB/TrEMBL
  ENSRNOT00000090593.2 UniProtKB/TrEMBL
  ENSRNOT00000092026.2 UniProtKB/TrEMBL
  ENSRNOT00000095029.1 UniProtKB/TrEMBL
  ENSRNOT00000117654.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.309.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.605.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  P5CDH/ALDH4A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:641316 UniProtKB/TrEMBL
NCBI Gene 641316 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Aldh4a1 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/TrEMBL
TIGRFAMs D1pyr5carbox1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JUB9_RAT UniProtKB/TrEMBL
  A0A0G2JUT5_RAT UniProtKB/TrEMBL
  A0A0G2JVM0_RAT UniProtKB/TrEMBL
  A0A0G2K9I7_RAT UniProtKB/TrEMBL
  A0A8I5YBT1_RAT UniProtKB/TrEMBL
  A0A8I6A130_RAT UniProtKB/TrEMBL
  A0A8L2R1U3_RAT UniProtKB/TrEMBL
  AL4A1_RAT UniProtKB/Swiss-Prot
  B4F768 ENTREZGENE, UniProtKB/TrEMBL
  P0C2X9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-12-02 Aldh4a1   aldehyde dehydrogenase 4 family, member A1  LOC641316  similar to aldehyde dehydrogenase 4 family, member A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-03 LOC641316  similar to aldehyde dehydrogenase 4 family, member A1      Symbol and Name status set to provisional 70820 PROVISIONAL