Capzb (capping actin protein of muscle Z-line subunit beta) - Rat Genome Database

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Gene: Capzb (capping actin protein of muscle Z-line subunit beta) Rattus norvegicus
Analyze
Symbol: Capzb
Name: capping actin protein of muscle Z-line subunit beta
RGD ID: 1359099
Description: Predicted to enable actin filament binding activity and beta-tubulin binding activity. Predicted to be involved in several processes, including barbed-end actin filament capping; regulation of cell morphogenesis; and regulation of plasma membrane bounded cell projection assembly. Predicted to act upstream of or within several processes, including actin polymerization or depolymerization; negative regulation of microtubule polymerization; and plasma membrane bounded cell projection organization. Located in dendritic spine and neuronal cell body. Biomarker of dementia. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: capping actin protein of muscle Z-line beta subunit; capping protein (actin filament) muscle Z-line, beta; capZ beta; F-actin capping protein beta subunit; F-actin-capping protein subunit beta; MGC95097
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25151,435,600 - 151,535,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,434,871 - 151,535,409 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,133,022 - 154,233,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,907,343 - 156,007,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,888,276 - 155,988,134 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,642,742 - 157,742,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,642,751 - 157,742,478 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,383,315 - 161,482,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,980,877 - 158,080,682 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,990,915 - 158,090,719 (+)NCBI
Celera5149,816,061 - 149,915,748 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
CU-O LINKAGE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential protein levels and post-translational modifications in spinal cord injury of the rat. Afjehi-Sadat L, etal., J Proteome Res. 2010 Mar 5;9(3):1591-7. doi: 10.1021/pr901049a.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Vertebrate isoforms of actin capping protein beta have distinct functions In vivo. Hart MC and Cooper JA, J Cell Biol 1999 Dec 13;147(6):1287-98.
5. Activity-dependent localization in spines of the F-actin capping protein CapZ screened in a rat model of dementia. Kitanishi T, etal., Genes Cells. 2010 Jun;15(7):737-47. doi: 10.1111/j.1365-2443.2010.01411.x. Epub 2010 Jun 10.
6. Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells. Kitazawa M, etal., Biochem Biophys Res Commun. 2005 May 27;331(1):181-6.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11604420   PMID:12089068   PMID:15294161   PMID:17656356   PMID:18076569   PMID:18272787   PMID:18723693   PMID:19056867   PMID:19199708   PMID:19267422   PMID:19295171   PMID:19341723  
PMID:19806181   PMID:19922875   PMID:20458337   PMID:20884878   PMID:21834987   PMID:22114352   PMID:22871113   PMID:23376485   PMID:23493359   PMID:23533145   PMID:24043251   PMID:24093776  
PMID:24625528   PMID:25468996   PMID:25810514   PMID:26237647   PMID:26429793   PMID:27185186   PMID:28493397   PMID:29476059   PMID:30026308   PMID:30053369  


Genomics

Comparative Map Data
Capzb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25151,435,600 - 151,535,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,434,871 - 151,535,409 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,133,022 - 154,233,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,907,343 - 156,007,613 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,888,276 - 155,988,134 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,642,742 - 157,742,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,642,751 - 157,742,478 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,383,315 - 161,482,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,980,877 - 158,080,682 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,990,915 - 158,090,719 (+)NCBI
Celera5149,816,061 - 149,915,748 (+)NCBICelera
Cytogenetic Map5q36NCBI
CAPZB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,338,775 - 19,485,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,338,775 - 19,485,539 (-)EnsemblGRCh38hg38GRCh38
GRCh37119,665,269 - 19,812,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,537,860 - 19,684,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 34119,411,069 - 19,491,551NCBI
Celera117,992,290 - 18,138,980 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,911,593 - 18,058,372 (-)NCBIHuRef
CHM1_1119,774,569 - 19,921,335 (-)NCBICHM1_1
T2T-CHM13v2.0119,162,310 - 19,308,992 (-)NCBIT2T-CHM13v2.0
Capzb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,920,210 - 139,019,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,920,210 - 139,019,129 (+)EnsemblGRCm39 Ensembl
GRCm384139,192,899 - 139,291,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,192,899 - 139,291,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,748,846 - 138,847,727 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,465,007 - 138,563,888 (+)NCBIMGSCv36mm8
Celera4140,979,100 - 141,078,244 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.59NCBI
Capzb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545230,589 - 169,693 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545234,454 - 168,514 (-)NCBIChiLan1.0ChiLan1.0
CAPZB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11206,746,732 - 206,893,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,297,434 - 18,444,011 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,343,400 - 19,489,072 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,344,154 - 19,488,133 (-)Ensemblpanpan1.1panPan2
CAPZB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,182,668 - 79,311,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,181,851 - 79,311,518 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,695,344 - 75,825,750 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,804,060 - 79,934,792 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,804,081 - 79,934,830 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,565,507 - 76,695,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,575,195 - 77,705,390 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,644,515 - 78,775,092 (+)NCBIUU_Cfam_GSD_1.0
Capzb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505839,769,740 - 39,884,578 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364745,594,152 - 5,709,315 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364745,594,193 - 5,656,665 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPZB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,780,682 - 77,912,617 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1677,780,682 - 77,912,653 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,842,816 - 71,985,460 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAPZB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120113,062,077 - 113,207,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20113,062,192 - 113,210,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660332,951,087 - 3,096,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capzb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247644,473,606 - 4,601,286 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247644,473,880 - 4,601,260 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Capzb
457 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:56
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000010308
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat

Markers in Region
RH128327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,535,126 - 151,535,346 (+)MAPPERmRatBN7.2
Rnor_6.05157,742,202 - 157,742,421NCBIRnor6.0
Rnor_5.05161,482,436 - 161,482,655UniSTSRnor5.0
RGSC_v3.45158,080,400 - 158,080,619UniSTSRGSC3.4
Celera5149,915,466 - 149,915,685UniSTS
RH 3.4 Map51035.9UniSTS
Cytogenetic Map5q36UniSTS
RH143222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25151,514,735 - 151,514,883 (+)MAPPERmRatBN7.2
Rnor_6.05157,721,814 - 157,721,961NCBIRnor6.0
Rnor_5.05161,462,048 - 161,462,195UniSTSRnor5.0
RGSC_v3.45158,060,012 - 158,060,159UniSTSRGSC3.4
Celera5149,895,049 - 149,895,196UniSTS
RH 3.4 Map51036.4UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000010308   ⟹   ENSRNOP00000010308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,435,680 - 151,535,409 (+)Ensembl
Rnor_6.0 Ensembl5157,642,777 - 157,742,478 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083577   ⟹   ENSRNOP00000070586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,458,196 - 151,535,409 (+)Ensembl
Rnor_6.0 Ensembl5157,642,751 - 157,742,161 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099328   ⟹   ENSRNOP00000085427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,436,582 - 151,535,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100786   ⟹   ENSRNOP00000090455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,435,934 - 151,535,344 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101104   ⟹   ENSRNOP00000086771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,434,871 - 151,535,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104673   ⟹   ENSRNOP00000093194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,482,499 - 151,535,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106969   ⟹   ENSRNOP00000092671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,436,582 - 151,535,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110243   ⟹   ENSRNOP00000093333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,475,626 - 151,535,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115619   ⟹   ENSRNOP00000097982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,441,001 - 151,535,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118044   ⟹   ENSRNOP00000092834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5151,440,515 - 151,535,409 (+)Ensembl
RefSeq Acc Id: NM_001005903   ⟹   NP_001005903
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,435,704 - 151,535,409 (+)NCBI
Rnor_6.05157,642,777 - 157,742,484 (+)NCBI
Rnor_5.05161,383,315 - 161,482,718 (+)NCBI
RGSC_v3.45157,980,877 - 158,080,682 (+)RGD
Celera5149,816,061 - 149,915,748 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239172   ⟹   XP_006239234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,436,871 - 151,535,384 (+)NCBI
Rnor_6.05157,643,460 - 157,742,437 (+)NCBI
Rnor_5.05161,383,315 - 161,482,718 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239175   ⟹   XP_006239237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,436,412 - 151,535,384 (+)NCBI
Rnor_6.05157,643,465 - 157,742,437 (+)NCBI
Rnor_5.05161,383,315 - 161,482,718 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239177   ⟹   XP_006239239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,435,600 - 151,535,402 (+)NCBI
Rnor_6.05157,642,742 - 157,742,487 (+)NCBI
Rnor_5.05161,383,315 - 161,482,718 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109680   ⟹   XP_038965608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,436,825 - 151,532,528 (+)NCBI
RefSeq Acc Id: XM_039109681   ⟹   XP_038965609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,436,412 - 151,532,528 (+)NCBI
RefSeq Acc Id: XM_039109682   ⟹   XP_038965610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25151,436,225 - 151,535,402 (+)NCBI
RefSeq Acc Id: NP_001005903   ⟸   NM_001005903
- UniProtKB: Q5XI32 (UniProtKB/Swiss-Prot),   A6ITK5 (UniProtKB/TrEMBL),   A0A8I6AWP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239239   ⟸   XM_006239177
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AWP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239237   ⟸   XM_006239175
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A3B7 (UniProtKB/TrEMBL),   A0A8I6AWP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239234   ⟸   XM_006239172
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AG02 (UniProtKB/TrEMBL),   A0A8L2Q5I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010308   ⟸   ENSRNOT00000010308
RefSeq Acc Id: ENSRNOP00000070586   ⟸   ENSRNOT00000083577
RefSeq Acc Id: XP_038965610   ⟸   XM_039109682
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AWP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965609   ⟸   XM_039109681
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AWP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965608   ⟸   XM_039109680
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q5I8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092671   ⟸   ENSRNOT00000106969
RefSeq Acc Id: ENSRNOP00000090455   ⟸   ENSRNOT00000100786
RefSeq Acc Id: ENSRNOP00000093194   ⟸   ENSRNOT00000104673
RefSeq Acc Id: ENSRNOP00000097982   ⟸   ENSRNOT00000115619
RefSeq Acc Id: ENSRNOP00000092834   ⟸   ENSRNOT00000118044
RefSeq Acc Id: ENSRNOP00000085427   ⟸   ENSRNOT00000099328
RefSeq Acc Id: ENSRNOP00000086771   ⟸   ENSRNOT00000101104
RefSeq Acc Id: ENSRNOP00000093333   ⟸   ENSRNOT00000110243

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI32-F1-model_v2 AlphaFold Q5XI32 1-272 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694203
Promoter ID:EPDNEW_R4726
Type:initiation region
Name:Capzb_1
Description:capping actin protein of muscle Z-line beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05157,642,760 - 157,642,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359099 AgrOrtholog
BioCyc Gene G2FUF-39422 BioCyc
Ensembl Genes ENSRNOG00000007330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010308.8 UniProtKB/TrEMBL
  ENSRNOT00000083577.2 UniProtKB/TrEMBL
  ENSRNOT00000099328 ENTREZGENE
  ENSRNOT00000099328.1 UniProtKB/TrEMBL
  ENSRNOT00000100786.1 UniProtKB/TrEMBL
  ENSRNOT00000101104 ENTREZGENE
  ENSRNOT00000101104.1 UniProtKB/TrEMBL
  ENSRNOT00000104673.1 UniProtKB/TrEMBL
  ENSRNOT00000106969 ENTREZGENE
  ENSRNOT00000106969.1 UniProtKB/TrEMBL
  ENSRNOT00000110243.1 UniProtKB/TrEMBL
  ENSRNOT00000115619.1 UniProtKB/TrEMBL
  ENSRNOT00000118044.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Capz alpha-1 subunit UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126848 IMAGE-MGC_LOAD
InterPro CapZ_alpha/beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CapZ_alpha/beta_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPZB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPZB_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-actin_capping_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298584 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95097 IMAGE-MGC_LOAD
NCBI Gene 298584 ENTREZGENE
PANTHER F-ACTIN-CAPPING PROTEIN SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F_actin_cap_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Capzb PhenoGen
PRINTS FACTINCAPB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE F_ACTIN_CAPPING_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007330 RatGTEx
Superfamily-SCOP SSF90096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYB1_RAT UniProtKB/TrEMBL
  A0A8I6A3B7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIB2_RAT UniProtKB/TrEMBL
  A0A8I6ATR2_RAT UniProtKB/TrEMBL
  A0A8I6AWP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWW7_RAT UniProtKB/TrEMBL
  A0A8I6GFB3_RAT UniProtKB/TrEMBL
  A0A8I6GIW5_RAT UniProtKB/TrEMBL
  A0A8L2Q5I8 ENTREZGENE, UniProtKB/TrEMBL
  A6ITK5 ENTREZGENE, UniProtKB/TrEMBL
  A6ITK6_RAT UniProtKB/TrEMBL
  A6ITK7_RAT UniProtKB/TrEMBL
  A6ITL0_RAT UniProtKB/TrEMBL
  CAPZB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Capzb  capping actin protein of muscle Z-line subunit beta  Capzb  capping actin protein of muscle Z-line beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Capzb  capping actin protein of muscle Z-line beta subunit  Capzb  capping protein (actin filament) muscle Z-line, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Capzb  capping protein (actin filament) muscle Z-line, beta    F-actin capping protein beta subunit  Name updated 1299863 APPROVED
2005-07-29 Capzb  F-actin capping protein beta subunit      Symbol and Name status set to provisional 70820 PROVISIONAL