Gene: Akr7a2 (aldo-keto reductase family 7, member A2) Rattus norvegicus
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Symbol: Akr7a2
Name: aldo-keto reductase family 7, member A2
Description: ENCODES a protein that exhibits alditol:NADP+ 1-oxidoreductase activity; phenanthrene-9,10-epoxide hydrolase activity (ortholog); INVOLVED IN daunorubicin metabolic process (ortholog); doxorubicin metabolic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); pancreatic ductal adenocarcinoma (ortholog); FOUND IN cytoplasm; Golgi apparatus; nuclear envelope; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol
AGR Description: Exhibits alditol:NADP+ 1-oxidoreductase activity; predicted to be involved in daunorubicin metabolic process and doxorubicin metabolic process; localizes to the Golgi apparatus; orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2).
Merged Description: Exhibits alditol:NADP+ 1-oxidoreductase activity; predicted to be involved in daunorubicin metabolic process and doxorubicin metabolic process; localizes to the Golgi apparatus; orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aflatoxin B1 aldehyde reductase member 2; Aiar; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); rAFAR2; SSA reductase; succinic semialdehyde reductase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05157,759,448 - 157,768,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05161,499,603 - 161,508,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,097,679 - 158,106,217 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15158,107,717 - 158,116,254 (+)NCBI
Celera5149,932,592 - 149,941,127 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Akr7a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620311
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.