AKR7A2 (aldo-keto reductase family 7 member A2) - Rat Genome Database

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Gene: AKR7A2 (aldo-keto reductase family 7 member A2) Homo sapiens
Analyze
Symbol: AKR7A2
Name: aldo-keto reductase family 7 member A2
RGD ID: 732683
HGNC Page HGNC:389
Description: Enables phenanthrene-9,10-epoxide hydrolase activity. Involved in daunorubicin metabolic process and doxorubicin metabolic process. Located in Golgi apparatus and cytosol. Biomarker of Alzheimer's disease and pancreatic ductal adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AFAR; AFAR1; AFB1 aldehyde reductase 1; AFB1-AR 1; AFB1-AR1; aflatoxin aldehyde reductase; aflatoxin B1 aldehyde reductase member 2; aflatoxin beta1 aldehyde reductase; AKR7; aldo-keto reductase family 7, member A2; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); aldoketoreductase 7; epididymis secretory sperm binding protein Li 166mP; HEL-S-166mP; SSA reductase; succinic semialdehyde reductase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AKR7A2P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,302,708 - 19,312,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,301,991 - 19,312,144 (-)EnsemblGRCh38hg38GRCh38
GRCh37119,629,202 - 19,638,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,503,046 - 19,511,227 (-)NCBINCBI36Build 36hg18NCBI36
Build 34119,375,768 - 19,383,946NCBI
Celera117,957,442 - 17,965,624 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,875,577 - 17,884,829 (-)NCBIHuRef
CHM1_1119,738,505 - 19,747,943 (-)NCBICHM1_1
T2T-CHM13v2.0119,126,242 - 19,135,681 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
16-Ketoestrone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (EXP)
2-nitrobenzaldehyde  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-nitrobenzaldehyde  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (EXP)
4-nitrobenzaldehyde  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
9,10-phenanthroquinone  (EXP,ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (EXP)
alpha-pinene  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
antimycin A  (EXP)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene-7,8-dione  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (EXP)
Brodifacoum  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
chlordecone  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
deguelin  (EXP)
deoxycholic acid  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
etacrynic acid  (ISO)
fenpyroximate  (EXP)
folic acid  (ISO)
FR900359  (EXP)
fulvestrant  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
hexanal  (ISO)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (ISO)
isatin  (EXP,ISO)
ivermectin  (EXP)
L-ethionine  (ISO)
leflunomide  (ISO)
menadione  (EXP,ISO)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP,ISO)
Muconic dialdehyde  (EXP,ISO)
N-nitrosomorpholine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalenes  (EXP)
naringin  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
non-2-enal  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phlorizin  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
Propiverine  (ISO)
pyrimidifen  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
succinic semialdehyde  (EXP,ISO)
superoxide  (EXP)
tartrazine  (EXP)
tebufenpyrad  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
umbelliferone  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IDA,TAS)
extracellular exosome  (HDA)
Golgi apparatus  (IDA,IEA)
mitochondrion  (HTP,IEA)
nuclear envelope  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. Cui Y, etal., Pancreatology. 2009;9(1-2):89-98. Epub 2008 Dec 12.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease. Picklo MJ, etal., Brain Res. 2001 Oct 19;916(1-2):229-38.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:8889549   PMID:9576847   PMID:9823300   PMID:12071861   PMID:12477932   PMID:12879023   PMID:15489334   PMID:15967462   PMID:16189514   PMID:16429158   PMID:16710414  
PMID:17591773   PMID:18752886   PMID:19056867   PMID:19738201   PMID:20837989   PMID:20877624   PMID:21044367   PMID:21873635   PMID:22623428   PMID:23533145   PMID:25027672   PMID:25416956  
PMID:25451587   PMID:26186194   PMID:26344197   PMID:26496610   PMID:27432908   PMID:28380382   PMID:28514442   PMID:28536627   PMID:29150431   PMID:30561431   PMID:30817976   PMID:31091453  
PMID:31182584   PMID:31515488   PMID:32296183   PMID:32814053   PMID:32989298   PMID:33545068   PMID:33845483   PMID:33961781   PMID:34349018   PMID:34800366   PMID:35032548   PMID:35256949  
PMID:35446349   PMID:35831314   PMID:35944360   PMID:36215168   PMID:36339263   PMID:36736316   PMID:36758106   PMID:37506885   PMID:38334954  


Genomics

Comparative Map Data
AKR7A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,302,708 - 19,312,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,301,991 - 19,312,144 (-)EnsemblGRCh38hg38GRCh38
GRCh37119,629,202 - 19,638,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36119,503,046 - 19,511,227 (-)NCBINCBI36Build 36hg18NCBI36
Build 34119,375,768 - 19,383,946NCBI
Celera117,957,442 - 17,965,624 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef117,875,577 - 17,884,829 (-)NCBIHuRef
CHM1_1119,738,505 - 19,747,943 (-)NCBICHM1_1
T2T-CHM13v2.0119,126,242 - 19,135,681 (-)NCBIT2T-CHM13v2.0
Akr7a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394139,038,005 - 139,046,097 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4139,038,055 - 139,045,737 (+)EnsemblGRCm39 Ensembl
GRCm384139,310,720 - 139,318,786 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4139,310,744 - 139,318,426 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,866,659 - 138,874,701 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,582,820 - 138,590,501 (+)NCBIMGSCv36mm8
Celera4141,097,258 - 141,105,993 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.64NCBI
Akr7a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,835,589 - 156,844,127 (+)NCBIGRCr8
mRatBN7.25151,552,375 - 151,560,914 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,552,343 - 151,560,909 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5154,250,866 - 154,259,404 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05156,025,214 - 156,033,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05156,006,202 - 156,014,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,759,448 - 157,768,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,759,416 - 157,768,471 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,499,603 - 161,508,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45158,097,679 - 158,106,217 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15158,107,717 - 158,116,254 (+)NCBI
Celera5149,932,592 - 149,941,127 (+)NCBICelera
Cytogenetic Map5q36NCBI
Akr7a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554526,844 - 13,868 (-)NCBIChiLan1.0ChiLan1.0
LOC100981962
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,802,957 - 207,822,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,919,935 - 206,938,840 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,262,631 - 18,270,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,309,211 - 19,317,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,309,471 - 19,317,227 (-)Ensemblpanpan1.1panPan2
AKR7A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,334,179 - 79,343,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,334,205 - 79,343,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,849,105 - 75,858,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,956,898 - 79,965,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,956,898 - 79,968,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,717,803 - 76,726,853 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,727,438 - 77,736,710 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,798,535 - 78,808,663 (+)NCBIUU_Cfam_GSD_1.0
LOC101974041
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505839,740,406 - 39,748,246 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364745,565,715 - 5,573,048 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR7A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl677,754,174 - 77,761,667 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1677,754,172 - 77,761,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2671,816,268 - 71,823,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225480
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120113,234,257 - 113,242,445 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660332,916,852 - 2,925,038 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in AKR7A2
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.21-36.12(chr1:15385267-20980349)x1 copy number loss See cases [RCV000051146] Chr1:15385267..20980349 [GRCh38]
Chr1:15711763..21306842 [GRCh37]
Chr1:15584350..21179429 [NCBI36]
Chr1:1p36.21-36.12		 pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:13110797-20670207)x3 copy number gain See cases [RCV000051797] Chr1:13110797..20670207 [GRCh38]
Chr1:13178269..20996700 [GRCh37]
Chr1:13100856..20869287 [NCBI36]
Chr1:1p36.21-36.12		 pathogenic
GRCh38/hg38 1p36.13-36.12(chr1:18347821-22512894)x1 copy number loss See cases [RCV000053789] Chr1:18347821..22512894 [GRCh38]
Chr1:18674315..22839387 [GRCh37]
Chr1:18546902..22711974 [NCBI36]
Chr1:1p36.13-36.12		 pathogenic
GRCh38/hg38 1p36.22-36.12(chr1:10556797-22557907)x1 copy number loss See cases [RCV000053760] Chr1:10556797..22557907 [GRCh38]
Chr1:10616854..22884400 [GRCh37]
Chr1:10539441..22756987 [NCBI36]
Chr1:1p36.22-36.12		 pathogenic
GRCh38/hg38 1p36.13(chr1:18989947-19499528)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053791]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053791]|See cases [RCV000053791] Chr1:18989947..19499528 [GRCh38]
Chr1:19316441..19826022 [GRCh37]
Chr1:19189028..19698609 [NCBI36]
Chr1:1p36.13		 pathogenic
GRCh38/hg38 1p36.13(chr1:19093306-20063342)x1 copy number loss See cases [RCV000053793] Chr1:19093306..20063342 [GRCh38]
Chr1:19419800..20389835 [GRCh37]
Chr1:19292387..20262422 [NCBI36]
Chr1:1p36.13		 pathogenic
GRCh38/hg38 1p36.21-36.13(chr1:15681812-19662339)x1 copy number loss See cases [RCV000138070] Chr1:15681812..19662339 [GRCh38]
Chr1:16008307..19988832 [GRCh37]
Chr1:15880894..19861419 [NCBI36]
Chr1:1p36.21-36.13		 pathogenic
GRCh38/hg38 1p36.13(chr1:19169253-19797307)x3 copy number gain See cases [RCV000141322] Chr1:19169253..19797307 [GRCh38]
Chr1:19495747..20123800 [GRCh37]
Chr1:19368334..19996387 [NCBI36]
Chr1:1p36.13		 likely benign
GRCh38/hg38 1p36.13(chr1:19169253-19415934)x1 copy number loss See cases [RCV000140822] Chr1:19169253..19415934 [GRCh38]
Chr1:19495747..19742428 [GRCh37]
Chr1:19368334..19615015 [NCBI36]
Chr1:1p36.13		 uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11		 uncertain significance
chr1:17555508-24706269 complex variant complex Breast ductal adenocarcinoma [RCV000207266] Chr1:17555508..24706269 [GRCh37]
Chr1:1p36.13-36.11		 uncertain significance
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1 copy number loss See cases [RCV000446470] Chr1:2749920..22564787 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
GRCh37/hg19 1p36.21-36.13(chr1:13178371-19961858)x1 copy number loss See cases [RCV000447987] Chr1:13178371..19961858 [GRCh37]
Chr1:1p36.21-36.13		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_003689.4(AKR7A2):c.1076G>A (p.Arg359His) single nucleotide variant not specified [RCV004320930] Chr1:19304229 [GRCh38]
Chr1:19630723 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.374C>T (p.Thr125Met) single nucleotide variant not specified [RCV004287928] Chr1:19308567 [GRCh38]
Chr1:19635061 [GRCh37]
Chr1:1p36.13		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NC_000001.10:g.(?_19199339)_(22987879_?)dup duplication Autosomal recessive early-onset Parkinson disease 6 [RCV003113320]|Congenital disorder of glycosylation type Ir [RCV003113321]|Hyperprolinemia type 2 [RCV003107740] Chr1:19199339..22987879 [GRCh37]
Chr1:1p36.13-36.12		 uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:16785250-23491592)x1 copy number loss 1p36.1 deletion syndrome [RCV001614471] Chr1:16785250..23491592 [GRCh37]
Chr1:1p36.13-36.12		 pathogenic
NM_003689.4(AKR7A2):c.538G>A (p.Glu180Lys) single nucleotide variant not provided [RCV000970938] Chr1:19308211 [GRCh38]
Chr1:19634705 [GRCh37]
Chr1:1p36.13		 benign
GRCh37/hg19 1p36.13-36.12(chr1:17284906-21778495)x1 copy number loss not provided [RCV001259567] Chr1:17284906..21778495 [GRCh37]
Chr1:1p36.13-36.12		 pathogenic
GRCh37/hg19 1p36.21-36.12(chr1:16041431-21295864)x1 copy number loss not provided [RCV001259568] Chr1:16041431..21295864 [GRCh37]
Chr1:1p36.21-36.12		 pathogenic
GRCh37/hg19 1p36.13(chr1:16773001-20221073)x1 copy number loss not provided [RCV001829114] Chr1:16773001..20221073 [GRCh37]
Chr1:1p36.13		 pathogenic
NC_000001.10:g.(?_19199339)_(24690861_?)dup duplication Deficiency of hydroxymethylglutaryl-CoA lyase [RCV003122155] Chr1:19199339..24690861 [GRCh37]
Chr1:1p36.13-36.11		 uncertain significance
NM_003689.4(AKR7A2):c.443C>A (p.Pro148Gln) single nucleotide variant not specified [RCV004327261] Chr1:19308498 [GRCh38]
Chr1:19634992 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.425C>T (p.Ala142Val) single nucleotide variant not specified [RCV004100774] Chr1:19308516 [GRCh38]
Chr1:19635010 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.857C>T (p.Ala286Val) single nucleotide variant not specified [RCV004077209] Chr1:19306079 [GRCh38]
Chr1:19632573 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.614G>A (p.Arg205Gln) single nucleotide variant not specified [RCV004202903] Chr1:19307388 [GRCh38]
Chr1:19633882 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.44A>G (p.His15Arg) single nucleotide variant not specified [RCV004084616] Chr1:19312081 [GRCh38]
Chr1:19638575 [GRCh37]
Chr1:1p36.13		 likely benign
NM_003689.4(AKR7A2):c.25G>T (p.Val9Phe) single nucleotide variant not specified [RCV004132218] Chr1:19312100 [GRCh38]
Chr1:19638594 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.10G>T (p.Ala4Ser) single nucleotide variant not specified [RCV004100576] Chr1:19312115 [GRCh38]
Chr1:19638609 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.115G>T (p.Ala39Ser) single nucleotide variant not specified [RCV004225516] Chr1:19312010 [GRCh38]
Chr1:19638504 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.716A>G (p.Tyr239Cys) single nucleotide variant not specified [RCV004115876] Chr1:19307074 [GRCh38]
Chr1:19633568 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.76C>T (p.Arg26Cys) single nucleotide variant not specified [RCV004174850] Chr1:19312049 [GRCh38]
Chr1:19638543 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.443C>T (p.Pro148Leu) single nucleotide variant not specified [RCV004209053] Chr1:19308498 [GRCh38]
Chr1:19634992 [GRCh37]
Chr1:1p36.13		 uncertain significance
NC_000001.10:g.4481271_20530242del deletion Chromosome 1p36 deletion syndrome [RCV003159574] Chr1:4481271..20530242 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
NM_003689.4(AKR7A2):c.556A>C (p.Lys186Gln) single nucleotide variant not specified [RCV004318438] Chr1:19308193 [GRCh38]
Chr1:19634687 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.935C>G (p.Ala312Gly) single nucleotide variant not specified [RCV004314218] Chr1:19304370 [GRCh38]
Chr1:19630864 [GRCh37]
Chr1:1p36.13		 uncertain significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1		 pathogenic
GRCh37/hg19 1p36.13-36.12(chr1:17291707-23016395)x4 copy number gain not provided [RCV003485339] Chr1:17291707..23016395 [GRCh37]
Chr1:1p36.13-36.12		 likely pathogenic
GRCh37/hg19 1p36.13(chr1:18127009-20315260)x3 copy number gain not provided [RCV003484009] Chr1:18127009..20315260 [GRCh37]
Chr1:1p36.13		 uncertain significance
GRCh37/hg19 1p36.21-36.12(chr1:16194137-20561434)x1 copy number loss not specified [RCV003986551] Chr1:16194137..20561434 [GRCh37]
Chr1:1p36.21-36.12		 pathogenic
NM_003689.4(AKR7A2):c.584T>A (p.Val195Glu) single nucleotide variant not specified [RCV004399977] Chr1:19308165 [GRCh38]
Chr1:19634659 [GRCh37]
Chr1:1p36.13		 uncertain significance
GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2 copy number loss not provided [RCV004577440] Chr1:4436802..22782007 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
NM_003689.4(AKR7A2):c.724A>G (p.Lys242Glu) single nucleotide variant not specified [RCV004399986] Chr1:19307066 [GRCh38]
Chr1:19633560 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.1010C>T (p.Pro337Leu) single nucleotide variant not specified [RCV004399950] Chr1:19304295 [GRCh38]
Chr1:19630789 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.730G>A (p.Gly244Arg) single nucleotide variant not specified [RCV004399991] Chr1:19307060 [GRCh38]
Chr1:19633554 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.197G>T (p.Arg66Leu) single nucleotide variant not specified [RCV004399960] Chr1:19311928 [GRCh38]
Chr1:19638422 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.37G>A (p.Ala13Thr) single nucleotide variant not specified [RCV004399965] Chr1:19312088 [GRCh38]
Chr1:19638582 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.7A>C (p.Ser3Arg) single nucleotide variant not specified [RCV004399996] Chr1:19312118 [GRCh38]
Chr1:19638612 [GRCh37]
Chr1:1p36.13		 likely benign
NM_003689.4(AKR7A2):c.826G>C (p.Val276Leu) single nucleotide variant not specified [RCV004400002] Chr1:19306110 [GRCh38]
Chr1:19632604 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.92C>A (p.Ser31Tyr) single nucleotide variant not specified [RCV004634863] Chr1:19312033 [GRCh38]
Chr1:19638527 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.758G>C (p.Gly253Ala) single nucleotide variant not specified [RCV004634880] Chr1:19307032 [GRCh38]
Chr1:19633526 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.550C>T (p.Leu184Phe) single nucleotide variant not specified [RCV004634853] Chr1:19308199 [GRCh38]
Chr1:19634693 [GRCh37]
Chr1:1p36.13		 uncertain significance
NM_003689.4(AKR7A2):c.242A>G (p.Gln81Arg) single nucleotide variant not specified [RCV004634871] Chr1:19311883 [GRCh38]
Chr1:19638377 [GRCh37]
Chr1:1p36.13		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1093
Count of miRNA genes:574
Interacting mature miRNAs:641
Transcripts:ENST00000235835, ENST00000330072, ENST00000481966, ENST00000489286, ENST00000492217
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
407391723GWAS1040699_Haflatoxin B1 aldehyde reductase member 2 measurement QTL GWAS1040699 (human)4e-46aflatoxin B1 aldehyde reductase member 2 measurement11930364919303650Human
407158401GWAS807377_Hurinary metabolite measurement QTL GWAS807377 (human)2e-26urinary metabolite measurement11930851719308518Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
406960397GWAS609373_Haflatoxin B1 aldehyde reductase member 2 measurement QTL GWAS609373 (human)4e-20aflatoxin B1 aldehyde reductase member 2 measurement11931181519311816Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
407153483GWAS802459_Hurinary metabolite measurement QTL GWAS802459 (human)2e-412urinary metabolite measurement11930851719308518Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407391514GWAS1040490_HX-24462 measurement QTL GWAS1040490 (human)2e-779X-24462 measurement11930328519303286Human
407391515GWAS1040491_HX-24462 measurement QTL GWAS1040491 (human)9e-991X-24462 measurement11930328519303286Human
407214801GWAS863777_Hblood protein measurement QTL GWAS863777 (human)2e-09blood protein measurementblood protein measurement (CMO:0000028)11931181519311816Human
406959833GWAS608809_Haging QTL GWAS608809 (human)3e-08aging11930364919303650Human
407409777GWAS1058753_HX-24462 measurement QTL GWAS1058753 (human)4e-426X-24462 measurement11930328519303286Human
407210748GWAS859724_Hviral load QTL GWAS859724 (human)2e-17viral load11930847019308471Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human

Markers in Region
STS-AA037839  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,629,207 - 19,629,449UniSTSGRCh37
Build 36119,501,794 - 19,502,036RGDNCBI36
Celera117,956,190 - 17,956,432RGD
Cytogenetic Map1p36.13UniSTS
HuRef117,875,582 - 17,875,824UniSTS
GeneMap99-GB4 RH Map173.55UniSTS
NCBI RH Map1104.1UniSTS
D1S316E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,630,602 - 19,630,673UniSTSGRCh37
Build 36119,503,189 - 19,503,260RGDNCBI36
Celera117,957,585 - 17,957,656RGD
Cytogenetic Map1p36.13UniSTS
HuRef117,876,977 - 17,877,048UniSTS
D1S2409  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,630,638 - 19,630,757UniSTSGRCh37
Build 36119,503,225 - 19,503,344RGDNCBI36
Celera117,957,621 - 17,957,740RGD
Cytogenetic Map1p36.13UniSTS
HuRef117,877,013 - 17,877,132UniSTS
GeneMap99-GB4 RH Map174.02UniSTS
GeneMap99-GB4 RH Map175.38UniSTS
Whitehead-RH Map168.2UniSTS
Whitehead-YAC Contig Map1 UniSTS
SHGC-74333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37119,630,682 - 19,630,779UniSTSGRCh37
GRCh37119,593,757 - 19,593,854UniSTSGRCh37
Build 36119,466,344 - 19,466,441RGDNCBI36
Celera117,957,665 - 17,957,762UniSTS
Celera117,920,741 - 17,920,838RGD
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map1p35-p36.1UniSTS
HuRef117,840,127 - 17,840,224UniSTS
HuRef117,877,057 - 17,877,154UniSTS
GeneMap99-GB4 RH Map175.38UniSTS
NCBI RH Map1110.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001320979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054339348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_946785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA037839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF026947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG385885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG386786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK000395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM551906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU944847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX401279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000235835   ⟹   ENSP00000235835
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,303,965 - 19,312,144 (-)Ensembl
Ensembl Acc Id: ENST00000330072   ⟹   ENSP00000339084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,301,991 - 19,312,124 (-)Ensembl
Ensembl Acc Id: ENST00000481966   ⟹   ENSP00000417891
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,304,285 - 19,308,505 (-)Ensembl
Ensembl Acc Id: ENST00000489286   ⟹   ENSP00000419936
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,304,166 - 19,311,907 (-)Ensembl
Ensembl Acc Id: ENST00000492217
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,307,739 - 19,312,103 (-)Ensembl
RefSeq Acc Id: NM_001320979   ⟹   NP_001307908
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,302,708 - 19,312,146 (-)NCBI
CHM1_1119,738,505 - 19,747,943 (-)NCBI
T2T-CHM13v2.0119,126,242 - 19,135,681 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003689   ⟹   NP_003680
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,303,965 - 19,312,144 (-)NCBI
GRCh37119,629,202 - 19,638,640 (-)NCBI
Build 36119,503,046 - 19,511,227 (-)NCBI Archive
HuRef117,875,577 - 17,884,829 (-)NCBI
CHM1_1119,738,505 - 19,747,943 (-)NCBI
T2T-CHM13v2.0119,127,499 - 19,135,679 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047433095   ⟹   XP_047289051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,307,002 - 19,312,144 (-)NCBI
RefSeq Acc Id: XM_054339348   ⟹   XP_054195323
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0119,130,537 - 19,135,679 (-)NCBI
RefSeq Acc Id: NP_003680   ⟸   NM_003689
- Peptide Label: isoform 1
- UniProtKB: O75749 (UniProtKB/Swiss-Prot),   Q5TG63 (UniProtKB/Swiss-Prot),   O43488 (UniProtKB/Swiss-Prot),   V9HWA2 (UniProtKB/TrEMBL),   H3BLU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307908   ⟸   NM_001320979
- Peptide Label: isoform 2
- UniProtKB: H3BLU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000417891   ⟸   ENST00000481966
Ensembl Acc Id: ENSP00000235835   ⟸   ENST00000235835
Ensembl Acc Id: ENSP00000419936   ⟸   ENST00000489286
Ensembl Acc Id: ENSP00000339084   ⟸   ENST00000330072
RefSeq Acc Id: XP_047289051   ⟸   XM_047433095
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054195323   ⟸   XM_054339348
- Peptide Label: isoform X1
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O43488-F1-model_v2 AlphaFold O43488 1-359 view protein structure

Promoters
RGD ID:6854326
Promoter ID:EPDNEW_H327
Type:initiation region
Name:AKR7A2_1
Description:aldo-keto reductase family 7 member A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,312,103 - 19,312,163EPDNEW
RGD ID:6784594
Promoter ID:HG_KWN:1089
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000330072,   NM_001040125,   NM_001040126,   NM_017765,   UC001BBX.1,   UC001BCB.1,   UC001BCC.1,   UC009VPI.1,   UC009VPJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36119,511,051 - 19,511,982 (-)MPROMDB
RGD ID:6853216
Promoter ID:EP74429
Type:initiation region
Name:HS_AKR7A2
Description:Aldo-keto reductase family 7, member A2 (aflatoxin aldehydereductase).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36119,511,169 - 19,511,229EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:389 AgrOrtholog
COSMIC AKR7A2 COSMIC
Ensembl Genes ENSG00000053371 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000235835 ENTREZGENE
  ENST00000235835.8 UniProtKB/Swiss-Prot
  ENST00000330072 ENTREZGENE
  ENST00000330072.9 UniProtKB/TrEMBL
  ENST00000481966.1 UniProtKB/TrEMBL
  ENST00000489286.5 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000053371 GTEx
HGNC ID HGNC:389 ENTREZGENE
Human Proteome Map AKR7A2 Human Proteome Map
InterPro AKR_Detox_Biosynth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8574 ENTREZGENE
OMIM 603418 OMIM
PANTHER NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24682 PharmGKB
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARK72_HUMAN UniProtKB/Swiss-Prot
  B4DZX4_HUMAN UniProtKB/TrEMBL
  H3BLU7 ENTREZGENE, UniProtKB/TrEMBL
  H7C4Q7_HUMAN UniProtKB/TrEMBL
  H7C5H7_HUMAN UniProtKB/TrEMBL
  O43488 ENTREZGENE
  O75749 ENTREZGENE
  Q5TG63 ENTREZGENE
  V9HWA2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O75749 UniProtKB/Swiss-Prot
  Q5TG63 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-07 AKR7A2  aldo-keto reductase family 7 member A2    aldo-keto reductase family 7, member A2  Symbol and/or name change 5135510 APPROVED
2015-06-09 AKR7A2  aldo-keto reductase family 7, member A2    aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)  Symbol and/or name change 5135510 APPROVED