OSTEAR17_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: OSTEAR17_H (Osteoarthritis QTL 17 (human)) Homo sapiens

Symbol: OSTEAR17_H
Name: Osteoarthritis QTL 17 (human)
RGD ID: 1298451
Previously known as: OA17_H
Trait: Joint/bone inflammation
Measurement Type: osteoarthritis
LOD Score: 2.4
P Value: 4.0E-4
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3811 - 25,188,105RGD_MAPPER_PIPELINEGRCh38
GRCh3711 - 25,248,162RGD_MAPPER_PIPELINEGRCh37
Build 3611 - 25,170,755RGDNCBI36
Build 34111 - 27,161,408RGD
Population Stats: affected sib pairs who have undergone total joint replacement surgery for ideopathic osteoarthritis
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
OSTEAR17_HHumanosteoarthritis  IDA 1285222 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
OSTEAR17_HHumanArthritis  QTM 1285222 RGD 

#
Reference Title
Reference Citation
1. Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage. Chapman K, etal., Am J Hum Genet 1999 Jul;65(1):167-74.


1 to 20 of 3418 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
3231842DDX11L1DEAD/H-box helicase 11 like 1 (pseudogene)11187414409Human
4145492WASH7PWASP family homolog 7, pseudogene11436229370Human
8551045MIR6859-1microRNA 6859-111736917436Human
155782958LOC127898558H3K4me1 hESC enhancer GRCh37_chr1:20498-2134612049821346Human
11563962MIR1302-2HGMIR1302-2 host gene12977435418Human
2312889MIR1302-2microRNA 1302-213036630503Human
2303654FAM138Afamily with sequence similarity 138 member A13461136081Human
1352059OR4G4Polfactory receptor family 4 subfamily G member 4 pseudogene15245353396Human
1354219OR4G11Polfactory receptor family 4 subfamily G member 11 pseudogene16301663885Human
1346395OR4F5olfactory receptor family 4 subfamily F member 516541971585Human
151669486LOC124903816uncharacterized LOC124903816195222107727Human
151673033LOC124900384uncharacterized LOC1249003841120849175246Human
10755371SEPTIN14P18septin 14 pseudogene 181126642129225Human
7247019CICP27capicua transcriptional repressor pseudogene 271131068134836Human
38661053LOC729737uncharacterized LOC7297371134773140566Human
10412466RNU6-1100PRNA, U6 small nuclear 1100, pseudogene1157784157887Human
11041832GTF2IP10general transcription factor IIi pseudogene 101164689164792Human
155634060LOC127266738H3K4me1 hESC enhancer GRCh37_chr1:172206-1727061172206172706Human
151672655LOC124903814uncharacterized LOC1249038141177308180105Human
30310006DDX11L17DEAD/H-box helicase 11 like 17 (pseudogene)1182388184878Human

1 to 20 of 3418 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
2181539D1S372013812058543520585572Humanregion

Peak: (TNFRSF1B)
Human AssemblyChrPosition (strand)Source
GRCh38112,166,991 - 12,209,220 (+)NCBI
GRCh38.p14 Ensembl112,166,991 - 12,209,228 (+)Ensembl
GRCh37112,227,048 - 12,269,277 (+)NCBI
Build 36112,149,647 - 12,191,864 (+)NCBI
Build 34112,161,325 - 12,203,542NCBI
Celera111,340,352 - 11,382,470 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,380,310 - 11,422,542 (+)NCBI
CHM1_1112,214,947 - 12,257,256 (+)NCBI
T2T-CHM13v2.0111,711,114 - 11,753,352 (+)NCBI


1 to 10 of 5560 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597459869GWAS1555943_Hcorneal resistance factor QTL GWAS1555943 (human)5e-12corneal resistance factor11154064811540649Human
597246876GWAS1342950_Halkaline phosphatase measurement QTL GWAS1342950 (human)2e-23alkaline phosphatase measurementblood alkaline phosphatase activity level (CMO:0000576)12182362721823628Human
597607319GWAS1664179_Hsystolic blood pressure QTL GWAS1664179 (human)3e-50systolic blood pressuresystolic blood pressure (CMO:0000004)11073680910736810Human
597279632GWAS1375706_Hhypothyroidism QTL GWAS1375706 (human)7e-10hypothyroidism11220386212203863Human
597410704GWAS1506778_Hremission QTL GWAS1506778 (human)0.0000006remission12196216321962164Human
597599120GWAS1655980_Hserum alanine aminotransferase measurement QTL GWAS1655980 (human)2e-16serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11618439916184400Human
407001165GWAS650141_Hresponse to non-steroidal anti-inflammatory, drug-induced liver injury QTL GWAS650141 (human)0.0000003response to non-steroidal anti-inflammatory, drug-induced liver injury168456516845652Human
597091206GWAS1187280_Hbody mass index QTL GWAS1187280 (human)0.0000006body mass indexbody mass index (BMI) (CMO:0000105)117915921791593Human
597271433GWAS1367507_Hresponse to lithium ion QTL GWAS1367507 (human)0.000004response to lithium ion135433033543304Human
596968324GWAS1087843_Hsystolic blood pressure QTL GWAS1087843 (human)7e-13systolic blood pressure11572245615722457Human

1 to 10 of 5560 rows


Database
Acc Id
Source(s)
NCBI Gene OSTEAR17_H
OMIM 165720


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 OSTEAR17_H  Osteoarthritis QTL 17 (human)  OA17_H    Symbol updated 1299863 APPROVED

Note Type Note Reference
qtl_population affected sib pairs who have undergone total joint replacement surgery for ideopathic osteoarthritis 1285222
qtl_population_details genomewide scans were conducted from 481 families from the United Kingdom that contained at least one affected sib pair; 641 total individuals included 394 women and 247 men of average age 66 yrs 1285222
qtl_statistics_details linkage analysis was performed with SIBPAIR module of ANALYZE program 1285222
qtl_statistics_details greater evidence for linkage in females with hip-replacement (P = 0.0024) than with knee-replacement (P = 0.5); males showed no significant linkage 1285222
qtl_statistics_details for female sib pairs, corrected LOD = 2.54 and P = 0.0003; no significant linkage was found among male sib pairs 1285222