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Gene: CLCNKA (chloride voltage-gated channel Ka) Homo sapiens
Symbol: CLCNKA
Name: chloride voltage-gated channel Ka
Description: This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel Ka; chloride channel protein ClC-Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; ClC-K1; CLCK1; hClC-Ka; MGC61490
Mus musculus (house mouse) : Clcnka (chloride channel, voltage-sensitive Ka)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcnka (chloride voltage-gated channel Ka)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CLCNKA (chloride voltage-gated channel Ka)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcnka (chloride voltage-gated channel Ka)
Sus scrofa (pig) : CLCNKA (chloride channel protein ClC-Ka)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38116,022,036 - 16,034,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,348,486 - 16,360,548 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,221,073 - 16,233,132 (+)NCBINCBI36hg18NCBI36
Build 34116,094,415 - 16,105,850NCBI
Celera114,828,391 - 14,840,450 (+)NCBI
Cytogenetic Map1p36.13NCBI
HuRef114,867,532 - 14,879,195 (+)NCBIHuRef
CHM1_1116,146,987 - 16,159,046 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCNKA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68651
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.