GWAS1157308_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1157308_H (FEV/FVC ratio QTL GWAS1157308 (human)) Homo sapiens

Symbol: GWAS1157308_H
Name: FEV/FVC ratio QTL GWAS1157308 (human)
RGD ID: 597061234
Trait: FEV/FVC ratio
Measurement Type: forced expiratory volume to forced vital capacity ratio   (CMO:0000241)    
LOD Score: Not Available
P Value: 2.0E-14
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38124,914,625 - 24,914,626RGD_MAPPER_PIPELINEGRCh38
GRCh37125,241,116 - 25,241,117RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model




Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1157308_HHumanforced expiratory volume to forced vital capacity ratio  IAGPrs9438876405850206 GWAS_CATALOGPMID:30595370

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1157308_HHumanFEV/FVC ratio  IAGPrs9438876405850206 GWAS_CATALOGPMID:30595370

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records


The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1351530RUNX3RUNX family transcription factor 312489951124965138Human
155633309LOC127268142H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25240971-2524148612491448024914995Human


Peak: (rs9438876)
Human AssemblyChrPosition (strand)Source
GRCh38124,914,625 - 24,914,626RGD_MAPPER_PIPELINE


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
597061234GWAS1157308_HFEV/FVC ratio QTL GWAS1157308 (human)2e-14FEV/FVC ratioforced expiratory volume to forced vital capacity ratio (CMO:0000241)12491462524914626Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
597326231GWAS1422305_HFEV/FVC ratio QTL GWAS1422305 (human)4e-14FEV/FVC ratioforced expiratory volume to forced vital capacity ratio (CMO:0000241)12491462524914626Human
597139529GWAS1235603_Hchronic obstructive pulmonary disease QTL GWAS1235603 (human)3e-13lung integrity trait (VT:0010906)12491462524914626Human



Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1157308_H GCST007080 Lung function (FEV1/FVC) approximately 370,000 European ancestry individuals ? NR 2E-14 13.699 rs9438876 N/A FEV/FVC ratio (EFO:0004713)
 PMID:30595370
GWAS1712735_H GCST007841 Height approximately 458,000 European ancestry individuals ? NR 1E-8 8 rs9438876 N/A body height (OBA:VT0001253)
 PMID:30595370
GWAS1235603_H GCST90244098 Chronic obstructive pulmonary disease liability (machine learning-based score) 325,027 European ancestry individuals A NR 3E-13 12.523 rs9438876 0.0152315 chronic obstructive pulmonary disease (EFO:0000341)
 PMID:37069358
GWAS1422305_H GCST90244094 Lung function (FEV1/FVC) 475,645 European ancestry individuals, 8,590 African ancestry individuals, 85,279 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 14,668 Hispanic or Latin American individuals A 0.514 4E-14 13.398 rs9438876 7.57 FEV/FVC ratio (EFO:0004713)
 PMID:36914875
Database
Acc Id
Source(s)
GWAS Catalog GCST007080 GWAS Catalog

Note Type Note Reference