GWAS1497417_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1497417_H (serum alanine aminotransferase measurement QTL GWAS1497417 (human)) Homo sapiens

Symbol: GWAS1497417_H
Name: serum alanine aminotransferase measurement QTL GWAS1497417 (human)
RGD ID: 597401343
Trait: serum alanine aminotransferase measurement
Measurement Type: serum alanine aminotransferase activity level   (CMO:0000575)    
LOD Score: Not Available
P Value: 1.0E-54
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38116,178,825 - 16,178,826RGD_MAPPER_PIPELINEGRCh38
GRCh37116,505,320 - 16,505,321RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model




Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1497417_HHumanserum alanine aminotransferase activity level  IAGPrs1497406405850206 GWAS_CATALOGPMID:33547301

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1497417_HHumanserum alanine aminotransferase measurement  IAGPrs1497406405850206 GWAS_CATALOGPMID:33547301

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records



Peak: (rs1497406)
Human AssemblyChrPosition (strand)Source
GRCh38116,178,825 - 16,178,826RGD_MAPPER_PIPELINE


1 to 10 of 39 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
597599198GWAS1656058_Hserum alanine aminotransferase measurement QTL GWAS1656058 (human)5e-16serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
597606174GWAS1663034_Hserum alanine aminotransferase measurement QTL GWAS1663034 (human)2e-20serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
597409755GWAS1505829_Hnon-high density lipoprotein cholesterol measurement QTL GWAS1505829 (human)1e-14non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)11617882516178826Human
597485023GWAS1581097_Hserum alanine aminotransferase measurement QTL GWAS1581097 (human)3e-58serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
597605910GWAS1662770_Haspartate aminotransferase to alanine aminotransferase ratio QTL GWAS1662770 (human)6e-21aspartate aminotransferase to alanine aminotransferase ratioserum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio (CMO:0002245)11617882516178826Human
597370002GWAS1466076_Hserum gamma-glutamyl transferase measurement QTL GWAS1466076 (human)3e-19serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
597509335GWAS1605409_Hlow density lipoprotein cholesterol measurement QTL GWAS1605409 (human)7e-17low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)11617882516178826Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
597496145GWAS1592219_Hserum gamma-glutamyl transferase measurement QTL GWAS1592219 (human)4e-48serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human

1 to 10 of 39 rows


1 to 20 of 38 rows
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1497417_H GCST90011898 Alanine aminotransferase levels 390,812 European ancestry individuals G 0.58 1E-54 54 rs1497406 15.6 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33547301
GWAS1652481_H GCST90475205 High cholesterol 176,604 European ancestry cases, 139,064 European ancestry controls A 0.4294 3E-11 10.523 rs1497406 0.03032 Hypercholesterolemia (HP:0003124)
 PMID:39024449
GWAS1656058_H GCST90479508 Alanine transaminase (ALT, minimum, inv-norm transformed) 115,132 African American or Afro-Caribbean individuals, 55,858 Hispanic or Latin American individuals, 6,027 East Asian ancestry individuals, 406,784 European ancestry individuals A 0.5079 5E-16 15.302 rs1497406 0.02017 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:39024449
GWAS1656745_H GCST90475454 mean corpuscular hemoglobin concentration (MCHC, maximum, inv-norm transformed) 407,343 European ancestry individuals A 0.4289 1E-22 22 rs1497406 0.02548 mean corpuscular hemoglobin concentration (EFO:0004528)
 PMID:39024449
GWAS1662770_H GCST90475121 Aspartate aminotransferase (AST, mean, inv-norm transformed) 389,192 European ancestry individuals A 0.429 6E-21 20.222 rs1497406 0.02526 aspartate aminotransferase to alanine aminotransferase ratio (EFO:0010934)
 PMID:39024449
GWAS1663034_H GCST90475112 Alanine transaminase (ALT, mean, inv-norm transformed) 406,803 European ancestry individuals A 0.4288 2E-20 19.699 rs1497406 0.02276 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:39024449
GWAS1663038_H GCST90475109 Alanine transaminase (ALT, maximum, inv-norm transformed) 406,783 European ancestry individuals A 0.4288 3E-16 15.523 rs1497406 0.01998 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:39024449
GWAS1663305_H GCST90475118 Aspartate aminotransferase (AST, maximum, inv-norm transformed) 389,396 European ancestry individuals A 0.429 1E-13 13 rs1497406 0.01939 aspartate aminotransferase to alanine aminotransferase ratio (EFO:0010934)
 PMID:39024449
GWAS1666650_H GCST90475124 Aspartate aminotransferase (AST, minimum, inv-norm transformed) 389,315 European ancestry individuals A 0.429 5E-18 17.302 rs1497406 0.02316 aspartate aminotransferase to alanine aminotransferase ratio (EFO:0010934)
 PMID:39024449
GWAS1466076_H GCST001277 Liver enzyme levels (gamma-glutamyl transferase) Up to 52,350 European ancestry individuals, up to 8,739 Indian Asian ancestry individuals G 0.56 3E-19 18.523 rs1497406 3.8 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:22001757
GWAS1466840_H GCST001307 Gamma glutamyl transferase levels 12,526 European ancestry individuals T 0.41 4E-8 7.398 rs1497406 0.078 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:22010049
GWAS1488327_H GCST007380 Gamma glutamyl transferase levels in low alcohol consumption 8,716 individuals ? NR 4E-7 6.398 rs1497406 0.0211 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:30589442
GWAS1782563_H GCST90027080 Albumin levels 158,000 British ancestry women G 0.58 1E-8 8 rs1497406 0.07 serum albumin amount (OBA:2050068)
 PMID:34321204
GWAS1505605_H GCST90018944 Aspartate aminotransferase levels 342,990 European ancestry individuals, 150,068 East Asian ancestry individuals G NR 1E-42 42 rs1497406 0.028 aspartate aminotransferase measurement (EFO:0004736)
 PMID:34594039
GWAS1505829_H GCST90239670 Non-HDL cholesterol levels 1,320,016 European ancestry individuals A 0.414111 1E-14 14 rs1497406 0.0150012 non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS1516281_H GCST90134483 Liver enzyme levels (gamma-glutamyl transferase) 5,694 African ancestry individuals, 1,988 East Asian ancestry individuals, 336,298 European ancestry individuals, 6,036 South Asian ancestry individuals ? NR 5E-72 71.302 rs1497406 N/A serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:35810165
GWAS1523697_H GCST90455669 Serum urate levels 630,117 European ancestry individuals A 0.4205 1E-10 10 rs1497406 0.0149 urate measurement (EFO:0004531)
 PMID:39406924
None Available GCST90018819 Cholelithiasis 26,122 European ancestry cases, 461,431 European ancestry controls, 9,305 East Asian ancestry cases, 168,253 East Asian ancestry controls G NR 4E-8 7.398 rs1497406 0.0487 cholelithiasis (EFO:0004799)
 PMID:34594039
GWAS1537934_H GCST90129602 Chronic elevation of alanine aminotransferase (cALT) levels 95,472 European ancestry cases, 68,725 European ancestry controls A 0.426 1E-8 8 rs1497406 0.042 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:35654975
GWAS1540022_H GCST90018734 Gamma glutamyl transpeptidase 133,471 East Asian ancestry individuals G 0.805721 1E-40 40 rs1497406 0.0586691 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:34594039
1 to 20 of 38 rows
Database
Acc Id
Source(s)
GWAS Catalog GCST90011898 GWAS Catalog

Note Type Note Reference