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Symbol:

GWAS1422186_H

Name:

FEV/FVC ratio QTL GWAS1422186 (human)

RGD ID:

597326112

Trait:

FEV/FVC ratio

Measurement Type:

forced expiratory volume to forced vital capacity ratio (CMO:0000241)

LOD Score:

Not Available

P Value:

2.0E-10

Variance:

Not Available

Position

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh38	1	22,214,785 - 22,214,786	RGD_MAPPER_PIPELINE	GRCh38
GRCh37	1	22,541,278 - 22,541,279	RGD_MAPPER_PIPELINE	GRCh37

Population Stats:

Not Available

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Clinical Measurement

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
GWAS1422186_H	Human	forced expiratory volume to forced vital capacity ratio		IAGP	rs71638832	405850206		GWAS_CATALOG	PMID:36914875

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
GWAS1422186_H	Human	FEV/FVC ratio		IAGP	rs71638832	405850206		GWAS_CATALOG	PMID:36914875

#	Reference Title	Reference Citation
1.	RGD GWAS Catalog Import Pipeline	RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	22,214,785 - 22,214,786	RGD_MAPPER_PIPELINE

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298451	OSTEAR17_H	Osteoarthritis QTL 17 (human)	2.4	0.0004	Joint/bone inflammation	osteoarthritis	11	1	25188105	Human
1576329	MYI9_H	Myocardial infarction susceptibility QTL 9 (human)	12		Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
597326112	GWAS1422186_H	FEV/FVC ratio QTL GWAS1422186 (human)		2e-10	FEV/FVC ratio	forced expiratory volume to forced vital capacity ratio (CMO:0000241)	1	22214785	22214786	Human
1298463	BP9_H	Blood pressure QTL 9 (human)	3.9		Blood pressure	hypertension susceptibility	1	1	25188105	Human
1576325	MYI1_H	Myocardial infarction susceptibility QTL 1 (human)	11.68	1e-12	Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
1643380	BW316_H	Body weight QTL 316 (human)	2.62	0.0002	Body weight	BMI	1	7585503	33585503	Human

Data has come from the GWAS Catalog		Download
The highlighted row represents the current QTL

QTL	GWAS Catalog Study	Disease Trait	Study Size	Risk Allele	Risk Allele Frequency	P Value	P Value MLOG	Peak Marker	Reported Odds Ratio or Beta-coefficient	Ontology Accession	PubMed
GWAS1422186_H	GCST90244094	Lung function (FEV1/FVC)	475,645 European ancestry individuals, 8,590 African ancestry individuals, 85,279 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 14,668 Hispanic or Latin American individuals	T	0.255	2E-10	9.699	rs71638832	6.396	FEV/FVC ratio (EFO:0004713)	PMID:36914875

Database	Acc Id	Source(s)
GWAS Catalog	GCST90244094	GWAS Catalog

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
		Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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