EPHB2 (EPH receptor B2) - Rat Genome Database

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Gene: EPHB2 (EPH receptor B2) Homo sapiens
Analyze
Symbol: EPHB2
Name: EPH receptor B2
RGD ID: 1605126
HGNC Page HGNC
Description: Predicted to enable amyloid-beta binding activity and transmembrane-ephrin receptor activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of gene expression; and regulation of blood coagulation. Located in nucleoplasm and plasma membrane. Implicated in blood platelet disease. Biomarker of cognitive disorder and human immunodeficiency virus infectious disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDPLT22; CAPB; developmentally-regulated Eph-related tyrosine kinase; DRT; EK5; elk-related tyrosine kinase; eph tyrosine kinase 3; EPH-like kinase 5; ephrin type-B receptor 2; EPHT3; ERK; Hek5; MGC87492; PCBC; protein-tyrosine kinase HEK5; renal carcinoma antigen NY-REN-47; Tyro5; tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase TYRO5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,710,770 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISS)
animal organ morphogenesis  (ISO)
axon guidance  (IBA,ISO,ISS)
axonal fasciculation  (ISS)
B cell activation  (IMP)
camera-type eye morphogenesis  (IEA,ISO)
cell morphogenesis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
central nervous system projection neuron axonogenesis  (IBA,ISO)
commissural neuron axon guidance  (ISS)
corpus callosum development  (ISS)
dendritic spine development  (ISS)
dendritic spine morphogenesis  (ISO,ISS)
ephrin receptor signaling pathway  (IEA,ISO,ISS)
hindbrain tangential cell migration  (ISO)
inner ear morphogenesis  (ISS)
learning  (ISO,ISS)
learning or memory  (ISS)
negative regulation of axonogenesis  (IEA,ISO)
negative regulation of cell adhesion  (IMP)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISS)
negative regulation of NMDA glutamate receptor activity  (ISS)
negative regulation of protein kinase activity  (ISS)
negative regulation of protein phosphorylation  (ISS)
negative regulation of Ras protein signal transduction  (ISS)
nervous system development  (TAS)
neuron projection retraction  (IEA)
optic nerve morphogenesis  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
phosphorylation  (ISS)
positive regulation of B cell proliferation  (IMP)
positive regulation of cell migration  (IGI)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISS)
positive regulation of immunoglobulin production  (IMP)
positive regulation of kinase activity  (IBA)
positive regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (ISS)
positive regulation of NMDA glutamate receptor activity  (ISS)
positive regulation of protein localization to plasma membrane  (ISS)
positive regulation of synapse assembly  (ISO,ISS)
positive regulation of synaptic plasticity  (ISS)
positive regulation of tumor necrosis factor production  (IMP)
postsynaptic membrane assembly  (IEA)
protein phosphorylation  (IEA,ISO)
regulation of axonogenesis  (ISO)
regulation of behavioral fear response  (ISO)
regulation of blood coagulation  (IMP)
regulation of body fluid levels  (ISS)
regulation of filopodium assembly  (ISO)
regulation of neuronal synaptic plasticity  (ISO,ISS)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of synapse assembly  (ISO)
regulation of T-helper 17 type immune response  (ISO)
retinal ganglion cell axon guidance  (IEA,ISO)
roof of mouth development  (ISS)
tight junction assembly  (ISO)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  (IEA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,ISO)
urogenital system development  (ISS)
vesicle-mediated intercellular transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bundesen LQ, etal., J Neurosci. 2003 Aug 27;23(21):7789-800.
2. Cissé M, etal., Nature. 2011 Jan 6;469(7328):47-52. doi: 10.1038/nature09635. Epub 2010 Nov 28.
3. He YD, etal., Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2395-9.
4. Ma P, etal., Pain. 2020 Jul;161(7):1584-1596. doi: 10.1097/j.pain.0000000000001855.
5. Mimche PN, etal., Hepatology. 2015 Sep;62(3):900-14. doi: 10.1002/hep.27792. Epub 2015 Apr 22.
6. OMIM Disease Annotation Pipeline
7. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. RGD automated import pipeline for gene-chemical interactions
10. Sun CL, etal., Pain Res Manag. 2021 Apr 7;2021:7582494. doi: 10.1155/2021/7582494. eCollection 2021.
11. Sun W, etal., J Immunol. 2021 Apr 1;206(7):1419-1423. doi: 10.4049/jimmunol.2001373. Epub 2021 Mar 8.
12. Wang DJ, etal., J Pediatr Surg. 2009 Mar;44(3):592-9. doi: 10.1016/j.jpedsurg.2008.08.017.
13. Wu J, etal., CNS Neurosci Ther. 2021 Jun;27(6):714-724. doi: 10.1111/cns.13641. Epub 2021 Apr 1.
14. Xing S, etal., Brain Res. 2008 Sep 16;1230:237-46. doi: 10.1016/j.brainres.2008.06.097. Epub 2008 Jul 2.
15. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
16. Yu T, etal., Stem Cell Res Ther. 2021 Mar 15;12(1):181. doi: 10.1186/s13287-021-02232-w.
17. Yuferov V, etal., J Neuroimmune Pharmacol. 2013 Mar;8(1):333-44. doi: 10.1007/s11481-012-9429-1. Epub 2013 Jan 12.
18. Zhang L, etal., FASEB J. 2019 Dec;33(12):13644-13659. doi: 10.1096/fj.201901192R. Epub 2019 Oct 25.
Additional References at PubMed
PMID:1648701   PMID:7601466   PMID:7688222   PMID:7816602   PMID:7898931   PMID:8033077   PMID:8589679   PMID:8755474   PMID:8798570   PMID:8878483   PMID:9233798   PMID:9267020  
PMID:9499402   PMID:9530499   PMID:9576626   PMID:9632142   PMID:9696046   PMID:9707552   PMID:9883737   PMID:9933164   PMID:10053012   PMID:10207129   PMID:10330152   PMID:10480933  
PMID:10508479   PMID:10523848   PMID:10537323   PMID:10542222   PMID:10570155   PMID:10572014   PMID:10644995   PMID:10648599   PMID:10730216   PMID:10839360   PMID:11042694   PMID:11128993  
PMID:11186936   PMID:11256076   PMID:11494128   PMID:11580899   PMID:11585923   PMID:11641781   PMID:11754835   PMID:11780069   PMID:11799243   PMID:11940661   PMID:11956217   PMID:12039842  
PMID:12058067   PMID:12063024   PMID:12136247   PMID:12297313   PMID:12389031   PMID:12477932   PMID:12546821   PMID:12972619   PMID:14702039   PMID:14968112   PMID:15107857   PMID:15126357  
PMID:15300251   PMID:15718372   PMID:15722342   PMID:15821731   PMID:15848800   PMID:15951569   PMID:15973414   PMID:16155194   PMID:16166419   PMID:16272170   PMID:16298995   PMID:16344560  
PMID:16582626   PMID:16710414   PMID:16740153   PMID:16819508   PMID:16840724   PMID:17192257   PMID:17234965   PMID:17255949   PMID:17295683   PMID:17318185   PMID:17443671   PMID:17655843  
PMID:18628988   PMID:18682749   PMID:18695888   PMID:18713744   PMID:18797457   PMID:18957513   PMID:19366806   PMID:19454503   PMID:19597185   PMID:19661068   PMID:19913121   PMID:19962662  
PMID:20046096   PMID:20233847   PMID:20339854   PMID:20628086   PMID:20634891   PMID:20838624   PMID:21161727   PMID:21292437   PMID:21387540   PMID:21503576   PMID:21603658   PMID:21737611  
PMID:21809346   PMID:21873635   PMID:22010211   PMID:22233626   PMID:22310282   PMID:22374425   PMID:22544902   PMID:22610405   PMID:22723427   PMID:23383108   PMID:23413357   PMID:23711177  
PMID:23835497   PMID:23887168   PMID:24211352   PMID:24222164   PMID:24439224   PMID:24522257   PMID:24612059   PMID:24677421   PMID:24803541   PMID:25012246   PMID:25148033   PMID:25257729  
PMID:25281742   PMID:25643922   PMID:25801123   PMID:26119563   PMID:26186194   PMID:26195670   PMID:26224839   PMID:26344197   PMID:26407069   PMID:26760575   PMID:26870995   PMID:26871627  
PMID:27476799   PMID:27503909   PMID:27504909   PMID:27597758   PMID:27617966   PMID:28065597   PMID:28231727   PMID:28319085   PMID:28514442   PMID:28687409   PMID:28747399   PMID:28800788  
PMID:28931592   PMID:29180619   PMID:29210177   PMID:29416088   PMID:29507755   PMID:29731254   PMID:29987050   PMID:30213874   PMID:30898150   PMID:31089935   PMID:31147453   PMID:31391242  
PMID:31586073   PMID:32060095   PMID:32337793   PMID:32467578   PMID:32694731   PMID:32727758   PMID:33845483   PMID:34079125  


Genomics

Candidate Gene Status
EPHB2 is a candidate Gene for QTL PRSTS10_H
Comparative Map Data
EPHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,710,770 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
Ephb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBImm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
Ephb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,889,574 - 149,077,027 (-)NCBI
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ephb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
EPHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0panPan3
EPHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
Ephb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBI
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,747,883 - 109,954,936 (-)NCBI
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)Ensembl
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBI
Ephb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2904
Count of miRNA genes:1009
Interacting mature miRNAs:1267
Transcripts:ENST00000374627, ENST00000374630, ENST00000374632, ENST00000400191, ENST00000465676, ENST00000490436, ENST00000544305
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 338 2 97 32 48 33 54 35 123 79 261 231 9 1 3 2 1
Low 1335 1583 1240 241 668 124 2459 500 3417 278 1098 1351 123 1071 1347 2 1
Below cutoff 765 1396 381 343 1019 300 1829 1650 194 61 99 28 43 133 1433

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006710441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006710442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB210018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF025304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL035704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL158086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL512444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL530874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL611946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX671066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ641281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA417154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D37827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB282024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM868975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM437237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000374627   ⟹   ENSP00000363758
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,775,178 - 22,913,752 (+)Ensembl
RefSeq Acc Id: ENST00000374630   ⟹   ENSP00000363761
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,710,965 - 22,913,743 (+)Ensembl
RefSeq Acc Id: ENST00000374632   ⟹   ENSP00000363763
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,710,970 - 22,914,270 (+)Ensembl
RefSeq Acc Id: ENST00000400191   ⟹   ENSP00000383053
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,710,965 - 22,921,500 (+)Ensembl
RefSeq Acc Id: ENST00000465676
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,800,240 - 22,896,478 (+)Ensembl
RefSeq Acc Id: ENST00000490436
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,865,159 - 22,882,840 (+)Ensembl
RefSeq Acc Id: ENST00000544305   ⟹   ENSP00000444174
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl122,710,839 - 22,891,265 (+)Ensembl
RefSeq Acc Id: NM_001309192   ⟹   NP_001296121
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,710,839 - 22,921,500 (+)NCBI
CHM1_1123,149,831 - 23,360,325 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309193   ⟹   NP_001296122
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,710,839 - 22,921,500 (+)NCBI
CHM1_1123,149,831 - 23,360,325 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004442   ⟹   NP_004433
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,710,838 - 22,921,500 (+)NCBI
GRCh37123,037,263 - 23,241,823 (+)NCBI
Build 36122,909,918 - 23,114,410 (+)NCBI Archive
HuRef121,351,920 - 21,485,793 (+)ENTREZGENE
CHM1_1123,149,831 - 23,360,325 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017449   ⟹   NP_059145
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,710,839 - 22,921,500 (+)NCBI
GRCh37123,037,263 - 23,241,823 (+)NCBI
Build 36122,909,918 - 23,114,410 (+)NCBI Archive
HuRef121,351,920 - 21,485,793 (+)ENTREZGENE
CHM1_1123,149,831 - 23,360,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006710441   ⟹   XP_006710504
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,774,341 - 22,915,330 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006710442   ⟹   XP_006710505
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,710,770 - 22,915,330 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024453895   ⟹   XP_024309663
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,882,356 - 22,915,330 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004433   ⟸   NM_004442
- Peptide Label: isoform 2 precursor
- UniProtKB: P29323 (UniProtKB/Swiss-Prot),   Q6NVW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_059145   ⟸   NM_017449
- Peptide Label: isoform 1 precursor
- UniProtKB: P29323 (UniProtKB/Swiss-Prot),   Q4LE53 (UniProtKB/TrEMBL),   Q6NVW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006710505   ⟸   XM_006710442
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006710504   ⟸   XM_006710441
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001296122   ⟸   NM_001309193
- Peptide Label: isoform 4 precursor
- UniProtKB: P29323 (UniProtKB/Swiss-Prot),   Q4LE53 (UniProtKB/TrEMBL),   Q6NVW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001296121   ⟸   NM_001309192
- Peptide Label: isoform 3 precursor
- UniProtKB: B4DSE0 (UniProtKB/TrEMBL),   Q4LE53 (UniProtKB/TrEMBL),   Q6NVW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024309663   ⟸   XM_024453895
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000444174   ⟸   ENST00000544305
RefSeq Acc Id: ENSP00000363758   ⟸   ENST00000374627
RefSeq Acc Id: ENSP00000363763   ⟸   ENST00000374632
RefSeq Acc Id: ENSP00000363761   ⟸   ENST00000374630
RefSeq Acc Id: ENSP00000383053   ⟸   ENST00000400191
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Promoters
RGD ID:6854448
Promoter ID:EPDNEW_H389
Type:initiation region
Name:EPHB2_1
Description:EPH receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H390  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,710,839 - 22,710,899EPDNEW
RGD ID:6854450
Promoter ID:EPDNEW_H390
Type:initiation region
Name:EPHB2_2
Description:EPH receptor B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H389  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38122,711,006 - 22,711,066EPDNEW
RGD ID:6785509
Promoter ID:HG_KWN:1270
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:NM_004442,   NM_017449,   OTTHUMT00000008060
Position:
Human AssemblyChrPosition (strand)Source
Build 36122,909,716 - 22,910,216 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004442.7(EPHB2):c.812-3C>G single nucleotide variant not provided [RCV000522615] Chr1:22863034 [GRCh38]
Chr1:23189527 [GRCh37]
Chr1:1p36.12
uncertain significance
NM_004442.7(EPHB2):c.2167C>T (p.Gln723Ter) single nucleotide variant Prostate cancer/brain cancer susceptibility [RCV000009058] Chr1:22907980 [GRCh38]
Chr1:23234473 [GRCh37]
Chr1:1p36.12
pathogenic|other
NM_004442.7(EPHB2):c.835G>T (p.Ala279Ser) single nucleotide variant Prostate cancer/brain cancer susceptibility [RCV000009059]|not provided [RCV000894397] Chr1:22863060 [GRCh38]
Chr1:23189553 [GRCh37]
Chr1:1p36.12
pathogenic|benign|other
NM_004442.7(EPHB2):c.2035G>A (p.Asp679Asn) single nucleotide variant Prostate cancer/brain cancer susceptibility [RCV000009060]|not provided [RCV000974432] Chr1:22906853 [GRCh38]
Chr1:23233346 [GRCh37]
Chr1:1p36.12
pathogenic|likely benign|other
NM_004442.7(EPHB2):c.*187A>T single nucleotide variant Prostate cancer/brain cancer susceptibility [RCV000009061] Chr1:22913757 [GRCh38]
Chr1:23240250 [GRCh37]
Chr1:1p36.12
pathogenic|risk factor
GRCh37/hg19 1p36.12(chr1:23106615-23241148)x3 copy number gain See cases [RCV000446040] Chr1:23106615..23241148 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.787G>A (p.Val263Ile) single nucleotide variant Irido-corneo-trabecular dysgenesis [RCV000207356] Chr1:22785052 [GRCh38]
Chr1:23111545 [GRCh37]
Chr1:1p36.12
likely benign
Single allele complex Ductal breast carcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11
uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
chr1:17555508-24706269 complex variant complex Ductal breast carcinoma [RCV000207266] Chr1:17555508..24706269 [GRCh37]
Chr1:1p36.13-36.11
uncertain significance
NM_004442.7(EPHB2):c.2359G>A (p.Gly787Arg) single nucleotide variant Neoplasm of the large intestine [RCV000434509] Chr1:22909025 [GRCh38]
Chr1:23235518 [GRCh37]
Chr1:1p36.12
likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_004442.7(EPHB2):c.595C>T (p.Arg199Cys) single nucleotide variant not provided [RCV000709948] Chr1:22784860 [GRCh38]
Chr1:23111353 [GRCh37]
Chr1:1p36.12
not provided
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.12(chr1:23091273-23267090)x3 copy number gain not provided [RCV000748943] Chr1:23091273..23267090 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.240C>A (p.Arg80=) single nucleotide variant not provided [RCV000976738] Chr1:22784505 [GRCh38]
Chr1:23110998 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1185C>T (p.Ile395=) single nucleotide variant not provided [RCV000916955] Chr1:22865094 [GRCh38]
Chr1:23191587 [GRCh37]
Chr1:1p36.12
likely benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_004442.7(EPHB2):c.2130C>T (p.Ser710=) single nucleotide variant not provided [RCV000898677] Chr1:22906948 [GRCh38]
Chr1:23233441 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1689C>A (p.Ile563=) single nucleotide variant not provided [RCV000923407] Chr1:22895569 [GRCh38]
Chr1:23222062 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.732C>T (p.Asp244=) single nucleotide variant not provided [RCV000921499] Chr1:22784997 [GRCh38]
Chr1:23111490 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.2229T>C (p.Tyr743=) single nucleotide variant not provided [RCV000899150] Chr1:22908042 [GRCh38]
Chr1:23234535 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.930C>T (p.Tyr310=) single nucleotide variant not provided [RCV000968821] Chr1:22863155 [GRCh38]
Chr1:23189648 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.624G>A (p.Gln208=) single nucleotide variant not provided [RCV000946454] Chr1:22784889 [GRCh38]
Chr1:23111382 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.1952T>C (p.Val651Ala) single nucleotide variant not provided [RCV000969133] Chr1:22906770 [GRCh38]
Chr1:23233263 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.210C>T (p.Asn70=) single nucleotide variant not provided [RCV000929413] Chr1:22784475 [GRCh38]
Chr1:23110968 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.681C>T (p.Ile227=) single nucleotide variant not provided [RCV000922501] Chr1:22784946 [GRCh38]
Chr1:23111439 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.2628A>G (p.Gln876=) single nucleotide variant not provided [RCV000950048] Chr1:22910504 [GRCh38]
Chr1:23236997 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.1769-9G>T single nucleotide variant not provided [RCV000899506] Chr1:22905978 [GRCh38]
Chr1:23232471 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.1429G>A (p.Glu477Lys) single nucleotide variant not provided [RCV000882999] Chr1:22892884 [GRCh38]
Chr1:23219377 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1700+10G>A single nucleotide variant not provided [RCV000895773] Chr1:22895590 [GRCh38]
Chr1:23222083 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1891+9C>T single nucleotide variant not provided [RCV000963746] Chr1:22906118 [GRCh38]
Chr1:23232611 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.2236C>T (p.Arg746Cys) single nucleotide variant Bleeding disorder, platelet-type, 22 [RCV000782357] Chr1:22908049 [GRCh38]
Chr1:23234542 [GRCh37]
Chr1:1p36.12
pathogenic
NM_004442.7(EPHB2):c.1233G>C (p.Val411=) single nucleotide variant not provided [RCV000916216] Chr1:22865142 [GRCh38]
Chr1:23191635 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.2700-9C>T single nucleotide variant not provided [RCV000914981] Chr1:22912435 [GRCh38]
Chr1:23238928 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.510C>T (p.Ser170=) single nucleotide variant not provided [RCV000949465] Chr1:22784775 [GRCh38]
Chr1:23111268 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.1856T>A (p.Ile619Asn) single nucleotide variant not provided [RCV000978430] Chr1:22906074 [GRCh38]
Chr1:23232567 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1959C>T (p.Ile653=) single nucleotide variant not provided [RCV000961877] Chr1:22906777 [GRCh38]
Chr1:23233270 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.981G>A (p.Ala327=) single nucleotide variant not provided [RCV000908670] Chr1:22864890 [GRCh38]
Chr1:23191383 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.2034C>T (p.Phe678=) single nucleotide variant not provided [RCV000930640] Chr1:22906852 [GRCh38]
Chr1:23233345 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.561C>T (p.Leu187=) single nucleotide variant not provided [RCV000926252] Chr1:22784826 [GRCh38]
Chr1:23111319 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.2754G>A (p.Thr918=) single nucleotide variant not provided [RCV000931277] Chr1:22912498 [GRCh38]
Chr1:23238991 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.909T>C (p.Cys303=) single nucleotide variant not provided [RCV000932044] Chr1:22863134 [GRCh38]
Chr1:23189627 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1545C>T (p.Gly515=) variation not provided [RCV000964631] Chr1:22893000 [GRCh38]
Chr1:23219493 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.657G>A (p.Leu219=) single nucleotide variant not provided [RCV000907466] Chr1:22784922 [GRCh38]
Chr1:23111415 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.1476G>A (p.Thr492=) single nucleotide variant not provided [RCV000921803] Chr1:22892931 [GRCh38]
Chr1:23219424 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.726C>T (p.Asn242=) single nucleotide variant not provided [RCV000944030] Chr1:22784991 [GRCh38]
Chr1:23111484 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.261C>T (p.His87=) single nucleotide variant not provided [RCV000912272] Chr1:22784526 [GRCh38]
Chr1:23111019 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1707G>A (p.Arg569=) single nucleotide variant not provided [RCV000911631] Chr1:22896417 [GRCh38]
Chr1:23222910 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1365G>A (p.Ser455=) single nucleotide variant not provided [RCV000913798] Chr1:22882420 [GRCh38]
Chr1:23208913 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1106G>A (p.Arg369Gln) single nucleotide variant not provided [RCV000958264] Chr1:22865015 [GRCh38]
Chr1:23191508 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.2643A>G (p.Leu881=) single nucleotide variant not provided [RCV000913931] Chr1:22910519 [GRCh38]
Chr1:23237012 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.1725C>T (p.Asp575=) single nucleotide variant not provided [RCV000890230] Chr1:22896435 [GRCh38]
Chr1:23222928 [GRCh37]
Chr1:1p36.12
benign
NM_004442.7(EPHB2):c.2322C>T (p.Asp774=) single nucleotide variant not provided [RCV000911463] Chr1:22908135 [GRCh38]
Chr1:23234628 [GRCh37]
Chr1:1p36.12
likely benign
NM_004442.7(EPHB2):c.2358C>T (p.Gly786=) single nucleotide variant not provided [RCV000935018] Chr1:22909024 [GRCh38]
Chr1:23235517 [GRCh37]
Chr1:1p36.12
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3393 AgrOrtholog
COSMIC EPHB2 COSMIC
Ensembl Genes ENSG00000133216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000363758 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000363761 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000363763 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000383053 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000444174 UniProtKB/TrEMBL
Ensembl Transcript ENST00000374627 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000374630 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000374632 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000400191 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000544305 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000133216 GTEx
HGNC ID HGNC:3393 ENTREZGENE
Human Proteome Map EPHB2 Human Proteome Map
InterPro Eph_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EphB2_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2048 ENTREZGENE
OMIM 600997 OMIM
  603688 OMIM
  618462 OMIM
Pfam EphA2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27825 PharmGKB
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1AKC9_HUMAN UniProtKB/TrEMBL
  B4DSE0 ENTREZGENE, UniProtKB/TrEMBL
  E2I6F7_HUMAN UniProtKB/TrEMBL
  EPHB2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q4LE53 ENTREZGENE, UniProtKB/TrEMBL
  Q6NVW1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O43477 UniProtKB/Swiss-Prot
  Q5T0U6 UniProtKB/Swiss-Prot
  Q5T0U7 UniProtKB/Swiss-Prot
  Q5T0U8 UniProtKB/Swiss-Prot