MIR3115 (microRNA 3115) - Rat Genome Database

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Gene: MIR3115 (microRNA 3115) Homo sapiens
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Symbol: MIR3115
Name: microRNA 3115
RGD ID: 4109042
HGNC Page HGNC:38371
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-3115
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,044,305 - 23,044,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,044,305 - 23,044,372 (+)EnsemblGRCh38hg38GRCh38
GRCh37123,370,798 - 23,370,865 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera121,692,934 - 21,693,001 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef121,615,659 - 21,615,726 (+)NCBIHuRef
CHM1_1123,483,510 - 23,483,577 (+)NCBICHM1_1
T2T-CHM13v2.0122,869,974 - 22,870,041 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:21037258   PMID:21199797  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1
pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8116
Count of gene targets:4178
Count of transcripts:6899
Interacting mature miRNAs:hsa-miR-3115
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 33 17 20 6 87 8 36 20 34 17 32 32 7 8 2
Below cutoff 18 1 6 3 25 4 15 15 15 5 13 15 2 4

Sequence


RefSeq Acc Id: ENST00000577915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl123,044,305 - 23,044,372 (+)Ensembl
RefSeq Acc Id: NR_036057
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38123,044,305 - 23,044,372 (+)NCBI
GRCh37123,370,798 - 23,370,865 (+)RGD
Celera121,692,934 - 21,693,001 (+)RGD
HuRef121,615,659 - 21,615,726 (+)RGD
CHM1_1123,483,510 - 23,483,577 (+)NCBI
T2T-CHM13v2.0122,869,974 - 22,870,041 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR3115 COSMIC
Ensembl Genes ENSG00000263793 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000577915 ENTREZGENE
GTEx ENSG00000263793 GTEx
HGNC ID HGNC:38371 ENTREZGENE
Human Proteome Map MIR3115 Human Proteome Map
miRBase MI0014127 ENTREZGENE
NCBI Gene 100422866 ENTREZGENE
PharmGKB PA165751624 PharmGKB
RNAcentral URS00000BB229 RNACentral
  URS0000759AC2 RNACentral