PLA2G2A (phospholipase A2 group IIA) - Rat Genome Database

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Gene: PLA2G2A (phospholipase A2 group IIA) Homo sapiens
Analyze
Symbol: PLA2G2A
Name: phospholipase A2 group IIA
RGD ID: 731016
HGNC Page HGNC:9031
Description: Enables calcium-dependent phospholipase A2 activity and phospholipid binding activity. Involved in several processes, including defense response to Gram-positive bacterium; glycerophospholipid metabolic process; and positive regulation of ERK1 and ERK2 cascade. Located in endoplasmic reticulum and extracellular space. Implicated in cholecystolithiasis; colorectal cancer; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Biomarker of adult respiratory distress syndrome; allergic conjunctivitis; and depressive disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GIIC sPLA2; group IIA phospholipase A2; MOM1; non-pancreatic secretory phospholipase A2; NPS-PLA2; phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); phospholipase A2, membrane associated; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
RGD Orthologs
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,975,431 - 19,980,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,975,431 - 19,980,416 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,301,924 - 20,306,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,174,518 - 20,179,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 34120,047,239 - 20,052,215NCBI
Celera118,628,736 - 18,633,743 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef118,547,710 - 18,552,716 (-)NCBIHuRef
CHM1_1120,411,642 - 20,416,650 (-)NCBICHM1_1
T2T-CHM13v2.0119,799,116 - 19,804,113 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acetic acid  (ISO)
aflatoxin B1  (EXP)
aflatoxin M1  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (EXP)
anthocyanin  (ISO)
antirheumatic drug  (EXP)
baicalein  (ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP)
beta-D-glucosamine  (ISO)
betulinic acid  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
CGP 52608  (EXP)
chromium(6+)  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP)
clothianidin  (EXP)
colforsin daropate hydrochloride  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenzofuran  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
EC 3.1.1.4 (phospholipase A2) inhibitor  (EXP)
ellagic acid  (EXP)
entinostat  (EXP)
erythromycin A  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
ibuprofen  (EXP)
indometacin  (EXP)
kaempferol 3-O-beta-D-galactoside  (EXP)
lead diacetate  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lycopene  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
melittin  (ISO)
methotrexate  (EXP)
methylarsonic acid  (ISO)
mithramycin  (EXP)
N'-Nitrosonornicotine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP)
nitrofen  (ISO)
olaparib  (ISO)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (ISO)
pirinixic acid  (ISO)
prostaglandin E2  (EXP)
prothioconazole  (ISO)
quercetagetin  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
rofecoxib  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
scutellarin  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
thiram  (EXP)
thromboxane A2  (EXP)
thromboxane B2  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
varespladib  (EXP,ISO)
varespladib methyl  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Abu-Maziad A, etal., Pediatr Res. 2010 Oct;68(4):323-9.
2. The secretory phospholipase A2 gene is required for gastroesophageal reflux-related changes in murine esophagus. Babu A, etal., J Gastrointest Surg. 2009 Dec;13(12):2212-8. Epub 2009 Aug 12.
3. Correlation between sPLA2-IIA and phosgene-induced rat acute lung injury. Chen HL, etal., Inhal Toxicol. 2009 Feb;21(4):374-80.
4. Expression of Pla2g2a prevents carcinogenesis in Muc2-deficient mice. Fijneman RJ, etal., Cancer Sci. 2008 Nov;99(11):2113-9.
5. The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. Galecki P, etal., J Affect Disord. 2012 May;138(3):360-6. Epub 2012 Feb 12.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones. Kano M, etal., Hepatology. 1998 Aug;28(2):302-13.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Quantification of tear proteins and sPLA2-IIa alteration in patients with allergic conjunctivitis. Li K, etal., Mol Vis. 2010 Oct 14;16:2084-91.
10. Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method. Limou S, etal., Biomed Pharmacother. 2008 Jan;62(1):31-40. Epub 2007 Dec 3.
11. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. Lopez-Vales R, etal., FASEB J. 2011 Dec;25(12):4240-52. Epub 2011 Aug 25.
12. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. MacPhee M, etal., Cell 1995 Jun 16;81(6):957-66.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Secretory Phospholipase A2-Mediated Depletion of Phosphatidylglycerol in Early Acute Respiratory Distress Syndrome. Seeds MC, etal., Am J Med Sci. 2011 Dec 14.
20. Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death. Titsworth WL, etal., Glia. 2009 Nov 1;57(14):1521-37.
21. Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. Wu F and Chakravarti S, J Immunol. 2007 Nov 15;179(10):6988-7000.
22. Changes of inflammation and apoptosis in adrenal gland after experimental injury in rats with acute necrotizing pancreatitis. Yu J, etal., Inflammation. 2012 Feb;35(1):11-22.
Additional References at PubMed
PMID:1948070   PMID:2046470   PMID:2062381   PMID:2239446   PMID:2708461   PMID:2775276   PMID:2925608   PMID:2925633   PMID:3202859   PMID:3240982   PMID:7664108   PMID:7721806  
PMID:8175726   PMID:8399335   PMID:8824283   PMID:8831753   PMID:8838795   PMID:8889548   PMID:9032461   PMID:9155583   PMID:9272153   PMID:9377118   PMID:9538252   PMID:9745929  
PMID:9811056   PMID:9848887   PMID:10358193   PMID:10747008   PMID:10771478   PMID:11076863   PMID:11256614   PMID:11752212   PMID:11839587   PMID:11903045   PMID:12085323   PMID:12244093  
PMID:12359734   PMID:12456890   PMID:12477932   PMID:12501175   PMID:12574380   PMID:12616631   PMID:12626587   PMID:12694401   PMID:12773489   PMID:12829607   PMID:14499668   PMID:14639048  
PMID:15007070   PMID:15259375   PMID:15299314   PMID:15318030   PMID:15474031   PMID:15489334   PMID:15489336   PMID:15576846   PMID:15688033   PMID:15802623   PMID:15897607   PMID:15964894  
PMID:16169070   PMID:16177112   PMID:16253130   PMID:16278219   PMID:16368710   PMID:16381901   PMID:16461407   PMID:16585943   PMID:16603549   PMID:16617059   PMID:16710414   PMID:16712791  
PMID:17029400   PMID:17069818   PMID:17164967   PMID:17264305   PMID:17447002   PMID:17545304   PMID:17565722   PMID:17892360   PMID:17932742   PMID:17936881   PMID:18037706   PMID:18089561  
PMID:18192373   PMID:18508504   PMID:18519687   PMID:18540439   PMID:18635536   PMID:18676680   PMID:18752058   PMID:18755682   PMID:18827909   PMID:18848929   PMID:18992148   PMID:19065693  
PMID:19169647   PMID:19170196   PMID:19245588   PMID:19276398   PMID:19449149   PMID:19490893   PMID:19495570   PMID:19621421   PMID:19625176   PMID:19647092   PMID:19692168   PMID:19798476  
PMID:19818633   PMID:19850087   PMID:19913121   PMID:19962957   PMID:20008021   PMID:20056178   PMID:20061576   PMID:20301390   PMID:20357262   PMID:20432503   PMID:20600872   PMID:20628086  
PMID:20639215   PMID:20812222   PMID:20837598   PMID:21068383   PMID:21099324   PMID:21255140   PMID:21382622   PMID:21404895   PMID:21417548   PMID:21455584   PMID:21544859   PMID:21799821  
PMID:21813137   PMID:21848517   PMID:21873635   PMID:21884198   PMID:21900206   PMID:22042222   PMID:22056971   PMID:22075700   PMID:22118674   PMID:22127954   PMID:22266334   PMID:22406427  
PMID:22837859   PMID:22989727   PMID:23026567   PMID:23079010   PMID:23343574   PMID:23438648   PMID:23451150   PMID:23482564   PMID:23533145   PMID:23580065   PMID:23609358   PMID:23664539  
PMID:23722320   PMID:23852891   PMID:23883784   PMID:23901095   PMID:23913269   PMID:24061501   PMID:24113843   PMID:24115030   PMID:24269828   PMID:24508801   PMID:24521628   PMID:24641411  
PMID:24913497   PMID:25082876   PMID:25247183   PMID:25286228   PMID:25290234   PMID:25317799   PMID:25347447   PMID:25366587   PMID:25393083   PMID:25398877   PMID:25422234   PMID:25429648  
PMID:25713085   PMID:25794429   PMID:26106157   PMID:26488172   PMID:26506412   PMID:26644377   PMID:26659873   PMID:26711221   PMID:27060751   PMID:27377346   PMID:27608594   PMID:27864802  
PMID:27941821   PMID:28055018   PMID:28056488   PMID:28077172   PMID:28249041   PMID:28250920   PMID:28440478   PMID:28528433   PMID:28663239   PMID:29229414   PMID:29342349   PMID:29515164  
PMID:29709018   PMID:29784864   PMID:29872016   PMID:30684134   PMID:31064688   PMID:31111824   PMID:31132981   PMID:31342824   PMID:31521610   PMID:31524254   PMID:32179174   PMID:32217848  
PMID:32401671   PMID:32852622   PMID:32998383   PMID:33734490   PMID:34175441   PMID:34216520   PMID:34230154   PMID:34428181   PMID:34474084   PMID:34963487   PMID:35241529   PMID:35944360  
PMID:36233022   PMID:36244648   PMID:36385678   PMID:36982611   PMID:37087406   PMID:37673297   PMID:39449149  


Genomics

Comparative Map Data
PLA2G2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,975,431 - 19,980,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,975,431 - 19,980,416 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,301,924 - 20,306,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,174,518 - 20,179,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 34120,047,239 - 20,052,215NCBI
Celera118,628,736 - 18,633,743 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef118,547,710 - 18,552,716 (-)NCBIHuRef
CHM1_1120,411,642 - 20,416,650 (-)NCBICHM1_1
T2T-CHM13v2.0119,799,116 - 19,804,113 (-)NCBIT2T-CHM13v2.0
Pla2g2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,559,168 - 138,562,500 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,559,171 - 138,562,497 (+)EnsemblGRCm39 Ensembl
GRCm384138,831,857 - 138,835,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,831,857 - 138,835,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,387,772 - 138,391,104 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,103,933 - 138,107,259 (+)NCBIMGSCv36mm8
Celera4140,618,192 - 140,621,524 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.57NCBI
Pla2g2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,359,725 - 156,362,302 (+)NCBIGRCr8
mRatBN7.25151,076,442 - 151,079,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,076,442 - 151,079,014 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,773,843 - 153,776,420 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,548,152 - 155,550,729 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,529,916 - 155,532,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,282,650 - 157,285,295 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,282,669 - 157,285,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,024,039 - 161,026,650 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,654,786 - 157,657,360 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,664,332 - 157,667,400 (+)NCBI
Celera5149,464,001 - 149,466,577 (+)NCBICelera
Cytogenetic Map5q36NCBI
PLA2G2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,109,330 - 207,143,737 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,226,298 - 206,260,589 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,930,294 - 18,934,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,973,352 - 19,977,627 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,971,084 - 19,977,627 (-)Ensemblpanpan1.1panPan2
Pla2g2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,267,196 - 40,271,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,091,941 - 6,096,057 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,091,978 - 6,095,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,327,319 - 78,330,699 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,327,728 - 78,339,546 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,517,061 - 72,556,712 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,564,414 - 112,569,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,565,165 - 112,569,786 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660333,610,631 - 3,615,025 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,144,549 - 5,151,995 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,144,549 - 5,152,517 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G2A
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001395463.1(PLA2G2A):c.144_145del (p.Cys48fs) microsatellite Familial colorectal cancer [RCV000014605] Chr1:19978420..19978421 [GRCh38]
Chr1:20304913..20304914 [GRCh37]
Chr1:1p36.13
pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:15385267-20980349)x1 copy number loss See cases [RCV000051146] Chr1:15385267..20980349 [GRCh38]
Chr1:15711763..21306842 [GRCh37]
Chr1:15584350..21179429 [NCBI36]
Chr1:1p36.21-36.12
pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:13110797-20670207)x3 copy number gain See cases [RCV000051797] Chr1:13110797..20670207 [GRCh38]
Chr1:13178269..20996700 [GRCh37]
Chr1:13100856..20869287 [NCBI36]
Chr1:1p36.21-36.12
pathogenic
GRCh38/hg38 1p36.13-36.12(chr1:18347821-22512894)x1 copy number loss See cases [RCV000053789] Chr1:18347821..22512894 [GRCh38]
Chr1:18674315..22839387 [GRCh37]
Chr1:18546902..22711974 [NCBI36]
Chr1:1p36.13-36.12
pathogenic
GRCh38/hg38 1p36.22-36.12(chr1:10556797-22557907)x1 copy number loss See cases [RCV000053760] Chr1:10556797..22557907 [GRCh38]
Chr1:10616854..22884400 [GRCh37]
Chr1:10539441..22756987 [NCBI36]
Chr1:1p36.22-36.12
pathogenic
GRCh38/hg38 1p36.13(chr1:19093306-20063342)x1 copy number loss See cases [RCV000053793] Chr1:19093306..20063342 [GRCh38]
Chr1:19419800..20389835 [GRCh37]
Chr1:19292387..20262422 [NCBI36]
Chr1:1p36.13
pathogenic
GRCh38/hg38 1p36.13-36.12(chr1:19548795-20935131)x1 copy number loss See cases [RCV000138079] Chr1:19548795..20935131 [GRCh38]
Chr1:19875289..21261624 [GRCh37]
Chr1:19747876..21134211 [NCBI36]
Chr1:1p36.13-36.12
likely pathogenic|uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:19809419-20418333)x3 copy number gain See cases [RCV000239783] Chr1:19809419..20418333 [GRCh37]
Chr1:1p36.13-36.12
uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11
uncertain significance
chr1:17555508-24706269 complex variant complex Breast ductal adenocarcinoma [RCV000207266] Chr1:17555508..24706269 [GRCh37]
Chr1:1p36.13-36.11
uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:20067124-22537862)x1 copy number loss See cases [RCV000447314] Chr1:20067124..22537862 [GRCh37]
Chr1:1p36.13-36.12
pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1 copy number loss See cases [RCV000446470] Chr1:2749920..22564787 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
NM_001395463.1(PLA2G2A):c.403A>G (p.Lys135Glu) single nucleotide variant not specified [RCV004329548] Chr1:19975733 [GRCh38]
Chr1:20302226 [GRCh37]
Chr1:1p36.13
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_001395463.1(PLA2G2A):c.55C>T (p.His19Tyr) single nucleotide variant PLA2G2A-related disorder [RCV003983245]|not provided [RCV000885012] Chr1:19978510 [GRCh38]
Chr1:20305003 [GRCh37]
Chr1:1p36.13
benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NC_000001.10:g.(?_19199339)_(22987879_?)dup duplication Autosomal recessive early-onset Parkinson disease 6 [RCV003113320]|Congenital disorder of glycosylation type Ir [RCV003113321]|Hyperprolinemia type 2 [RCV003107740] Chr1:19199339..22987879 [GRCh37]
Chr1:1p36.13-36.12
uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:16785250-23491592)x1 copy number loss 1p36.1 deletion syndrome [RCV001614471] Chr1:16785250..23491592 [GRCh37]
Chr1:1p36.13-36.12
pathogenic
NM_001395463.1(PLA2G2A):c.18G>A (p.Leu6=) single nucleotide variant not provided [RCV000970939] Chr1:19978756 [GRCh38]
Chr1:20305249 [GRCh37]
Chr1:1p36.13
benign
GRCh37/hg19 1p36.13-36.12(chr1:20100416-20549013)x3 copy number gain not provided [RCV001005074] Chr1:20100416..20549013 [GRCh37]
Chr1:1p36.13-36.12
uncertain significance
GRCh37/hg19 1p36.21-36.12(chr1:16041431-21295864)x1 copy number loss not provided [RCV001259568] Chr1:16041431..21295864 [GRCh37]
Chr1:1p36.21-36.12
pathogenic
NC_000001.10:g.(?_20208747)_(20503856_?)dup duplication not provided [RCV001372151] Chr1:20208747..20503856 [GRCh37]
Chr1:1p36.13-36.12
uncertain significance
NC_000001.10:g.(?_19199339)_(24690861_?)dup duplication Deficiency of hydroxymethylglutaryl-CoA lyase [RCV003122155] Chr1:19199339..24690861 [GRCh37]
Chr1:1p36.13-36.11
uncertain significance
NC_000001.10:g.4481271_20530242del deletion Chromosome 1p36 deletion syndrome [RCV003159574] Chr1:4481271..20530242 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
NM_001395463.1(PLA2G2A):c.313A>G (p.Ser105Gly) single nucleotide variant not specified [RCV004088797] Chr1:19975823 [GRCh38]
Chr1:20302316 [GRCh37]
Chr1:1p36.13
uncertain significance
NM_001395463.1(PLA2G2A):c.239G>T (p.Gly80Val) single nucleotide variant not specified [RCV004361857] Chr1:19978068 [GRCh38]
Chr1:20304561 [GRCh37]
Chr1:1p36.13
uncertain significance
NM_001395463.1(PLA2G2A):c.184C>T (p.Arg62Cys) single nucleotide variant not specified [RCV004356287] Chr1:19978381 [GRCh38]
Chr1:20304874 [GRCh37]
Chr1:1p36.13
uncertain significance
GRCh37/hg19 1p36.13(chr1:18127009-20315260)x3 copy number gain not provided [RCV003484009] Chr1:18127009..20315260 [GRCh37]
Chr1:1p36.13
uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:17291707-23016395)x4 copy number gain not provided [RCV003485339] Chr1:17291707..23016395 [GRCh37]
Chr1:1p36.13-36.12
likely pathogenic
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1
pathogenic
NM_001395463.1(PLA2G2A):c.186C>T (p.Arg62=) single nucleotide variant not specified [RCV004511439] Chr1:19978121 [GRCh38]
Chr1:20304614 [GRCh37]
Chr1:1p36.13
likely benign
GRCh37/hg19 1p36.21-36.12(chr1:16194137-20561434)x1 copy number loss not specified [RCV003986551] Chr1:16194137..20561434 [GRCh37]
Chr1:1p36.21-36.12
pathogenic
NM_001395463.1(PLA2G2A):c.158G>A (p.Arg53Lys) single nucleotide variant not specified [RCV004511438] Chr1:19978407 [GRCh38]
Chr1:20304900 [GRCh37]
Chr1:1p36.13
likely benign
NM_001395463.1(PLA2G2A):c.132C>T (p.Tyr44=) single nucleotide variant PLA2G2A-related disorder [RCV003973869] Chr1:19978433 [GRCh38]
Chr1:20304926 [GRCh37]
Chr1:1p36.13
benign
NM_001395463.1(PLA2G2A):c.428G>A (p.Arg143His) single nucleotide variant PLA2G2A-related disorder [RCV003921875] Chr1:19975708 [GRCh38]
Chr1:20302201 [GRCh37]
Chr1:1p36.13
benign
NM_001395463.1(PLA2G2A):c.110C>T (p.Ala37Val) single nucleotide variant not specified [RCV004511437] Chr1:19978455 [GRCh38]
Chr1:20304948 [GRCh37]
Chr1:1p36.13
uncertain significance
NM_001395463.1(PLA2G2A):c.96G>C (p.Thr32=) single nucleotide variant PLA2G2A-related disorder [RCV003979707] Chr1:19978469 [GRCh38]
Chr1:20304962 [GRCh37]
Chr1:1p36.13
benign
NM_001395463.1(PLA2G2A):c.389A>T (p.Gln130Leu) single nucleotide variant not specified [RCV004511440] Chr1:19975747 [GRCh38]
Chr1:20302240 [GRCh37]
Chr1:1p36.13
uncertain significance
GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2 copy number loss not provided [RCV004577440] Chr1:4436802..22782007 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
GRCh37/hg19 1p36.13-36.12(chr1:17284906-21778495)x1 copy number loss not provided [RCV001259567] Chr1:17284906..21778495 [GRCh37]
Chr1:1p36.13-36.12
pathogenic
NM_001395463.1(PLA2G2A):c.52G>A (p.Ala18Thr) single nucleotide variant PLA2G2A-related disorder [RCV003981346] Chr1:19978513 [GRCh38]
Chr1:20305006 [GRCh37]
Chr1:1p36.13
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1564
Count of miRNA genes:605
Interacting mature miRNAs:680
Transcripts:ENST00000375111, ENST00000400520, ENST00000461140, ENST00000469162, ENST00000482011, ENST00000491964, ENST00000496748
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
407199367GWAS848343_Hblood protein measurement QTL GWAS848343 (human)1e-292blood protein measurementblood protein measurement (CMO:0000028)11997965319979654Human
406892963GWAS541939_Hphospholipase A2, membrane associated measurement QTL GWAS541939 (human)2e-384phospholipase A2, membrane associated measurement11997965319979654Human
407288672GWAS937648_Hphospholipase A2, membrane associated measurement QTL GWAS937648 (human)1e-64phospholipase A2, membrane associated measurement11997965319979654Human
407289120GWAS938096_Hphospholipase A2, membrane associated measurement QTL GWAS938096 (human)2e-126phospholipase A2, membrane associated measurement11997965319979654Human
406938694GWAS587670_Hblood protein measurement QTL GWAS587670 (human)2e-111blood protein measurementblood protein measurement (CMO:0000028)11997843319978434Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
406951212GWAS600188_Hphospholipase A2, membrane associated measurement QTL GWAS600188 (human)2e-1000phospholipase A2, membrane associated measurement11997965319979654Human
407165364GWAS814340_Hphospholipase A2, membrane associated measurement QTL GWAS814340 (human)1e-38phospholipase A2, membrane associated measurement11997965319979654Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
406893014GWAS541990_Hphospholipase A2, membrane associated measurement QTL GWAS541990 (human)8e-367phospholipase A2, membrane associated measurement11997836419978365Human
407154931GWAS803907_Hprotein measurement QTL GWAS803907 (human)3e-26protein measurement11997857219978573Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407262715GWAS911691_Hphospholipase A2, membrane associated measurement QTL GWAS911691 (human)3e-441phospholipase A2, membrane associated measurement11997836419978365Human
407262489GWAS911465_Hphospholipase A2, membrane associated measurement QTL GWAS911465 (human)5e-472phospholipase A2, membrane associated measurement11997965319979654Human

Markers in Region
SHGC-74294  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37120,302,040 - 20,302,228UniSTSGRCh37
Build 36120,174,627 - 20,174,815RGDNCBI36
Celera118,628,852 - 18,629,040RGD
Cytogenetic Map1p35UniSTS
HuRef118,547,826 - 18,548,014UniSTS
TNG Radiation Hybrid Map17573.0UniSTS
GeneMap99-GB4 RH Map164.37UniSTS
PLA2G2A_2785  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37120,301,843 - 20,302,377UniSTSGRCh37
Build 36120,174,430 - 20,174,964RGDNCBI36
Celera118,628,655 - 18,629,189RGD
HuRef118,547,629 - 18,548,163UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2399 2788 2230 4767 1693 2149 4 612 1361 450 2215 6517 5880 11 3571 1 683 1646 1432 166 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001161727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001161728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001161729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047422593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047422594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047422595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF154852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF154853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF224774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF368841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL358253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY462114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY656695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY656696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM708748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU626291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX641714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB132375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000375111   ⟹   ENSP00000364252
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,438 - 19,980,416 (-)Ensembl
Ensembl Acc Id: ENST00000400520   ⟹   ENSP00000383364
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,431 - 19,979,607 (-)Ensembl
Ensembl Acc Id: ENST00000461140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,978,246 - 19,979,067 (-)Ensembl
Ensembl Acc Id: ENST00000469162
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,431 - 19,979,607 (-)Ensembl
Ensembl Acc Id: ENST00000482011
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,435 - 19,979,618 (-)Ensembl
Ensembl Acc Id: ENST00000491964
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,465 - 19,980,407 (-)Ensembl
Ensembl Acc Id: ENST00000496748
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,438 - 19,979,614 (-)Ensembl
Ensembl Acc Id: ENST00000649436   ⟹   ENSP00000496912
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl119,975,431 - 19,979,621 (-)Ensembl
RefSeq Acc Id: NM_000300   ⟹   NP_000291
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,435 - 19,980,434 (-)NCBI
GRCh37120,301,924 - 20,306,932 (-)ENTREZGENE
Build 36120,174,518 - 20,179,496 (-)NCBI Archive
HuRef118,547,710 - 18,552,716 (-)ENTREZGENE
CHM1_1120,411,642 - 20,416,650 (-)NCBI
T2T-CHM13v2.0119,799,120 - 19,804,113 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001161727   ⟹   NP_001155199
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,435 - 19,980,434 (-)NCBI
GRCh37120,301,924 - 20,306,932 (-)ENTREZGENE
HuRef118,547,710 - 18,552,716 (-)ENTREZGENE
CHM1_1120,411,642 - 20,416,650 (-)NCBI
T2T-CHM13v2.0119,799,120 - 19,804,113 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001161728   ⟹   NP_001155200
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,435 - 19,980,434 (-)NCBI
GRCh37120,301,924 - 20,306,932 (-)ENTREZGENE
HuRef118,547,710 - 18,552,716 (-)ENTREZGENE
CHM1_1120,411,642 - 20,416,650 (-)NCBI
T2T-CHM13v2.0119,799,120 - 19,804,113 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001161729   ⟹   NP_001155201
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,431 - 19,979,659 (-)NCBI
GRCh37120,301,924 - 20,306,932 (-)ENTREZGENE
HuRef118,547,710 - 18,552,716 (-)ENTREZGENE
CHM1_1120,411,642 - 20,415,870 (-)NCBI
T2T-CHM13v2.0119,799,116 - 19,803,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001395463   ⟹   NP_001382392
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,435 - 19,979,618 (-)NCBI
T2T-CHM13v2.0119,799,120 - 19,803,297 (-)NCBI
RefSeq Acc Id: XM_047422593   ⟹   XP_047278549
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,431 - 19,980,434 (-)NCBI
RefSeq Acc Id: XM_047422594   ⟹   XP_047278550
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,431 - 19,980,434 (-)NCBI
RefSeq Acc Id: XM_047422595   ⟹   XP_047278551
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,975,431 - 19,980,434 (-)NCBI
RefSeq Acc Id: XM_054337077   ⟹   XP_054193052
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0119,799,116 - 19,804,113 (-)NCBI
RefSeq Acc Id: XM_054337078   ⟹   XP_054193053
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0119,799,116 - 19,804,113 (-)NCBI
RefSeq Acc Id: XM_054337079   ⟹   XP_054193054
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0119,799,116 - 19,804,113 (-)NCBI
Protein Sequences
Protein RefSeqs NP_000291 (Get FASTA)   NCBI Sequence Viewer  
  NP_001155199 (Get FASTA)   NCBI Sequence Viewer  
  NP_001155200 (Get FASTA)   NCBI Sequence Viewer  
  NP_001155201 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382392 (Get FASTA)   NCBI Sequence Viewer  
  XP_047278549 (Get FASTA)   NCBI Sequence Viewer  
  XP_047278550 (Get FASTA)   NCBI Sequence Viewer  
  XP_047278551 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193052 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193053 (Get FASTA)   NCBI Sequence Viewer  
  XP_054193054 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA36549 (Get FASTA)   NCBI Sequence Viewer  
  AAA36550 (Get FASTA)   NCBI Sequence Viewer  
  AAG49535 (Get FASTA)   NCBI Sequence Viewer  
  AAH05919 (Get FASTA)   NCBI Sequence Viewer  
  AAK57824 (Get FASTA)   NCBI Sequence Viewer  
  AAK57825 (Get FASTA)   NCBI Sequence Viewer  
  AAM21271 (Get FASTA)   NCBI Sequence Viewer  
  AAR16084 (Get FASTA)   NCBI Sequence Viewer  
  AAT73043 (Get FASTA)   NCBI Sequence Viewer  
  AAT73044 (Get FASTA)   NCBI Sequence Viewer  
  BAF83991 (Get FASTA)   NCBI Sequence Viewer  
  CAG33146 (Get FASTA)   NCBI Sequence Viewer  
  EAW94907 (Get FASTA)   NCBI Sequence Viewer  
  EAW94908 (Get FASTA)   NCBI Sequence Viewer  
  EAW94909 (Get FASTA)   NCBI Sequence Viewer  
  EAW94910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000364252
  ENSP00000364252.3
  ENSP00000383364
  ENSP00000383364.3
  ENSP00000496912.1
  ENSP00000504762
  ENSP00000504762.1
GenBank Protein P14555 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001155200   ⟸   NM_001161728
- Peptide Label: precursor
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   Q6DN23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001155199   ⟸   NM_001161727
- Peptide Label: precursor
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   Q6DN23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000291   ⟸   NM_000300
- Peptide Label: precursor
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   Q6DN23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001155201   ⟸   NM_001161729
- Peptide Label: precursor
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   Q6DN23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000496912   ⟸   ENST00000649436
Ensembl Acc Id: ENSP00000383364   ⟸   ENST00000400520
Ensembl Acc Id: ENSP00000364252   ⟸   ENST00000375111
RefSeq Acc Id: NP_001382392   ⟸   NM_001395463
- Peptide Label: precursor
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot),   Q6DN23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047278551   ⟸   XM_047422595
- Peptide Label: isoform X1
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047278549   ⟸   XM_047422593
- Peptide Label: isoform X1
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047278550   ⟸   XM_047422594
- Peptide Label: isoform X1
- UniProtKB: Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot),   Q9UCD2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054193054   ⟸   XM_054337079
- Peptide Label: isoform X1
- UniProtKB: Q9UCD2 (UniProtKB/Swiss-Prot),   Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054193052   ⟸   XM_054337077
- Peptide Label: isoform X1
- UniProtKB: Q9UCD2 (UniProtKB/Swiss-Prot),   Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054193053   ⟸   XM_054337078
- Peptide Label: isoform X1
- UniProtKB: Q9UCD2 (UniProtKB/Swiss-Prot),   Q6IBD9 (UniProtKB/Swiss-Prot),   Q6DN24 (UniProtKB/Swiss-Prot),   P14555 (UniProtKB/Swiss-Prot),   A8K5I7 (UniProtKB/Swiss-Prot)
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14555-F1-model_v2 AlphaFold P14555 1-144 view protein structure

Promoters
RGD ID:6854354
Promoter ID:EPDNEW_H341
Type:initiation region
Name:PLA2G2A_1
Description:phospholipase A2 group IIA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H342  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,979,618 - 19,979,678EPDNEW
RGD ID:6854356
Promoter ID:EPDNEW_H342
Type:initiation region
Name:PLA2G2A_2
Description:phospholipase A2 group IIA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H341  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38119,980,434 - 19,980,494EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9031 AgrOrtholog
COSMIC PLA2G2A COSMIC
Ensembl Genes ENSG00000188257 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000375111 ENTREZGENE
  ENST00000375111.7 UniProtKB/Swiss-Prot
  ENST00000400520 ENTREZGENE
  ENST00000400520.8 UniProtKB/Swiss-Prot
  ENST00000482011 ENTREZGENE
  ENST00000482011.3 UniProtKB/Swiss-Prot
  ENST00000649436.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000188257 GTEx
HGNC ID HGNC:9031 ENTREZGENE
Human Proteome Map PLA2G2A Human Proteome Map
InterPro PLipase_A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5320 UniProtKB/Swiss-Prot
NCBI Gene 5320 ENTREZGENE
OMIM 172411 OMIM
PANTHER PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA270 PharmGKB, RGD
PRINTS PHPHLIPASEA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PA2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B3IRX2_HUMAN UniProtKB/TrEMBL
  A8K5I7 ENTREZGENE
  P14555 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6DN23 ENTREZGENE, UniProtKB/TrEMBL
  Q6DN24 ENTREZGENE
  Q6IBD9 ENTREZGENE
  Q8NI47_HUMAN UniProtKB/TrEMBL
  Q9UCD2 ENTREZGENE
UniProt Secondary A8K5I7 UniProtKB/Swiss-Prot
  Q6DN24 UniProtKB/Swiss-Prot
  Q6IBD9 UniProtKB/Swiss-Prot
  Q9UCD2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLA2G2A  phospholipase A2 group IIA    phospholipase A2, group IIA (platelets, synovial fluid)  Symbol and/or name change 5135510 APPROVED