MIR34A (microRNA 34a) - Rat Genome Database

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Gene: MIR34A (microRNA 34a) Homo sapiens
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Symbol: MIR34A
Name: microRNA 34a
RGD ID: 1343452
HGNC Page HGNC:31635
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of smooth muscle cell migration; and regulation of gene expression. Acts upstream of or within negative regulation of gene expression. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of arteriovenous malformation; hepatoblastoma; hepatocellular carcinoma; metabolic dysfunction-associated steatotic liver disease; and osteoarthritis.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-34; mir-34a; MIRN34A; miRNA34A
RGD Orthologs
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,151,668 - 9,151,777 (-)EnsemblGRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36Build 36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
T2T-CHM13v2.018,685,973 - 8,686,082 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-acetamidofluorene  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-D-galactose  (EXP,ISO)
aniline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Betanin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (EXP)
cannabidiol  (ISO)
chenodeoxycholic acid  (EXP)
chlorendic acid  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
crocin-1  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexmedetomidine  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
furan  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
genistein  (EXP)
hydrogen peroxide  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
melatonin  (ISO)
mercaptopurine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
mitomycin C  (EXP)
monuron  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
Pentoxifylline  (ISO)
propanal  (EXP)
propranolol  (ISO)
purine-6-thiol  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
titanium dioxide  (EXP)
tributyl phosphate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid stimulus  (ISO)
cellular response to hypoxia  (IDA)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to tumor necrosis factor  (ISO)
cholesterol homeostasis  (ISS)
DNA damage response  (IDA)
miRNA-mediated post-transcriptional gene silencing  (HDA,IDA,IEA,IGI,ISO)
myelination  (ISO)
negative regulation of amyloid-beta clearance  (ISS)
negative regulation of angiogenesis  (IDA)
negative regulation of B cell receptor signaling pathway  (IDA)
negative regulation of calcium ion import  (IDA)
negative regulation of chemokine production  (IDA)
negative regulation of gene expression  (IMP)
negative regulation of intracellular signal transduction  (IMP)
negative regulation of IP-10 production  (IDA)
negative regulation of lipid transporter activity  (ISS)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISS)
negative regulation of protein serine/threonine kinase activity  (IMP)
negative regulation of smooth muscle cell chemotaxis  (IDA)
negative regulation of sprouting angiogenesis  (IDA,ISS)
negative regulation of transmembrane transport  (IDA)
negative regulation of vascular associated smooth muscle cell migration  (IDA)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA)
negative regulation of vascular endothelial cell proliferation  (IDA)
negative regulation of vascular endothelial growth factor production  (HMP)
negative regulation of vascular wound healing  (IDA)
ossification  (ISO)
positive regulation of blood vessel endothelial cell differentiation  (IDA)
positive regulation of cardiac muscle cell apoptotic process  (IDA)
positive regulation of cellular senescence  (IDA)
positive regulation of connective tissue replacement  (ISS)
positive regulation of gene expression  (IDA)
positive regulation of leukocyte apoptotic process  (IMP)
positive regulation of lipid storage  (IMP)
positive regulation of protein acetylation  (IDA)
positive regulation of smooth muscle cell differentiation  (IDA)
positive regulation of stem cell differentiation  (ISO)
programmed cell death in response to reactive oxygen species  (IMP)
regulation of cell cycle  (ISS)
response to axon injury  (ISS)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)
triglyceride homeostasis  (ISS)
tumor necrosis factor-mediated signaling pathway  (IDA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Combined low miR-34s are associated with unfavorable prognosis in children with hepatoblastoma: A Chinese population-based study. Jiao C, etal., J Pediatr Surg. 2016 Aug;51(8):1355-61. doi: 10.1016/j.jpedsurg.2016.02.091. Epub 2016 Mar 14.
2. Protective effects of crocin and zinc sulfate on hepatic ischemia-reperfusion injury in rats: a comparative experimental model study. Mard SA, etal., Biomed Pharmacother. 2017 Dec;96:48-55. doi: 10.1016/j.biopha.2017.09.123. Epub 2017 Nov 24.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. Salvoza NC, etal., PLoS One. 2016 Apr 14;11(4):e0153497. doi: 10.1371/journal.pone.0153497. eCollection 2016.
5. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
6. Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure. Tian C, etal., Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H928-H939. doi: 10.1152/ajpheart.00602.2017. Epub 2018 Jan 26.
7. MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma. Xiang ZL, etal., Oncotarget. 2016 Dec 27;7(52):87246-87256. doi: 10.18632/oncotarget.13531.
8. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Xiao Z, etal., Cancer Res. 2014 Nov 1;74(21):6236-47. doi: 10.1158/0008-5472.CAN-14-0855. Epub 2014 Sep 12.
9. MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism. Zhang HF, etal., Mol Med Rep. 2018 Mar;17(3):4483-4489. doi: 10.3892/mmr.2018.8399. Epub 2018 Jan 9.
10. Elevated circulating microRNA-210 levels in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: a potential new biomarker. Zhang Q, etal., Biomarkers. 2013 Feb;18(1):23-9. doi: 10.3109/1354750X.2012.728624. Epub 2012 Oct 10.
11. MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. Zhang W, etal., Cell Physiol Biochem. 2018;48(3):1304-1316. doi: 10.1159/000492090. Epub 2018 Jul 26.
Additional References at PubMed
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PMID:32502839   PMID:32531952   PMID:32559619   PMID:32585876   PMID:32602014   PMID:32626991   PMID:32634429   PMID:32648233   PMID:32654473   PMID:32659427   PMID:32660221   PMID:32700738  
PMID:32719987   PMID:32738890   PMID:32748742   PMID:32755834   PMID:32798250   PMID:32826862   PMID:32841775   PMID:32856736   PMID:32894541   PMID:32901838   PMID:32921986   PMID:32928232  
PMID:32928372   PMID:32929850   PMID:33015156   PMID:33028635   PMID:33034147   PMID:33037254   PMID:33074217   PMID:33092644   PMID:33098868   PMID:33112434   PMID:33125091   PMID:33155244  
PMID:33190281   PMID:33201337   PMID:33215424   PMID:33229509   PMID:33275235   PMID:33338854   PMID:33359304   PMID:33374832   PMID:33378474   PMID:33398374   PMID:33398678   PMID:33400820  
PMID:33416118   PMID:33416133   PMID:33432364   PMID:33438362   PMID:33463130   PMID:33492448   PMID:33507132   PMID:33528317   PMID:33581076   PMID:33596979   PMID:33601073   PMID:33629295  
PMID:33642822   PMID:33650650   PMID:33673143   PMID:33706708   PMID:33878446   PMID:33904680   PMID:33932899   PMID:33942341   PMID:33962397   PMID:33977112   PMID:33986456   PMID:34011046  
PMID:34024195   PMID:34038763   PMID:34039781   PMID:34062187   PMID:34102608   PMID:34195933   PMID:34296298   PMID:34350522   PMID:34403518   PMID:34467896   PMID:34468014   PMID:34511356  
PMID:34550549   PMID:34591390   PMID:34652615   PMID:34698884   PMID:34751414   PMID:34783292   PMID:34860809   PMID:34861059   PMID:34944497   PMID:34990478   PMID:34993814   PMID:34999254  
PMID:35226569   PMID:35274224   PMID:35286466   PMID:35397570   PMID:35444864   PMID:35484046   PMID:35484885   PMID:35485349   PMID:35525840   PMID:35579419   PMID:35625530   PMID:35666377  
PMID:35699451   PMID:35732008   PMID:35809313   PMID:35840896   PMID:35877019   PMID:35930398   PMID:36181617   PMID:36197268   PMID:36227666   PMID:36352176   PMID:36361993   PMID:36399467  
PMID:36401685   PMID:36477596   PMID:36597176   PMID:36617839   PMID:36651252   PMID:36672841   PMID:36801480   PMID:36833430   PMID:36905274   PMID:36951490   PMID:37013480   PMID:37148744  
PMID:37209045   PMID:37414399   PMID:37758217   PMID:37774081   PMID:37960269   PMID:38018996   PMID:38057687   PMID:38129593   PMID:38215077   PMID:38270305   PMID:38366093   PMID:38445462  
PMID:38452772   PMID:38490506   PMID:38748366   PMID:38757341   PMID:38819446   PMID:38880321   PMID:39080798   PMID:39183355  


Genomics

Comparative Map Data
MIR34A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,151,668 - 9,151,777 (-)EnsemblGRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36Build 36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
T2T-CHM13v2.018,685,973 - 8,686,082 (-)NCBIT2T-CHM13v2.0
Mir34a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,152,911 - 150,153,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,152,911 - 150,153,012 (+)EnsemblGRCm39 Ensembl
GRCm384150,068,454 - 150,068,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,068,454 - 150,068,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,442,563 - 149,442,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera4152,344,303 - 152,344,404 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.85NCBI
Mir34a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,815,952 - 165,816,053 (+)NCBIGRCr8
mRatBN7.25160,533,002 - 160,533,103 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,533,002 - 160,533,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,249,485 - 163,249,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,071,851 - 165,071,952 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,028,223 - 165,028,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,092,491 - 167,092,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,092,491 - 167,092,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,733,242 - 170,733,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5158,795,110 - 158,795,211 (+)NCBICelera
Cytogenetic Map5q36NCBI
MIR34A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,485,832 - 62,485,897 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,485,832 - 62,485,897 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,502,877 - 62,502,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,712,027 - 62,712,092 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,712,027 - 62,712,092 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,710,061 - 62,710,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,573,923 - 62,573,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,978,341 - 62,978,406 (-)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.31-36.21(chr1:6652339-12724844)x3 copy number gain See cases [RCV000051794] Chr1:6652339..12724844 [GRCh38]
Chr1:6712399..12784811 [GRCh37]
Chr1:6634986..12707398 [NCBI36]
Chr1:1p36.31-36.21
pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6853513-17326813)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]|See cases [RCV000051795] Chr1:6853513..17326813 [GRCh38]
Chr1:6913573..17685411 [GRCh37]
Chr1:6836160..17557998 [NCBI36]
Chr1:1p36.31-36.13
pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:844347-10809098)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052038]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052038]|See cases [RCV000052038] Chr1:844347..10809098 [GRCh38]
Chr1:779727..10869155 [GRCh37]
Chr1:769590..10791742 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.32-36.22(chr1:5274008-9329925)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053727]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053727]|See cases [RCV000053727] Chr1:5274008..9329925 [GRCh38]
Chr1:5334068..9389984 [GRCh37]
Chr1:5233928..9312571 [NCBI36]
Chr1:1p36.32-36.22
pathogenic
GRCh38/hg38 1p36.31-36.22(chr1:5682528-10863843)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053730]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053730]|See cases [RCV000053730] Chr1:5682528..10863843 [GRCh38]
Chr1:5742588..10923900 [GRCh37]
Chr1:5665175..10846487 [NCBI36]
Chr1:1p36.31-36.22
pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:2963330-12666744)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053713]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053713]|See cases [RCV000053713] Chr1:2963330..12666744 [GRCh38]
Chr1:2879895..12726755 [GRCh37]
Chr1:2869755..12649342 [NCBI36]
Chr1:1p36.32-36.21
pathogenic
GRCh38/hg38 1p36.32-36.13(chr1:3006193-17688934)x1 copy number loss See cases [RCV000053714] Chr1:3006193..17688934 [GRCh38]
Chr1:2922757..18015429 [GRCh37]
Chr1:2912617..17888016 [NCBI36]
Chr1:1p36.32-36.13
pathogenic
GRCh38/hg38 1p36.32-36.22(chr1:3319336-11243395)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053716]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053716]|See cases [RCV000053716] Chr1:3319336..11243395 [GRCh38]
Chr1:3235900..11303452 [GRCh37]
Chr1:3225760..11226039 [NCBI36]
Chr1:1p36.32-36.22
pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:4898439-13111056)x1 copy number loss See cases [RCV000053724] Chr1:4898439..13111056 [GRCh38]
Chr1:4958499..13178528 [GRCh37]
Chr1:4858359..13101115 [NCBI36]
Chr1:1p36.32-36.21
pathogenic
GRCh38/hg38 1p36.23-36.21(chr1:7165036-13111056)x1 copy number loss See cases [RCV000053755] Chr1:7165036..13111056 [GRCh38]
Chr1:7225096..13178528 [GRCh37]
Chr1:7147683..13101115 [NCBI36]
Chr1:1p36.23-36.21
pathogenic
GRCh38/hg38 1p36.23-36.13(chr1:9034671-16441465)x1 copy number loss See cases [RCV000053756] Chr1:9034671..16441465 [GRCh38]
Chr1:9094730..16767960 [GRCh37]
Chr1:9017317..16640547 [NCBI36]
Chr1:1p36.23-36.13
pathogenic
GRCh38/hg38 1p36.23-36.21(chr1:9064492-12666744)x1 copy number loss See cases [RCV000133779] Chr1:9064492..12666744 [GRCh38]
Chr1:9124551..12726755 [GRCh37]
Chr1:9047138..12649342 [NCBI36]
Chr1:1p36.23-36.21
pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8283694-12470133)x1 copy number loss See cases [RCV000135807] Chr1:8283694..12470133 [GRCh38]
Chr1:8343754..12530188 [GRCh37]
Chr1:8266341..12452775 [NCBI36]
Chr1:1p36.23-36.22
pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8804244-10102950)x3 copy number gain See cases [RCV000137134] Chr1:8804244..10102950 [GRCh38]
Chr1:8864303..10163008 [GRCh37]
Chr1:8786890..10085595 [NCBI36]
Chr1:1p36.23-36.22
uncertain significance
GRCh38/hg38 1p36.33-36.22(chr1:844347-12470133)x1 copy number loss See cases [RCV000136695] Chr1:844347..12470133 [GRCh38]
Chr1:779727..12530188 [GRCh37]
Chr1:769590..12452775 [NCBI36]
Chr1:1p36.33-36.22
pathogenic|likely pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:4898439-12911913)x1 copy number loss See cases [RCV000137461] Chr1:4898439..12911913 [GRCh38]
Chr1:4958499..12971757 [GRCh37]
Chr1:4858359..12894344 [NCBI36]
Chr1:1p36.32-36.21
pathogenic
GRCh38/hg38 1p36.31-36.21(chr1:6303641-15799093)x1 copy number loss See cases [RCV000137948] Chr1:6303641..15799093 [GRCh38]
Chr1:6363701..16125588 [GRCh37]
Chr1:6286288..15998175 [NCBI36]
Chr1:1p36.31-36.21
pathogenic|likely benign
GRCh38/hg38 1p36.33-36.22(chr1:914086-9567122)x1 copy number loss See cases [RCV000141970] Chr1:914086..9567122 [GRCh38]
Chr1:849466..9627180 [GRCh37]
Chr1:839329..9549767 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:902111-9556305)x1 copy number loss See cases [RCV000141577] Chr1:902111..9556305 [GRCh38]
Chr1:837491..9616363 [GRCh37]
Chr1:827354..9538950 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6554885-16056011)x3 copy number gain See cases [RCV000142906] Chr1:6554885..16056011 [GRCh38]
Chr1:6614945..16382506 [GRCh37]
Chr1:6537532..16255093 [NCBI36]
Chr1:1p36.31-36.13
pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:911300-9329925)x1 copy number loss See cases [RCV000142615] Chr1:911300..9329925 [GRCh38]
Chr1:846680..9389984 [GRCh37]
Chr1:836543..9312571 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:5363826-18360302)x1 copy number loss See cases [RCV000142771] Chr1:5363826..18360302 [GRCh38]
Chr1:5423886..18686796 [GRCh37]
Chr1:5323746..18559383 [NCBI36]
Chr1:1p36.31-36.13
pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8819278-9634691)x3 copy number gain See cases [RCV000143200] Chr1:8819278..9634691 [GRCh38]
Chr1:8879337..9694749 [GRCh37]
Chr1:8801924..9617336 [NCBI36]
Chr1:1p36.23-36.22
uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11
uncertain significance
chr1:909238-16736132 complex variant complex Breast ductal adenocarcinoma [RCV000207094] Chr1:909238..16736132 [GRCh37]
Chr1:1p36.33-36.13
uncertain significance
GRCh37/hg19 1p36.33-36.22(chr1:82154-12699337)x1 copy number loss See cases [RCV000239416] Chr1:82154..12699337 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.23-36.21(chr1:8255222-12785220)x3 copy number gain See cases [RCV000240284] Chr1:8255222..12785220 [GRCh37]
Chr1:1p36.23-36.21
likely pathogenic
GRCh37/hg19 1p36.33-36.21(chr1:746608-15077159)x1 copy number loss See cases [RCV000240403] Chr1:746608..15077159 [GRCh37]
Chr1:1p36.33-36.21
pathogenic
GRCh37/hg19 1p36.32-36.22(chr1:2817420-10670878)x1 copy number loss See cases [RCV000449468] Chr1:2817420..10670878 [GRCh37]
Chr1:1p36.32-36.22
pathogenic
GRCh37/hg19 1p36.33-36.22(chr1:849466-9683808)x1 copy number loss See cases [RCV000446331] Chr1:849466..9683808 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.32-36.21(chr1:4558588-13187457)x1 copy number loss See cases [RCV000446359] Chr1:4558588..13187457 [GRCh37]
Chr1:1p36.32-36.21
pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1 copy number loss See cases [RCV000446470] Chr1:2749920..22564787 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:7301946-11143298)x3 copy number gain See cases [RCV000448222] Chr1:7301946..11143298 [GRCh37]
Chr1:1p36.23-36.22
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:8855705-9389530)x1 copy number loss See cases [RCV000510311] Chr1:8855705..9389530 [GRCh37]
Chr1:1p36.23-36.22
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.23-36.13(chr1:8850514-16272383)x1 copy number loss See cases [RCV000512226] Chr1:8850514..16272383 [GRCh37]
Chr1:1p36.23-36.13
likely pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:7331314-9427796)x1 copy number loss not provided [RCV000684545] Chr1:7331314..9427796 [GRCh37]
Chr1:1p36.23-36.22
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:7391956-9775929)x1 copy number loss not provided [RCV000684546] Chr1:7391956..9775929 [GRCh37]
Chr1:1p36.23-36.22
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-36.22(chr1:82154-11784118)x1 copy number loss See cases [RCV000790592] Chr1:82154..11784118 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787413] Chr1:554375..9779842 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:8698108-9266627)x3 copy number gain not provided [RCV000846820] Chr1:8698108..9266627 [GRCh37]
Chr1:1p36.23-36.22
uncertain significance
GRCh37/hg19 1p36.33-36.13(chr1:849466-17525065)x1 copy number loss not provided [RCV001832902] Chr1:849466..17525065 [GRCh37]
Chr1:1p36.33-36.13
pathogenic
NC_000001.10:g.(?_8616514)_(12476900_?)dup duplication Immunodeficiency 14 [RCV001920571] Chr1:8616514..12476900 [GRCh37]
Chr1:1p36.23-36.22
uncertain significance
NC_000001.10:g.(?_6485016)_(12569078_?)del deletion not provided [RCV001940096] Chr1:6485016..12569078 [GRCh37]
Chr1:1p36.31-36.22
uncertain significance
GRCh37/hg19 1p36.33-36.22(chr1:849466-10258804) copy number loss Chromosome 1p36 deletion syndrome, proximal [RCV002280717] Chr1:849466..10258804 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
NC_000001.10:g.4481271_20530242del deletion Chromosome 1p36 deletion syndrome [RCV003159574] Chr1:4481271..20530242 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
GRCh37/hg19 1p36.33-36.22(chr1:849467-12448956)x1 copy number loss not provided [RCV002473951] Chr1:849467..12448956 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.31-36.13(chr1:6758933-19287770)x1 copy number loss not provided [RCV002474779] Chr1:6758933..19287770 [GRCh37]
Chr1:1p36.31-36.13
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:8473813-9852687)x1 copy number loss not provided [RCV002472637] Chr1:8473813..9852687 [GRCh37]
Chr1:1p36.23-36.22
likely pathogenic
GRCh37/hg19 1p36.33-36.22(chr1:849467-9627901)x1 copy number loss not provided [RCV003482961] Chr1:849467..9627901 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1
pathogenic
GRCh37/hg19 1p36.31-36.21(chr1:6330828-12910774)x1 copy number loss not specified [RCV003987128] Chr1:6330828..12910774 [GRCh37]
Chr1:1p36.31-36.21
pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2 copy number loss not provided [RCV004577440] Chr1:4436802..22782007 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
NC_000001.10:g.(?_5923325)_(12071622_?)del deletion not provided [RCV004579132] Chr1:5923325..12071622 [GRCh37]
Chr1:1p36.31-36.22
uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BIRC3hsa-miR-34a-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)17540599
GRM7hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20388499
GRM7hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;ProteomicsFunctional MTI21566225
JAG1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20351093
JAG1hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//MicroFunctional MTI19398721
FOSL1hsa-miR-34a-5pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI22198213
MYChsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI19696787
MYChsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21294122
MYChsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22159222
MYChsa-miR-34a-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
MYBhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Luciferase reporter assayFunctional MTI19584398
MYBhsa-miR-34a-5pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)21566225
HMGA2hsa-miR-34a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19461653
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19461653
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18834857
METhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19006648
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Northern Functional MTI19029026
METhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20309880
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19773441
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22457788
METhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21240262
CDK4hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//MicroarraFunctional MTI17914404
CDK4hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI21128241
EPHA5hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22079638
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18504438
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Luciferase reporter assayFunctional MTI18505919
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI17297439
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22020437
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI22662276
SYT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22160687
CCND3hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI18406353
CDK6hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI18406353
CDK6hsa-miR-34a-5pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI21240262
ULBP2hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Western blotFunctional MTI22102694
IMPDH2hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22301190
WNT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19336450
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI17252019
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//qRT-PCRFunctional MTI (Weak)17875987
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Western bFunctional MTI17297439
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI20889924
DLL1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI14697198
DLL1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20144220
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assayFunctional MTI18834855
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Northern Functional MTI18755897
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20185821
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19221490
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20627091
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Luciferase reporter assay//qRT-PCR//Western Functional MTI20470934
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19683563
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18803879
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI17656095
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//ReporFunctional MTI20598588
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;OtherFunctional MTI21399894
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI17150773
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoImmunofluorescence//Immunohistochemistry//LuciferaFunctional MTI22363487
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22684561
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23085450
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI23226240
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
HNF4Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20018894
HNF4Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22232426
YY1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI21182263
MAGEA12hsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI21177782
MAGEA6hsa-miR-34a-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//qRFunctional MTI21177782
MAP2K1hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
PEA15hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI20388802
VEGFAhsa-miR-34a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayNon-Functional MTI18320040
IFNB1hsa-miR-34a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
E2F1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI21128241
NOTCH2hsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Immunocytochemistry//Luciferase reportFunctional MTI22363487
CD44hsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blot//ReporFunctional MTI21240262
FOXP1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21460242
MAP3K9hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotNon-Functional MTI21266077
CEBPBhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayNon-Functional MTI20598588
ZAP70hsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI21205967
PDGFRAhsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//Microarray/Functional MTI22479456
AXLhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21814748
CCL22hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22975373
KLBhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22988100
TP53hsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//ImmunocytochemistryFunctional MTI (Weak)23292869
PPP1R10hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23426265
ACSL4hsa-miR-34a-5pMirtarbaseexternal_infoProteomics//Reporter assay;ProteomicsFunctional MTI21566225
MTA2hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI20018894
UHRF1hsa-miR-34a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
HPRT1hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)19696787
ACSL1hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;Proteomics//ProteomicsFunctional MTI21566225
CDKN2Chsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;qRT-PCRFunctional MTI21128241
CDK6hsa-miR-34a-5pTarbaseexternal_infoReporter GenePOSITIVE
E2F3hsa-miR-34a-5pTarbaseexternal_infoWesternblitPOSITIVE
UBQLN2hsa-miR-34a-5pTarbaseexternal_infoProteomicsPOSITIVE
SIRT1hsa-miR-34a-5pTarbaseexternal_infoqPCRNEGATIVE
E2F1hsa-miR-34a-5pTarbaseexternal_infoWesternblitNEGATIVE
CDKN2Chsa-miR-34a-5pTarbaseexternal_infoqPCRPOSITIVE
BCL2hsa-miR-34a-5pTarbaseexternal_infoOtherPOSITIVE
CEBPBhsa-miR-34a-5pTarbaseexternal_infoReporter GeneNEGATIVE
MYChsa-miR-34a-5pTarbaseexternal_infoMicroarrayNEGATIVE
B4GALT3hsa-miR-34a-5pTarbaseexternal_infoSequencingPOSITIVE
ARhsa-miR-34a-5pOncomiRDBexternal_infoNANA23145211
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA23085450
FOSL1hsa-miR-34a-5pOncomiRDBexternal_infoNANA23001043
CCL22hsa-miR-34a-5pOncomiRDBexternal_infoNANA22975373
ARHGAP1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22850877
PDGFRAhsa-miR-34a-5pOncomiRDBexternal_infoNANA22750848
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22684561
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA22623155
PDGFRAhsa-miR-34a-5pOncomiRDBexternal_infoNANA22479456
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA22457788
IMPDH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22301190
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA22235332
FOSL1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22198213
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA22159222
SNAI1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22134354
ARAFhsa-miR-34a-5pOncomiRDBexternal_infoNANA22102825
SNAI1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22024162
DLL1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21931765
MSI1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21881409
AXLhsa-miR-34a-5pOncomiRDBexternal_infoNANA21814748
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21743299
CDK6hsa-miR-34a-5pOncomiRDBexternal_infoNANA21702042
MYCNhsa-miR-34a-5pOncomiRDBexternal_infoNANA21654684
FOXP1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21460242
ARhsa-miR-34a-5pOncomiRDBexternal_infoNANA21343391
AXLhsa-miR-34a-5pOncomiRDBexternal_infoNANA21317930
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA21297663
CD44hsa-miR-34a-5pOncomiRDBexternal_infoNANA21240262
YY1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21182263
MAGEA2hsa-miR-34a-5pOncomiRDBexternal_infoNANA21177782
E2F3hsa-miR-34a-5pOncomiRDBexternal_infoNANA20889924
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA20687223
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA20470934
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA20351093
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA19773441
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA19696787
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA19029026
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA19006648
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA18834855
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA18803879
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA18755897
CDK6hsa-miR-34a-5pOncomiRDBexternal_infoNANA18719384
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA18505919
MYCNhsa-miR-34a-5pOncomiRDBexternal_infoNANA18504438
CCND1hsa-miR-34a-5pOncomiRDBexternal_infoNANA18406353
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA17656095
E2F3hsa-miR-34a-5pOncomiRDBexternal_infoNANA17297439
XIAPhsa-miR-34a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22161761
DLL1hsa-miR-34a-3pMirecordsexternal_infoNANA14697198
E2F3hsa-miR-34a-3pMirecordsexternal_infoNANA17297439
VEGFAhsa-miR-34a-3pMirecordsexternal_infoNANA18320040
BCL2hsa-miR-34a-3pMirecordsexternal_infoNANA17656095
MYCNhsa-miR-34a-3pMirecordsexternal_infoNANA18504438
HMGA2hsa-miR-34a-3pMirecordsexternal_info{changed}NA18803879
BCL2hsa-miR-34a-3pMirecordsexternal_infoNANA18803879
SIRT1hsa-miR-34a-3pMirecordsexternal_infoNANA18755897
CDK6hsa-miR-34a-3pMirecordsexternal_infoNANA18834855
BCL2hsa-miR-34a-3pMirecordsexternal_infoNANA20433755
MYChsa-miR-34a-3pMirecordsexternal_info{changed}NA20212154
NOTCH1hsa-miR-34a-3pMirecordsexternal_infoNANA20351093
MAP2K1hsa-miR-34a-3pMirecordsexternal_infoNANA20299489
METhsa-miR-34a-3pMirecordsexternal_infoNANA19773441
MYBhsa-miR-34a-3pMirecordsexternal_info{changed}NA19584398
WNT1hsa-miR-34a-3pMirecordsexternal_infoNANA19398721
AXIN2hsa-miR-34a-3pMirecordsexternal_infoNANA19336450
CD44hsa-miR-34a-3pMirecordsexternal_info{changed}NA21240262
AXLhsa-miR-34a-3pMirecordsexternal_info{changed}NA21317930
EPHA5hsa-miR-34a-3pMirecordsexternal_infoNANA22079638

Predicted Targets
Summary Value
Count of predictions:43688
Count of gene targets:15701
Count of transcripts:34459
Interacting mature miRNAs:hsa-miR-34a-3p, hsa-miR-34a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENST00000385130
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl19,151,668 - 9,151,777 (-)Ensembl
RefSeq Acc Id: NR_029610
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3819,151,668 - 9,151,777 (-)NCBI
GRCh3719,211,727 - 9,211,836 (-)ENTREZGENE
HuRef18,362,551 - 8,362,660 (-)ENTREZGENE
CHM1_119,201,981 - 9,202,090 (-)NCBI
T2T-CHM13v2.018,685,973 - 8,686,082 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31635 AgrOrtholog
COSMIC MIR34A COSMIC
Ensembl Genes ENSG00000284357 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385130 ENTREZGENE
GTEx ENSG00000284357 GTEx
HGNC ID HGNC:31635 ENTREZGENE
Human Proteome Map MIR34A Human Proteome Map
miRBase MI0000268 ENTREZGENE
NCBI Gene 407040 ENTREZGENE
OMIM 611172 OMIM
PharmGKB PA164722675 PharmGKB
RNAcentral URS00000EED18 RNACentral
  URS000030BD69 RNACentral
  URS000033F823 RNACentral