MIR34A (microRNA 34a) - Rat Genome Database

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Gene: MIR34A (microRNA 34a) Homo sapiens
Analyze
Symbol: MIR34A
Name: microRNA 34a
RGD ID: 1343452
HGNC Page HGNC
Description: Predicted to act upstream of or within with a positive effect on bone growth. Predicted to act upstream of or within with a negative effect on bone resorption and osteoclast development. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of stem cell differentiation; and sensory perception of sound. Implicated in hepatocellular carcinoma. Biomarker of hepatoblastoma; hepatocellular carcinoma; and non-alcoholic fatty liver disease.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-34; mir-34a; MIRN34A; miRNA34A
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl19,151,668 - 9,151,777 (-)EnsemblGRCh38hg38GRCh38
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-acetamidofluorene  (ISO)
3,7-dihydropurine-6-thione  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-D-galactose  (EXP,ISO)
aristolochic acid  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Betanin  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
camptothecin  (EXP)
cannabidiol  (ISO)
chenodeoxycholic acid  (EXP)
chlorendic acid  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
furan  (ISO)
galactose  (EXP,ISO)
genistein  (EXP)
hydrogen peroxide  (EXP)
irinotecan  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
mercaptopurine  (ISO)
methapyrilene  (ISO)
mitomycin C  (EXP)
monuron  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
Pentoxifylline  (ISO)
propanal  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
titanium dioxide  (EXP)
tributyl phosphate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

Additional References at PubMed
PMID:12554860   PMID:12624257   PMID:16381832   PMID:17297439   PMID:17540598   PMID:17540599   PMID:17554199   PMID:17604727   PMID:17616659   PMID:17875987   PMID:17888029   PMID:18320040  
PMID:18406353   PMID:18451145   PMID:18504438   PMID:18505919   PMID:18719384   PMID:18755897   PMID:18803879   PMID:18818704   PMID:18834855   PMID:18941118   PMID:19006648   PMID:19158830  
PMID:19258450   PMID:19347736   PMID:19398721   PMID:19443717   PMID:19461653   PMID:19584398   PMID:19632201   PMID:19643983   PMID:19696787   PMID:19714243   PMID:19736307   PMID:19921694  
PMID:20089965   PMID:20118199   PMID:20130213   PMID:20186752   PMID:20190569   PMID:20299489   PMID:20351093   PMID:20424141   PMID:20442590   PMID:20466628   PMID:20470934   PMID:20627091  
PMID:20689156   PMID:20889907   PMID:21037258   PMID:21067862   PMID:21177782   PMID:21182263   PMID:21225432   PMID:21266077   PMID:21317930   PMID:21367750   PMID:21421997   PMID:21460242  
PMID:21566225   PMID:21575235   PMID:21702042   PMID:21743299   PMID:21809390   PMID:21814748   PMID:21909380   PMID:21914401   PMID:21923954   PMID:21931765   PMID:21960059   PMID:22024162  
PMID:22045851   PMID:22079638   PMID:22082000   PMID:22102825   PMID:22102859   PMID:22114136   PMID:22134354   PMID:22140441   PMID:22159222   PMID:22162084   PMID:22198089   PMID:22198213  
PMID:22235332   PMID:22237142   PMID:22246523   PMID:22292433   PMID:22301190   PMID:22363487   PMID:22364258   PMID:22389628   PMID:22457788   PMID:22496226   PMID:22562822   PMID:22568628  
PMID:22624980   PMID:22629428   PMID:22651868   PMID:22672425   PMID:22684560   PMID:22684561   PMID:22810507   PMID:22841474   PMID:22844109   PMID:22850877   PMID:22870278   PMID:22902550  
PMID:22975373   PMID:22992310   PMID:23001043   PMID:23036084   PMID:23047694   PMID:23140286   PMID:23166734   PMID:23226240   PMID:23243217   PMID:23292869   PMID:23298640   PMID:23312020  
PMID:23314380   PMID:23323620   PMID:23327670   PMID:23349340   PMID:23426265   PMID:23462268   PMID:23525472   PMID:23525797   PMID:23529798   PMID:23569431   PMID:23593387   PMID:23624843  
PMID:23642368   PMID:23720881   PMID:23743335   PMID:23759592   PMID:23770290   PMID:23790975   PMID:23794259   PMID:23796712   PMID:23805317   PMID:23828613   PMID:23836017   PMID:23860128  
PMID:23862748   PMID:23902763   PMID:23942619   PMID:23970470   PMID:23991105   PMID:24001901   PMID:24019906   PMID:24032460   PMID:24048733   PMID:24050776   PMID:24068565   PMID:24078448  
PMID:24081307   PMID:24091633   PMID:24094113   PMID:24123326   PMID:24130780   PMID:24185900   PMID:24220341   PMID:24232982   PMID:24238045   PMID:24249224   PMID:24260422   PMID:24307639  
PMID:24362009   PMID:24370784   PMID:24393844   PMID:24402874   PMID:24412053   PMID:24415058   PMID:24418846   PMID:24423412   PMID:24438466   PMID:24447044   PMID:24457968   PMID:24481728  
PMID:24482044   PMID:24497324   PMID:24504520   PMID:24528540   PMID:24530915   PMID:24548601   PMID:24551227   PMID:24559316   PMID:24573638   PMID:24595209   PMID:24607549   PMID:24621885  
PMID:24625819   PMID:24637697   PMID:24642471   PMID:24792364   PMID:24796666   PMID:24811488   PMID:24832862   PMID:24837198   PMID:24866595   PMID:24884974   PMID:24910152   PMID:24912852  
PMID:24957404   PMID:24970812   PMID:24981249   PMID:24988056   PMID:25015333   PMID:25032850   PMID:25038915   PMID:25053345   PMID:25068403   PMID:25173798   PMID:25174400   PMID:25179842  
PMID:25231528   PMID:25242229   PMID:25250818   PMID:25265426   PMID:25268950   PMID:25333573   PMID:25348795   PMID:25352462   PMID:25355491   PMID:25362853   PMID:25366387   PMID:25368020  
PMID:25370690   PMID:25395581   PMID:25396727   PMID:25403318   PMID:25436980   PMID:25452192   PMID:25474246   PMID:25491743   PMID:25499621   PMID:25501507   PMID:25526086   PMID:25551284  
PMID:25556547   PMID:25562151   PMID:25579512   PMID:25585539   PMID:25587085   PMID:25596083   PMID:25623948   PMID:25656948   PMID:25658813   PMID:25675046   PMID:25698383   PMID:25762634  
PMID:25773680   PMID:25783790   PMID:25788289   PMID:25846116   PMID:25855231   PMID:25860861   PMID:25862914   PMID:25878394   PMID:25896587   PMID:25908274   PMID:25909221   PMID:25910896  
PMID:25924769   PMID:25954903   PMID:25973020   PMID:26027785   PMID:26077733   PMID:26091620   PMID:26100857   PMID:26103003   PMID:26104764   PMID:26126715   PMID:26153151   PMID:26177460  
PMID:26180794   PMID:26191210   PMID:26209160   PMID:26214687   PMID:26238271   PMID:26262588   PMID:26287733   PMID:26313360   PMID:26318298   PMID:26323460   PMID:26324236   PMID:26330104  
PMID:26335888   PMID:26359358   PMID:26381333   PMID:26385595   PMID:26403328   PMID:26415802   PMID:26464633   PMID:26493107   PMID:26499184   PMID:26523671   PMID:26553365   PMID:26572867  
PMID:26616853   PMID:26648462   PMID:26667302   PMID:26677981   PMID:26678891   PMID:26684239   PMID:26718338   PMID:26782413   PMID:26802970   PMID:26854484   PMID:26895471   PMID:26902416  
PMID:26923637   PMID:26940669   PMID:26940952   PMID:26944831   PMID:26949937   PMID:26956717   PMID:26996824   PMID:26996957   PMID:27039384   PMID:27056900   PMID:27077950   PMID:27121375  
PMID:27144431   PMID:27165229   PMID:27176117   PMID:27220728   PMID:27221871   PMID:27233077   PMID:27235866   PMID:27246008   PMID:27247228   PMID:27250838   PMID:27302634   PMID:27312544  
PMID:27362652   PMID:27380024   PMID:27391063   PMID:27423514   PMID:27444357   PMID:27449099   PMID:27450916   PMID:27453008   PMID:27456356   PMID:27458977   PMID:27461446   PMID:27468165  
PMID:27486773   PMID:27513856   PMID:27513895   PMID:27524218   PMID:27529373   PMID:27545688   PMID:27561942   PMID:27594424   PMID:27596137   PMID:27623940   PMID:27631879   PMID:27635790  
PMID:27644439   PMID:27767101   PMID:27780189   PMID:27813227   PMID:27836543   PMID:27840975   PMID:27858840   PMID:27879964   PMID:27924478   PMID:27956809   PMID:27977785   PMID:28008152  
PMID:28035390   PMID:28045889   PMID:28073349   PMID:28084588   PMID:28098757   PMID:28100259   PMID:28126925   PMID:28130497   PMID:28145431   PMID:28157629   PMID:28178621   PMID:28192603  
PMID:28218742   PMID:28250026   PMID:28259991   PMID:28260055   PMID:28275089   PMID:28276476   PMID:28277300   PMID:28281638   PMID:28334277   PMID:28340489   PMID:28348487   PMID:28356515  
PMID:28399871   PMID:28404901   PMID:28423483   PMID:28431233   PMID:28468587   PMID:28478444   PMID:28485160   PMID:28498458   PMID:28512015   PMID:28525978   PMID:28534990   PMID:28624481  
PMID:28635396   PMID:28639625   PMID:28667334   PMID:28688900   PMID:28699360   PMID:28705115   PMID:28708282   PMID:28713966   PMID:28721584   PMID:28731182   PMID:28744338   PMID:28798470  
PMID:28810936   PMID:28859546   PMID:28893346   PMID:28915924   PMID:28923203   PMID:28934017   PMID:28943452   PMID:28955068   PMID:28963640   PMID:28988111   PMID:28990049   PMID:29022890  
PMID:29025958   PMID:29028450   PMID:29037220   PMID:29054762   PMID:29057547   PMID:29060932   PMID:29061308   PMID:29079808   PMID:29080815   PMID:29082244   PMID:29094237   PMID:29102917  
PMID:29104726   PMID:29128099   PMID:29197627   PMID:29197895   PMID:29207015   PMID:29292727   PMID:29295989   PMID:29298665   PMID:29302057   PMID:29315816   PMID:29328474   PMID:29331104  
PMID:29355113   PMID:29371016   PMID:29373969   PMID:29391755   PMID:29393501   PMID:29487007   PMID:29511160   PMID:29561664   PMID:29576507   PMID:29578002   PMID:29607782   PMID:29658562  
PMID:29674133   PMID:29679755   PMID:29748184   PMID:29750293   PMID:29771420   PMID:29775159   PMID:29795112   PMID:29885402   PMID:29895719   PMID:29916548   PMID:29941603   PMID:29945348  
PMID:29946193   PMID:29957876   PMID:29960168   PMID:29970122   PMID:29980240   PMID:29989838   PMID:30001529   PMID:30021364   PMID:30048987   PMID:30093634   PMID:30111844   PMID:30138895  
PMID:30142428   PMID:30165351   PMID:30175154   PMID:30203457   PMID:30216788   PMID:30221494   PMID:30221696   PMID:30231924   PMID:30243489   PMID:30256056   PMID:30256916   PMID:30262862  
PMID:30275195   PMID:30282072   PMID:30289954   PMID:30312725   PMID:30362332   PMID:30365098   PMID:30386383   PMID:30387807   PMID:30387834   PMID:30389523   PMID:30446443   PMID:30463570  
PMID:30468908   PMID:30474870   PMID:30478927   PMID:30488208   PMID:30551433   PMID:30592284   PMID:30617054   PMID:30627547   PMID:30716314   PMID:30718475   PMID:30742065   PMID:30779057  
PMID:30779084   PMID:30851271   PMID:30860027   PMID:30905732   PMID:30920025   PMID:30951682   PMID:30968145   PMID:30980790   PMID:31042325   PMID:31113203   PMID:31114993   PMID:31115495  
PMID:31115528   PMID:31119955   PMID:31130368   PMID:31132353   PMID:31139863   PMID:31158382   PMID:31170665   PMID:31204933   PMID:31218746   PMID:31235998   PMID:31294899   PMID:31297834  
PMID:31298326   PMID:31311583   PMID:31314593   PMID:31343368   PMID:31349954   PMID:31355469   PMID:31376385   PMID:31376409   PMID:31397599   PMID:31405216   PMID:31425738   PMID:31432176  
PMID:31438837   PMID:31450568   PMID:31506763   PMID:31524250   PMID:31544897   PMID:31545515   PMID:31554373   PMID:31604677   PMID:31619517   PMID:31635187   PMID:31658284   PMID:31661551  
PMID:31663131   PMID:31672604   PMID:31701846   PMID:31710448   PMID:31711057   PMID:31715633   PMID:31718694   PMID:31732824   PMID:31760527   PMID:31775690   PMID:31777195   PMID:31777260  
PMID:31781973   PMID:31799656   PMID:31802650   PMID:31814518   PMID:31830533   PMID:31891569   PMID:31922215   PMID:31923418   PMID:31926946   PMID:31983127   PMID:32001264   PMID:32044957  
PMID:32046388   PMID:32054948   PMID:32056304   PMID:32070036   PMID:32114390   PMID:32162890   PMID:32181973   PMID:32186770   PMID:32220540   PMID:32248643   PMID:32255309   PMID:32301035  
PMID:32304779   PMID:32319382   PMID:32323786   PMID:32336272   PMID:32349744   PMID:32357442   PMID:32376568   PMID:32391804   PMID:32412799   PMID:32439864   PMID:32445780   PMID:32461691  
PMID:32484698   PMID:32502839   PMID:32531952   PMID:32559619   PMID:32585876   PMID:32602014   PMID:32626991   PMID:32634429   PMID:32648233   PMID:32654473   PMID:32659427   PMID:32660221  
PMID:32700738   PMID:32719987   PMID:32738890   PMID:32748742   PMID:32755834   PMID:32798250   PMID:32826862   PMID:32841775   PMID:32856736   PMID:32894541   PMID:32901838   PMID:32921986  
PMID:32928232   PMID:32928372   PMID:32929850   PMID:33015156   PMID:33028635   PMID:33034147   PMID:33037254   PMID:33074217   PMID:33092644   PMID:33098868   PMID:33112434   PMID:33125091  
PMID:33155244   PMID:33190281   PMID:33201337   PMID:33215424   PMID:33229509   PMID:33275235   PMID:33359304   PMID:33374832   PMID:33378474   PMID:33398374   PMID:33398678   PMID:33400820  
PMID:33416118   PMID:33416133   PMID:33432364   PMID:33438362   PMID:33463130   PMID:33492448   PMID:33507132   PMID:33528317   PMID:33581076   PMID:33596979   PMID:33601073   PMID:33629295  
PMID:33642822   PMID:33650650   PMID:33650673   PMID:33673143   PMID:33706708   PMID:33904680   PMID:33932899   PMID:33962397   PMID:34011046   PMID:34024195   PMID:34038763   PMID:34062187  
PMID:34102608   PMID:34296298  


Genomics

Comparative Map Data
MIR34A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl19,151,668 - 9,151,777 (-)EnsemblGRCh38hg38GRCh38
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
Mir34a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,152,911 - 150,153,012 (+)NCBIGRCm39mm39
GRCm39 Ensembl4150,152,911 - 150,153,012 (+)Ensembl
GRCm384150,068,454 - 150,068,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,068,454 - 150,068,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,442,563 - 149,442,664 (+)NCBIGRCm37mm9NCBIm37
Celera4152,344,303 - 152,344,404 (+)NCBICelera
Cytogenetic Map4E2NCBI
Mir34a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,533,002 - 160,533,103 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5160,533,002 - 160,533,103 (+)Ensembl
Rnor_6.05167,092,491 - 167,092,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,092,491 - 167,092,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,733,242 - 170,733,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5158,795,110 - 158,795,211 (+)NCBICelera
Cytogenetic Map5q36NCBI
MIR34A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,485,832 - 62,485,897 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,485,832 - 62,485,897 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,502,877 - 62,502,942 (-)NCBI
ROS_Cfam_1.0562,712,027 - 62,712,092 (-)NCBI
UMICH_Zoey_3.1562,710,061 - 62,710,126 (-)NCBI
UNSW_CanFamBas_1.0562,573,923 - 62,573,988 (-)NCBI
UU_Cfam_GSD_1.0562,978,341 - 62,978,406 (-)NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BIRC3hsa-miR-34a-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)17540599
GRM7hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20388499
GRM7hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;ProteomicsFunctional MTI21566225
JAG1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20351093
JAG1hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//MicroFunctional MTI19398721
FOSL1hsa-miR-34a-5pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI22198213
MYChsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI19696787
MYChsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21294122
MYChsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22159222
MYChsa-miR-34a-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
MYBhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Luciferase reporter assayFunctional MTI19584398
MYBhsa-miR-34a-5pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)21566225
HMGA2hsa-miR-34a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19461653
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19461653
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18834857
METhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19006648
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Northern Functional MTI19029026
METhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20309880
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19773441
METhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22457788
METhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21240262
CDK4hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//MicroarraFunctional MTI17914404
CDK4hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI21128241
EPHA5hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22079638
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18504438
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Luciferase reporter assayFunctional MTI18505919
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI17297439
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22020437
MYCNhsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI22662276
SYT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22160687
CCND3hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI18406353
CDK6hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI18406353
CDK6hsa-miR-34a-5pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI21240262
ULBP2hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Western blotFunctional MTI22102694
IMPDH2hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22301190
WNT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19336450
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI17252019
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//qRT-PCRFunctional MTI (Weak)17875987
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Western bFunctional MTI17297439
E2F3hsa-miR-34a-5pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI20889924
DLL1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI14697198
DLL1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20144220
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assayFunctional MTI18834855
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Northern Functional MTI18755897
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20185821
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19221490
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20627091
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Luciferase reporter assay//qRT-PCR//Western Functional MTI20470934
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19683563
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18803879
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI17656095
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//ReporFunctional MTI20598588
BCL2hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;OtherFunctional MTI21399894
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI17150773
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoImmunofluorescence//Immunohistochemistry//LuciferaFunctional MTI22363487
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22684561
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23085450
NOTCH1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI23226240
SIRT1hsa-miR-34a-5pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
HNF4Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20018894
HNF4Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22232426
YY1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI21182263
MAGEA12hsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI21177782
MAGEA6hsa-miR-34a-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//qRFunctional MTI21177782
MAP2K1hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
PEA15hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI20388802
VEGFAhsa-miR-34a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayNon-Functional MTI18320040
IFNB1hsa-miR-34a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
E2F1hsa-miR-34a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI21128241
NOTCH2hsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Immunocytochemistry//Luciferase reportFunctional MTI22363487
CD44hsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blot//ReporFunctional MTI21240262
FOXP1hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21460242
MAP3K9hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotNon-Functional MTI21266077
CEBPBhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayNon-Functional MTI20598588
ZAP70hsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI21205967
PDGFRAhsa-miR-34a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//Microarray/Functional MTI22479456
AXLhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21814748
CCL22hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22975373
KLBhsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22988100
TP53hsa-miR-34a-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//ImmunocytochemistryFunctional MTI (Weak)23292869
PPP1R10hsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23426265
ACSL4hsa-miR-34a-5pMirtarbaseexternal_infoProteomics//Reporter assay;ProteomicsFunctional MTI21566225
MTA2hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI20018894
UHRF1hsa-miR-34a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
HPRT1hsa-miR-34a-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)19696787
ACSL1hsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;Proteomics//ProteomicsFunctional MTI21566225
CDKN2Chsa-miR-34a-5pMirtarbaseexternal_infoReporter assay;qRT-PCRFunctional MTI21128241
CDK6hsa-miR-34a-5pTarbaseexternal_infoReporter GenePOSITIVE
E2F3hsa-miR-34a-5pTarbaseexternal_infoWesternblitPOSITIVE
UBQLN2hsa-miR-34a-5pTarbaseexternal_infoProteomicsPOSITIVE
SIRT1hsa-miR-34a-5pTarbaseexternal_infoqPCRNEGATIVE
E2F1hsa-miR-34a-5pTarbaseexternal_infoWesternblitNEGATIVE
CDKN2Chsa-miR-34a-5pTarbaseexternal_infoqPCRPOSITIVE
BCL2hsa-miR-34a-5pTarbaseexternal_infoOtherPOSITIVE
CEBPBhsa-miR-34a-5pTarbaseexternal_infoReporter GeneNEGATIVE
MYChsa-miR-34a-5pTarbaseexternal_infoMicroarrayNEGATIVE
B4GALT3hsa-miR-34a-5pTarbaseexternal_infoSequencingPOSITIVE
ARhsa-miR-34a-5pOncomiRDBexternal_infoNANA23145211
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA23085450
FOSL1hsa-miR-34a-5pOncomiRDBexternal_infoNANA23001043
CCL22hsa-miR-34a-5pOncomiRDBexternal_infoNANA22975373
ARHGAP1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22850877
PDGFRAhsa-miR-34a-5pOncomiRDBexternal_infoNANA22750848
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22684561
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA22623155
PDGFRAhsa-miR-34a-5pOncomiRDBexternal_infoNANA22479456
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA22457788
IMPDH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22301190
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA22235332
FOSL1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22198213
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA22159222
SNAI1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22134354
ARAFhsa-miR-34a-5pOncomiRDBexternal_infoNANA22102825
SNAI1hsa-miR-34a-5pOncomiRDBexternal_infoNANA22024162
DLL1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21931765
MSI1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21881409
AXLhsa-miR-34a-5pOncomiRDBexternal_infoNANA21814748
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21743299
CDK6hsa-miR-34a-5pOncomiRDBexternal_infoNANA21702042
MYCNhsa-miR-34a-5pOncomiRDBexternal_infoNANA21654684
FOXP1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21460242
ARhsa-miR-34a-5pOncomiRDBexternal_infoNANA21343391
AXLhsa-miR-34a-5pOncomiRDBexternal_infoNANA21317930
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA21297663
CD44hsa-miR-34a-5pOncomiRDBexternal_infoNANA21240262
YY1hsa-miR-34a-5pOncomiRDBexternal_infoNANA21182263
MAGEA2hsa-miR-34a-5pOncomiRDBexternal_infoNANA21177782
E2F3hsa-miR-34a-5pOncomiRDBexternal_infoNANA20889924
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA20687223
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA20470934
NOTCH1hsa-miR-34a-5pOncomiRDBexternal_infoNANA20351093
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA19773441
MYChsa-miR-34a-5pOncomiRDBexternal_infoNANA19696787
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA19029026
METhsa-miR-34a-5pOncomiRDBexternal_infoNANA19006648
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA18834855
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA18803879
SIRT1hsa-miR-34a-5pOncomiRDBexternal_infoNANA18755897
CDK6hsa-miR-34a-5pOncomiRDBexternal_infoNANA18719384
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA18505919
MYCNhsa-miR-34a-5pOncomiRDBexternal_infoNANA18504438
CCND1hsa-miR-34a-5pOncomiRDBexternal_infoNANA18406353
BCL2hsa-miR-34a-5pOncomiRDBexternal_infoNANA17656095
E2F3hsa-miR-34a-5pOncomiRDBexternal_infoNANA17297439
XIAPhsa-miR-34a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22161761
DLL1hsa-miR-34a-3pMirecordsexternal_infoNANA14697198
E2F3hsa-miR-34a-3pMirecordsexternal_infoNANA17297439
VEGFAhsa-miR-34a-3pMirecordsexternal_infoNANA18320040
BCL2hsa-miR-34a-3pMirecordsexternal_infoNANA17656095
MYCNhsa-miR-34a-3pMirecordsexternal_infoNANA18504438
HMGA2hsa-miR-34a-3pMirecordsexternal_info{changed}NA18803879
BCL2hsa-miR-34a-3pMirecordsexternal_infoNANA18803879
SIRT1hsa-miR-34a-3pMirecordsexternal_infoNANA18755897
CDK6hsa-miR-34a-3pMirecordsexternal_infoNANA18834855
BCL2hsa-miR-34a-3pMirecordsexternal_infoNANA20433755
MYChsa-miR-34a-3pMirecordsexternal_info{changed}NA20212154
NOTCH1hsa-miR-34a-3pMirecordsexternal_infoNANA20351093
MAP2K1hsa-miR-34a-3pMirecordsexternal_infoNANA20299489
METhsa-miR-34a-3pMirecordsexternal_infoNANA19773441
MYBhsa-miR-34a-3pMirecordsexternal_info{changed}NA19584398
WNT1hsa-miR-34a-3pMirecordsexternal_infoNANA19398721
AXIN2hsa-miR-34a-3pMirecordsexternal_infoNANA19336450
CD44hsa-miR-34a-3pMirecordsexternal_info{changed}NA21240262
AXLhsa-miR-34a-3pMirecordsexternal_info{changed}NA21317930
EPHA5hsa-miR-34a-3pMirecordsexternal_infoNANA22079638

Predicted Targets
Summary Value
Count of predictions:43688
Count of gene targets:15701
Count of transcripts:34459
Interacting mature miRNAs:hsa-miR-34a-3p, hsa-miR-34a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385130
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl19,151,668 - 9,151,777 (-)Ensembl
RefSeq Acc Id: NR_029610
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3819,151,668 - 9,151,777 (-)NCBI
GRCh3719,211,727 - 9,211,836 (-)ENTREZGENE
HuRef18,362,551 - 8,362,660 (-)ENTREZGENE
CHM1_119,201,981 - 9,202,090 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.31-36.21(chr1:6652339-12724844)x3 copy number gain See cases [RCV000051794] Chr1:6652339..12724844 [GRCh38]
Chr1:6712399..12784811 [GRCh37]
Chr1:6634986..12707398 [NCBI36]
Chr1:1p36.31-36.21
pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6853513-17326813)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]|See cases [RCV000051795] Chr1:6853513..17326813 [GRCh38]
Chr1:6913573..17685411 [GRCh37]
Chr1:6836160..17557998 [NCBI36]
Chr1:1p36.31-36.13
pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:844347-10809098)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052038]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052038]|See cases [RCV000052038] Chr1:844347..10809098 [GRCh38]
Chr1:779727..10869155 [GRCh37]
Chr1:769590..10791742 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.32-36.22(chr1:5274008-9329925)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053727]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053727]|See cases [RCV000053727] Chr1:5274008..9329925 [GRCh38]
Chr1:5334068..9389984 [GRCh37]
Chr1:5233928..9312571 [NCBI36]
Chr1:1p36.32-36.22
pathogenic
GRCh38/hg38 1p36.31-36.22(chr1:5682528-10863843)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053730]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053730]|See cases [RCV000053730] Chr1:5682528..10863843 [GRCh38]
Chr1:5742588..10923900 [GRCh37]
Chr1:5665175..10846487 [NCBI36]
Chr1:1p36.31-36.22
pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:2963330-12666744)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053713]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053713]|See cases [RCV000053713] Chr1:2963330..12666744 [GRCh38]
Chr1:2879895..12726755 [GRCh37]
Chr1:2869755..12649342 [NCBI36]
Chr1:1p36.32-36.21
pathogenic
GRCh38/hg38 1p36.32-36.13(chr1:3006193-17688934)x1 copy number loss See cases [RCV000053714] Chr1:3006193..17688934 [GRCh38]
Chr1:2922757..18015429 [GRCh37]
Chr1:2912617..17888016 [NCBI36]
Chr1:1p36.32-36.13
pathogenic
GRCh38/hg38 1p36.32-36.22(chr1:3319336-11243395)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053716]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053716]|See cases [RCV000053716] Chr1:3319336..11243395 [GRCh38]
Chr1:3235900..11303452 [GRCh37]
Chr1:3225760..11226039 [NCBI36]
Chr1:1p36.32-36.22
pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:4898439-13111056)x1 copy number loss See cases [RCV000053724] Chr1:4898439..13111056 [GRCh38]
Chr1:4958499..13178528 [GRCh37]
Chr1:4858359..13101115 [NCBI36]
Chr1:1p36.32-36.21
pathogenic
GRCh38/hg38 1p36.23-36.21(chr1:7165036-13111056)x1 copy number loss See cases [RCV000053755] Chr1:7165036..13111056 [GRCh38]
Chr1:7225096..13178528 [GRCh37]
Chr1:7147683..13101115 [NCBI36]
Chr1:1p36.23-36.21
pathogenic
GRCh38/hg38 1p36.23-36.13(chr1:9034671-16441465)x1 copy number loss See cases [RCV000053756] Chr1:9034671..16441465 [GRCh38]
Chr1:9094730..16767960 [GRCh37]
Chr1:9017317..16640547 [NCBI36]
Chr1:1p36.23-36.13
pathogenic
GRCh38/hg38 1p36.23-36.21(chr1:9064492-12666744)x1 copy number loss See cases [RCV000133779] Chr1:9064492..12666744 [GRCh38]
Chr1:9124551..12726755 [GRCh37]
Chr1:9047138..12649342 [NCBI36]
Chr1:1p36.23-36.21
pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8283694-12470133)x1 copy number loss See cases [RCV000135807] Chr1:8283694..12470133 [GRCh38]
Chr1:8343754..12530188 [GRCh37]
Chr1:8266341..12452775 [NCBI36]
Chr1:1p36.23-36.22
pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8804244-10102950)x3 copy number gain See cases [RCV000137134] Chr1:8804244..10102950 [GRCh38]
Chr1:8864303..10163008 [GRCh37]
Chr1:8786890..10085595 [NCBI36]
Chr1:1p36.23-36.22
uncertain significance
GRCh38/hg38 1p36.33-36.22(chr1:844347-12470133)x1 copy number loss See cases [RCV000136695] Chr1:844347..12470133 [GRCh38]
Chr1:779727..12530188 [GRCh37]
Chr1:769590..12452775 [NCBI36]
Chr1:1p36.33-36.22
pathogenic|likely pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:4898439-12911913)x1 copy number loss See cases [RCV000137461] Chr1:4898439..12911913 [GRCh38]
Chr1:4958499..12971757 [GRCh37]
Chr1:4858359..12894344 [NCBI36]
Chr1:1p36.32-36.21
pathogenic
GRCh38/hg38 1p36.31-36.21(chr1:6303641-15799093)x1 copy number loss See cases [RCV000137948] Chr1:6303641..15799093 [GRCh38]
Chr1:6363701..16125588 [GRCh37]
Chr1:6286288..15998175 [NCBI36]
Chr1:1p36.31-36.21
pathogenic|likely benign
GRCh38/hg38 1p36.33-36.22(chr1:914086-9567122)x1 copy number loss See cases [RCV000141970] Chr1:914086..9567122 [GRCh38]
Chr1:849466..9627180 [GRCh37]
Chr1:839329..9549767 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:902111-9556305)x1 copy number loss See cases [RCV000141577] Chr1:902111..9556305 [GRCh38]
Chr1:837491..9616363 [GRCh37]
Chr1:827354..9538950 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6554885-16056011)x3 copy number gain See cases [RCV000142906] Chr1:6554885..16056011 [GRCh38]
Chr1:6614945..16382506 [GRCh37]
Chr1:6537532..16255093 [NCBI36]
Chr1:1p36.31-36.13
pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:911300-9329925)x1 copy number loss See cases [RCV000142615] Chr1:911300..9329925 [GRCh38]
Chr1:846680..9389984 [GRCh37]
Chr1:836543..9312571 [NCBI36]
Chr1:1p36.33-36.22
pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:5363826-18360302)x1 copy number loss See cases [RCV000142771] Chr1:5363826..18360302 [GRCh38]
Chr1:5423886..18686796 [GRCh37]
Chr1:5323746..18559383 [NCBI36]
Chr1:1p36.31-36.13
pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8819278-9634691)x3 copy number gain See cases [RCV000143200] Chr1:8819278..9634691 [GRCh38]
Chr1:8879337..9694749 [GRCh37]
Chr1:8801924..9617336 [NCBI36]
Chr1:1p36.23-36.22
uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11
uncertain significance
chr1:909238-16736132 complex variant complex Ductal breast carcinoma [RCV000207094] Chr1:909238..16736132 [GRCh37]
Chr1:1p36.33-36.13
uncertain significance
GRCh37/hg19 1p36.33-36.22(chr1:82154-12699337)x1 copy number loss See cases [RCV000239416] Chr1:82154..12699337 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.23-36.21(chr1:8255222-12785220)x3 copy number gain See cases [RCV000240284] Chr1:8255222..12785220 [GRCh37]
Chr1:1p36.23-36.21
likely pathogenic
GRCh37/hg19 1p36.33-36.21(chr1:746608-15077159)x1 copy number loss See cases [RCV000240403] Chr1:746608..15077159 [GRCh37]
Chr1:1p36.33-36.21
pathogenic
GRCh37/hg19 1p36.32-36.22(chr1:2817420-10670878)x1 copy number loss See cases [RCV000449468] Chr1:2817420..10670878 [GRCh37]
Chr1:1p36.32-36.22
pathogenic
GRCh37/hg19 1p36.33-36.22(chr1:849466-9683808)x1 copy number loss See cases [RCV000446331] Chr1:849466..9683808 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.32-36.21(chr1:4558588-13187457)x1 copy number loss See cases [RCV000446359] Chr1:4558588..13187457 [GRCh37]
Chr1:1p36.32-36.21
pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1 copy number loss See cases [RCV000446470] Chr1:2749920..22564787 [GRCh37]
Chr1:1p36.32-36.12
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:7301946-11143298)x3 copy number gain See cases [RCV000448222] Chr1:7301946..11143298 [GRCh37]
Chr1:1p36.23-36.22
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:8855705-9389530)x1 copy number loss See cases [RCV000510311] Chr1:8855705..9389530 [GRCh37]
Chr1:1p36.23-36.22
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.23-36.13(chr1:8850514-16272383)x1 copy number loss See cases [RCV000512226] Chr1:8850514..16272383 [GRCh37]
Chr1:1p36.23-36.13
likely pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:7331314-9427796)x1 copy number loss not provided [RCV000684545] Chr1:7331314..9427796 [GRCh37]
Chr1:1p36.23-36.22
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:7391956-9775929)x1 copy number loss not provided [RCV000684546] Chr1:7391956..9775929 [GRCh37]
Chr1:1p36.23-36.22
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-36.22(chr1:82154-11784118)x1 copy number loss See cases [RCV000790592] Chr1:82154..11784118 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787413] Chr1:554375..9779842 [GRCh37]
Chr1:1p36.33-36.22
pathogenic
GRCh37/hg19 1p36.23-36.22(chr1:8698108-9266627)x3 copy number gain not provided [RCV000846820] Chr1:8698108..9266627 [GRCh37]
Chr1:1p36.23-36.22
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31635 AgrOrtholog
COSMIC MIR34A COSMIC
Ensembl Genes ENSG00000284357 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385130 ENTREZGENE
GTEx ENSG00000284357 GTEx
HGNC ID HGNC:31635 ENTREZGENE
Human Proteome Map MIR34A Human Proteome Map
miRBase MI0000268 ENTREZGENE
NCBI Gene 407040 ENTREZGENE
OMIM 611172 OMIM
PharmGKB PA164722675 PharmGKB
RNAcentral URS00000EED18 RNACentral
  URS000030BD69 RNACentral
  URS000033F823 RNACentral