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Gene: HNF4A (hepatocyte nuclear factor 4 alpha) Homo sapiens
Symbol: HNF4A
Name: hepatocyte nuclear factor 4 alpha
RGD ID: 69093
Description: Exhibits several functions, including DNA-binding transcription factor activity; fatty acid binding activity; and protein homodimerization activity. Involved in several processes, including blood coagulation; ornithine metabolic process; and regulation of transcription, DNA-templated. Localizes to cytoplasm and nucleoplasm. Implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ39654; FRTS4; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4 4 alpha variant 1; hepatocyte nuclear factor 4 4 alpha variant 2; hepatocyte nuclear factor 4 4 alpha variant 4; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4alpha10/11/12; MODY; MODY1; NR2A1; NR2A21; nuclear receptor subfamily 2 group A member 1; TCF; TCF-14; TCF14; transcription factor 14; transcription factor HNF-4; transcription factor-14
Mus musculus (house mouse) : Hnf4a (hepatic nuclear factor 4, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hnf4a (hepatocyte nuclear factor 4, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF4A (hepatocyte nuclear factor 4 alpha)
Canis lupus familiaris (dog) : HNF4A (hepatocyte nuclear factor 4 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Sus scrofa (pig) : HNF4A (hepatocyte nuclear factor 4 alpha)
Chlorocebus sabaeus (African green monkey) : HNF4A (hepatocyte nuclear factor 4 alpha)
Heterocephalus glaber (naked mole-rat) : Hnf4a (hepatocyte nuclear factor 4 alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2044,355,700 - 44,434,596 (+)EnsemblGRCh38hg38GRCh38
GRCh382044,355,699 - 44,434,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372042,984,441 - 43,061,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,417,855 - 42,493,444 (+)NCBINCBI36hg18NCBI36
Build 342042,463,337 - 42,486,690NCBI
Celera2039,693,092 - 39,768,681 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2039,720,990 - 39,802,805 (+)NCBIHuRef
CHM1_12042,886,684 - 42,964,390 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HNF4A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69093
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.