Mir34a (microRNA 34a) - Rat Genome Database

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Gene: Mir34a (microRNA 34a) Rattus norvegicus
Analyze
Symbol: Mir34a
Name: microRNA 34a
RGD ID: 2325584
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in cellular response to tumor necrosis factor. Located in extracellular exosome. Used to study osteoarthritis. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR34A (microRNA 34a); INTERACTS WITH 2-acetamidofluorene; 3,7-dihydropurine-6-thione; aflatoxin B1.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-34a; rno-mir-34a
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,533,002 - 160,533,103 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,533,002 - 160,533,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,249,485 - 163,249,586 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,071,851 - 165,071,952 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,028,223 - 165,028,324 (+)NCBIRnor_WKY
Rnor_6.05167,092,491 - 167,092,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,092,491 - 167,092,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,733,242 - 170,733,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5158,795,110 - 158,795,211 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP,ISO)
aristolochic acid  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Betanin  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
chenodeoxycholic acid  (ISO)
chlorendic acid  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
crocin-1  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP)
dexmedetomidine  (EXP)
dibutyl phthalate  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galactose  (EXP,ISO)
gallic acid  (EXP)
genistein  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
mercaptopurine  (EXP)
methapyrilene  (EXP)
mitomycin C  (ISO)
monuron  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Pentoxifylline  (EXP)
propanal  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone growth  (ISO)
bone resorption  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to tumor necrosis factor  (IEP)
cellular senescence  (ISO)
miRNA-mediated gene silencing  (ISO)
myelination  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of B cell receptor signaling pathway  (ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intracellular signal transduction  (ISO)
negative regulation of IP-10 production  (ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of transmembrane transport  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
negative regulation of vascular wound healing  (ISO)
obsolete cell aging  (ISO)
osteoclast development  (ISO)
positive regulation of blood vessel endothelial cell differentiation  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hydrogen peroxide-induced cell death  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of protein acetylation  (ISO)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of stem cell differentiation  (ISO)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Combined low miR-34s are associated with unfavorable prognosis in children with hepatoblastoma: A Chinese population-based study. Jiao C, etal., J Pediatr Surg. 2016 Aug;51(8):1355-61. doi: 10.1016/j.jpedsurg.2016.02.091. Epub 2016 Mar 14.
2. Protective effects of crocin and zinc sulfate on hepatic ischemia-reperfusion injury in rats: a comparative experimental model study. Mard SA, etal., Biomed Pharmacother. 2017 Dec;96:48-55. doi: 10.1016/j.biopha.2017.09.123. Epub 2017 Nov 24.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. Salvoza NC, etal., PLoS One. 2016 Apr 14;11(4):e0153497. doi: 10.1371/journal.pone.0153497. eCollection 2016.
5. Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure. Tian C, etal., Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H928-H939. doi: 10.1152/ajpheart.00602.2017. Epub 2018 Jan 26.
6. MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma. Xiang ZL, etal., Oncotarget. 2016 Dec 27;7(52):87246-87256. doi: 10.18632/oncotarget.13531.
7. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Xiao Z, etal., Cancer Res. 2014 Nov 1;74(21):6236-47. doi: 10.1158/0008-5472.CAN-14-0855. Epub 2014 Sep 12.
8. MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism. Zhang HF, etal., Mol Med Rep. 2018 Mar;17(3):4483-4489. doi: 10.3892/mmr.2018.8399. Epub 2018 Jan 9.
9. Elevated circulating microRNA-210 levels in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: a potential new biomarker. Zhang Q, etal., Biomarkers. 2013 Feb;18(1):23-9. doi: 10.3109/1354750X.2012.728624. Epub 2012 Oct 10.
10. MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway. Zhang W, etal., Cell Physiol Biochem. 2018;48(3):1304-1316. doi: 10.1159/000492090. Epub 2018 Jul 26.
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:17604727   PMID:18320040   PMID:18723672   PMID:19697704   PMID:19895913   PMID:20403161   PMID:20439489   PMID:20548288   PMID:20805985   PMID:21216258  
PMID:21719785   PMID:23217387   PMID:23323620   PMID:23646144   PMID:24421392   PMID:24638095   PMID:24728149   PMID:25106556   PMID:25405338   PMID:25483877   PMID:25633291   PMID:25751060  
PMID:25817785   PMID:26203862   PMID:26252661   PMID:26329269   PMID:26437572   PMID:26459758   PMID:27441728   PMID:27545688   PMID:27694688   PMID:27780189   PMID:28129650   PMID:28454497  
PMID:28544853   PMID:28599575   PMID:28709867   PMID:28894025   PMID:29551367   PMID:29578002   PMID:30447272   PMID:30877521   PMID:30964183   PMID:30968966   PMID:31002154   PMID:31081106  
PMID:31081107   PMID:31237127   PMID:31278961   PMID:31295983   PMID:31345016   PMID:31486508   PMID:31490756   PMID:31599430   PMID:32096191   PMID:32214804   PMID:33044326   PMID:33155431  
PMID:33275236   PMID:33400820   PMID:33435858   PMID:33465281   PMID:33638320   PMID:33661552   PMID:33909769   PMID:34227918   PMID:34296298   PMID:34318554   PMID:34400887   PMID:34735028  
PMID:34778900   PMID:35703738   PMID:35879917  


Genomics

Comparative Map Data
Mir34a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,533,002 - 160,533,103 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,533,002 - 160,533,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,249,485 - 163,249,586 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05165,071,851 - 165,071,952 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05165,028,223 - 165,028,324 (+)NCBIRnor_WKY
Rnor_6.05167,092,491 - 167,092,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,092,491 - 167,092,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,733,242 - 170,733,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5158,795,110 - 158,795,211 (+)NCBICelera
Cytogenetic Map5q36NCBI
MIR34A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl19,151,668 - 9,151,777 (-)EnsemblGRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36Build 36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
T2T-CHM13v2.018,685,973 - 8,686,082 (-)NCBIT2T-CHM13v2.0
Mir34a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,152,911 - 150,153,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,152,911 - 150,153,012 (+)EnsemblGRCm39 Ensembl
GRCm384150,068,454 - 150,068,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,068,454 - 150,068,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,442,563 - 149,442,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera4152,344,303 - 152,344,404 (+)NCBICelera
Cytogenetic Map4E2NCBI
MIR34A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,485,832 - 62,485,897 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,485,832 - 62,485,897 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,502,877 - 62,502,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,712,027 - 62,712,092 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,712,027 - 62,712,092 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,710,061 - 62,710,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,573,923 - 62,573,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,978,341 - 62,978,406 (-)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Taglnrno-miR-34a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mycnrno-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416
E2f3rno-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18942116
Grm7rno-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18704095

Predicted Targets
Summary Value
Count of predictions:14588
Count of gene targets:7925
Count of transcripts:8620
Interacting mature miRNAs:rno-miR-34a-3p, rno-miR-34a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 1 14 13 1 10 1 8 11
Below cutoff 1 2 1 2 2 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053746
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5160,533,002 - 160,533,103 (+)Ensembl
Rnor_6.0 Ensembl5167,092,491 - 167,092,592 (+)Ensembl
RefSeq Acc Id: NR_031850
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25160,533,002 - 160,533,103 (+)NCBI
Rnor_6.05167,092,491 - 167,092,592 (+)NCBI
Rnor_5.05170,733,242 - 170,733,343 (+)NCBI
Celera5158,795,110 - 158,795,211 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325584 AgrOrtholog
BioCyc Gene G2FUF-39083 BioCyc
Ensembl Genes ENSRNOG00000035623 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053746 ENTREZGENE
miRBase MI0000877 ENTREZGENE
NCBI Gene 100314015 ENTREZGENE
PhenoGen Mir34a PhenoGen
RNAcentral URS000030BD69 RNACentral
  URS000040249F RNACentral
  URS000075E4DE RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir34a  microRNA 34a  Mir34a  microRNA mir-34a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir34a  microRNA mir-34a      Symbol and Name status set to provisional 70820 PROVISIONAL