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Gene: Mir34a (microRNA 34a) Rattus norvegicus

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Symbol:

Mir34a

Name:

microRNA 34a

RGD ID:

2325584

Description:

Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in cellular response to tumor necrosis factor. Predicted to be located in extracellular exosome. Used to study osteoarthritis. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR34A (microRNA 34a); INTERACTS WITH 2-acetamidofluorene; 3,7-dihydropurine-6-thione; aflatoxin B1.

Type:

ncrna (Ensembl: miRNA)

RefSeq Status:

PROVISIONAL

Previously known as:

microRNA mir-34a; rno-mir-34a

RGD Orthologs

Human

Mouse

Dog

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	165,815,952 - 165,816,053 (+)	NCBI		GRCr8
mRatBN7.2	5	160,533,002 - 160,533,103 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	160,533,002 - 160,533,103 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	163,249,485 - 163,249,586 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,071,851 - 165,071,952 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,028,223 - 165,028,324 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,092,491 - 167,092,592 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,092,491 - 167,092,592 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	170,733,242 - 170,733,343 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	5	158,795,110 - 158,795,211 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	arteriovenous malformation		ISO	RGD:1343452	155582214	miRNA:increased expression:blood plasma (human)	RGD
Mir34a	Rat	Bone Metastasis	susceptibility	ISO	RGD:1343452	14694837	associated with hepatocellular carcinoma;miRNA:decreased expression:serum, bone	RGD
Mir34a	Rat	colorectal cancer		ISO	RGD:1343452	9068941	miRNA:increased expression:colorectum (human)	RGD	PMID:23322774\|REF_RGD_ID:153002793
Mir34a	Rat	congestive heart failure		IEP		26923905	RNA:increased expression:heart	RGD
Mir34a	Rat	hepatoblastoma	severity	ISO	RGD:1343452	14695006	miRNA:increased expression:liver	RGD
Mir34a	Rat	hepatocellular carcinoma	treatment	ISO	RGD:1343452	14694835	human cell line in a mouse model	RGD
Mir34a	Rat	hepatocellular carcinoma		ISO	RGD:1343452	14694836	miRNA:decreased expression:liver	RGD
Mir34a	Rat	Liver Reperfusion Injury		IEP		14695005	miRNA:increased expression:liver	RGD
Mir34a	Rat	metabolic dysfunction-associated steatotic liver disease		ISO	RGD:1343452	11533145	miRNA:increased expression:plasma	RGD
Mir34a	Rat	osteoarthritis	treatment	IMP		152177909		RGD
Mir34a	Rat	osteoarthritis		ISO	RGD:1343452	152177909	mRNA:increased expression:knee, hip (human)	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	chromosome 1p36 deletion syndrome		ISO	RGD:1343452	8554872	ClinVar Annotator: match by term: Chromosome 1p36 deletion syndrome	ClinVar
Mir34a	Rat	Neurodevelopmental Disorders		ISO	RGD:1343452	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	anxiety disorder		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:27424985
Mir34a	Rat	Chemical and Drug Induced Liver Injury		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28545106
Mir34a	Rat	Experimental Liver Neoplasms		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21035526
Mir34a	Rat	glucose intolerance		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23834033
Mir34a	Rat	heart disease		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25448438
Mir34a	Rat	Inflammation		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23834033
Mir34a	Rat	obesity		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23834033
Mir34a	Rat	steatotic liver disease		ISO	RGD:1343452	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23834033

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	(-)-citrinin	decreases expression	ISO	RGD:1343452	6480464	Citrinin results in decreased expression of MIR34A mRNA	CTD	PMID:30428381
Mir34a	Rat	1,3,5-trinitro-1,3,5-triazinane	decreases expression	ISO	RGD:1608206	6480464	cyclonite results in decreased expression of MIR34A mRNA	CTD	PMID:19270793
Mir34a	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1343452	6480464	Tetrachlorodibenzodioxin results in increased expression of MIR34A mRNA	CTD	PMID:30096437
Mir34a	Rat	2-acetamidofluorene	increases expression	EXP		6480464	2-Acetylaminofluorene results in increased expression of MIR34A mRNA	CTD	PMID:19167416\|PMID:22584684
Mir34a	Rat	3,7-dihydropurine-6-thione	increases expression	EXP		6480464	Mercaptopurine results in increased expression of MIR34A mRNA	CTD	PMID:23358152
Mir34a	Rat	3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione	decreases expression	ISO	RGD:1343452	6480464	bisindolylmaleimide I results in decreased expression of MIR34A	CTD	PMID:35134991
Mir34a	Rat	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	decreases expression	ISO	RGD:1343452	6480464	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of MIR34A mRNA	CTD	PMID:24726431
Mir34a	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of MIR34A mRNA	CTD	PMID:24472605
Mir34a	Rat	all-trans-retinoic acid	multiple interactions	ISO	RGD:1343452	6480464	[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of MIR34A mRNA	CTD	PMID:23284745
Mir34a	Rat	alpha-D-galactose	multiple interactions	ISO	RGD:1343452	6480464	MIR34A mRNA promotes the reaction [Galactose results in decreased expression of ATG7 protein]; MIR34A mRNA more ...	CTD	PMID:28302704
Mir34a	Rat	alpha-D-galactose	increases expression	ISO	RGD:1343452	6480464	Galactose results in increased expression of MIR34A mRNA	CTD	PMID:28302704
Mir34a	Rat	alpha-D-galactose	increases expression	EXP		6480464	Galactose results in increased expression of MIR34A mRNA	CTD	PMID:28302704
Mir34a	Rat	aniline	decreases expression	EXP		6480464	aniline results in decreased expression of MIR34A	CTD	PMID:28463034
Mir34a	Rat	aristolochic acid A	increases expression	EXP		6480464	aristolochic acid I results in increased expression of MIR34A mRNA	CTD	PMID:27422293
Mir34a	Rat	arsane	multiple interactions	EXP		6480464	[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MIR34A more ...	CTD	PMID:38229313
Mir34a	Rat	arsenic atom	multiple interactions	EXP		6480464	[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MIR34A more ...	CTD	PMID:38229313
Mir34a	Rat	arsenite(3-)	increases expression	ISO	RGD:1343452	6480464	arsenite results in increased expression of MIR34A mRNA	CTD	PMID:25281835
Mir34a	Rat	arsenite(3-)	decreases methylation	ISO	RGD:1343452	6480464	arsenite results in decreased methylation of MIR34A promoter	CTD	PMID:25281835
Mir34a	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1343452	6480464	arsenite promotes the reaction [TP53 protein binds to MIR34A promoter]	CTD	PMID:25281835
Mir34a	Rat	arsenite(3-)	affects folding	ISO	RGD:1343452	6480464	arsenite affects the folding of MIR34A promoter	CTD	PMID:25281835
Mir34a	Rat	arsenous acid	increases expression	ISO	RGD:1608206	6480464	Arsenic Trioxide results in increased expression of MIR34A mRNA	CTD	PMID:36707890
Mir34a	Rat	arsenous acid	decreases expression	ISO	RGD:1608206	6480464	Arsenic Trioxide results in decreased expression of MIR34A mRNA	CTD	PMID:35676786
Mir34a	Rat	arsenous acid	multiple interactions	ISO	RGD:1608206	6480464	MIR34A affects the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; MIR34A affects more ...	CTD	PMID:36707890
Mir34a	Rat	atrazine	increases expression	EXP		6480464	Atrazine results in increased expression of MIR34A mRNA	CTD	PMID:31185338\|PMID:34030342
Mir34a	Rat	benzene	decreases expression	ISO	RGD:1608206	6480464	Benzene results in decreased expression of MIR34A mRNA	CTD	PMID:32105654
Mir34a	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1608206	6480464	Benzo(a)pyrene results in increased expression of MIR34A mRNA	CTD	PMID:21964900
Mir34a	Rat	benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of MIR34A mRNA	CTD	PMID:35378083
Mir34a	Rat	benzo[a]pyrene	multiple interactions	EXP		6480464	Benzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in decreased expression of MIR34A mRNA]; Dibutyl Phthalate more ...	CTD	PMID:35378083
Mir34a	Rat	Betanin	multiple interactions	EXP		6480464	betanin inhibits the reaction [Cisplatin results in increased expression of MIR34A mRNA]	CTD	PMID:33661552
Mir34a	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1608206	6480464	Diethylhexyl Phthalate results in increased expression of MIR34A	CTD	PMID:32642447
Mir34a	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate] affects the expression of MIR34A	CTD	PMID:36226823
Mir34a	Rat	bisphenol A	increases expression	ISO	RGD:1343452	6480464	bisphenol A results in increased expression of MIR34A mRNA	CTD	PMID:28483554
Mir34a	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of MIR34A gene	CTD	PMID:28505145
Mir34a	Rat	bleomycin A2	affects expression	EXP		6480464	Bleomycin affects the expression of MIR34A mRNA	CTD	PMID:25933445
Mir34a	Rat	bleomycin A2	decreases expression	EXP		6480464	Bleomycin results in decreased expression of MIR34A mRNA	CTD	PMID:34425168
Mir34a	Rat	buta-1,3-diene	increases expression	ISO	RGD:1608206	6480464	1,3-butadiene results in increased expression of MIR34A mRNA	CTD	PMID:29038090
Mir34a	Rat	Butylbenzyl phthalate	multiple interactions	ISO	RGD:1343452	6480464	MIR34A mRNA inhibits the reaction [butylbenzyl phthalate results in decreased expression of CDKN1A protein]; MIR34A more ...	CTD	PMID:30243731
Mir34a	Rat	Butylbenzyl phthalate	multiple interactions	ISO	RGD:1608206	6480464	MIR34A mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of NAMPT protein]	CTD	PMID:34520170
Mir34a	Rat	Butylbenzyl phthalate	increases expression	ISO	RGD:1608206	6480464	butylbenzyl phthalate results in increased expression of MIR34A mRNA	CTD	PMID:34520170
Mir34a	Rat	Butylbenzyl phthalate	decreases expression	ISO	RGD:1343452	6480464	butylbenzyl phthalate results in decreased expression of MIR34A mRNA	CTD	PMID:30243731
Mir34a	Rat	cadmium atom	multiple interactions	EXP		6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR34A more ...	CTD	PMID:34558789
Mir34a	Rat	cadmium dichloride	increases expression	ISO	RGD:1608206	6480464	Cadmium Chloride results in increased expression of MIR34A mRNA	CTD	PMID:35183672
Mir34a	Rat	cadmium dichloride	multiple interactions	EXP		6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR34A more ...	CTD	PMID:34558789
Mir34a	Rat	cadmium dichloride	increases expression	ISO	RGD:1343452	6480464	Cadmium Chloride results in increased expression of MIR34A mRNA	CTD	PMID:35183672
Mir34a	Rat	camptothecin	increases expression	ISO	RGD:1343452	6480464	Camptothecin results in increased expression of MIR34A mRNA	CTD	PMID:24726431
Mir34a	Rat	cannabidiol	multiple interactions	ISO	RGD:1608206	6480464	[Cannabidiol co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MIR34A mRNA	CTD	PMID:30742662
Mir34a	Rat	cannabidiol	increases expression	ISO	RGD:1608206	6480464	Cannabidiol results in increased expression of MIR34A mRNA	CTD	PMID:30742662
Mir34a	Rat	chenodeoxycholic acid	decreases expression	ISO	RGD:1343452	6480464	Chenodeoxycholic Acid results in decreased expression of MIR34A mRNA	CTD	PMID:27174168
Mir34a	Rat	chlorendic acid	increases expression	EXP		6480464	chlorendic acid results in increased expression of MIR34A mRNA	CTD	PMID:22584684
Mir34a	Rat	choline	multiple interactions	ISO	RGD:1608206	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20548288
Mir34a	Rat	cisplatin	increases expression	EXP		6480464	Cisplatin results in increased expression of MIR34A mRNA	CTD	PMID:24880025\|PMID:27397436\|PMID:32777238\|PMID:33661552
Mir34a	Rat	cisplatin	increases expression	ISO	RGD:1608206	6480464	Cisplatin results in increased expression of MIR34A mRNA	CTD	PMID:28119452
Mir34a	Rat	cisplatin	multiple interactions	ISO	RGD:1343452	6480464	[[MIR34A binds to MAGEA12 3' UTR] which results in decreased expression of MAGEA12 protein] which more ...	CTD	PMID:21177782
Mir34a	Rat	cisplatin	multiple interactions	EXP		6480464	betanin inhibits the reaction [Cisplatin results in increased expression of MIR34A mRNA]; Pentoxifylline inhibits the more ...	CTD	PMID:32777238\|PMID:33661552
Mir34a	Rat	crocin-1	multiple interactions	ISO	RGD:1343452	6480464	MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA more ...	CTD	PMID:35085590
Mir34a	Rat	curcumin	multiple interactions	EXP		6480464	Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA]	CTD	PMID:32569592
Mir34a	Rat	cyclosporin A	multiple interactions	EXP		6480464	Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA]	CTD	PMID:32569592
Mir34a	Rat	cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of MIR34A mRNA	CTD	PMID:32569592
Mir34a	Rat	dexmedetomidine	decreases response to substance	EXP		6480464	MIR34A mRNA results in decreased susceptibility to Dexmedetomidine	CTD	PMID:35527005
Mir34a	Rat	diarsenic trioxide	increases expression	ISO	RGD:1608206	6480464	Arsenic Trioxide results in increased expression of MIR34A mRNA	CTD	PMID:36707890
Mir34a	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1608206	6480464	Arsenic Trioxide results in decreased expression of MIR34A mRNA	CTD	PMID:35676786
Mir34a	Rat	diarsenic trioxide	multiple interactions	ISO	RGD:1608206	6480464	MIR34A affects the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; MIR34A affects more ...	CTD	PMID:36707890
Mir34a	Rat	dibutyl phthalate	multiple interactions	EXP		6480464	[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate] affects the expression of MIR34A; more ...	CTD	PMID:35378083\|PMID:36226823
Mir34a	Rat	dibutyl phthalate	decreases expression	EXP		6480464	Dibutyl Phthalate results in decreased expression of MIR34A mRNA	CTD	PMID:35378083
Mir34a	Rat	diethyl phthalate	multiple interactions	ISO	RGD:1343452	6480464	[diethyl phthalate results in increased abundance of monoethyl phthalate] which affects the secretion of MIR34A	CTD	PMID:33885134
Mir34a	Rat	diisononyl phthalate	multiple interactions	EXP		6480464	[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate] affects the expression of MIR34A	CTD	PMID:36226823
Mir34a	Rat	Diosbulbin B	increases expression	ISO	RGD:1608206	6480464	diosbulbin B results in increased expression of MIR34A mRNA	CTD	PMID:28844483
Mir34a	Rat	dioxygen	increases expression	EXP		6480464	Oxygen results in increased expression of MIR34A mRNA	CTD	PMID:22911455
Mir34a	Rat	dorsomorphin	multiple interactions	ISO	RGD:1343452	6480464	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Mir34a	Rat	doxorubicin	increases expression	ISO	RGD:1343452	6480464	Doxorubicin results in increased expression of MIR34A mRNA	CTD	PMID:26842497
Mir34a	Rat	doxorubicin	increases expression	EXP		6480464	Doxorubicin results in increased expression of MIR34A mRNA	CTD	PMID:30831132
Mir34a	Rat	doxorubicin	increases expression	ISO	RGD:1608206	6480464	Doxorubicin results in increased expression of MIR34A mRNA	CTD	PMID:25448438
Mir34a	Rat	ethanol	increases expression	ISO	RGD:1343452	6480464	Ethanol results in increased expression of MIR34A	CTD	PMID:21878650
Mir34a	Rat	ethanol	increases expression	ISO	RGD:1608206	6480464	Ethanol results in increased expression of MIR34A mRNA	CTD	PMID:35038560
Mir34a	Rat	ethanol	multiple interactions	ISO	RGD:1608206	6480464	MIR34A mRNA affects the reaction [Ethanol results in decreased expression of SNAI1 mRNA]; MIR34A mRNA more ...	CTD	PMID:35038560
Mir34a	Rat	folic acid	multiple interactions	ISO	RGD:1608206	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20548288
Mir34a	Rat	folic acid	affects expression	ISO	RGD:1343452	6480464	Folic Acid affects the expression of MIR34A mRNA	CTD	PMID:28752528
Mir34a	Rat	formaldehyde	decreases expression	ISO	RGD:1343452	6480464	Formaldehyde results in decreased expression of MIR34A mRNA	CTD	PMID:21147603
Mir34a	Rat	fulvestrant	increases methylation	ISO	RGD:1343452	6480464	Fulvestrant results in increased methylation of MIR34A gene	CTD	PMID:31601247
Mir34a	Rat	furan	increases expression	EXP		6480464	furan results in increased expression of MIR34A mRNA	CTD	PMID:26194646\|PMID:27371368
Mir34a	Rat	furan	increases expression	ISO	RGD:1608206	6480464	furan results in increased expression of MIR34A mRNA	CTD	PMID:37517673
Mir34a	Rat	furan	multiple interactions	EXP		6480464	furan deficiency inhibits the reaction [furan results in increased expression of MIR34A mRNA]	CTD	PMID:27371368
Mir34a	Rat	galactose	increases expression	ISO	RGD:1343452	6480464	Galactose results in increased expression of MIR34A mRNA	CTD	PMID:28302704
Mir34a	Rat	galactose	increases expression	EXP		6480464	Galactose results in increased expression of MIR34A mRNA	CTD	PMID:28302704
Mir34a	Rat	galactose	multiple interactions	ISO	RGD:1343452	6480464	MIR34A mRNA promotes the reaction [Galactose results in decreased expression of ATG7 protein]; MIR34A mRNA more ...	CTD	PMID:28302704
Mir34a	Rat	gallic acid	multiple interactions	EXP		6480464	Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of MIR34A more ...	CTD	PMID:33953864\|PMID:34745924
Mir34a	Rat	genistein	decreases response to substance	ISO	RGD:1343452	6480464	MIR34A mRNA results in decreased susceptibility to Genistein	CTD	PMID:28688900
Mir34a	Rat	genistein	multiple interactions	ISO	RGD:1343452	6480464	Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MIR34A mRNA]; more ...	CTD	PMID:28688900
Mir34a	Rat	hydrogen peroxide	increases response to substance	ISO	RGD:1343452	6480464	MIR34A mRNA results in increased susceptibility to Hydrogen Peroxide	CTD	PMID:23600198
Mir34a	Rat	irinotecan	increases expression	ISO	RGD:1343452	6480464	Irinotecan results in increased expression of MIR34A mRNA	CTD	PMID:22898888
Mir34a	Rat	L-methionine	multiple interactions	ISO	RGD:1608206	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20548288
Mir34a	Rat	lipopolysaccharide	decreases expression	EXP		6480464	Lipopolysaccharides results in decreased expression of MIR34A mRNA	CTD	PMID:32147387
Mir34a	Rat	lipopolysaccharide	multiple interactions	EXP		6480464	MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of more ...	CTD	PMID:32147387
Mir34a	Rat	lithium atom	multiple interactions	ISO	RGD:1343452	6480464	[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased more ...	CTD	PMID:26074776
Mir34a	Rat	lithium chloride	multiple interactions	ISO	RGD:1343452	6480464	[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased more ...	CTD	PMID:26074776
Mir34a	Rat	lithium hydride	multiple interactions	ISO	RGD:1343452	6480464	[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased more ...	CTD	PMID:26074776
Mir34a	Rat	melatonin	multiple interactions	EXP		6480464	Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in more ...	CTD	PMID:38229313
Mir34a	Rat	mercaptopurine	increases expression	EXP		6480464	Mercaptopurine results in increased expression of MIR34A mRNA	CTD	PMID:23358152
Mir34a	Rat	methanol	decreases expression	ISO	RGD:1608206	6480464	Methanol results in decreased expression of MIR34A	CTD	PMID:36780935
Mir34a	Rat	methapyrilene	increases expression	EXP		6480464	Methapyrilene results in increased expression of MIR34A mRNA	CTD	PMID:22584684\|PMID:24880025
Mir34a	Rat	mitomycin C	multiple interactions	ISO	RGD:1343452	6480464	[[MIR34A binds to MAGEA12 3' UTR] which results in decreased expression of MAGEA12 protein] which more ...	CTD	PMID:21177782
Mir34a	Rat	monoethyl phthalate	multiple interactions	ISO	RGD:1343452	6480464	[diethyl phthalate results in increased abundance of monoethyl phthalate] which affects the secretion of MIR34A	CTD	PMID:33885134
Mir34a	Rat	monuron	increases expression	EXP		6480464	monuron results in increased expression of MIR34A mRNA	CTD	PMID:22584684
Mir34a	Rat	N-ethyl-N-nitrosourea	increases expression	ISO	RGD:1608206	6480464	Ethylnitrosourea results in increased expression of MIR34A mRNA	CTD	PMID:22297810
Mir34a	Rat	N-methyl-4-phenylpyridinium	increases expression	ISO	RGD:1343452	6480464	1-Methyl-4-phenylpyridinium results in increased expression of MIR34A mRNA	CTD	PMID:30221494
Mir34a	Rat	N-methyl-4-phenylpyridinium	increases expression	EXP		6480464	1-Methyl-4-phenylpyridinium results in increased expression of MIR34A mRNA	CTD	PMID:29631008
Mir34a	Rat	NAD zwitterion	multiple interactions	ISO	RGD:1608206	6480464	[[MIR34A mRNA binds to NAMPT 3' UTR] which results in decreased expression of NAMPT mRNA] more ...	CTD	PMID:23834033
Mir34a	Rat	NAD zwitterion	decreases abundance	ISO	RGD:1608206	6480464	MIR34A mRNA results in decreased abundance of NAD	CTD	PMID:23834033
Mir34a	Rat	NAD(+)	multiple interactions	ISO	RGD:1608206	6480464	[[MIR34A mRNA binds to NAMPT 3' UTR] which results in decreased expression of NAMPT mRNA] more ...	CTD	PMID:23834033
Mir34a	Rat	NAD(+)	decreases abundance	ISO	RGD:1608206	6480464	MIR34A mRNA results in decreased abundance of NAD	CTD	PMID:23834033
Mir34a	Rat	NMN zwitterion	multiple interactions	ISO	RGD:1608206	6480464	Nicotinamide Mononucleotide inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased more ...	CTD	PMID:23834033
Mir34a	Rat	ochratoxin A	increases expression	ISO	RGD:1608206	6480464	ochratoxin A results in increased expression of MIR34A mRNA	CTD	PMID:28710020
Mir34a	Rat	ochratoxin A	multiple interactions	ISO	RGD:1608206	6480464	sulforaphane inhibits the reaction [ochratoxin A results in increased expression of MIR34A mRNA]	CTD	PMID:28710020
Mir34a	Rat	p-chloromercuribenzoic acid	multiple interactions	ISO	RGD:1343452	6480464	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Mir34a	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of MIR34A mRNA	CTD	PMID:27397436
Mir34a	Rat	paracetamol	increases expression	ISO	RGD:1343452	6480464	Acetaminophen results in increased expression of MIR34A mRNA	CTD	PMID:28545106
Mir34a	Rat	paracetamol	affects expression	ISO	RGD:1343452	6480464	Acetaminophen affects the expression of MIR34A mRNA	CTD	PMID:22285215
Mir34a	Rat	paraquat	increases expression	ISO	RGD:1343452	6480464	Paraquat results in increased expression of MIR34A mRNA	CTD	PMID:26074776
Mir34a	Rat	paraquat	multiple interactions	ISO	RGD:1343452	6480464	[Lithium Chloride results in increased abundance of Lithium] inhibits the reaction [Paraquat results in increased more ...	CTD	PMID:26074776
Mir34a	Rat	Pentoxifylline	multiple interactions	EXP		6480464	Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MIR34A mRNA]	CTD	PMID:32777238
Mir34a	Rat	propanal	increases expression	ISO	RGD:1343452	6480464	propionaldehyde results in increased expression of MIR34A mRNA	CTD	PMID:26079696
Mir34a	Rat	propranolol	multiple interactions	ISO	RGD:1608206	6480464	Propranolol inhibits the reaction [Arsenic Trioxide results in increased expression of MIR34A mRNA]	CTD	PMID:36707890
Mir34a	Rat	purine-6-thiol	increases expression	EXP		6480464	Mercaptopurine results in increased expression of MIR34A mRNA	CTD	PMID:23358152
Mir34a	Rat	quercetin	multiple interactions	ISO	RGD:1343452	6480464	MIR34A mRNA affects the reaction [Quercetin results in decreased expression of SIRT1 protein]; MIR34A mRNA more ...	CTD	PMID:25896587
Mir34a	Rat	quercetin	affects response to substance	ISO	RGD:1343452	6480464	MIR34A mRNA affects the susceptibility to Quercetin	CTD	PMID:25896587
Mir34a	Rat	quercetin	increases expression	ISO	RGD:1343452	6480464	Quercetin results in increased expression of MIR34A mRNA	CTD	PMID:25896587
Mir34a	Rat	resveratrol	increases expression	ISO	RGD:1343452	6480464	resveratrol results in increased expression of MIR34A mRNA	CTD	PMID:22016468\|PMID:23954321
Mir34a	Rat	resveratrol	multiple interactions	ISO	RGD:1343452	6480464	[Plant Extracts co-treated with Resveratrol] results in decreased expression of MIR34A mRNA	CTD	PMID:23557933
Mir34a	Rat	resveratrol	decreases response to substance	ISO	RGD:1608206	6480464	MIR34A mRNA results in decreased susceptibility to Resveratrol	CTD	PMID:24073240
Mir34a	Rat	resveratrol	multiple interactions	ISO	RGD:1608206	6480464	[MIR34A mRNA results in decreased expression of SIRT1 protein] which results in decreased susceptibility to more ...	CTD	PMID:23834033\|PMID:24073240
Mir34a	Rat	resveratrol	decreases expression	ISO	RGD:1343452	6480464	resveratrol results in decreased expression of MIR34A mRNA	CTD	PMID:23251493
Mir34a	Rat	rifampicin	decreases expression	ISO	RGD:1343452	6480464	Rifampin results in decreased expression of MIR34A mRNA	CTD	PMID:24552687
Mir34a	Rat	rotenone	increases expression	ISO	RGD:1608206	6480464	Rotenone results in increased expression of MIR34A mRNA	CTD	PMID:21893155
Mir34a	Rat	rotenone	multiple interactions	ISO	RGD:1608206	6480464	TRP53 affects the reaction [Rotenone results in increased expression of MIR34A mRNA]	CTD	PMID:21893155
Mir34a	Rat	SB 431542	multiple interactions	ISO	RGD:1343452	6480464	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Mir34a	Rat	sevoflurane	multiple interactions	EXP		6480464	MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of more ...	CTD	PMID:32147387
Mir34a	Rat	sevoflurane	increases response to substance	EXP		6480464	MIR34A mRNA results in increased susceptibility to Sevoflurane	CTD	PMID:32147387
Mir34a	Rat	sodium arsenite	decreases expression	ISO	RGD:1343452	6480464	sodium arsenite results in decreased expression of MIR34A mRNA	CTD	PMID:24431212
Mir34a	Rat	sodium arsenite	multiple interactions	EXP		6480464	[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MIR34A more ...	CTD	PMID:38229313
Mir34a	Rat	sodium arsenite	increases expression	ISO	RGD:1608206	6480464	sodium arsenite results in increased expression of MIR34A mRNA	CTD	PMID:24896083\|PMID:27723467\|PMID:32068019
Mir34a	Rat	sodium arsenite	multiple interactions	ISO	RGD:1608206	6480464	Plant Extracts inhibits the reaction [sodium arsenite results in increased expression of MIR34A mRNA]; TRP53 more ...	CTD	PMID:27723467
Mir34a	Rat	sodium arsenite	increases expression	ISO	RGD:1343452	6480464	sodium arsenite results in increased expression of MIR34A mRNA	CTD	PMID:24431212\|PMID:27054085\|PMID:32844245\|PMID:34032870
Mir34a	Rat	sodium fluoride	increases expression	ISO	RGD:1608206	6480464	Sodium Fluoride results in increased expression of MIR34A mRNA	CTD	PMID:29127033
Mir34a	Rat	sulforaphane	multiple interactions	ISO	RGD:1608206	6480464	sulforaphane inhibits the reaction [ochratoxin A results in increased expression of MIR34A mRNA]	CTD	PMID:28710020
Mir34a	Rat	tamoxifen	multiple interactions	EXP		6480464	[Tamoxifen results in increased expression of MIR34A mRNA] which results in decreased expression of NOTCH1 more ...	CTD	PMID:17343880
Mir34a	Rat	tamoxifen	increases expression	EXP		6480464	Tamoxifen results in increased expression of MIR34A mRNA	CTD	PMID:17343880
Mir34a	Rat	titanium dioxide	multiple interactions	ISO	RGD:1343452	6480464	MIR34A mRNA inhibits the reaction [titanium dioxide results in increased expression of BCL2 mRNA]; MIR34A more ...	CTD	PMID:27226226
Mir34a	Rat	titanium dioxide	decreases expression	ISO	RGD:1343452	6480464	titanium dioxide results in decreased expression of MIR34A mRNA	CTD	PMID:27226226
Mir34a	Rat	tributyl phosphate	decreases expression	ISO	RGD:1608206	6480464	tributyl phosphate results in decreased expression of MIR34A mRNA	CTD	PMID:32105654
Mir34a	Rat	zinc atom	increases expression	EXP		6480464	Zinc deficiency results in increased expression of MIR34A mRNA	CTD	PMID:22689922
Mir34a	Rat	zinc(0)	increases expression	EXP		6480464	Zinc deficiency results in increased expression of MIR34A mRNA	CTD	PMID:22689922

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	cellular response to amino acid stimulus	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:20548288	RGD	PMID:20548288
Mir34a	Rat	cellular response to hypoxia	involved_in	ISO	RGD:1343452	1624291	PMID:27302634	RGD	PMID:27302634
Mir34a	Rat	cellular response to leukemia inhibitory factor	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:20439489	RGD	PMID:20439489
Mir34a	Rat	cellular response to tumor necrosis factor		IEP		26923905		RGD
Mir34a	Rat	DNA damage response	involved_in	ISO	RGD:1343452	1624291	PMID:30111844	RGD	PMID:30111844
Mir34a	Rat	miRNA-mediated post-transcriptional gene silencing	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:20439489	RGD	PMID:20439489
Mir34a	Rat	miRNA-mediated post-transcriptional gene silencing	involved_in	ISO	RGD:1343452	1624291	RNAcentral:URS00002C7B2B_9606 PMID:20424141, PMID:23047694, PMID:23426265, PMID:23462268, PMID:24637697, PMID:24792364, PMID:25355491, PMID:26330104, PMID:26949937, PMID:27302634, PMID:27780189, PMID:28073349, PMID:28340489, more ...	RGD	PMID:20424141\|PMID:23047694\|PMID:23426265\|PMID:23462268\|PMID:24637697\|PMID:24792364\|PMID:25355491\|PMID:26330104\|PMID:26949937\|PMID:27302634\|PMID:27780189\|PMID:28073349\|PMID:28340489\|PMID:28348487\|PMID:30111844\|PMID:33229509
Mir34a	Rat	myelination	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:20805985	RGD	PMID:20805985
Mir34a	Rat	negative regulation of angiogenesis	involved_in	ISO	RGD:1343452	1624291	PMID:20424141, PMID:24048733	RGD	PMID:20424141\|PMID:24048733
Mir34a	Rat	negative regulation of B cell receptor signaling pathway	involved_in	ISO	RGD:1343452	1624291	PMID:30111844	RGD	PMID:30111844
Mir34a	Rat	negative regulation of calcium ion import	involved_in	ISO	RGD:1343452	1624291	PMID:27302634	RGD	PMID:27302634
Mir34a	Rat	negative regulation of chemokine production	involved_in	ISO	RGD:1343452	1624291	PMID:33229509	RGD	PMID:33229509
Mir34a	Rat	negative regulation of gene expression	acts_upstream_of_or_within	ISO	RGD:1343452	1624291	PMID:26330104	RGD	PMID:26330104
Mir34a	Rat	negative regulation of gene expression	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:19895913	RGD	PMID:19895913
Mir34a	Rat	negative regulation of IP-10 production	involved_in	ISO	RGD:1343452	1624291	PMID:33229509	RGD	PMID:33229509
Mir34a	Rat	negative regulation of peroxisome proliferator activated receptor signaling pathway	involved_in	ISO	RGD:1343452	1624291	PMID:26330104	RGD	PMID:26330104
Mir34a	Rat	negative regulation of smooth muscle cell chemotaxis	involved_in	ISO	RGD:1343452	1624291	PMID:26493107	RGD	PMID:26493107
Mir34a	Rat	negative regulation of sprouting angiogenesis	involved_in	ISO	RGD:1343452	1624291	PMID:23426265	RGD	PMID:23426265
Mir34a	Rat	negative regulation of transmembrane transport	acts_upstream_of	ISO	RGD:1343452	1624291	PMID:28073349	RGD	PMID:28073349
Mir34a	Rat	negative regulation of vascular associated smooth muscle cell migration	involved_in	ISO	RGD:1343452	1624291	PMID:26493107, PMID:27302634	RGD	PMID:26493107\|PMID:27302634
Mir34a	Rat	negative regulation of vascular associated smooth muscle cell proliferation	involved_in	ISO	RGD:1343452	1624291	PMID:24792364, PMID:26493107, PMID:27302634	RGD	PMID:24792364\|PMID:26493107\|PMID:27302634
Mir34a	Rat	negative regulation of vascular endothelial cell proliferation	involved_in	ISO	RGD:1343452	1624291	PMID:28276476	RGD	PMID:28276476
Mir34a	Rat	negative regulation of vascular endothelial growth factor production	involved_in	ISO	RGD:1343452	9068941	PMID:18320040	BHF-UCL	PMID:18320040
Mir34a	Rat	negative regulation of vascular wound healing	involved_in	ISO	RGD:1343452	1624291	PMID:26493107	RGD	PMID:26493107
Mir34a	Rat	ossification	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:25751060	RGD	PMID:25751060
Mir34a	Rat	positive regulation of blood vessel endothelial cell differentiation	involved_in	ISO	RGD:1343452	1624291	PMID:24792364	RGD	PMID:24792364
Mir34a	Rat	positive regulation of cardiac muscle cell apoptotic process	involved_in	ISO	RGD:1343452	1624291	PMID:23426265	RGD	PMID:23426265
Mir34a	Rat	positive regulation of cellular senescence	involved_in	ISO	RGD:1343452	1624291	PMID:20424141	RGD	PMID:20424141
Mir34a	Rat	positive regulation of gene expression	involved_in	ISO	RGD:1343452	1624291	PMID:27302634	RGD	PMID:27302634
Mir34a	Rat	positive regulation of leukocyte apoptotic process	involved_in	ISO	RGD:1343452	1624291	PMID:22651868	RGD	PMID:22651868
Mir34a	Rat	positive regulation of lipid storage	acts_upstream_of	ISO	RGD:1343452	1624291	PMID:26330104	RGD	PMID:26330104
Mir34a	Rat	positive regulation of smooth muscle cell differentiation	involved_in	ISO	RGD:1343452	1624291	PMID:25526086	RGD	PMID:25526086
Mir34a	Rat	positive regulation of stem cell differentiation	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:20439489	RGD	PMID:20439489
Mir34a	Rat	programmed cell death in response to reactive oxygen species	involved_in	ISO	RGD:1343452	1624291	PMID:22651868	RGD	PMID:22651868
Mir34a	Rat	response to oxygen levels	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:18723672	RGD	PMID:18723672
Mir34a	Rat	sensory perception of sound	acts_upstream_of_or_within	ISO	RGD:1608206	1624291	PMID:23646144	RGD	PMID:23646144
Mir34a	Rat	tumor necrosis factor-mediated signaling pathway	involved_in	ISO	RGD:1343452	1624291	PMID:26949937	RGD	PMID:26949937

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	extracellular exosome	located_in	ISO	RGD:1343452	1624291	PMID:31926946	RGD	PMID:31926946

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mir34a	Rat	mRNA 3'-UTR binding	enables	ISO	RGD:1343452	1624291	PMID:24637697, PMID:25355491, PMID:26330104, PMID:28073349, PMID:33229509	RGD	PMID:24637697\|PMID:25355491\|PMID:26330104\|PMID:28073349\|PMID:33229509
Mir34a	Rat	mRNA base-pairing post-transcriptional repressor activity	enables	ISO	RGD:1343452	1624291	PMID:23426265, PMID:23462268, PMID:24637697, PMID:24792364, PMID:25355491, PMID:26330104, PMID:26949937, PMID:27302634, PMID:28073349, PMID:28340489, PMID:28348487, PMID:30111844, PMID:33229509	RGD	PMID:23426265\|PMID:23462268\|PMID:24637697\|PMID:24792364\|PMID:25355491\|PMID:26330104\|PMID:26949937\|PMID:27302634\|PMID:28073349\|PMID:28340489\|PMID:28348487\|PMID:30111844\|PMID:33229509

Disease Annotations Click to see Annotation Detail View

anxiety disorder (ISO)

arteriovenous malformation (ISO)

Bone Metastasis (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chromosome 1p36 deletion syndrome (ISO)

colorectal cancer (ISO)

congestive heart failure (IEP)

Experimental Liver Neoplasms (ISO)

glucose intolerance (ISO)

heart disease (ISO)

hepatoblastoma (ISO)

hepatocellular carcinoma (ISO)

Inflammation (ISO)

Liver Reperfusion Injury (IEP)

metabolic dysfunction-associated steatotic liver disease (ISO)

Neurodevelopmental Disorders (ISO)

obesity (ISO)

osteoarthritis (IMP,ISO)

steatotic liver disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-citrinin (ISO)

1,3,5-trinitro-1,3,5-triazinane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-acetamidofluorene (EXP)

3,7-dihydropurine-6-thione (EXP)

3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (ISO)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

alpha-D-galactose (EXP,ISO)

aniline (EXP)

aristolochic acid A (EXP)

arsane (EXP)

arsenic atom (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzene (ISO)

benzo[a]pyrene (EXP,ISO)

Betanin (EXP)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

buta-1,3-diene (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

camptothecin (ISO)

cannabidiol (ISO)

chenodeoxycholic acid (ISO)

chlorendic acid (EXP)

choline (ISO)

cisplatin (EXP,ISO)

crocin-1 (ISO)

curcumin (EXP)

cyclosporin A (EXP)

dexmedetomidine (EXP)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (ISO)

diisononyl phthalate (EXP)

Diosbulbin B (ISO)

dioxygen (EXP)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

ethanol (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP,ISO)

galactose (EXP,ISO)

gallic acid (EXP)

genistein (ISO)

hydrogen peroxide (ISO)

irinotecan (ISO)

L-methionine (ISO)

lipopolysaccharide (EXP)

lithium atom (ISO)

lithium chloride (ISO)

lithium hydride (ISO)

melatonin (EXP)

mercaptopurine (EXP)

methanol (ISO)

methapyrilene (EXP)

mitomycin C (ISO)

monoethyl phthalate (ISO)

monuron (EXP)

N-ethyl-N-nitrosourea (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

NMN zwitterion (ISO)

ochratoxin A (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

Pentoxifylline (EXP)

propanal (ISO)

propranolol (ISO)

purine-6-thiol (EXP)

quercetin (ISO)

resveratrol (ISO)

rifampicin (ISO)

rotenone (ISO)

SB 431542 (ISO)

sevoflurane (EXP)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

tamoxifen (EXP)

titanium dioxide (ISO)

tributyl phosphate (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid stimulus (ISO)

cellular response to hypoxia (ISO)

cellular response to leukemia inhibitory factor (ISO)

cellular response to tumor necrosis factor (IEP)

DNA damage response (ISO)

miRNA-mediated post-transcriptional gene silencing (ISO)

myelination (ISO)

negative regulation of angiogenesis (ISO)

negative regulation of B cell receptor signaling pathway (ISO)

negative regulation of calcium ion import (ISO)

negative regulation of chemokine production (ISO)

negative regulation of gene expression (ISO)

negative regulation of IP-10 production (ISO)

negative regulation of peroxisome proliferator activated receptor signaling pathway (ISO)

negative regulation of smooth muscle cell chemotaxis (ISO)

negative regulation of sprouting angiogenesis (ISO)

negative regulation of transmembrane transport (ISO)

negative regulation of vascular associated smooth muscle cell migration (ISO)

negative regulation of vascular associated smooth muscle cell proliferation (ISO)

negative regulation of vascular endothelial cell proliferation (ISO)

negative regulation of vascular endothelial growth factor production (ISO)

negative regulation of vascular wound healing (ISO)

ossification (ISO)

positive regulation of blood vessel endothelial cell differentiation (ISO)

positive regulation of cardiac muscle cell apoptotic process (ISO)

positive regulation of cellular senescence (ISO)

positive regulation of gene expression (ISO)

positive regulation of leukocyte apoptotic process (ISO)

positive regulation of lipid storage (ISO)

positive regulation of smooth muscle cell differentiation (ISO)

positive regulation of stem cell differentiation (ISO)

programmed cell death in response to reactive oxygen species (ISO)

response to oxygen levels (ISO)

sensory perception of sound (ISO)

tumor necrosis factor-mediated signaling pathway (ISO)

Cellular Component

extracellular exosome (ISO)

Molecular Function

mRNA 3'-UTR binding (ISO)

mRNA base-pairing post-transcriptional repressor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Combined low miR-34s are associated with unfavorable prognosis in children with hepatoblastoma: A Chinese population-based study.	Jiao C, etal., J Pediatr Surg. 2016 Aug;51(8):1355-61. doi: 10.1016/j.jpedsurg.2016.02.091. Epub 2016 Mar 14.
2.	Protective effects of crocin and zinc sulfate on hepatic ischemia-reperfusion injury in rats: a comparative experimental model study.	Mard SA, etal., Biomed Pharmacother. 2017 Dec;96:48-55. doi: 10.1016/j.biopha.2017.09.123. Epub 2017 Nov 24.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease.	Salvoza NC, etal., PLoS One. 2016 Apr 14;11(4):e0153497. doi: 10.1371/journal.pone.0153497. eCollection 2016.
5.	Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure.	Tian C, etal., Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H928-H939. doi: 10.1152/ajpheart.00602.2017. Epub 2018 Jan 26.
6.	MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma.	Xiang ZL, etal., Oncotarget. 2016 Dec 27;7(52):87246-87256. doi: 10.18632/oncotarget.13531.
7.	A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma.	Xiao Z, etal., Cancer Res. 2014 Nov 1;74(21):6236-47. doi: 10.1158/0008-5472.CAN-14-0855. Epub 2014 Sep 12.
8.	MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism.	Zhang HF, etal., Mol Med Rep. 2018 Mar;17(3):4483-4489. doi: 10.3892/mmr.2018.8399. Epub 2018 Jan 9.
9.	Elevated circulating microRNA-210 levels in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: a potential new biomarker.	Zhang Q, etal., Biomarkers. 2013 Feb;18(1):23-9. doi: 10.3109/1354750X.2012.728624. Epub 2012 Oct 10.
10.	MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway.	Zhang W, etal., Cell Physiol Biochem. 2018;48(3):1304-1316. doi: 10.1159/000492090. Epub 2018 Jul 26.

Additional References at PubMed

PMID:14691248	PMID:16381832	PMID:17604727	PMID:18320040	PMID:18723672	PMID:19697704	PMID:19895913	PMID:20403161	PMID:20439489	PMID:20548288	PMID:20805985	PMID:21216258
PMID:21719785	PMID:23217387	PMID:23323620	PMID:23646144	PMID:24421392	PMID:24638095	PMID:25106556	PMID:25405338	PMID:25483877	PMID:25633291	PMID:25751060	PMID:25817785
PMID:26203862	PMID:26252661	PMID:26329269	PMID:26437572	PMID:26459758	PMID:27441728	PMID:27545688	PMID:27694688	PMID:27780189	PMID:28129650	PMID:28544853	PMID:28599575
PMID:28709867	PMID:28894025	PMID:29551367	PMID:29578002	PMID:30447272	PMID:30877521	PMID:30964183	PMID:30968966	PMID:31002154	PMID:31081106	PMID:31081107	PMID:31237127
PMID:31278961	PMID:31295983	PMID:31345016	PMID:31486508	PMID:31490756	PMID:31599430	PMID:32096191	PMID:32214804	PMID:32683849	PMID:33044326	PMID:33155431	PMID:33275236
PMID:33400820	PMID:33435858	PMID:33465281	PMID:33638320	PMID:33661552	PMID:33909769	PMID:34227918	PMID:34296298	PMID:34318554	PMID:34400887	PMID:34735028	PMID:34778900
PMID:35703738	PMID:35879917	PMID:36427097	PMID:38650126	PMID:39075107

Genomics

Comparative Map Data

Mir34a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	165,815,952 - 165,816,053 (+)	NCBI		GRCr8
mRatBN7.2	5	160,533,002 - 160,533,103 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	160,533,002 - 160,533,103 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	163,249,485 - 163,249,586 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,071,851 - 165,071,952 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,028,223 - 165,028,324 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,092,491 - 167,092,592 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,092,491 - 167,092,592 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	170,733,242 - 170,733,343 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	5	158,795,110 - 158,795,211 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

MIR34A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	9,151,668 - 9,151,777 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	9,151,668 - 9,151,777 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	9,211,727 - 9,211,836 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	9,134,313 - 9,134,422 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	8,321,161 - 8,321,270 (-)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	8,362,551 - 8,362,660 (-)	NCBI		HuRef
CHM1_1	1	9,201,981 - 9,202,090 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	8,685,973 - 8,686,082 (-)	NCBI		T2T-CHM13v2.0

Mir34a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	150,152,911 - 150,153,012 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	150,152,911 - 150,153,012 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	150,068,454 - 150,068,555 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	150,068,454 - 150,068,555 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	149,442,563 - 149,442,664 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	4	152,344,303 - 152,344,404 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	80.85	NCBI

MIR34A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	62,485,832 - 62,485,897 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	62,485,832 - 62,485,897 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	62,502,877 - 62,502,942 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	62,712,027 - 62,712,092 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	62,712,027 - 62,712,092 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	62,710,061 - 62,710,126 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	62,573,923 - 62,573,988 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	62,978,341 - 62,978,406 (-)	NCBI		UU_Cfam_GSD_1.0

miRNA Target Status (No longer updated)

Confirmed Targets

Gene Target	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Tagln	rno-miR-34a-5p	Mirtarbase	external_info	Microarray	Functional MTI (Weak)	18258830
Mycn	rno-miR-34a-5p	Mirtarbase	external_info	Western blot	Functional MTI	19167416
E2f3	rno-miR-34a-5p	Mirtarbase	external_info	Western blot	Functional MTI	18942116
Grm7	rno-miR-34a-5p	Mirtarbase	external_info	Western blot	Functional MTI	18704095

Predicted Targets

	Summary Value
Count of predictions:	14588
Count of gene targets:	7925
Count of transcripts:	8620
Interacting mature miRNAs:	rno-miR-34a-3p, rno-miR-34a-5p
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	1	9	41	36	35	6	20	6	6	67	50	21	3	23	29

Sequence

Nucleotide Sequences


RefSeq Transcripts	NR_031850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000053746

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	160,533,002 - 160,533,103 (+)	Ensembl
Rnor_6.0 Ensembl	5	167,092,491 - 167,092,592 (+)	Ensembl

RefSeq Acc Id:

NR_031850

RefSeq Status:

PROVISIONAL

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	165,815,952 - 165,816,053 (+)	NCBI
mRatBN7.2	5	160,533,002 - 160,533,103 (+)	NCBI
Rnor_6.0	5	167,092,491 - 167,092,592 (+)	NCBI
Rnor_5.0	5	170,733,242 - 170,733,343 (+)	NCBI
Celera	5	158,795,110 - 158,795,211 (+)	NCBI

Sequence:

show sequence

CCGGCTGTGAGTAATTCTTTGGCAGTGTCTTAGCTGGTTGTTGTGAGTATTAGCTAAGGAAGCA
ATCAGCAAGTATACTGCCCTAGAAGTGCTGCACGTTGT

hide sequence

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2325584	AgrOrtholog
BioCyc Gene	G2FUF-39083	BioCyc
Ensembl Genes	ENSRNOG00000035623	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000053746	ENTREZGENE
miRBase	MI0000877	ENTREZGENE
NCBI Gene	100314015	ENTREZGENE
PhenoGen	Mir34a	PhenoGen
RatGTEx	ENSRNOG00000035623	RatGTEx
RNAcentral	URS000030BD69	RNACentral
	URS000040249F	RNACentral
	URS000075E4DE	RNACentral

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-14	Mir34a	microRNA 34a	Mir34a	microRNA mir-34a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-06-02	Mir34a	microRNA mir-34a			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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