MYC (MYC proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: MYC (MYC proto-oncogene, bHLH transcription factor) Homo sapiens
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Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
RGD ID: 731438
HGNC Page HGNC
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; eukaryotic initiation factor eIF2 binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of fibroblast proliferation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within positive regulation of cell population proliferation and regulation of gene expression. Located in chromatin; nucleus; and rough endoplasmic reticulum. Part of protein-containing complex. Implicated in several diseases, including demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; prostate cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including hepatitis C; leukemia (multiple); liver disease (multiple); polycystic kidney disease 1; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: avian myelocytomatosis viral oncogene homolog; bHLHe39; c-Myc; class E basic helix-loop-helix protein 39; cMyc; MRTL; myc proto-oncogene protein; myc-related translation/localization regulatory factor; MYCC; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8127,735,434 - 127,742,951 (+)EnsemblGRCh38hg38GRCh38
GRCh388127,735,434 - 127,742,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378128,747,680 - 128,755,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368128,817,498 - 128,822,856 (+)NCBINCBI36hg18NCBI36
Build 348128,817,685 - 128,822,853NCBI
Celera8124,928,812 - 124,934,177 (+)NCBI
Cytogenetic Map8q24.21NCBI
HuRef8124,069,829 - 124,075,195 (+)NCBIHuRef
CHM1_18128,788,551 - 128,793,916 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (IEP)
acute myeloid leukemia  (EXP)
acute promyelocytic leukemia  (IEP,IMP)
adenocarcinoma  (EXP)
Alcoholic Liver Diseases  (IEP,ISO)
angiosarcoma  (EXP)
Animal Disease Models  (EXP)
autosomal dominant polycystic kidney disease  (EXP,ISO)
autosomal recessive polycystic kidney disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
breast cancer  (IAGP,ISO,ISS)
Breast Neoplasms  (ISO)
Burkitt lymphoma  (IAGP)
carcinoma  (EXP)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
Chromosome Breakage  (EXP)
chronic lymphocytic leukemia  (IEP)
clear cell renal cell carcinoma  (IEP)
cleft lip  (EXP)
cleft palate  (EXP)
Colonic Neoplasms  (EXP,ISO)
Colorectal Neoplasms  (EXP)
coronary restenosis  (ISO)
COVID-19  (HEP)
demyelinating disease  (IAGP)
diffuse large B-cell lymphoma  (EXP)
disease of cellular proliferation  (EXP,IAGP)
Disease Progression  (EXP)
Ductal Carcinoma  (EXP)
Endometrial Neoplasms  (EXP)
esophageal carcinoma  (IAGP)
Esophageal Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Liver Neoplasms  (EXP,ISO)
fatty liver disease  (EXP)
glioblastoma  (EXP)
Hemorrhagic Shock  (ISO)
hepatitis C  (IEP)
hepatocellular carcinoma  (EXP,IEP,ISO)
hyperparathyroidism  (IEP)
hypertrophic cardiomyopathy  (EXP)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (EXP)
leiomyoma  (ISO)
liver cirrhosis  (IEP)
Liver Injury  (ISO)
Liver Neoplasms  (EXP)
lung adenocarcinoma  (EXP,IAGP,IDA)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (EXP)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (EXP)
Merkel cell carcinoma  (EXP)
myelodysplastic syndrome  (EXP)
Neoplasm Metastasis  (EXP)
Neoplastic Cell Transformation  (EXP)
nephroblastoma  (IEP,ISO)
neuroblastoma  (EXP,IAGP)
neuroectodermal tumor  (EXP)
non-Hodgkin lymphoma  (IAGP)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (EXP)
Ovarian Neoplasms  (EXP)
pancreatic cancer  (EXP,ISO)
pancreatic carcinoma  (ISS)
polycystic kidney disease  (ISO)
polycystic kidney disease 1  (IEP,ISO)
primary ovarian insufficiency  (IAGP)
prolactinoma  (ISO)
prostate adenocarcinoma  (IMP)
prostate cancer  (IAGP,IEP)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (EXP)
pulmonary hypertension  (ISO)
renal cell carcinoma  (IEP,ISO)
renal fibrosis  (ISO)
rhabdoid cancer  (IEP)
skin melanoma  (IAGP)
Sporadic Papillary Renal Cell Carcinoma  (IEP)
squamous cell carcinoma  (EXP)
Stomach Neoplasms  (EXP)
thyroid gland cancer  (ISO)
thyroid gland papillary carcinoma  (IEP)
Transplant Rejection  (ISO)
trichorhinophalangeal syndrome type I  (IAGP)
urinary bladder cancer  (EXP,IAGP,IEP,ISO)
Uterine Cervical Neoplasms  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (ISO)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (EXP)
(20S)-ginsenoside Rg3  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-dichlorobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
2-nitrofluorene  (ISO)
2-nitrotoluene  (ISO)
26-hydroxycholesterol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (EXP,ISO)
3-aminobenzamide  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-Hydroxy-N-desmethyltamoxifen  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7beta-aminocephalosporanic acid  (EXP)
8-Br-cAMP  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP)
acetaldehyde  (ISO)
acetohydrazide  (ISO)
acetylleucyl-leucyl-norleucinal  (EXP)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
adenosine  (EXP)
Aeroplysinin 1  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
AH23848  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (EXP)
amifostine  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
amsacrine  (EXP)
androstane  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
aprepitant  (EXP)
aristolochic acid  (EXP)
arsenic acid  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Asimicin  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP)
Azaspiracid  (EXP)
bathocuproine disulfonic acid  (EXP)
benazepril  (ISO)
benzamide  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoates  (EXP)
benzoic acid  (EXP)
benzylpenicillin  (ISO)
berberine  (ISO)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
betulin  (EXP)
betulinic acid  (EXP)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bleomycin A5  (EXP)
bortezomib  (EXP)
bromobenzene  (ISO)
bromochloroacetic acid  (ISO)
bromodichloromethane  (ISO)
bromoform  (ISO)
bucladesine  (EXP)
budesonide  (ISO)
bufalin  (EXP)
busulfan  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (ISO)
calcein am  (EXP)
calcitriol  (EXP)
calcium dichloride  (ISO)
calmidazolium  (ISO)
camptothecin  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbofuran  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
carboplatin  (EXP)
carvedilol  (ISO)
catechol  (EXP)
celastrol  (EXP,ISO)
celecoxib  (EXP)
chalcone  (EXP)
chelerythrine  (EXP)
CHIR 99021  (EXP)
chlorambucil  (EXP)
Chlorodibromomethane  (ISO)
chloroform  (ISO)
chlorohydrocarbon  (EXP)
chloropicrin  (EXP)
chlorpromazine  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (EXP)
cisplatin  (EXP)
clofarabine  (EXP)
clofibrate  (EXP,ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP)
CU-O LINKAGE  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanamide  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP)
DDE  (EXP)
DDT  (EXP,ISO)
Deguelin  (EXP,ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (EXP)
diazinon  (ISO)
dibenziodolium  (EXP)
dibenzoylmethane  (EXP)
dibromoacetic acid  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroartemisinin  (EXP)
Dimaprit  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enzalutamide  (EXP)
epichlorohydrin  (EXP)
erythromycin estolate  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP)
eugenol  (ISO)
everolimus  (EXP)
Evodiamine  (EXP)
fenofibrate  (ISO)
fenthion  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (EXP)
fucoidan  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-linolenic acid  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (EXP)
gemcitabine  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutethimide  (ISO)
glycerol  (EXP)
glycidol  (ISO)
glycine betaine  (ISO)
glyphosate  (EXP)
guanosine  (EXP)
guggulsterone  (EXP)
GW 4064  (EXP)
harmine  (EXP)
hemin  (EXP)
heparin  (EXP,ISO)
hesperetin  (ISO)
hexachlorophene  (EXP)
hexamethylene diisocyanate  (EXP)
hexanal  (EXP)
Honokiol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxamic acid  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
leflunomide  (EXP)
letrozole  (EXP)
limonene  (ISO)
linalool  (EXP)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (EXP,ISO)
losartan  (ISO)
lupeol  (ISO)
m-xylene  (ISO)
mancozeb  (ISO)
maneb  (ISO)
masoprocol  (EXP)
Matrine  (EXP)
mebendazole  (EXP)
menadione  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (ISO)
mercury(0)  (EXP,ISO)
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+)  (EXP)
mestranol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
metoprolol  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
mitoxantrone  (EXP)
ML-7  (EXP)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myricetin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-dimethylaniline  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nafenopin  (ISO)
naloxone  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP)
nitrofurazone  (ISO)
nitroprusside  (EXP)
Nodularin  (EXP)
NS-398  (EXP)
o-anisidine  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oleanolic acid  (EXP,ISO)
oridonin  (EXP)
ortho-Aminoazotoluene  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (EXP)
phenylhydrazine  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (ISO)
picene  (EXP)
pinosylvin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (EXP)
poly(I:C)  (EXP)
ponatinib  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP)
promethazine  (ISO)
propiconazole  (ISO)
propylparaben  (EXP)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
pterostilbene  (EXP)
puerarin  (EXP)
putrescine  (ISO)
pyrrolidine dithiocarbamate  (EXP)
pyrvinium  (EXP)
quartz  (EXP)
quercetin  (EXP)
quinacrine  (EXP)
quinapril hydrochloride  (ISO)
quinidine  (ISO)
quinolone  (EXP)
quizartinib  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
riboflavin  (EXP)
ritonavir  (EXP)
rotenone  (ISO)
saccharin  (ISO)
Salinomycin  (EXP)
SB 431542  (EXP)
Securinine  (EXP)
selenium atom  (EXP,ISO)
selumetinib  (ISO)
serpentine asbestos  (EXP)
sertraline  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
sorafenib  (EXP)
staurosporine  (EXP)
styrene oxide  (EXP)
SU6656  (EXP)
succimer  (ISO)
succinic acid  (EXP)
sulfates  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (EXP,ISO)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP,ISO)
taurocholic acid  (EXP,ISO)
tebufenpyrad  (EXP)
temozolomide  (EXP)
teniposide  (EXP)
terbufos  (EXP)
terbutylazine  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
theaflavin  (ISO)
theophylline  (EXP,ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
thiophenes  (EXP)
thiram  (EXP)
thymidine  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (EXP)
tiazofurine  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
toxaphene  (ISO)
trametinib  (EXP)
trans-chalcone  (EXP)
trans-pinosylvin  (EXP)
Tributyltin oxide  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP)
tunicamycin  (EXP)
undecane  (ISO)
urethane  (EXP,ISO)
uridine  (EXP)
valproic acid  (EXP,ISO)
vemurafenib  (EXP)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP,ISO)
vinyl carbamate  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
WR-1065  (EXP)
xanthohumol  (ISO)
zearalenone  (EXP)
zerumbone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
amino acid transport  (IEA,ISO)
B cell apoptotic process  (ISO)
biological_process  (ND)
branching involved in ureteric bud morphogenesis  (ISS)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (ISO)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (ISO)
cell population proliferation  (IEA,ISO)
cellular iron ion homeostasis  (IDA)
cellular response to angiotensin  (IEA,ISO)
cellular response to arsenite(3-)  (IEA,ISO)
cellular response to carbohydrate stimulus  (IEA,ISO)
cellular response to cycloheximide  (IEA,ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to dimethyl sulfoxide  (IEA,ISO)
cellular response to DNA damage stimulus  (IDA,ISO)
cellular response to endothelin  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA,ISO)
cellular response to estrogen stimulus  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (IEA,ISO)
cellular response to growth hormone stimulus  (IEA,ISO)
cellular response to hydrostatic pressure  (IEA,ISO)
cellular response to hypoxia  (IDA)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to interferon-alpha  (ISO)
cellular response to interferon-gamma  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to lectin  (IEA,ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (IEA,ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to prolactin  (IEA,ISO)
cellular response to putrescine  (IEA,ISO)
cellular response to retinoic acid  (IEA,ISO)
cellular response to testosterone stimulus  (IEA,ISO)
cellular response to UV  (IEP)
cellular response to xenobiotic stimulus  (IDA,IEA,ISO)
chromatin remodeling  (IDA)
chromosome organization  (IDA)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
DNA-templated transcription, initiation  (IEA,ISO)
energy reserve metabolic process  (NAS)
ERK1 and ERK2 cascade  (IDA)
fibroblast apoptotic process  (TAS)
flavonoid metabolic process  (IEA)
fungal-type cell wall polysaccharide metabolic process  (IEA)
G0 to G1 transition  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
hypothalamus development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inner mitochondrial membrane organization  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
lactic acid secretion  (IEA,ISO)
liver regeneration  (IEA,ISO)
MAPK cascade  (IMP)
middle ear morphogenesis  (ISO)
negative regulation of apoptotic process  (ISS)
negative regulation of cell death  (IEA,ISO)
negative regulation of cell division  (IDA)
negative regulation of fibroblast proliferation  (IDA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of glucose import  (IEA,ISO)
negative regulation of monocyte differentiation  (IMP)
negative regulation of protein binding  (ISO)
negative regulation of stress-activated MAPK cascade  (ISS)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO)
ovarian follicle development  (IEA,ISO)
ovulation  (IEA,ISO)
oxygen transport  (NAS)
pigmentation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (IEA,ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of cell population proliferation  (IBA,IDA,ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
positive regulation of DNA binding  (IEA,ISO)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of DNA methylation  (IMP)
positive regulation of epithelial cell proliferation  (IDA)
positive regulation of fibroblast proliferation  (IDA,IEA,IMP,ISO)
positive regulation of gene expression  (IDA,IGI)
positive regulation of glial cell proliferation  (IEA,ISO)
positive regulation of glycolytic process  (IEA,ISO)
positive regulation of mesenchymal cell proliferation  (ISS)
positive regulation of metanephric cap mesenchymal cell proliferation  (ISS)
positive regulation of mitochondrial membrane potential  (IEA,ISO)
positive regulation of oxidative phosphorylation  (IEA,ISO)
positive regulation of response to DNA damage stimulus  (IDA)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of telomerase activity  (ISS)
positive regulation of transcription by RNA po