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Gene: MYC (MYC proto-oncogene, bHLH transcription factor) Homo sapiens
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Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ERK1 and ERK2 cascade; regulation of fibroblast proliferation; and regulation of nucleobase-containing compound metabolic process. Localizes to nucleus; protein-containing complex; and rough endoplasmic reticulum. Implicated in several diseases, including demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; prostate cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including hepatitis C; leukemia (multiple); liver disease (multiple); polycystic kidney disease 1; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: avian myelocytomatosis viral oncogene homolog; bHLHe39; c-Myc; class E basic helix-loop-helix protein 39; cMyc; MRTL; myc proto-oncogene protein; myc-related translation/localization regulatory factor; MYCC; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Myc (myelocytomatosis oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myc (MYC proto-oncogene, bHLH transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myc (MYC proto-oncogene, bHLH transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MYC (MYC proto-oncogene, bHLH transcription factor)
Canis lupus familiaris (dog) : MYC (MYC proto-oncogene, bHLH transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myc (MYC proto-oncogene, bHLH transcription factor)
Sus scrofa (pig) : MYC (MYC proto-oncogene, bHLH transcription factor)
Chlorocebus sabaeus (African green monkey) : MYC (MYC proto-oncogene, bHLH transcription factor)
Heterocephalus glaber (naked mole-rat) : Myc (MYC proto-oncogene, bHLH transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8127,735,434 - 127,742,951 (+)EnsemblGRCh38hg38GRCh38
GRCh388127,735,434 - 127,742,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378128,748,315 - 128,753,680 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368128,817,498 - 128,822,856 (+)NCBINCBI36hg18NCBI36
Build 348128,817,685 - 128,822,853NCBI
Celera8124,928,812 - 124,934,177 (+)NCBI
Cytogenetic Map8q24.21NCBI
HuRef8124,069,829 - 124,075,195 (+)NCBIHuRef
CHM1_18128,788,551 - 128,793,916 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated