MIR98 (microRNA 98) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: MIR98 (microRNA 98) Homo sapiens
Analyze
Symbol: MIR98
Name: microRNA 98
RGD ID: 1344194
HGNC Page HGNC:31649
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of biosynthetic process; and negative regulation of signal transduction. Acts upstream of or within negative regulation of osteoblast differentiation. Located in extracellular space. Biomarker of colorectal cancer.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-98; miR-98; MIRLET7L; MIRN98
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,556,223 - 53,556,341 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,556,223 - 53,556,341 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,583,184 - 53,583,302 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,599,908 - 53,600,026 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,414,753 - 57,414,871 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,639,144 - 50,639,262 (-)NCBIHuRef
CHM1_1X53,574,160 - 53,574,278 (-)NCBICHM1_1
T2T-CHM13v2.0X52,842,581 - 52,842,699 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98Humancolorectal cancer  IEP 153002793miRNA:increased expression:colorectum (human)RGD 
MIR98Humanlung cancer treatmentISOMir98 (Mus musculus)153344587 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98HumanAtkin Syndrome  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Atkin Flaitz Patil Smith syndromeClinVarPMID:26059843 and PMID:28492532
MIR98Humanautistic disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
MIR98HumanCornelia de Lange syndrome 2  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital muscular hypertrophy-cerebral syndromeClinVarPMID:26386245 more ...
MIR98Humannon-syndromic X-linked intellectual disability 1  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER and X-LINKED 1ClinVarPMID:26059843 and PMID:28492532
MIR98Humansyndromic X-linked intellectual disability Lubs type  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98HumanColonic Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27270317
MIR98Humancongestive heart failure  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
MIR98HumanEsophageal Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27270317
MIR98HumanExperimental Liver Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21035526
MIR98HumanLung Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27270317
MIR98Humanovarian carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:30365097
MIR98Humanpre-malignant neoplasm  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21035526
MIR98Humantype 2 diabetes mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28545106

1 to 20 of 49 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98Human(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of MIR98 mRNACTDPMID:27270317
MIR98Human(S)-nicotine multiple interactionsISOMir98 (Mus musculus)6480464MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein] more ...CTDPMID:33082140
MIR98Human(S)-nicotine decreases expressionISOMir98 (Mus musculus)6480464Nicotine results in decreased expression of MIR98 mRNACTDPMID:33082140
MIR98Human(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of MIR98 mRNACTDPMID:33082140
MIR98Human1,3,5-trinitro-1,3,5-triazinane increases expressionISOMir98 (Rattus norvegicus)6480464cyclonite results in increased expression of MIR98 mRNACTDPMID:25559034
MIR98Human1,3,5-trinitro-1,3,5-triazinane affects expressionISOMir98 (Mus musculus)6480464cyclonite affects the expression of MIR98 mRNACTDPMID:19270793
MIR98Human17beta-hydroxy-5alpha-androstan-3-one increases expressionEXP 6480464Dihydrotestosterone results in increased expression of MIR98 mRNACTDPMID:25846647
MIR98Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MIR98 mRNACTDPMID:30096437
MIR98Human2-hydroxypropanoic acid increases expressionEXP 6480464Lactic Acid results in increased expression of MIR98 mRNACTDPMID:30851411
MIR98Humanacrolein increases expressionEXP 6480464Acrolein results in increased expression of MIR98CTDPMID:24812010
MIR98Humanarsenous acid increases expressionEXP 6480464Arsenic Trioxide results in increased expression of MIR98 mRNACTDPMID:22072212
MIR98Humanbenzene decreases expressionISOMir98 (Mus musculus)6480464Benzene results in decreased expression of MIR98 mRNACTDPMID:32105654
MIR98Humanbenzo[a]pyrene decreases methylationEXP 6480464Benzo(a)pyrene results in decreased methylation of MIR98 promoterCTDPMID:27901495
MIR98Humanbis(2-ethylhexyl) phthalate increases expressionISOMir98 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of MIR98CTDPMID:32642447
MIR98Humanbleomycin A2 decreases expressionISOMir98 (Rattus norvegicus)6480464Bleomycin results in decreased expression of MIR98 mRNACTDPMID:25933445
MIR98Humancadmium atom multiple interactionsISOMir98 (Rattus norvegicus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR98 mRNACTDPMID:33652105
MIR98Humancadmium dichloride multiple interactionsISOMir98 (Rattus norvegicus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR98 mRNACTDPMID:33652105
MIR98Humanchenodeoxycholic acid decreases expressionEXP 6480464Chenodeoxycholic Acid results in decreased expression of MIR98 mRNACTDPMID:27174168
MIR98Humanchloroform decreases expressionISOMir98 (Mus musculus)6480464Chloroform results in decreased expression of MIR98 mRNACTDPMID:32105654
MIR98Humancisplatin decreases expressionEXP 6480464Cisplatin results in decreased expression of MIR98CTDPMID:21274007

1 to 20 of 49 rows

Biological Process
1 to 20 of 33 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98Humancellular response to amyloid-beta involved_inIMP 150520179 PMID:27541017ARUK-UCLPMID:27541017
MIR98Humancellular response to lipopolysaccharide acts_upstream_of_or_withinISOMir98 (Mus musculus)9068941 PMID:21609717MGIPMID:21609717
MIR98Humanlong-term synaptic potentiation acts_upstream_of_or_withinISOMir98 (Mus musculus)9068941 PMID:25858512MGIPMID:25858512
MIR98HumanmiRNA-mediated gene silencing by inhibition of translation involved_inIDA 150520179 PMID:27541017ARUK-UCLPMID:27541017
MIR98HumanmiRNA-mediated gene silencing by mRNA destabilization involved_inIMP 150520179 PMID:28251559BHF-UCLPMID:28251559
MIR98HumanmiRNA-mediated gene silencing by mRNA destabilization involved_inIDA 150520179 PMID:27860183 and PMID:30195495BHF-UCLPMID:27860183 and PMID:30195495
MIR98HumanmiRNA-mediated post-transcriptional gene silencing involved_inIEARfam:RF00027150520179 RNAcentralGO_REF:0000115
MIR98HumanmiRNA-mediated post-transcriptional gene silencing involved_inIDA 150520179 PMID:22492871 more ...ARUK-UCLPMID:22492871 more ...
MIR98Humannegative regulation of BMP signaling pathway acts_upstream_ofIMP 150520179 PMID:27860183BHF-UCLPMID:27860183
MIR98Humannegative regulation of cell population proliferation acts_upstream_ofIDA 150520179 PMID:31886314ARUK-UCLPMID:31886314
MIR98Humannegative regulation of cholesterol biosynthetic process involved_inIDA 150520179 PMID:30195495BHF-UCLPMID:30195495
MIR98Humannegative regulation of cytokine production involved_inIDA 150520179 PMID:27860183BHF-UCLPMID:27860183
MIR98Humannegative regulation of cytokine production involved in inflammatory response involved_inIDA 150520179 PMID:31886314ARUK-UCLPMID:31886314
MIR98Humannegative regulation of extracellular matrix assembly acts_upstream_ofIMP 150520179 PMID:28251559BHF-UCLPMID:28251559
MIR98Humannegative regulation of extracellular matrix disassembly involved_inIDA 150520179 PMID:26587789ARUK-UCLPMID:26587789
MIR98Humannegative regulation of gene expression acts_upstream_ofIMP 150520179 PMID:27860183BHF-UCLPMID:27860183
MIR98Humannegative regulation of gene expression acts_upstream_ofIDA 150520179 PMID:31886314ARUK-UCLPMID:31886314
MIR98Humannegative regulation of interleukin-1 beta production acts_upstream_ofIDA 150520179 PMID:31886314ARUK-UCLPMID:31886314
MIR98Humannegative regulation of interleukin-10 production acts_upstream_of_or_withinISOMir98 (Mus musculus)9068941 PMID:21609717MGIPMID:21609717
MIR98Humannegative regulation of interleukin-10 production involved_inIDA 150520179 PMID:29702181ARUK-UCLPMID:29702181
1 to 20 of 33 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98Humanextracellular space located_inHDA 150520179 PMID:26646931BHF-UCLPMID:26646931
MIR98HumanRISC complex part_ofIEARfam:RF00027150520179 RNAcentralGO_REF:0000115

Molecular Function

  

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR98HumanAutism  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311

#
Reference Title
Reference Citation
1. Circ_0048856 competes with ABCC1 for miR-193a-5p/miR-98-5p binding sites to promote the cisplatin resistance and tumorigenesis in lung cancer. Liu L, etal., J Chemother. 2022 Mar 15:1-14. doi: 10.1080/1120009X.2022.2043515.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
1 to 10 of 10 rows
PMID:11914277   PMID:16381832   PMID:17604727   PMID:17616659   PMID:19592657   PMID:19671678   PMID:20486857   PMID:21037258   PMID:21228813   PMID:21880462   PMID:22282338   PMID:22492871  
PMID:22867052   PMID:23188821   PMID:23211491   PMID:23434382   PMID:23575983   PMID:24392454   PMID:24696733   PMID:24712372   PMID:24771265   PMID:25277211   PMID:25422988   PMID:25856466  
PMID:26098770   PMID:26244871   PMID:26367177   PMID:26502849   PMID:26587789   PMID:26646931   PMID:26722410   PMID:26846175   PMID:27270317   PMID:27323110   PMID:27422937   PMID:27541017  
PMID:27573367   PMID:27605397   PMID:27677076   PMID:27860183   PMID:27890434   PMID:27913008   PMID:28025745   PMID:28124208   PMID:28232182   PMID:28244848   PMID:28251559   PMID:28415380  
PMID:28431233   PMID:28436142   PMID:28629444   PMID:28724212   PMID:28730912   PMID:28760845   PMID:28784995   PMID:28946561   PMID:29095526   PMID:29333957   PMID:29670086   PMID:29695690  
PMID:29702181   PMID:29907673   PMID:29917180   PMID:29949140   PMID:29970191   PMID:30195495   PMID:30229812   PMID:30236205   PMID:30387848   PMID:30463687   PMID:30506722   PMID:30535507  
PMID:30664191   PMID:30692511   PMID:30868866   PMID:30923843   PMID:31033463   PMID:31207579   PMID:31220419   PMID:31235259   PMID:31282134   PMID:31646564   PMID:31670857   PMID:31731187  
PMID:31770107   PMID:31799646   PMID:31833733   PMID:31886314   PMID:31899049   PMID:32045359   PMID:32469170   PMID:32705261   PMID:32788584   PMID:32857843   PMID:32888161   PMID:32892409  
PMID:32950571   PMID:32990894   PMID:33156004   PMID:33393590   PMID:33629639   PMID:34010470   PMID:34155816   PMID:34455196   PMID:34796378   PMID:34837760   PMID:34895048   PMID:34931214  
PMID:35126933   PMID:35188624   PMID:35396910   PMID:35678981   PMID:35904181   PMID:37183710   PMID:37300672   PMID:38198612   PMID:38267060   PMID:38436805   PMID:38615043   PMID:38945840  
1 to 10 of 10 rows



MIR98
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,556,223 - 53,556,341 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,556,223 - 53,556,341 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,583,184 - 53,583,302 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,599,908 - 53,600,026 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,414,753 - 57,414,871 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,639,144 - 50,639,262 (-)NCBIHuRef
CHM1_1X53,574,160 - 53,574,278 (-)NCBICHM1_1
T2T-CHM13v2.0X52,842,581 - 52,842,699 (-)NCBIT2T-CHM13v2.0
Mir98
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,696,210 - 150,696,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,696,210 - 150,696,317 (+)EnsemblGRCm39 Ensembl
GRCm38X151,913,214 - 151,913,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,913,214 - 151,913,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,347,757 - 148,347,864 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX132,517,150 - 132,517,257 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Mir98
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,460,648 - 24,460,755 (+)NCBIGRCr8
mRatBN7.2X20,981,235 - 20,981,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,981,235 - 20,981,342 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,458,905 - 18,459,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,664,568 - 21,664,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,546,878 - 21,546,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X21,583,875 - 21,583,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,583,875 - 21,583,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,867,881 - 21,867,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX21,262,415 - 21,262,522 (+)NCBICelera
Cytogenetic MapXq13NCBI
MIR98
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,253,693 - 45,253,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,253,696 - 45,253,775 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X45,578,696 - 45,578,775 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X45,073,740 - 45,073,819 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,523,371 - 45,523,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,590,976 - 45,591,055 (-)NCBIUU_Cfam_GSD_1.0
MIR98
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,302,381 - 46,302,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,302,381 - 46,302,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,800,864 - 51,800,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3

.

1 to 10 of 191 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x3 copy number gain See cases [RCV000133911] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x1 copy number loss See cases [RCV000050811] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x3 copy number gain See cases [RCV000050810] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:3092486-155699618)x2 copy number gain See cases [RCV000050889] ChrX:3092486..155699618 [GRCh38]
ChrX:3010527..154929279 [GRCh37]
ChrX:3020527..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000050699] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss Global developmental delay [RCV000050386]|See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000050697] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp11.23-11.22(chrX:50086006-54030240)x1 copy number loss See cases [RCV000051663] ChrX:50086006..54030240 [GRCh38]
ChrX:49850663..53957191 [GRCh37]
ChrX:49737403..54073398 [NCBI36]
ChrX:Xp11.23-11.22		 pathogenic
GRCh38/hg38 Xp11.22-11.21(chrX:51664377-58055036)x3 copy number gain See cases [RCV000052392] ChrX:51664377..58055036 [GRCh38]
ChrX:51407309..58081470 [GRCh37]
ChrX:51424049..58098195 [NCBI36]
ChrX:Xp11.22-11.21		 pathogenic
1 to 10 of 191 rows

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
E2F1hsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19528081
E2F2hsa-miR-98-5pMirtarbaseexternal_infoNorthern blot//Western blot//qRT-PCR//ChIP//LucifeFunctional MTI19528081
HMGA2hsa-miR-98-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blot;OtherFunctional MTI17222355
HMGA2hsa-miR-98-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19088304
MYChsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI19528081
MYChsa-miR-98-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)17942906
TUSC2hsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19671678
SOCS4hsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI20486857
KLF13hsa-miR-98-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)20589685
CCL5hsa-miR-98-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)20589685
EZH2hsa-miR-98-5pMirtarbaseexternal_infoNorthern blotNon-Functional MTI (Weak)19818710
IL13hsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI21616524
MPLhsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20445018
CCNJhsa-miR-98-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23188821
ITGB3hsa-miR-98-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ACVR1Bhsa-miR-98-5pOncomiRDBexternal_infoNANA23211491
CCNJhsa-miR-98-5pOncomiRDBexternal_infoNANA23188821
PGRMC1hsa-miR-98-5pOncomiRDBexternal_infoNANA22492871
TP53hsa-miR-98-5pOncomiRDBexternal_infoNANA21880462
EZH2hsa-miR-98-5pOncomiRDBexternal_infoNANA21368858
PGRMC1hsa-miR-98-5pOncomiRDBexternal_infoNANA21109987
TUSC2hsa-miR-98-5pOncomiRDBexternal_infoNANA19671678
HMGA2hsa-miR-98-3pTarbaseexternal_infoWesternblitPOSITIVE
SOCS4hsa-miR-98-3pTarbaseexternal_infoReporter GenePOSITIVE
SOCS4hsa-miR-98-3pTarbaseexternal_infoqPCRNEGATIVE
TBC1D4hsa-miR-98-3pTarbaseexternal_infoMicroarrayPOSITIVE
IL13hsa-miR-98-3pTarbaseexternal_infoOtherNEGATIVE
HMGA2hsa-miR-98-3pMirecordsexternal_info{changed}{changed}NA17222355
TUSC2hsa-miR-98-3pMirecordsexternal_infoNANA19671678

Predicted Targets
Summary Value
Count of predictions:39510
Count of gene targets:13013
Count of transcripts:26801
Interacting mature miRNAs:hsa-miR-98-3p, hsa-miR-98-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
12 150 34 37 287 79 274 3 44 360 48 195 597 421 47 108 89 151 219 8



Ensembl Acc Id: ENST00000606724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX53,556,223 - 53,556,341 (-)Ensembl
RefSeq Acc Id: NR_029513
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X53,556,223 - 53,556,341 (-)NCBI
GRCh37X53,583,184 - 53,583,302 (-)RGD
CeleraX57,414,753 - 57,414,871 (-)RGD
HuRefX50,639,144 - 50,639,262 (-)RGD
CHM1_1X53,574,160 - 53,574,278 (-)NCBI
T2T-CHM13v2.0X52,842,581 - 52,842,699 (-)NCBI
Sequence:


1 to 13 of 13 rows
Database
Acc Id
Source(s)
COSMIC MIR98 COSMIC
Ensembl Genes ENSG00000271886 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000606724 ENTREZGENE
GTEx ENSG00000271886 GTEx
HGNC ID HGNC:31649 ENTREZGENE
Human Proteome Map MIR98 Human Proteome Map
miRBase MI0000100 ENTREZGENE
NCBI Gene 407054 ENTREZGENE
OMIM 300810 OMIM
PharmGKB PA164723023 PharmGKB
RNAcentral URS0000122ED0 RNACentral
  URS00004E0808 RNACentral
  URS000075BF40 RNACentral
1 to 13 of 13 rows