Gene: IL13 (interleukin 13) Homo sapiens
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Symbol: IL13
Name: interleukin 13
Description: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13; interleukin-13; MGC116786; MGC116788; MGC116789; P600
Orthologs:
Mus musculus (house mouse) : Il13 (interleukin 13)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il13 (interleukin 13)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il13 (interleukin 13)
Pan paniscus (bonobo/pygmy chimpanzee) : IL13 (interleukin 13)
Canis lupus familiaris (dog) : IL13 (interleukin 13)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il13 (interleukin 13)
Sus scrofa (pig) : IL13 (interleukin 13)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,656,524 - 132,661,109 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,993,865 - 131,996,801 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,021,764 - 132,024,700 (+)NCBINCBI36hg18NCBI36
Build 345132,021,763 - 132,024,700NCBI
Celera5128,123,995 - 128,126,931 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,186,169 - 127,189,105 (+)NCBIHuRef
CHM1_15131,427,162 - 131,430,098 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on IL13
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69008
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2019-06-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.