MIR98 (microRNA mir-98) - Rat Genome Database

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Pathways
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Gene: MIR98 (microRNA mir-98) Sus scrofa
Analyze
Symbol: MIR98 (Ensembl: ssc-mir-98)
Name: microRNA mir-98 (Ensembl:ssc-mir-98)
RGD ID: 14106561
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 98; ssc-mir-98
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,302,381 - 46,302,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,302,381 - 46,302,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,800,864 - 51,800,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholesterol biosynthetic process  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of extracellular matrix disassembly  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of myofibroblast differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron apoptotic process  (ISO)
regulation of cytokine production involved in inflammatory response  (ISO)

Cellular Component
RISC complex  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:19917043   PMID:24499489  


Genomics

Comparative Map Data
MIR98
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,302,381 - 46,302,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,302,381 - 46,302,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,800,864 - 51,800,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIR98
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,556,223 - 53,556,341 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,556,223 - 53,556,341 (-)EnsemblGRCh38hg38GRCh38
GRCh37X53,583,184 - 53,583,302 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,599,908 - 53,600,026 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX57,414,753 - 57,414,871 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,639,144 - 50,639,262 (-)NCBIHuRef
CHM1_1X53,574,160 - 53,574,278 (-)NCBICHM1_1
T2T-CHM13v2.0X52,842,581 - 52,842,699 (-)NCBIT2T-CHM13v2.0
Mir98
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,696,210 - 150,696,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX150,696,210 - 150,696,317 (+)EnsemblGRCm39 Ensembl
GRCm38X151,913,214 - 151,913,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,913,214 - 151,913,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X148,347,757 - 148,347,864 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX132,517,150 - 132,517,257 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Mir98
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,460,648 - 24,460,755 (+)NCBIGRCr8
mRatBN7.2X20,981,235 - 20,981,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX20,981,235 - 20,981,342 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX18,458,905 - 18,459,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,664,568 - 21,664,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X21,546,878 - 21,546,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X21,583,875 - 21,583,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,583,875 - 21,583,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X21,867,881 - 21,867,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX21,262,415 - 21,262,522 (+)NCBICelera
Cytogenetic MapXq13NCBI
MIR98
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,253,693 - 45,253,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,253,696 - 45,253,775 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X45,578,696 - 45,578,775 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X45,073,740 - 45,073,819 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,523,371 - 45,523,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,590,976 - 45,591,055 (-)NCBIUU_Cfam_GSD_1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system reproductive system
High
Medium
Low 5 1 2 1 9 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_038546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000021141
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX46,302,381 - 46,302,460 (-)Ensembl
RefSeq Acc Id: NR_038546
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X46,302,381 - 46,302,460 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000019546 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000021141 ENTREZGENE
miRBase MI0013122 ENTREZGENE
NCBI Gene MIR98 ENTREZGENE
RNAcentral URS00004E0808 RNACentral
  URS000075D5F6 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR98  microRNA mir-98    microRNA 98  Symbol and/or name change 5135510 APPROVED